microRNAs与肿瘤寡转移的研究进展

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Abstract Currently,the oligometastatic state of tumor is generally regarded as an intermediate stage between primary tumor and widespread spread.With the deepening of the understanding of oligometastatic tumor and the rapid development of functional imaging,the diagnosis of oligometastatic tumor is increasing.At the same time,it has been found in recent years that microRNAs can be involved in the process of tumor oligometastasis as an important regulation molecule of metastasis.However,people′s understanding of the biology of tumor metastasis and the molecular mechanism that drives the formation of tumor oligometastasis is still limited.In this paper,based on the introduction of microRNAs at home and abroad in recent ten years and the research on microRNAs in oligosaccharide metastasis,the definition of oligosaccharide metastasis,the role of microRNAs in oligosaccharide metastasis and the mechanism and function of target molecules,as well as the clinical value of microRNAs in oligosaccharide metastasis are summarized.The future development and challenges of microRNAs in precise diagnosis and treatment of tumors are prospected.

Key words： Oligometastases Metastases MicroRNAs Cancer

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