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Quick Search     Adv Search 2022 Vol. 29, No. 22 Published: 2022-08-08   5 Effect of low-dose Colchicine on myocardial fibrosis in patients with primary hypertension complicated with hyperuricemia LI Zelun1 WU Jieying2 FENG Yanling3 HUANG Bingsheng3 ZHANG Peng3 CHENG Ying Objective To explore the effect of low-dose Colchicine on myocardial fibrosis in patients with primary hypertension complicated with hyperuricemia.Methods A total of 100 patients with primary hypertension complicated with hyperuricemia treated in Panyu Maternal and Child Care Service Centre of Guangzhou from January 2017 to June 2020 were selected as the research objects.According to random number table method,they were divided into control group (n=50) and observation group (n=50).Both groups were given routine antihypertensive and uric acid treatment.On this basis,the observation group was treated with low-dose Colchicine and the control group was treated with placebo.The levels of uric acid,high sensitivity C-reactive protein (hs-CRP) and related indexes of myocardial fibrosis(osteopontin [OPN],transforming growth factor β1 [TGF-β1],plasminogen activator blocking factor-1 [PAI-1],type Ⅰprocollagen carboxy terminal peptide [PⅠCP],type Ⅰprocollagen carboxy terminal cross-linking peptide [CⅠTP],type Ⅲprocollagen amino terminal peptide [PⅢNP]) were compared between the two groups before and after treatment.The left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF) were compared between the two groups before and after treatment.Results After 6 months and 12 months of treatment,uric acid and hs-CRP in the observation group were lower than those in the control group,with statistically significant differences (P＜0.05).After 12 months of treatment,the levels of OPN,TGF-β1,PAI-1,PⅠCP,CⅠTP and PⅢNP in the observation group were lower than those in the control group,with statistically significant differences (P＜0.05).After 12 months of treatment,LVEDD and LVESD in the observation group were lower than those in the control group,and LVEF was higher than that in the control group,with statistically significant differences (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Low-dose Colchicine can effectively delay myocardial fibrosis in patients with primary hypertension complicated with hyperuricemia.It has high security. 2022 Vol. 29 (22): 5-9 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 10 Effect of Sacubitril Valsartan Sodium in the treatment of patients with maintenance hemodialysis combined with heart failure WEN Jing LIU Yan Objective To observe the clinical effect and adverse reactions of Sacubitril Valsartan Sodium in the treatment of patients with maintenance hemodialysis (MHD) combined with heart failure.Methods A total of 44 patients with MHD and heart failure who hospitalized in the Department of Nephrotic Rheumatism of the Central Hospital of Qianjiang from October 2017 to June 2019 were selected as the research subjects.They were divided into observation group and control group according to the random number table method,with 22 patients in each group.All patients received MHD and symptomatic support therapy,the observation group was treated with Sacubitril Valsartan Sodium on this basis.The total effective rate and the total incidence of adverse reactions during the treatment of two groups were compared,at the same time,the cardiac function indexes such as left ventricular end systolic diameter (LVESD),left ventricular end diastolic diameter (LVEDD),stroke volume (SV),left ventricular ejection fraction (LVEF) and the expression levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP),angiotensin Ⅱ(Ang Ⅱ),aldosterone(ALD) in the two groups before and after treatment were detected.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant (P＜0.05).There were no significant differences in cardiac function indexes between two groups before treatment (P＞0.05).After treatment,the LVEF and SV of two groups were higher than those of before treatment,the LVESD and LVEDD of two groups were lower than those before treatment,the LVEF and SV in observation group were higher than those of control group,and the LVESD and LVEDD in observation group were lower than those of control group,the differences were statistically significant(P＜0.05).There were no significant differences in the expression levels of cytokines between the two groups before treatment (P＞0.05).After treatment,the expression levels of cytokines such as NT-proBNP,Ang Ⅱ,ALD were lower than those of before treatment,and the indexes of observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The efficacy of Sacubitril Valsartan Sodium in the treatment of MHD patients with heart failure is significant,which can not only effectively inhibit ventricular remodeling,but also significantly improve the neuroendocrine status,and has a high safety and reliability. 2022 Vol. 29 (22): 10-13转17 [Abstract] ( 23 ) HTML (1 KB)  PDF (599 KB)  ( 82 ) 14 Application effect of acupuncture combined with Guipi Pills in frequent episodic tension-type headache HONG Yingdong； CHEN Ying； YU Renyu； GAO Qianren； CHEN Yifan； HUANG Jianbin Objective To explore the application effect of acupuncture combined with Guipi Pills in frequent episodic tension-type headache (FETTH).Methods A total of 50 FETTH patients admitted to the People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January to December 2021 were selected as the research subjects,and they were divided into experimental group (25 cases) and control group (25 cases) by random number table method.The patients in the experimental group were treated with acupuncture and oral Guipi Pills,and the patients in the control group were treated with oral Flupentixol and Melitracen Tablets.The headache visual analogue scale (VAS)score and headache symptom score were compared between the two groups.Results There was no significant difference in headache VAS score between the two groups before treatment (P＞0.05).The headache VAS score after treatment of two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).However,there was no significant difference of headache VAS sccore between the two groups after treatment (P＞0.05).There were no significant differences in the scores of headache symptoms between the two groups before treatment (P＞0.05).After treatment,the scores of headache symptoms in both groups were lower than those before treatment,the differences were statistically significant (P＜0.05).However,there were no significant differences in the scores of headache symptoms between the two groups after treatment (P＞0.05).Conclusion Acupuncture combined with Guipi Pills can effectively improve the headache symptoms of FETTH patients,and the curative effect is equivalent to that of Flupentixol and melitracen tablets. 2022 Vol. 29 (22): 14-17 [Abstract] ( 21 ) HTML (1 KB)  PDF (543 KB)  ( 68 ) 18 A systematic review and meta-analysis of a single erector spinae plane block in reducing opioid consumption and postoperative nausea and vomiting after thoracoscopic surgery ZHAO Dan1 ZHANG Quanyi1 WANG Hongkun Objective To evaluate the effect of erector spinae plane block (ESPB) in reducing opioid consumption and nausea and vomiting after thoracoscopic surgery.Methods In accordance with the retrieval strategies,two independent researchers conducted a series of studies in China Biomedical Literature Database,CNKI,Wanfang Database,VIP Database,PubMed,Web of Science,Embase and Cochrane randomized controlled trials (RCT) comparing general anesthesia combined with ESPB (ESPB group) and general anesthesia alone without block (control group) for thoracoscopic surgical analgesia were searched from Library Chinese and English database until January 1,2022.Outcomes included:①Incidence of postoperative nausea and vomiting;②The amount of postoperative opioid analgesics;③Pain scores at each time after surgery.Meta-analysis was performed using RevMan 5.4 and Stata 16.0 software.Results A total of 16 RCTs were included,including 1148 patients.There was no significant difference in the incidence of postoperative nausea and vomiting (PONV) 24 h after surgery between the ESPB group and the control group (relative risk [RR]=0.62,95%confidence interval [CI]=0.37-1.02,P=0.06).The incidence of postoperative PONV in the ESPB group was lower than that in the control group,and the difference was statistically significant (RR=0.47,95%CI=0.34-0.66,P＜0.001).The postoperative resting pain score and postoperative cough or exercise pain score in the ESPB group were lower than those in the control group,and the differences were statistically significant (P ＜0.05).The use of opioids in ESPB group was lower than that in the control group at 24 h postoperatively,the difference was statistically significant (mean difference [MD]=-17.48,95%CI=-18.66 to -16.30,P＜0.000 01),and the use of opioids at 48 h postoperatively was lower than that in the control group,the difference was statistically significant (MD=-17.31,95%CI=-19.72 to -14.89,P＜0.000 01).Conclusion The erector spinae plane block reduced pain scores and the incidence of postoperative nausea and vomiting in thoracoscopic patients 48 h after surgery,and significantly reduced the use of postoperative opioids in patients. 2022 Vol. 29 (22): 18-24 [Abstract] ( 23 ) HTML (1 KB)  PDF (1129 KB)  ( 24 ) 25 Research progress on pharmacological action and clinical application of Yishen Huashi Granules WU Lingling1 CHEN Yong2▲ LI Cairong1 LIU Xinran Yishen Huashi Granules is a traditional Chinese medicine preparation,from Li Gao′s "Shengyang Yiwei Decoction" of Treatise On The Spleen And Stomach contains ginseng,astragalus membranaceus,Rhizoma Atractylodis Macrocephalae,poria cohoe and Alisma orientale(Sam.)Juzep and other more than 10 kinds of traditional Chinese medicine ingredients,the whole prescription has the effect of rising yang tonifying spleen,tonifying kidney and dampness,benefiting water and swelling.Modern pharmacological studies have found that Yishen Huashi Granules have strong anti-inflammatory,anti-apoptosis,immune regulation and anti-oxidative stress and other pharmacological effects.Kidney is wet particles is mainly used for clinical treatment of chronic glomerulonephritis (CGN),can also be used in the treatment of diabetic nephropathy (DN),nephrotic syndrome (NS),membranous nephropathy (MN),henoch-schnlein purpura nephritis (HSPN),with lupus nephritis (LN),uremia and nutcracker syndrome (NCS),and other kidney disease,can significantly improve renal function,and achieved a good effect.In this paper,the pharmacological mechanism and clinical application of Yishen Huashi Granules will be systematically combed and elaborated in order to provide reference for further research and clinical application of Yishen Huashi Granules. 2022 Vol. 29 (22): 25-28 [Abstract] ( 21 ) HTML (1 KB)  PDF (439 KB)  ( 82 ) 29 Research advance of microRNAs and oligometastatic cancers LI Baobao GUO Aihong▲ WANG Bingju WU Manling LI Shan LU Zhaoying HAO Yingzi Currently,the oligometastatic state of tumor is generally regarded as an intermediate stage between primary tumor and widespread spread.With the deepening of the understanding of oligometastatic tumor and the rapid development of functional imaging,the diagnosis of oligometastatic tumor is increasing.At the same time,it has been found in recent years that microRNAs can be involved in the process of tumor oligometastasis as an important regulation molecule of metastasis.However,people′s understanding of the biology of tumor metastasis and the molecular mechanism that drives the formation of tumor oligometastasis is still limited.In this paper,based on the introduction of microRNAs at home and abroad in recent ten years and the research on microRNAs in oligosaccharide metastasis,the definition of oligosaccharide metastasis,the role of microRNAs in oligosaccharide metastasis and the mechanism and function of target molecules,as well as the clinical value of microRNAs in oligosaccharide metastasis are summarized.The future development and challenges of microRNAs in precise diagnosis and treatment of tumors are prospected. 2022 Vol. 29 (22): 29-32转37 [Abstract] ( 22 ) HTML (1 KB)  PDF (777 KB)  ( 38 ) 33 Advances in gender differences of psychological stress induced myocardial ischemia LI Ziyi1 NAN Nan2 SONG Xiantao At present,the research on the gender differences in mental stress induced myocardial ischemia (MSIMI)shows that the gender of patients could be an important factor affecting the incidence and treatment of MSIMI,and the morbidity of female is higher.Many studies have found that the incidence of MSIMI in women is higher than that in men due to coronary artery microcirculation disorders,high platelet reactivity and hormone/inflammatory factors when facing psychological stress.Recent study found that,differ from men,women are prone to have symptoms like angina,anxiety and depression which can aggravate coronary artery microcirculation disorders.These symptoms are considered to be susceptible factors for patients to develop MSIMI.Therefore,relying on the evaluation of the condition of coronary artery microcirculation to predict the occurrence of MSIMI and providing psychological decompression intervention to alleviate the symptoms of female patients are of great significance in the future clinical research.In addition,nuclear medicine examination and echocardiography are mainly used in the diagnosis of MSIMI.Existing studies have shown that the rate of MSIMI in female patients detected by echocardiography is higher than that in men.This article reviews the progress about the mechanism,concomitant symptoms,diagnostic methods and future research direction of gender differences in MSIMI.The purpose of this review is to summarize the existing experience and provide a basis for follow-up clinical research. 2022 Vol. 29 (22): 33-37 [Abstract] ( 21 ) HTML (1 KB)  PDF (451 KB)  ( 46 ) 38 Application effect of ultra-early enteral nutrition in patients with severe acute pancreatitis QU Qian LU Man LI Lanqing Objective To investigate the application effect of ultra-early enteral nutrition in the treatment of severe acute pancreatitis.Methods A total of 100 patients with severe acute pancreatitis admitted to the Second People′s Hospital of Foshan City from January 2017 to December 2021 were retrospectively selected as the research objects.They were divided into the experimental group and the control group according to the start time of enteral nutrition therapy,50 cases in each group.The experimental group was given ultra-early intervention,the patients were given enteral nutrition at 24-48 hours after the onset,the control group was given delayed intervention,and the patients were given enteral nutrition at ＞48-72 hours after the onset.The total effective rate,C-reactive protein (CRP),albumin,serum amylase recovery time,serum lipase recovery time,hospitalization time,acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) scores and complications were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in CRP and albumin levels between the two groups (P＞0.05).After treatment,the CRP levels of the two groups were lower than those before treatment,the albumin levels of the two groups were higher than those before treatment,and the CRP level of the experimental group was lower than that of the control group,and the albumin level of the experimental group was higher than that of the control group,the differences were statistically significant (P＜0.05).The serum amylase recovery time,serum lipase recovery time,hospitalization time in the experimental group were shorter than those in the control group,the differences were statistically significant (P＜0.05).Before treatment,there was no significant difference in APACHEⅡscore between the two groups (P＞0.05).After treatment,the APACHEⅡscores of the two groups were lower than those before treatment,and the APACHEⅡscore of the experimental group was lower than that of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of complications between the two groups (P＞0.05).Conclusion Compared with delayed intervention,ultra-early enteral nutrition can more effectively improve the nutritional level and inhibit the inflammatory reaction of severe acute pancreatitis patients,and is conducive to the recovery of patients.It is worthy of clinical application. 2022 Vol. 29 (22): 38-41 [Abstract] ( 24 ) HTML (1 KB)  PDF (561 KB)  ( 30 ) 42 Application of intelligent dispensing robot in clinical intravenous infusion dispensing DAI Lingyu PENG Lijuan FENG Yuanyu BAO Ruizhi WANG Ling SUN Yongmei Objective To explore the application effect of intelligent dispensing robot in clinical intravenous infusion dispensing.Methods A total of 86 nurses performed intravenous infusion dispensing in Peking University Shenzhen Hospital from March to June 2021 were selected and divided into the control group and the experimental group according to the random number table method,with 43 nurses in each group.The control group used conventional artificial drug configuration,while the experimental group used intelligent dispensing robot for drug configuration.The dispensing time,drug residue,dispensing error rate,drug leakage rate,and health injury incident rate were compared between the two groups.Results The dispensing time of the experimental group was longer than that of the control group,and the drug residue of the experimental group was less than that of the control group,the differences were statistically significant (P＜0.05).The dispensing error rate and drug leakage rate in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).The incidence rates of fatigue,ampule bottle scratch,finger chaps and syringe puncture in the experimental group were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion In clinical intravenous infusion dispensing,the use of intelligent dispensing robots by nurses can effectively ensure the safety and accuracy of patients′ medication,avoid dispensing errors,and reduce the risk of occupational injury for clinical nurses,which is worthy of popularization and application. 2022 Vol. 29 (22): 42-45转49 [Abstract] ( 20 ) HTML (1 KB)  PDF (645 KB)  ( 199 ) 46 Effect of vitamin D on fertility in women with polycystic ovary syndrome LI Yan WU Jingli CAO Dan LI Yue LI Jiena Objective To explore the effect of vitamin D on fertility indexes in women with polycystic ovary syndrome(PCOS).Methods A total of 270 infertile women with 25 hydroxyvitamin D level less than 20 ng/L admitted to department of gynecology and obstetrics in Heze Municipal Hospital from December 2019 to May 2021 were selected as the research objects.They were divided into vitamin D group and placebo group according to random number table method,with 135 cases in each group.The subjects in vitamin D group were divided into group A (n=75) and group B (n=60)according to whether they had PCOS.The subjects in the placebo group were divided into group C (n=75) and group D(n=60) according to whether they had PCOS.The levels of 25 hydroxyvitamin D,follicle-stimulating hormone (FSH),luteinizing hormone (LH),LH/FSH,anti-mullerian hormone (AMH),dehydroepiandrosterone sulfate (DHEAS) and estradiol were compared between the two groups.Menstrual recovery,ovulation and pregnancy were compared between group A and group C.Results The levels of 25 hydroxyvitamin D,FSH and DHEAS in group A were higher than those in group C,and the LH/FSH in group A was lower than that in group C,the differences were statistically significant(P＜0.05).There were no significant differences in the levels of LH,AMH and estradiol between group A and group C(P＞0.05).The level of 25 hydroxyvitamin D in group B was higher than that in group D,the difference was statistically significant (P＜0.05).There were no significant differences in the levels of FSH,LH,LH/FSH,AMH,estradiol and DHEAS between group B and group D (P＞0.05).The menstrual recovery rate and ovulation rate in group A were higher than those in group C,the differences were statistically significant (P＜0.05).There was no significant difference in pregnancy rate between group A and group C (P＞0.05).Conclusion Vitamin D may improve the level of endocrine hormone in women with PCOS,and have beneficial effect on fertility index. 2022 Vol. 29 (22): 46-49 [Abstract] ( 21 ) HTML (1 KB)  PDF (538 KB)  ( 51 ) 50 Effect of Metronidazole Gel combined with Doxycycline in the treatment of rosacea and its influence on patients′ symptom scores FANG Xing Objective To investigate the effect of Metronidazole Gel combined with Doxycycline in the treatment of rosacea and its influence on the patients′ symptom scores.Methods A total of 91 patients with rosacea who were admitted to Changzhou Center for Disease Control and Prevention from January to July 2020 were selected as subjects and divided into a control group (n=45) and an observation group (n=46) by random number table method.The patients in the control group were treated with Doxycycline,and the patients in the observation group were treated with Metronidazole Gel combined with Doxycycline.The clinical efficacy,skin condition and symptom scores before and after treatment were compared between the two groups.In addition,the adverse drug reactions were compared between the two groups.Results The total effectiveness rate in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no statistical differences in the skin condition and symptoms scores between the two groups (P＞0.05).After treatment,the water content of the stratum corneum in the observation group was higher than that of the control group,and the pH value,transepidermal water loss,skin erythema index,pruritus score,papule-pustule score,and erythema score in the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Metronidazole Gel combined with Doxycycline is effective in the treatment of patients with rosacea,and it has obvious effect on improving skin condition and clinical symptoms,and will not result in the adverse drug reactions.It has promotion value. 2022 Vol. 29 (22): 50-53 [Abstract] ( 22 ) HTML (1 KB)  PDF (526 KB)  ( 252 ) 54 Application effect of wearable long-term remote electrocardiogram monitor and traditional 24 h dynamic electrocardiogram in the diagnosis of senile arrhythmia GUO Guangyao1 ZHANG Yulan1▲ YU Yuanyuan1 XU Jingjing2 ZHANG Zhiguo1 OU Limin Objective To explore the application effect of wearable long-term remote electrocardiogram monitor and traditional 24 h dynamic electrocardiogram in the diagnosis of senile arrhythmia.Methods The clinical data of 150 elderly patients with cardiovascular disease in Fuzhou Seventh Hospital from October 2020 to September 2021 were retrospectively analyzed.According to different electrocardiogram monitor methods,they were divided into the control group,the observation group A and the observation group B,with 50 cases in each group.The control group was monitored by traditional 24 h dynamic electrocardiogram,and the observation group A and the observation group B were monitored by wearable long-term remote electrocardiogram monitor for 24 and 72 hours respectively.The detection rate of arrhythmia events and the incidence of adverse reactions were compared among the three groups.Results There was significant difference in the detection rate of arrhythmia events between the control group,the observation group A and the observation group B (P＜0.001).There was no significant difference in the detection rate of arrhythmia events between the control group and the observation group A (P＞0.05).The detection rate of arrhythmia events in the observation group B was higher than that in the control group and the observation group A,and the differences were statistically significant (P＜0.017).There were no significant differences in the incidence of erythema,edema,itching and pain among the three groups during the monitoring period (P＞0.05).Conclusion Compared with the traditional 24 h dynamic electrocardiogram,the wearable long-term remote electrocardiogram monitor can better detect arrhythmia in elderly patients with cardiovascular disease,and there is no obvious adverse reaction during the monitoring period,and the operation safety is higher. 2022 Vol. 29 (22): 54-56 [Abstract] ( 22 ) HTML (1 KB)  PDF (460 KB)  ( 95 ) 57 Influencing factors of quality of life in patients with recurrent coronary heart disease WANG Xiaobo LIU Jinping Objective To explore the influencing factors of quality of life in patients with recurrent coronary heart disease.Methods A total of 121 patients with recurrent coronary heart disease treated in Dalian Friendship Hospital from April 2018 to April 2019 were selected as research objects according to convenient sampling.The data was collected and sorted out,and the risk factors affecting their quality of life was analyzed.Results The total score of Chinese cardiovascular quality of life questionnaire (CQQC) in patients with recurrent coronary heart disease was(84.65±21.65) points,which was in the middle level.Univariate analysis showed that education level,family income per month,payment of medical expenses,hypertension,smoking history,diabetes mellitus and social support were related to the quality of life of patients with recurrent coronary heart disease (P＜0.05).Marital status,age,educational level,gender,course of disease,cardiac function grade and hyperlipidemia were not related to the quality of life of patients with recurrent coronary heart disease (P＞0.05).The results of multiple linear regression analysis showed that the risk factors of quality of life in patients with recurrent coronary heart disease were medical expenses,self education,education level,high school and below,smoking history,family per capita income less than 3000 yuan,diabetes mellitus,hypertension,resilience＜70 points,and social support＜45 points (P＜0.05).Conclusion The quality of life of patients with recurrent coronary heart disease is at a moderate level,which is influenced by the payment method of medical expenses,hypertension,education,smoking history,family income per month,diabetes mellitus and social support. 2022 Vol. 29 (22): 57-60 [Abstract] ( 21 ) HTML (1 KB)  PDF (455 KB)  ( 25 ) 61 Influence of antihypertensive regimen on the long-term prognosis of patients with hypertensive intracerebral hemorrhage WANG Yafei1 LU Lishan2 SU Changhai Objective To explore the influence of antihypertensive regimen on the long-term prognosis of patients with hypertensive intracerebral hemorrhage (HICH).Methods The case data of 324 patients with HICH discharged from Department of Neurosurgery of a class Ⅲhospital from January 1,2017 to December 31,2019 were retrospectively selected.According to the inclusion and exclusion criteria of this study,163 eligible patients were reviewed or followed up by telephone.The functional rating was performed with the modified Rankin Scale (mRS).The patients were divided into the good prognosis group (mRS＜3 points,72 cases) and the poor prognosis group (mRS≥3 points,91 cases).Firstly,the factors affecting the long-term prognosis of HICH were discussed by univariate analysis,and then the factors with P＜0.2 or close in the univariate analysis results were further analyzed by multivariate logistic regression analysis.Results Univariate analysis showed that age,drinking history,admission systolic blood pressure (SBP),chronic diseases before hospitalization,oral antihypertensive drugs (classes),Glasgow coma score (GCS) after admission,GCS score after discharge,multiple bleeding,history of antibiotic use after hospitalization and history of hematoma removal were significantly correlated with the poor prognosis of HICH patients,the differences were statistically significant (P＜0.05).Multivariate analysis by logistic regression model showed that there were chronic diseases before hospitalization (β=2.028,OR=7.597,95%CI=2.006-28.775) was an independent risk factor for poor prognosis in patients with HICH (P＜0.05).Oral antihypertensive drugs (class) (β=-0.889,OR=0.411,95%CI=0.215-0.787),discharge GCS score (β=-0.682,OR=0.506,95%CI=0.306-0.834) were protective factor for poor prognosis in patients with HICH (P＜0.05).Age (β=0.054,OR=1.055,95%CI=1.000-1.114) had a tendency to predict the poor prognosis of HICH (P=0.05).Conclusion After controlling the baseline level of patients including demographic characteristics,GCS score at discharge and factors of chronic diseases before hospitalization,this study found that the number of types of intravenous antihypertensive drugs and the course of intravenous administration have no significant impact on the long-term prognosis of HICH patients.The more types of oral antihypertensive drugs are used,the better the prognosis of patients may be. 2022 Vol. 29 (22): 61-65 [Abstract] ( 19 ) HTML (1 KB)  PDF (473 KB)  ( 27 ) 66 Relationship between intraventricular hemorrhage and prognosis of aneurysmal subarachnoid hemorrhage LIANG Rui ZHANG Guofeng TANG Youjia Objective To investigate the relationship between intraventricular hemorrhage(IVH)and prognosis of aneurysmal subarachnoid hemorrhage (aSAH).Methods A total of 60 aSAH patients with IVH admitted to the Department of Neurosurgery of Jiujiang First People′s Hospital,Jiangxi Province from January 2016 to January 2021 were selected as the research subjects.All patients were treated for aneurysm after completing examination after admission,and the score of total subarachnoid hemorrhage (SAH) and IVH volume were calculated.According to prognosis level by modified Rankin rating scale (mRS),sixty patients were divided into good prognosis group (mRS grade was 0 to 2,n=42) and poor prognosis group (mRS grade was 3 to 6,n=18).Receiver operating characteristic curve (ROC) was used to analyze the predictive value of score of total SAH and IVH volume for poor prognosis of aSAH patients with IVH.Results There was no significant difference in aneurysm size between the good prognosis group and the poor prognosis group(P＞0.05).The score of total SAH and IVH volume in the good prognosis group were lower than those in the poor prognosis group,with statistically significant differences (P＜0.05).The AUC of score of total SAH and IVH volume in predicting poor prognosis was 0.676 and 0.702,respectively,and the predictive value of combined detection was higher(AUC=0.823,95%CI=0.710-0.935,P＜0.001).Conclusion The score of total SAH and IVH volume of aSAH patients with IVH patients with good prognosis were lower than those with poor prognosis.Clinically,score of total SAH and IVH volume can be combined to improve the diagnostic efficiency of poor prognosis. 2022 Vol. 29 (22): 66-69 [Abstract] ( 18 ) HTML (1 KB)  PDF (673 KB)  ( 28 ) 70 Comparative study of long-term efficacy and comprehensive quality of life between Agomelatine and Paroxetine in the patients with depression SHEN Liancheng1 LI Zunqing1 LI Longfei1 LI Mingzhen2 HAN Peng Objective To compare the long-term efficacy and comprehensive quality of life between Agomelatine and Paroxetine in the patients with depression.Methods A total of 64 patients with depression who were hospitalized in the Department of Psychiatry,Shandong Daizhuang Hospital from March 2018 to March 2020 were selected as the research subjects,and they were divided into study group (33 cases) and control group (31 cases) by coin toss method.Patients in the study group were treated with agomelatine Antidepressant,and patients in the control group were treated with Paroxetine antidepressant.The clinical rehabilitation effects of the two groups were compared by Hamilton depression scale (HAMD) and medical outcomes study short-form 36 (SF-36) at admission,discharge and 1 year after discharge,respectively.Results At admission and discharge,there were no statistically significant differences in HAMD and SF-36 scores between the two groups (P＞0.05).One year after discharge,the total HAMD score in the study group was lower than that in the control group,the difference was statistically significant (P＜0.05).One year after discharge,the total score of SF-36 in the study group was higher than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Agomelatine has better long-term efficacy than Paroxetine in the treatment of depression,it can not only improve the clinical symptoms effectively and stabilize the condition,but also has advantages in improving the quality of life. 2022 Vol. 29 (22): 70-73 [Abstract] ( 23 ) HTML (1 KB)  PDF (675 KB)  ( 46 ) 74 Clinical study on endovascular treatment of intracranial arterial stenosis LUO Xiaohui LIAO Yuping JIANG Beibei Objective To investigate the clinical effect of endovascular treatment for intracranial arterial stenosis.Methods The clinical data of 90 patients with intracranial artery stenosis admitted to Xinyu People′s Hospital from January 2018 to June 2020 were retrospectively analyzed.According to different treatment methods,they were divided into stent implantation group (n=49) and drug treatment group (n=41).The drug treatment group received Aspirin Enteric-Coated Tablets and Clopidogrel orally,and the stent implantation group received intracranial vascular stent implantation on the basis of the drug treatment group.National Institutes of Health stroke scale (NIHSS) score,total incidence of complications and recurrence rate were compared between the two groups.Results The NIHSS score after treatment in the stent implantation group ([8.14±0.98] points) was lower than that in the drug treatment group ([15.46±2.20] points),and the difference was statistically significant (P＜0.05).The total incidence of complications in the stent implantation group (4.08%) was lower than that in the drug treatment group (21.95%),the difference was statistically significant (P＜0.05).The recurrence rate of patients in the stenting group (4.08%) was lower than that in the drug treatment group (26.83%),and the difference was statistically significant (P＜0.05).Conclusion Compared with oral drug therapy,intracranial vascular stent implantation in the treatment of intracranial artery stenosis can achieve better clinical effect,can effectively reduce the neurological impairment,and has fewer complications,lower recurrence rate,and high efficacy,which is worthy of promotion and application. 2022 Vol. 29 (22): 74-76转80 [Abstract] ( 22 ) HTML (1 KB)  PDF (651 KB)  ( 55 ) 77 Risk factors and prognosis of transient ischemic attack in the elderly LOU Qiuying LUO Chunxiang Objective To explore the risk factors and prognosis of transient ischemic attack (TIA) in the elderly.Methods The clinical data of 84 patients with TIA reated in the Second Affiliated Hospital of Nanchang University from September 2018 to September 2021 were analyzed retrospectively.They were divided into young and middle-aged group (≤65 years old,n=34) and elderly group (＞65 years old,n=50).The general data,blood lipid,blood glucose index level and prognosis of the two groups were collected,logistic regression was used to analyze the risk factors of TIA in the elderly.Results The ratio of diabetes in the elderly group (44.00%) was higher than that in the young and middle-aged group (14.71%),and the difference was statistically significant (P＜0.05).The levels of triglyceride (TG),fasting blood glucose (FBG),cholesterol (CHO) and low-density lipoprotein cholesterol (LDL-C) in the elderly group were higher than those in the young and middle-aged group,and the levels of high-density lipoprotein cholesterol (HDL-C)were lower than those in the young and middle-aged group (P＜0.05).Logistic regression analysis showed diabetes mellitus (β=1.334,OR=1.982,95%CI=1.318-2.984),CHO (β=3.853,OR=1.748,95%CI=1.361-2.937),HDL-C (β=2.841,OR=2.328,95%CI=1.472-3.386),LDL-C (β=1.596,OR=1.853,95%CI=1.653-2.740),FBG (β=0.967,OR=1.263,95%CI=1.037-3.194) were independent risk factors for transient ischemic attack in the elderly (P＜0.05).The incidence of serious vascular events within 90 days after the disease in the elderly group was higher than that in the young and middle-aged group,and the difference was statistically significant(P＜0.05).Conclusion Diabetes,CHO,HDL-C,LDL-C and FBG are the high risk factors of TIA.Early treatment should be taken to improve the prognosis of patients with TIA. 2022 Vol. 29 (22): 77-80 [Abstract] ( 24 ) HTML (1 KB)  PDF (642 KB)  ( 36 ) 81 Application of Aripiprazole combined with Risperidone in first-episode schizophrenia patients YANG Lei MAO Weiwei TU Xiaofang Objective To explore the application effect of Aripiprazole combined with Risperidone in patients with first-episode schizophrenia.Methods A total of 80 patients with first-episode schizophrenia admitted to the Third People′s Hospital of Ganzhou City from January 2021 to October 2021 were selected as the research object,and they were divided into the study group and the control group by random number table method,with 40 cases in each group.The control group was given Aripiprazole,and the study group was given Risperidone on the basis of the control group.The clinical efficacy,glucose and lipid metabolism (fasting blood glucose [FBG],glycosylated hemoglobin [HbA1c],triglyceride [TG],serum total cholesterol [TC]),electrocardiogram indexes (heart rate [HR],PR interval,QTc interval) and adverse reactions were compared between the two groups.Results The total effective rate of study group (87.50%) was higher than that of control group (67.50%),and the difference was statistically significant (P＜0.05).After 8 and 12 weeks of treatment,FBG,HbA1c,TG and TC in the two groups were higher than those before treatment,and the differences were statistically significant (P＜0.05).After 8 and 12 weeks of treatment,the HR in the two groups were higher than those before treatment,the PR and QTc intervals were longer than those before treatment,the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the study group (20.00%) and the control group (15.00%) (P＞0.05).Conclusion The combination of Aripiprazole and Risperidone in the treatment of first-episode schizophrenia can improve the curative effect,glucose and lipid metabolism and electrocardiogram index,which is safe and should be paid attention to clinically. 2022 Vol. 29 (22): 81-84 [Abstract] ( 25 ) HTML (1 KB)  PDF (642 KB)  ( 26 ) 85 Application effect of psychosocial intervention with adjuvant Zirazidone treatment in adolescent schizophrenia SONG Liu1 YU Suwei Objective To explore the application effect of psychosocial intervention with adjuvant Zasidone treatment in adolescent schizophrenia (SCH).Methods A total of 88 adolescent schizophrenia SCH patients admitted to the Fourth People′s Hospital of Yingkou City from July 2019 to July 2020 were selected as the study subjects.They were divided into the drug group and the adjuvant intervention group according to random number table method,with 44 cases in each group.The drug group was treated with Zirasidone orally,while the adjuvant intervention group performed a psychosocial intervention on the basis of taking Zirasidone.The clinical efficacy,insight and social function before and after treatment were compared between the two groups.Results The total effective rate of the adjuvant intervention group after treatment was higher than that of the drug group,the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the social disability screening schedule (SDSS) score and the insight and treatment attitude questionnaire (ITAQ) scores between the two groups (P＞0.05).After treatment,the scores of SDSS and ITAQ of the two groups were all lower than those before treatment,and the differences were statistically significant (P＜0.05).The scores of SDSS and ITAQ of the adjuvant intervention group after treatment were lower than those in the drug group,and the differences were statistically significant (P＜0.05).Conclusion For the adolescent children with SCH,psychosocial intervention with adjuvant Zirazidone treatment can improve their social function and self-knowledge state,and help to improve the clinical efficacy. 2022 Vol. 29 (22): 85-87 [Abstract] ( 19 ) HTML (1 KB)  PDF (630 KB)  ( 105 ) 88 Application effect of intravenous thrombolysis with recombinant tissuetype plasminogen activator combined with interventional therapy in patients with acute ischemic stroke SUN Yongjin PIAO Xiangyu Objective To investigate the application effect of intravenous thrombolysis with recombinant tissue-type plasminogen activator combined with interventional therapy in patients with acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke in Zhongshan Hospital Affiliated to Dalian University from January 2018 to may 2021 were selected as the research object.They were divided into the control group (50 cases) and the observation group (50 cases) according to the random number table method.The patients in the control group received intravenous thrombolysis with recombinant tissue-type plasminogen activator,the patients in the observation group received intravenous thrombolysis with recombinant tissue-type plasminogen activator combined with interventional therapy.The clinical efficacy,the severity of dysfunction (modified Rankin scale [MRS]),the ability of self-care (modified Barthel index [MBI]),the level of cerebral hemodynamics before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the MRS score,MBI score,cerebral blood flow velocity,minimum blood flow and dynamic impedance between the two groups (P＞0.05).After treatment,the MRS score of the observation group was lower than that of the control group,the MBI score,cerebral blood flow velocity,minimum blood flow and dynamic impedance in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Intravenous thrombolytic therapy with recombinant tissue-type plasminogen activator combined with interventional therapy has a good effect on patients with acute ischemic stroke,which can significantly improve their functional disorders and cerebral hemodynamic indexes,and promote the recovery of self-care ability,with fewer adverse reactions,and has a higher clinical promotion value. 2022 Vol. 29 (22): 88-91 [Abstract] ( 24 ) HTML (1 KB)  PDF (636 KB)  ( 153 ) 92 Comparison of clinical results of neuroendoscopic and microscopic pituitary tumor resection YANG Daoming LUO Wenwei ZHANG Chunlin WU Xiaolong Objective To compare the clinical effect of neuroendoscopic and microscopic resection of pituitary tumor.Methods A total of 136 patients with pituitary tumor admitted to the First Hospital of Nanping from February 2016 to June 2021 were selected as the research subjects.They were divided into the neuroendoscopy group and the microscope group according to random number table method,with 68 cases in each group.The neuroendoscopy group was operated by neuroendoscopy,and the microscope group was operated by microscope.The indicators of operation (operation time,intraoperative bleeding,postoperative hospital stay),changes of postoperative blood hormone levels and whether the tumor was completely removed were compared between the two groups.Results There was no significant difference in intraoperative bleeding between the two groups (P＞0.05).The postoperative hospital stay in neuroendoscopy group was shorter than that in microscope group,and the difference was statistically significant (P＜0.05).There was no significant difference in operation time between the two groups (P＞0.05).The hormone recovery rate of ≥50% in the neuroendoscope group was higher than that in the microscope group,and the difference was statistically significant (P＜0.05).The complete tumor resection rate in the neuroendoscopy group was higher than that in the microscope group,the difference was statistically significant (P＜0.05).Conclusion Neuroendoscopic excision of pituitary tumor has better effect on hormone rehabilitation than microscopical operation. 2022 Vol. 29 (22): 92-94 [Abstract] ( 21 ) HTML (1 KB)  PDF (627 KB)  ( 35 ) 95 Clinical effect of Sizi Powder hot compress combined with rehabilitation training in the treatment of upper limb spastic hemiplegia after stroke JIANG Meiling Objective To investigate the clinical effect of Sizi Powder hot compress combined with rehabilitation training in the treatment of upper limb spastic hemiplegia after stroke.Methods A total of 60 stroke patients with upper limb spastic hemiplegia who were admitted to the Department of Rehabilitation Medicine of The Fifth Affiliated(Zhuhai) Hospital of Zunyi Medical University from September 2019 to September 2021 were selected as the subjects.They were divided into experimental group and control group by random number table method,with 30 patients in each group.Patients in the control group received routine rehabilitation training,and patients in the experimental group were combined with Sizi Powder hot compress treatment on the basis of routine rehabilitation training.The course of treatment was 3 weeks.The degree of upper limb spasm,the changes of the upper limb part of the Fugl-Meyer motor function scale for upper 1imb (FMA-U) score and the clinical efficacy were compared between the two groups.Results There were no significant differences in the degree of upper limb spasm and FMA-U score between the two groups before intervention (P＞0.05).After 3 weeks of intervention,the degree of upper limb spasm in experimental group was lighter than that in control group,and the difference was statistically significant (P＜0.05).The FMA-U score of experimental group after 3 weeks of intervention was higher than that of control group,and the difference was statistically significant (P＜0.05).The total effective rate of clinical treatment in experimental group was higher than that in control group,the difference was statistically significant (P＜0.05).Conclusion Sizi Powder hot compress combined with rehabilitation training can improve the spasm degree of spasmodic hemiplegia of upper limbs after stroke,and improve the upper limb motor function,the curative effect is better than conventional rehabilitation training. 2022 Vol. 29 (22): 95-98 [Abstract] ( 18 ) HTML (1 KB)  PDF (674 KB)  ( 82 ) 99 Application effect of percutaneous nephroscopy in ureteral calculi LIU Renfu HUANG Shaoming XIONG Chuanchuan Objective To investigate application effect of percutaneous nephroscopy in patients with ureteral calculi.Methods A total of 84 patients with ureteral calculi treated in Ganzhou Municipal Hospital of Jiangxi Province from March 2017 to June 2021 were selected as the research objects.They were divided into the control group (n=42) and the observation group (n=42) according to random number table method.The control group was treated by ureteroscopy and the observation group was treated by percutaneous nephroscopy.The renal function related indexes [creatinine (Cr),glomerular filtration rate (GFR),blood urea nitrogen (BUN)],visual analogue scale (VAS),clinical indexes,stone clearance rate and postoperative complications were compared between the two groups.Results Before operation,there were no significant differences in Cr,GFR and BUN levels between the two groups (P＞0.05).One week after operation,the levels of Cr and BUN in the two groups were lower than those before operation,the GFR in the two groups was higher than that before operation,and the BUN level in the observation group was lower than that in the control group,the differences were statistically significant (P＜0.05).Before operation,there was no significant difference in VAS score between the two groups (P＞0.05).One week after operation,the VAS scores of the two groups were lower than those before operation,and the VAS score of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).The intraoperative blood loss of the observation group was more than that of the control group,the hospital stay of the observation group was longer than that of the control group,and the stone clearance rate of the observation group was higher than that of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in operation time between the two groups (P＞0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Percutaneous nephroscopy in the treatment of patients with ureteral calculi has the advantages of less complications,high stone clearance rate and improving renal function,but there is a risk of massive hemorrhage. 2022 Vol. 29 (22): 99-102 [Abstract] ( 21 ) HTML (1 KB)  PDF (444 KB)  ( 43 ) 103 Correlation between serum C-reactive protein,neutrophil-to-lymphocyte ratio and infectious peritonitis in uremic peritoneal dialysis patients QIU Meirong QIU Meilan LIANG Yufeng LAN Meijin Objective To investigate the correlation between serum C-reactive protein (CRP),neutrophil-to-lymphocyte ratio (NLR) and the occurrence of infectious peritonitis (SP) in uremic peritoneal dialysis (PD) patients.Methods A total of 196 patients with uremia received PD treatment in the Second Hospital of Longyan City from January 2018 to December 2020 were selected as the research objects,and they were divided into two groups according to whether they had SP or not,and 42 patients with SP were set as the observation group,154 patients without SP were set as the control group.The convenient sampling method was used.The serum CRP and NLR levels of the two groups were compared,and the correlation between the serum CRP and NLR levels and the occurrence of SP was analyzed,as well as the value of CRP and NLR in evaluating SP.Results The levels of serum CRP and NLR in the observation group were higher than those in the control group,and the difference was statistically significant (P＜0.05).Serum CRP and NLR levels were positively correlated with the occurrence of SP (P＜0.05).The area under curve (AUC) of CRP for the diagnosis of SP was 0.838 (95% confidence interval: 0.760-0.916),the sensitivity was 0.806,and the specificity was 0.833;the AUC of NLR for diagnosing SP was 0.867 (95% confidence interval: 0.786-0.948),the sensitivity was 0.871,and the specificity was 0.858.Conclusion Serum CRP and NLR levels are closely related to the occurrence of SP in uremic PD patients. 2022 Vol. 29 (22): 103-105 [Abstract] ( 20 ) HTML (1 KB)  PDF (442 KB)  ( 119 ) 106 Application effect of ultrasound-guided serratus anterior plane block in the resection of mediastinal tumors through right thoracotomy YUAN Lei ZENG Jianqiang HUANG Jinhua Objective To explore the application effect of ultrasound-guided serratus anterior plane block (SAPB) in mediastinal tumor resection with right thoracotomy and single lung ventilation.Methods A total of 40 patients with mediastinal tumor resection under general anesthesia through right thoracotomy and one-lung ventilation who were admitted to Ganzhou Cancer Hospital from January 2020 to December 2021 were selected as the research subjects,and they were divided into SAPB group (group S) and thoracic epidural block group (group E) using random number table method,with 20 cases in each group.Group S underwent the left lateral decubitus position after double-lumen bronchial intubation under general anesthesia,followed by ultrasound-guided anterior serratus muscle deep plane block.Group E had anterior thoracic epidural puncture and catheterization before anesthesia.The heart rate (HR) and mean arterial pressure (MAP) at entry (T1),5 min after thoracotomy (T2) and 5 min after thoracotomy (T3) were compared between the two groups.The visual analogue scale (VAS) score at 4,8 and 12 h after thoracotomy were compared between the two groups.Results At T2 and T3,the levels of MAP and HR in group E were lower than those in group S,with statistical significances (P＜0.05).The VAS score at 4 and 8 h after surgery in group E were lower than those in group S,with statistical significances (P＜0.05).Conclusion Ultrasound-guided SAPB has the same analgesic effect as thoracic epidural block after mediastinal tumor resection through right thoracotomy,but ultrasound-guided SAPB can better stabilize patients′ vital signs during surgery,which is worthy of clinical application. 2022 Vol. 29 (22): 106-109 [Abstract] ( 22 ) HTML (1 KB)  PDF (508 KB)  ( 12 ) 110 Effect of Dexmedetomidine combined with Sevoflurane on anesthesia effect and postoperative cognitive function in patients undergoing laparoscopic surgery GAO Shuping Objective To investigate the effect of Dexmedetomidine combined with Sevoflurane on anesthesia effect and postoperative cognitive function in patients undergoing laparoscopic surgery.Methods A total of 78 laparoscopic surgery patients admitted to the Affiliated Hospital of Xuzhou Medical University from February 2020 to March 2021 were selected as the research subjects.They were divided into group A and group B according to random lot method,with 39 cases in each group.Group B was anesthetized with Sevoflurane and group A was anesthetized with Dexmedetomidine on the basis of group B.The effect of anesthesia and cognitive function were compared between the two groups.Results There was no significant difference in anesthesia time between the two groups (P＞0.05).The recovery time of orientation,waking time and first breath time in group A were shorter than those in group B,and the differences were statistically significant (P＜0.05).There was no significant difference in preoperative mini-mental state examination(MMSE) score between two groups (P＞0.05).The MMSE score of 1 day after surgery in both groups were lower than those before surgery,and the MMSE score of 1 day after surgery in group A was higher than that in group B,the differences were statistically significant (P＜0.05).Conclusion Dexmedetomidine combined with Sevoflurane is effective in patients undergoing laparoscopic surgery,and can improve cognitive function. 2022 Vol. 29 (22): 110-112 [Abstract] ( 24 ) HTML (1 KB)  PDF (497 KB)  ( 117 ) 113 Application effect of different doses of Dexmedetomidine assisted low epidural anesthesia in orthopaedic lower limb surgery SHEN Xiaofeng Objective To investigate the appliction effect of different doses of Dexmedetomidine assisted low epidural anesthesia in orthopaedic lower limb surgery.Methods A total of 60 patients who underwent orthopedic lower limb surgery in Xintai People′s Hospital from December 2019 to May 2021 were selected as the research objects.They were divided into the study group (30 cases) and the control group (30 cases) by throwing sieve method.The study group received 0.5 μg/(kg·h) Dexmedetomidine for low epidural anesthesia,and the control group received 0.25 μg/(kg·h)Dexmedetomidine for low epidural anesthesia.The anesthesia effect,physical signs,adverse reactions and anesthesia indexes were compared between the two groups.Results The total effective rate of anesthesia in study group was higher than that in control group,and the difference was statistically significant (P＜0.05).After anesthesia,systolic blood pressure (SBP) in the study group was higher than that in the control group,and heart rate (HR) and respiratory rate (RR)were lower than those in the control group,with statistically significant differences (P＜0.05),while SpO2 in the two groups showed no statistically significant differences (P＞0.05).The total incidence of adr in the study group was lower than that in the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the recovery time between the two groups (P＞0.05).The pain score of the study group was lower than that of the control group,and early recovery time of the study group was shorter than that of the control group,and the differences were statistically significant (P＜0.05).Conclusion For patients undergoing orthopedic lower extremity surgery,0.5 μg/(kg·h) Dexmedetomidine assisted low epidural anesthesia has a stable effect,stable patient signs,high safety,and worthy of promotion. 2022 Vol. 29 (22): 113-116 [Abstract] ( 22 ) HTML (1 KB)  PDF (505 KB)  ( 10 ) 117 Effect of Dexmedetomidine combined with Ropivacaine on analgesia after cesarean section PANG Jing XU Xiaoyan ZHOU Qiaolin ZHANG Zhaodi WANG Tao Objective To evaluate the effect of Dexmedetomidine combined with Ropivacaine quadratus lumborum block on cesarean section puerpera and postoperative analgesia.Methods A total of 66 primipara who were treated in Shuyang Hospital from April 2019 to July 2021 and underwent elective single-session spinal anesthesia and cesarean section were selected as the research objects,and they were divided into two groups by random number table method,with 33 cases in each group.The control group was given Ropivacaine quadratus lumborum block after operation,the observation group was combined with Dexmedetomidine on the basic of the control group,and the two groups were given patient-controlled intravenous analgesia after operation.The resting pain score,exercise pain score,Sufentanil consumption at 48 h after surgery,the number of analgesic pump pressings at 48 h after surgery and the total incidence of adverse reactions were compared between the two groups.Results The visual analogue scale (VAS) score of rest and motion pain in the observation group were lower than those in the control group at 24,36 and 48 hours after operation,and the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence rate between the two groups (P＞0.05).The dosage of Sufentanil and the times of analgesic pump pressings in the observation group at 48 h after operation were less than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion In the postoperative analgesia of puerpera with cesarean section,the implementation of right Medetomidine combined with Ropivacaine block of psoas quadratus muscle can provide more perfect and long-term analgesia for puerpera,and the incidence of adverse reactions after medication is not high,with good safety.It is an ideal analgesic scheme in the postoperative analgesia of cesarean section,which is worthy of reference. 2022 Vol. 29 (22): 117-120 [Abstract] ( 24 ) HTML (1 KB)  PDF (507 KB)  ( 32 ) 121 Value of ultrasonography and liver function indexes in the diagnosis of biliary atresia LIU Huaping HU Jun WANG Ying ZHANG Yan HUANG Jinrong Objective To explore the value of ultrasound imaging and liver function index in the diagnosis of biliary atresia.Methods A total of 60 children with persistent jaundice or abnormal liver function treated in Ganzhou Maternal and Child Health Hospital from January 2020 to December 2021 were selected as the research objects.Among them,40 children with non biliary atresia were selected as the control group,and 20 children with biliary atresia were selected as the experimental group.All of them were tested by ultrasound imaging and liver function indexes,and Ultrasound signs and liver function indexes on admission were observed in the two groups,and the efficacy of ultrasound and liver function indexes in diagnosing biliary atresia was analyzed.Results Ultrasonographic findings showed that the proportion of portahepatis triangular cord sign (TC sign),rigid gallbladder shape,bile lake sign,rough thickening of intrahepatic duct wall,enhanced echo of intrahepatic duct wall,widened hepatic artery and gallbladder without gallbladder or lumen in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).The levels of alkaline phosphatase (ALP),glutamyl transpeptidase (GGT) and total bile acid (TBA) in experimental group were higher than those in control group,the differences were statistically significant (P＜0.05).There were no significant differences in the levels of total bilirubin (TB),direct bilirubin (DB),alanine aminotransferase(ALT),aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) between the two groups (P＞0.05).The areas under ROC curve of ALP,GGT and TBA for diagnosing biliary atresia were 0.652,0.842 and 0.764,respectively (P＜0.05).The diagnostic accuracy,sensitivity and specificity of the combined detection of ultrasonic signs and liver function indexes were the highest,96.66%,95.00% and 97.50%,respectively.Conclusion Ultrasound imaging and liver function indexes have good application value in the diagnosis of biliary atresia. 2022 Vol. 29 (22): 121-124 [Abstract] ( 19 ) HTML (1 KB)  PDF (530 KB)  ( 64 ) 125 Comparison of plaque characteristics in patients with different types of angina pectoris under 64-slice CT coronary angiography YU Changdong1 WANG Ming2 HU Die1 ZHOU Jiguang Objective To explore the differences of plaque characteristics in patients with different types of angina pectoris under 64-slice CT coronary angiography.Methods The clinical data of 80 patients with coronary heart disease diagnosed in Lushan Rehabilitation Center (Jiujiang 171 Hospital) from April 2019 to April 2021 were retrospectively selected,and they were divided into the stable angina pectoris (SAP) group (n=34) and unstable angina pectoris (UAP)group (n=46).All patients underwent 64-slice spiral CT coronary angiography.The number of plaques detected in different positions of the coronary artery (left anterior descending artery (LAD),left main coronary artery (LM),left circumflex artery (LCX),right coronary artery (RCA)],as well as the nature of plaque and stenosis of the two groups were compared.Results There was no significant difference in the number of plaques in different positions of coronary artery between the two groups (P＞0.05).The detection rate of soft plaque and mixed plaque in UAP group was higher than that in SAP group,and the detection rate of hard plaque was lower than that in SAP group,the differences were statistically significant (P＜0.05).The detection rates of mild stenosis and moderate stenosis in the UAP group were higher than those in the SAP group,and the detection rate of severe stenosis was lower than that in the SAP group,with statistically significant differences (P＜0.05).Conclusion 64-slice CT coronary angiography can clearly display the characteristics of plaques of different properties,clarify the properties of plaques at different locations,and effectively analyze the stenosis of blood vessels,which can provide a reference for clinical diagnosis and treatment. 2022 Vol. 29 (22): 125-127转131 [Abstract] ( 22 ) HTML (1 KB)  PDF (555 KB)  ( 41 ) 128 Effect of acupoint catgut embedding on gastrointestinal reaction and CT image quality during CT enhanced scanning ZHANG Qi XU Shaozhong▲ YANG Huijuan ZHENG Xiaosong XIE Huiying WU Chunhua Objective To investigate the effect of acupoint embedding on gastrointestinal reaction and CT image quality in patients with enhanced CT scanning.Methods The clinical data of 200 patients receiving enhanced CT scan in Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January to October 2021 were retrospectively analyzed.Patients were divided into control group (100 cases) and observation group (100 cases) according to different intervention methods before examination.The control group did not receive any special intervention before enhanced CT scanning,while the observation group received acupuncture point embedding intervention before enhanced CT scanning.The grade of gastrointestinal adverse reactions and CT image quality were compared between the two groups.Results The grade of gastrointestinal adverse reactions in the observation group was better than that in the control group,and the difference was statistically significant (P＜0.05).The rate of excellent CT image quality in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Acupoint catgut embedding before CT enhanced scanning can effectively reduce gastrointestinal adverse reactions and improve CT image quality. 2022 Vol. 29 (22): 128-131 [Abstract] ( 21 ) HTML (1 KB)  PDF (634 KB)  ( 47 ) 132 Imaging feature of shear wave elasticity imaging in tendon nodules of lumbar disc herniation ZHOU Feili1 TIAN Fengwei2 WU Xiaoming Objective Shear wave elasticity imaging (SWE) was used to investigate the image of tendon nodules in lumbar disc herniation (LDH) patients,investigate the application value of this technology on tendon nodules.Methods Patients admitted to the the clinic of Department of Acupuncture of Chongqing Traditional Chinese Medicine Hospital from November 2020 to June 2021 were selected as research objects.The position，image and Young′s modulus of the tendon nodules were recorded and measured by the SWE.Results Thirty tendon nodules were included,the average Young′s modulus was 25.47 (17.45,37.10) kPa.According to the distribution parts,they were divided into waist and sacroiliac part,according to different anatomical levels,they were divided into superficial fascia and deep fascia.From the SWE images,we can see that the tendon nodules were mainly exhibite disorderfibrous tissue,with high or low echo and disregular nodules.The average Young′s modulus was higher than that of normal tissue and fat necrosis.The image of the deep nodules is fuzzy,which may affect accuracy of the Young′s modulus.Conclusion The SWE is more visually and accurate,and the hardness of the tissue can be determined by the elastic modulus value of the tissue,so as to clarify the tendon knot,which can be used as an important evaluation method for the diagnosis and treatment of tendon knot.However,the tendon knot image of deep tissue is not clear,so this technology has certain limitations. 2022 Vol. 29 (22): 132-136 [Abstract] ( 23 ) HTML (1 KB)  PDF (982 KB)  ( 21 ) 137 Mining and analysis of Tolvaptan adverse reaction signal ZHANG Ke1 WANG Jiao2 LI Bo1 SONG Yin1 YUAN Hengjie1 LI Zhengxiang Objective To explore and analyze the safety signals of adverse reactions after the marketing of Tolvaptan,to provide evidence for clinical safe drug use.Methods The reporting odds ratio (ROR) method was used to mine the risk signals from the adverse reaction report data of Tolvaptan in the US Food and Drug Administration Public Data Open Project (OpenFDA) from May 19,2009 to December 25,2021.The reporting odds ratio (ROR) method was used to mine and analyze the data,and the results were classified according to systematic organ classification (SOC) and preferred term (PT).Results A total of 92 240 adverse reactions were reported during the retrieval period,of which 7816 were reported for Tolvaptan.A total of 49 risk signals of adverse reactions were obtained through analysis,among which sepsis (ROR=6.79),pneumonia (ROR=5.32) and fall (ROR=2.59) were not included in the manual.A total of 49 adverse reaction risk signals were analyzed in 12 systemic organs,including blood and lymphatic system diseases,infectious and infectious diseases,cardiovascular diseases,metabolic and nutritional disorders.Conclusion Through OpenFDA analysis,the signal intensity of adverse reactions after the marketing of Tolvaptan was obtained.In clinical use of Tolvaptan,close attention should be paid to its adverse reactions,especially to septicemia,pneumonia and fall,which are not included in the instructions,so as to avoid damage caused by them. 2022 Vol. 29 (22): 137-140转144 [Abstract] ( 21 ) HTML (1 KB)  PDF (564 KB)  ( 53 ) 141 Analysis of medical orders for irrational use of key monitoring drugs based on Pareto diagram GUO Xiaoning WAN Nisha ZHENG Yimeng RU Jiling Objective To analyze of the irrational use of key monitoring drugs through Pareto chart among inpatients,and to provide basis and reference for further control of the irrational use of key controlled drugs.Methods Medical records related to the use of key monitored drugs in discharged patients from January 2019 to June 2020 were selected through the electronic medical record platform of the inpatient system of the Central Hospital Affiliated to Shenyang Medical College.The main factors,secondary factors and general factors of irrational drug use were analyzed through the Pareto chart method.Results In total,5 types of irrational drug use were found from 720 medical records.The primary factors of irrational drug use were improper usage and dosage and sub-standard medication and inappropriate selection of drugs.The secondary factor was inappropriate indications.The general factor was repeated drug use.Conclusion Through pharmaceutical administration and intervention measures of rational drug use,the irrational drug use has been significantly improved,It is necessary to further refine the training content of rational drug use for physicians,gradually improve the level of rational drug use,and strengthen information support for the control of key monitoring drugs，which promote the reasonable use of key monitoring drugs. 2022 Vol. 29 (22): 141-144 [Abstract] ( 19 ) HTML (1 KB)  PDF (550 KB)  ( 37 ) 145 Application effect of Pantoprazole on gastrointestinal bleeding in patients with acute stroke LIU Qin Objective To analyze the effect of Pantoprazole on gastrointestinal bleeding in patients with acute stroke.Methods A total of 300 cases of acute stroke patients with gastrointestinal hemorrhage admitted to Ba′nan District Hospital of Traditional Chinese Medicine in Chongqing from January to December 2021 were selected as the research subjects,and they were divided into experimental group and control group by random number table method,with 150 cases in each group.Patients in control group were treated with comprehensive drug therapy,and patients in experimental group were treated with Pantoprazole.National Institute of Health stroke scale (NIHSS) score before and after treatment,gastrointestinal bleeding rate,mortality after 1 month of treatment and total incidence of adverse reactions were compared between the two groups.Results After treatment,NIHSS scores of the two groups were lower than those before treatment,and NIHSS score of experimental group was lower than that of control group,the differences were statistically significant (P＜0.05).The gastrointestinal bleeding rate and mortality after 1 month of treatment in experimental group were lower than those in control group,and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Pantoprazole can improve the condition and prognosis of patients with acute stroke and gastrointestinal bleeding,improve the survival rate,and has high safety.It is worth popularizing. 2022 Vol. 29 (22): 145-147 [Abstract] ( 21 ) HTML (1 KB)  PDF (468 KB)  ( 35 ) 148 Exploration of the medication rules of traditional Chinese medicine in the treatment of H-type hypertension based on data mining CAO Baoguo1 LIU Huijuan2 WEI Lingxia3▲ DONG Li4 WANG Heng1 FAN Hongbo Objective To analyze the clinical medication characteristics and prescription rules of traditional Chinese medicine in the treatment of H-type hypertension by data mining technology.Methods CNKI,Wanfang,VIP and other databases were used as literature sources,all compound prescriptions of traditional Chinese medicine for the clinical treatment of H-type hypertension were deleted according to the inclusion and exclusion criteria.SPSS Statistics 24.0 software was used to make classified statistics on the frequency,nature,taste,meridian and efficacy of traditional Chinese medicine,and systematic cluster analysis was carried out on high-frequency traditional Chinese medicine,the Apriori algorithm in SPSS Modeler 18.0 software was used to analyze the association rules of high-frequency traditional Chinese medicine.Results A total of 76 prescriptions were included,involving 147 traditional Chinese medicines,with a cumulative frequency of 748,and 21 traditional Chinese medicines with a frequency of ≥10,including Gastrodiae rhizoma,Pinelliae rhizoma and Poria.The medicines are mainly tonic medicines,blood-activating and stasis-removing medicines,and liver-relieving wind-suppressing medicines,which mainly enter the liver,spleen,and lung meridians.The drugs are mostly warm,cold and flat,and the taste is mostly sweet,bitter and pungent.The cluster analysis of high-frequency traditional Chinese medicines was clustered into 5 categories,and the association rule analysis obtained 7 binomial associations,29 three-item associations,11 four-item associations,and 1 five-item association.Conclusion The treatment of H-type hypertension with traditional Chinese medicine is mainly to invigorate deficiency,and also to regulate qi and spleen,dry dampness and phlegm,promote blood circulation and remove blood stasis. 2022 Vol. 29 (22): 148-152 [Abstract] ( 19 ) HTML (1 KB)  PDF (950 KB)  ( 49 ) 153 Clinical effect of warm acupuncture combined with massage around the hip in the treatment of knee osteoarthritis due to yang deficiency and cold coagulation CHEN Yong HAN Bing Objective To explore the effect of the combined treatment of warm acupuncture and massage on the hips on the curative effect of knee osteoarthritis of yang deficiency and cold congealing type.Methods A total of 80 patients with yang deficiency and cold coagulation knee osteoarthritis treated in the Department of Chinese Medicine Orthopedics,Beijing Sijiqing Hospital from January 2021 to January 2022 were selected as the research objects,and they were divided into control group and observation group by the sequential grouping method,with 40 cases in each group.The control group was treated with warm acupuncture alone,and the observation group was treated with warm acupuncture combined with perihip massage.Treatment outcomes,Western Ontario and McMaster University osteoarthritis index(WOMAC) and visual analogue scale (VAS) scores were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant (P＜0.05).There were no statistically significant differences in WOMAC score and VAS score between the two groups before treatment (P＞0.05).The WOMAC score and VAS score in the observation group were lower than those in the control group after treatment,the differences were statistically significant (P＜0.05).Conclusion Warm acupuncture combined with massage around the hip can effectively relieve the soft tissue spasm in patients with knee osteoarthritis,further relieve the pain and stiffness of the knee joint,improve the dysfunction,and improve the therapeutic effect,which is worthy of clinical application. 2022 Vol. 29 (22): 153-155转160 [Abstract] ( 18 ) HTML (1 KB)  PDF (519 KB)  ( 64 ) 156 Analysis of prescription medication law of ancient doctors of Huxiang medical school in the treatment of madness LI Shu1 SHAN Yanliang Objective Through data mining,the clinical experience and medication characteristics of the ancient doctors of Huxiang medical school on the theory,method,prescription and medicine of insanity were explored.Methods The software SPSS 18.0,SPSS Modeler 18.0 were used for cluster analysis and association analysis,to make a statistical analysis on high-frequency drugs,common drug efficacy,sexual and flavor meridians,high-frequency clustering,related drug groups and complex network correlation,and summarize their medication laws and related treatment methods in the Essence of Huxiang Famous Physicians′ Books.Results A total of 67 prescriptions for the treatment of madness were included in the Essence of Huxiang Famous Physicians′ Books,with a total of 147 herbs.There were 33 drugs with a frequency of ≥5,which were used a total of 293 times,accounting for 59.19% of the frequency of use of all drugs.Their efficacy is mainly based on 11 types of medicines such as tonic,heat-clearing,phlegm-relieving,coughrelieving and asthma-relieving medicines.Their properties mainly involve cold,warm and mild drugs,and their tastes mainly involve bitter,sweet and pungent.Statistics on the frequency of meridians return of organs show that they mainly involve lung,spleen,heart,stomach,liver and kidney.Fifteen core drug pairs were obtained by drug association rule analysis,among which "Licorice-Angelica" drug pair had the highest support.Licorice,Poria cocos,Tangerine peel,Pinellia ternata and other drugs were mainly used for compatibility,which was consistent with the C7 clustering drugs in the high-frequency cluster analysis results.Nine new drug combinations were obtained by high-frequency cluster analysis.Conclusion Ancient doctors of Huxiang medical school had attached importance to treat madness mainly by resolving phlegm and purging fire,eliminating evil,and also focusing on strengthening the righteousness.In addition,they needed to treat the meridians separately,treat the five zang organs separately,or treat the five zang organs together,and pay attention to healing. 2022 Vol. 29 (22): 156-160 [Abstract] ( 18 ) HTML (1 KB)  PDF (705 KB)  ( 7 ) 161 Investigation and analysis of cloud visitation in improving patient satisfaction in emergency intensive care unit LIU Yuan ZOU Qiong ZHOU Can ZHOU Aimei Objective To explore the application effect of cloud visitation in emergency intensive care unit (EICU) patient visitation management.Methods A total of 265 patients admitted to the EICU during the period of the routine bedside appointment visit mode in Jiujiang First People′s Hospital from January to December 2020 were selected as the control group,and 265 patients admitted to the EICU during the cloud visit mode in Jiujiang First People′s Hospital from January to December 2021 were selected as the observation group.The incidence of nosocomial infection,ICUacquired asthenia,the incidence of delirium,the psychological status of family members,patient satisfaction and the incidence of nurse-patient disputes were compared between the two groups.Results There was no significant difference in the psychological state of family members between the two groups before visiting (P＞0.05).The incidence rates of ventilator-related pneumonia,indwelling catheter-related infection and catheter-related blood infection in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of ICU-acquired weakness and delirium in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The scores of self-rating depression scale (SDS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The family satisfaction of the observation group was higher than that of the control group,and the incidence of nurse-patient disputes was lower than that of the control group,with statistical significances (P＜0.05).Conclusion Adopting cloud visitation in the visit management of EICU patients can reduce the incidence of infection and delirium,ensure the safety of patients seeking medical treatment,effectively reduce the negative emotions of patients′ families,reduce the contradiction between nurses and patients,and thus improve patient satisfaction. 2022 Vol. 29 (22): 161-164 [Abstract] ( 18 ) HTML (1 KB)  PDF (507 KB)  ( 57 ) 165 Psychological status and its influencing factors of family members of medical staff GUO Tong1 SUN YongLi Objective To understand the psychological status and its influencing factors of family members of medical staff,so as to provide theoretical basis for targeted psychological intervention.Methods From October 25 to October 31,2021,300 family members of medical staff in Henan hospital of traditional Chinese medicine were selected.The general information questionnaire and symptom checklist 90 (SCL-90) were used.The total score of SCL-90 and each factor score of participants were compared with the domestic norms.With basic demographic items as independent variables and SCL-90 scores as dependent variables,univariate analysis and multiple linear regression analysis were conducted.Univariate analysis and multivariate logistic regression analysis were conducted with the anxiety factor which differed most significantly from the domestic norm as the dependent variable.Results The total score of SCL-90 of the family members of medical staff in this survey was (135.49±32.96) points,and the scores of anxiety and depression factors were higher than the domestic norm,with significant difference (P＜0.05).Multiple linear regression analysis showed that age,basic diseases,time spent with family members as medical staffs,and daily working hours of family members as medical staffs were the main influencing factors of SCL-90 scores of medical staffs′ family members (P＜0.05).Multivariate logistic regression analysis showed that age,basic diseases,time spent with family members as medical staffs,and daily working hours of family members as medical staffs were the main influencing factors of anxiety factor scores of medical staff′s family members (P＜0.05).Conclusion The incidence of psychological problems among family members of medical staff who are older,suffering from basic diseases,having family members as medical staffs with longer working hours and less company is higher than that of the general population.Relevant psychological evaluation and intervention mechanisms should be established and various means should be adopted to improve their psychological status. 2022 Vol. 29 (22): 165-170 [Abstract] ( 19 ) HTML (1 KB)  PDF (525 KB)  ( 21 ) 171 Current status of depression and suicidal ideation in maintenance hemodialysis patients and factors influencing suicidal ideation FU Xiaoli QIN Yaorong TANG Liwen ZHUANG Lixia Objective To understand the status and influencing factors of depression and suicidal ideation in maintenance hemodialysis (MHD) patients,so as to provide basis for preventing suicide in hemodialysis patients.Methods A random sample of 106 kidney failure patients who underwent MHD in Dongguan Songshan Lake Donghua Hospital from March 2020 to March 2021 were investigated by the patient health questionnaire (PHQ-9) and the self-rating idea of suicide scale (SIOSS).Multivariate logistic regression model was used to analyze the status of depression and suicidal ideation and the influencing factors of suicidal ideation in MHD patients.Results The detection rate of depression in MHD patients was 49%.The detection rate of patients who had quit smoking was higher than that of non-smokers and smokers,the detection rate of primary school and below education was higher than that of middle school or specialized secondary school,university and above,the differences were statistically significant (P＜0.05).The detection rate of suicidal ideation in MHD patients was 19.8%,and the detection rate of patients with family income of ＜5000 yuan was higher than that of patients with family income of ≥5000 yuan,the detection rate of patients with an education level of primary school and below was higher than that of patients with an education level above primary school,the detection rate of self-paid patients was higher than that of patients paid by medical insurance,the detection rate of patients with dialysis months less than 12 months was higher than that of patients over 12 months,the differences were statistically significant (P＜0.05).Multiple factor analysis of logistic regression model showed that the low per capita income of the patients′ family (β=1.300,OR=1.273,95%CI=1.182-1.307) and the short age of dialysis months (β=0.856,OR=1.425,95%CI=1.185-1.679) were the risk factors for suicidal ideation in MHD patients (P＜0.05).Conclusion The depression and suicidal ideation are common in MHD patients.Medical staffs should popularize hemodialysis related knowledge to patients in multiple dimensions to improve patients′ awareness of hemodialysis and reduce depression and prevent suicidal ideation of them. 2022 Vol. 29 (22): 171-175 [Abstract] ( 17 ) HTML (1 KB)  PDF (523 KB)  ( 29 ) 176 Effect of the Changhai pain rating scale recording pain diary on the assessment of cancer pain JIN Xiaoqin XIONG Ping YANG Mei Objective To investigate the effect of Changhai pain rating scale recording pain diary on cancer pain assessment.Methods A total of 111 patients with cancer pain admitted to Nanchang First Hospital from May 2020 to May 2021 were selected as research objects,they were divided into study group (n=56) and control group (n=55) according to the odd and admission numbers.Patients in the control group were evaluated for cancer pain using the Changhai pain rating scale,while patients in the study group recorded pain diary according to the Changhai pain rating scale score.The effect of cancer pain control was compared between the two groups,and the treatment compliance and pain control satisfaction were compared between the two groups.Results The pain score of the study group was lower than that of the control group at 2,6,12 and 24 h after treatment,the difference was statistically significant (P＜0.05).The treatment compliance rate of the study group was 94.64% after recording the pain diary according to Changhai pain rating scale score,which was higher than 80.00% of the control group,the difference was statistically significant (P＜0.05).The satisfaction of pain control in the study group was 96.43%,which was higher than 81.82% of control group,the difference was statistically significant (P＜0.05).Conclusion Using record pain diary according to Changhai pain rating scale score can timely provide patients with accurate pain information for correct evaluation,and give suggestions on the feasibility of clinical treatment intervention,which can effectively improve patients′ treatment compliance,better control of cancer pain,and get higher satisfaction with pain control. 2022 Vol. 29 (22): 176-178转182 [Abstract] ( 14 ) HTML (1 KB)  PDF (593 KB)  ( 30 ) 179 Effect of operating room infection nursing based on evidence-based concept on infection in elderly patients after hip arthroplasty LIN Ruibao ZHAN Zhiru XU Lifen Objective To explore the effect of implementing evidence-based concept of operating room infection care on infection in elderly patients after hip replacement.Methods The clinical data of 108 patients who underwent hip arthroplasty in Zhongshan Hospital Affiliated to Xiamen University from July 2018 to August 2021 were retrospectively analyzed,and 54 patients were treated as the control group during the routine nursing period from July 2018 to January 2020.Fifty-four patients admitted during the implementation of evidence-based concept of operating room infection care from February 2020 to August 2021 were set as the observation group.The length of stay,qualified rate of infection detection in operating room,total incidence of infection and total nursing satisfaction were compared between the two groups.Results The length of hospitalization in the observation group was (14.82±2.53) d,shorter than that in the control group of (19.24±3.72) d,and the difference was statistically significant (P＜0.05).There was no significant difference in the qualified rate of air and sterile bags in the operating room between the two groups (P＞0.05).The qualified rates of hand,disinfectant and object surface detection in the observation group were 98.15%,94.44% and 92.59%,respectively,higher than 83.33%,77.78% and 75.93% of the control group,and the differences were statistically significant (P＜0.05).The total incidence of infection in the observation group was 7.41%,lower than that in the control group(22.22%),and the difference was statistically significant (P＜0.05).The total nursing satisfaction of the observation group was 98.15%,higher than that of the control group (83.33%),and the difference was statistically significant (P＜0.05).Conclusion The operating room infection nursing based on evidence-based concept can effectively improve the qualified rate of infection detection in the operating room,reduce the infection rate,and obtain higher nursing satisfaction. 2022 Vol. 29 (22): 179-182 [Abstract] ( 19 ) HTML (1 KB)  PDF (611 KB)  ( 30 ) 183 Application effect of amnesia curve home nursing in patients after neurosurgery WU Diqun LUO Shumin LUO Mengyuan Objective To explore the effect of amnesia curve home nursing in patients after neurosurgery.Methods A total of 40 neurosurgery patients admitted to Foshan Nanhai District People′s Hospital from January to June 2019 were selected as the control group,and 40 neurosurgery patients admitted to Foshan Nanhai District People′s Hospital from July 2019 to January 2020 were selected as an observation group.The control group received routine home care guidance,and the observation group received home care guidance based on forgetting curve.The self-management ability,modified Barthel index (MBI) and the MOS 36-item short form health survey (SF-36) scores were compared between the two groups.Results The scores of symptom management,social management,emotion management,information management and life management in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The scores of MBI and SF-36 in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Home nursing based on forgetting curve can fully improve the postoperative self-management ability of neurosurgical patients,and significantly improve their activity ability and quality of life. 2022 Vol. 29 (22): 183-185 [Abstract] ( 20 ) HTML (1 KB)  PDF (610 KB)  ( 42 ) 186 Application effect of humanistic care service combined with WeChat group interaction intervention in modified electroconvulsive therapy for patients with schizophrenia CHEN Zhichun XIAO Guifeng Objective To explore the application effect of humanistic care combined with WeChat group interaction intervention on patients with schizophrenia treated by modified electroconvulsive therapy (MECT).Methods A total of 98 patients with schizophrenia treated in Shangrao Third People′s Hospital between June 2019 and June 2021 were selected as the research subjects,and they were divided into the control group (n=49) and the observation group (n=49) according to the random number table method.The control group adopted humanistic care service,while the observation group was given humanistic care combined with WeChat group interaction.The brief psychiatric rating scale (BPRS)score,medication compliance and risk occurrence were compared between the two groups.Results There were no significant differences in BPRS scores between the two groups before intervention (P＞0.05).After intervention,the scores of hallucination perception,mood depression,evil concept and affectation in both groups were lower than those before intervention,and the scores of observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The compliance of observation group was higher than that in the control group after intervention,the difference was statistically significant (P＜0.05).The total risk incidence of the observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Combined nursing of humanistic care and WeChat group has a positive effect on MECT treatment of patients with schizophrenia,and it can enhance the medication compliance and improve the mental symptoms,with clinical promotion value. 2022 Vol. 29 (22): 186-189 [Abstract] ( 17 ) HTML (1 KB)  PDF (580 KB)  ( 21 ) 190 Application effect of perioperative nursing intervention under the concept of enhanced recovery after surgery for thoracolumbar fractures treated with the TiRobot LIN Mei1 LIN Yuxia1 TANG Yiqun1 HU Hongxin Objective To evaluate the effect of perioperative nursing intervention under the concept of enhanced recovery after surgery for thoracolumbar fractures treated with the TiRobot.Methods Sixty patients with Thoracolumbar fractures treated with the TiRobot from November 2020 to November 2021 in Affiliated Hospital of Putian University were selected,and they were divided into a control group and an observation group using the random number table method,with 30 cases in each group.In the control group,conventional nursing intervention was used,and in the observation group,perioperative nursing intervention under the concept of ERAS was used.Time of urinary catheter removal,time of first feeding,time of getting off the floor,and time of discharge was recorded and analyzed in both groups.The degree of pain was scored by visual analog scale (VAS) score on the 1st,3rd day after the operation.Complications and satisfaction with nursing care in both groups were observed and recorded.Results The time of urinary catheter removal,time of first feeding,time of getting off the floor,and time of discharge after surgery in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The VAS scores in the first day and third day after the operation in the observation group were lower than in the control group,and the differences were statistically significant (P＜0.05).The total incidence of perioperative complications in the observation group was lower than in the control group,and the difference was statistically significant (P＜0.05).The degree of satisfaction of perioperative nursing care in the observation group was higher than that in the control group,with statistically significant difference (P＜0.05).Conclusion The perioperative care intervention under the concept of ERAS in patients with thoracolumbar fractures treated with the TiRobot assisted can effectively shorten the postoperative recovery time,reduce pain and decrease perioperative complications. 2022 Vol. 29 (22): 190-193 [Abstract] ( 21 ) HTML (1 KB)  PDF (612 KB)  ( 86 ) 194 Application of high quality operating room nursing cooperation in elderly patients undergoing cataract phacoemulsification LI Na1 WU Yang2 REN Pengjuan2 ZHANG Chunjing2 HUANG Jiatong Objective To explore the effect of high-quality operating room nursing cooperation in elderly patients undergoing cataract phacoemulsification.Methods A total of 72 elderly patients who underwent cataract phacoemulsification in Hongqi Hospital Affiliated to Mudanjiang Medical College from January 2021 to July 2021 were selected as the research objects.They were divided into control group and observation group according to random number table method,with 36 cases in each group.The patients in the control group were treated with routine operating room nursing cooperation,and the patients in the observation group were treated with high-quality operating room nursing cooperation.The changes of visual acuity,intraocular pressure and the incidence of complications before and 3 months after operation were compared between the two groups.Results The visual acuity of the observation group was higher than that of the control group 3 months after operation,the difference was statistically significant (P＜0.05).The intraocular pressure of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion The application of high-quality operating room nursing cooperation in senile cataract phacoemulsification can not only ensure the smooth development of the operation,but also improve the curative effect and reduce the risk of complications,so it is worthy of reference. 2022 Vol. 29 (22): 194-196 [Abstract] ( 20 ) HTML (1 KB)  PDF (574 KB)  ( 20 )

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