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Quick Search     Adv Search 2021 Vol. 28, No. 30 Published: 2021-10-28   4 Effect of CYP3A4, PXR and IL-10 polymorphisms on the pharmacokinetics of Amlodipine in 43 healthy Chinese subjects before and after meal LIU Lin-lin；IsaiahTakau；LIU Jian-fang； CHEN Lin；LIU Dan； XIE Hong-bo； LIU Ming-yi； XIA Chun-hua Objective To investigate the effect of gene polymorphisms of cytochrome P450 3A4 (CYP3A4), pregnane X receptor (PXR) and interleukin-10 (IL-10) on the pharmacokinetics of amlodipine in 43 healthy Chinese subjects.Methods Genetic polymorphisms of CYP3A4, PXR, and IL-10 were evaluated for 43 healthy Chinese male subjects from a study permitted by ethical committee of the hospital and finalized in 2015. CYP3A4 genotype in 17776 A insertion, 15820C>G, 13989A>G, and PXR genotype in 24381A>C, 3'UTR11193T>C, 3'UTR10719G>A, and IL-10 genotype in 1082G>A, 819C>T and 592C>A were assessed by PCR–RFLP assays. The plasma concentrations of amlodipine in subjects after being orally administrated 10 mg Amlodipine were measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) method. Results Three CYP3A4 genotypes, three PXR genotypes and three IL-10 genotypes had no significant effect on the pharmacokinetic parameters of amlodipine in vivo (P＞0.05). The peak concentration (cmax), area under the curve (AUC0-t) and AUC0-∞of amlodipine in postprandial group were higher than those in fasting group, and the differences were statistically significant (P＜0.05). Conclusion There are no influences of the genetic polymorphisms of CYP3A4, PXR, IL-10 on the pharmacokinetics of Amlodipine in Chinese healthy subjects.And the high-fat and high-calorie diet could significantly promote the absorption of Amlodipine in human. 2021 Vol. 28 (30): 4-7转12 [Abstract] ( 54 ) HTML (42 KB)  PDF  (0 KB)  ( 6 ) 8 Effect of electroacupuncture on urodynamics and mechanism of neurogenic bladder retention after sacral pulp injury in rats HU Ying-qiu；WANG Kai-yang；FU Liu-xiang；WU Li-dong； XU Mei-ling Objective To study the effect and mechanism of electroacupuncture on urodynamics of neurogenic bladder retention after sacral pulp injury in rats. Methods Thirty healthy male rats were selected and divided into model group,control group and electroacupuncture group according to random number table method, with 10 rats in each group. The control group was not modeled or treated, and the model group was only modeled and not treated, and the electroacupuncture group received electroacupuncture treatment after modeling. After treatment, the urodynamic changes and other related index in the three groups of rats were detected. Results Compliance, leakage point pressure, basic bladder pressure and maximum bladder volume in model group and electroacupuncture group were higher than those in control group, and the differences were statistically significant (P＜0.05). The above indexes in electroacupuncture group were lower than those in model group, and the differences were statistically significant (P＜0.05). The mRNA levels of heat shock protein 20 (HSP-20), phosphatase and tensin homologous protein (PTEN) in spinal cord tissue of rats in model group and electroacupuncture group were higher than those in control group, and the differences were statistically significant (P＜0.05). The mRNA level of HSP20 in electroacupuncture group was higher than that in model group, while the mRNA level of PTEN was lower than that in model group, with statistical significance (P＜0.05). The levels of Blymphocytoma-2 gene (Bcl-2) and protein kinase B (Akt) in model group and electroacupuncture group were lower than those in control group, the differences were statistically significant (P＜0.05). BCL2-associated X protein (Bax),FOXO1 and caspa se -9 in model group and electroacupuncture group were higher than those in control group, the differences were statistically significant (P＜0.05). The levels of Bax, FOXO1 and Caspase-9 in electroacupuncture group were lower than those in model group, while the levels of Bcl-2 were higher than those in model group, the differences were statistically significant (P＜0.05). There was no significant difference in Akt between electroacupuncture group and model group(P＞0.05).Conclusion Electroacupuncture treatment of neurogenic bladder urinary retention rats after sacral spinal cord injury can improve their urodynamics. The specific mechanism of action can be analyzed and inhibited PTEN expression, promoted HSP20 phosphorylation and expression, and further inhibited apoptotic pathways and increased Akt activity Relevant. 2021 Vol. 28 (30): 8-12 [Abstract] ( 51 ) HTML (43 KB)  PDF  (0 KB)  ( 6 ) 13 Meta-analysis of efficacy and safety of Magnesium Isoglycyrrhizinate combined therapy in the treatment of chronic hepatitis B ZENG Xue-liang；ZHONG Wen-min；LI Bei Objective To systematically evaluate the efficacy and safety of Magnesium Isoglycyrrhizinate combined therapy in the treatment of chronic hepatitis B. Methods Literatures published in China Biology Medicine (CBM),Wanfang Data, China National Knowledge Infrastructure (CNKI), PubMed, and Cochrane Library from its establishment to October 2020 were searched, randomized controlled trials (RCT) of Magnesium Isoglycyrrhizinate combined therapy in the treatment of chronic hepatitis B was included. The included literatures were screened, extracted and evaluated for quality, and meta-analysis was performed using Review Manager 5.3 software. Results Sixteen RCT studies were included, including 1932 patients, 979 in the experimental group and 953 in the control group. Meta-analysis results showed that the overall efficacy of the experimental group was higher than that of the control group, and the difference was statistically significant (OR=3.34，95%CI=[2.14，5.22]，P＜0.000 01). The levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST) and total bilirubin (TBil) in experimental group decreased more significantly than those in control group, ALT (MD=-17.26, 95%CI=[-22.32, -12.21], P＜0.000 01), AST(MD=-13.62, 95%CI=[-22.20, -5.03], P=0.002), TBil (MD=-4.80, 95%CI=[-6.10, -3.51], P＜0.000 01). The incidence of adverse reactions in experimental group was lower than that in control group, and the difference was statistically significant (OR=0.54, 95%CI=[0.32, 0.91], P=0.02). Conclusion Magnesium Isoglycyrrhizinate combination therapy can significantly reduce the levels of ALT, AST and TBiL in chronic hepatitis B patients, and the adverse reaction rate is lower than that of monotherapy. 2021 Vol. 28 (30): 13-17 [Abstract] ( 55 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 18 Clinical study of empirical de-escalation treatment of sepsis after use of carbapenem antibiotics HONG Cheng-ying；CHEN Huai-sheng；LIU Xiao-jun；NAN Chuan-chuan；LIU Xue-yan Objective To investigate the influencing factors and safety of empirical de-escalation treatment of sepsis after the use carbapenem antibiotics. Methods A total of 29 patients with sepsis who were given empirical de-escalation treatment after the use of carbapenem antibiotics under the guidance of antibiotic management team in the Intensive Care Unit (ICU) of Shenzhen People's Hospital from January 2018 to June 2019 were selected. They were divided into the successful group (18 cases) and the unsuccessful group (11 cases) according to whether the de-escalation treatment succeeded. The etiology situation, inflammatory indicators (procalcitonin [PCT], interleukin-6 [IL-6], neutrophilic granulocyte percentage [N%], and lymphocyte counts), sequential organ failure assessment score (SOFA score), acute physiology and chronic health evaluation Ⅱ (APEACHE Ⅱ) score, length of ICU hospitalization, duration of mechanical ventilation, and duration of shock were compared between the two groups. Results Among 29 included patients, there were 18 patients in the successful group of de-escalation treatment, accounting for 62%. There were significant differences in pathogens and specimen sources between the two groups. At admission, the PCT level of the successful group was higher than that of the unsuccessful group, with statistically significant difference (P＜0.05). At admission, there were no statistically significant differences of SOFA, APACHE Ⅱscores and IL-6 levels between the two groups (P＞0.05).At de-escalation treatment, there were no statistically significant differences of SOFA, APACHE Ⅱscores and IL-6, PCT levels between the two groups (P＞0.05). Before admission, at day 3, 5 of admission, there was no statistically significant difference of N% between the two groups (P＞0.05). Before admission, at day 3, 5 of admission, the lymphocyte counts of the successful group were higher than those of the unsuccessful group in the same-time,with statistically significant differences (P＜0.05). There were no significant differences in length of ICU hospitalization,duration of mechanical ventilation time and duration of shock between the two groups (P＞0.05). Conclusion The differences of pathogens and their sources, and dynamic changes of PCT, IL-6, and peripheral lymphocytes may be important influencing factors for the successful implementation of de-escalation treatment of sepsis after the use of carbapenem antibiotics. The involvement of antibiotic management team may facilitate the implementation of de-escalation treatment. The empirical de-escalation strategy is relatively safe. 2021 Vol. 28 (30): 18-22 [Abstract] ( 67 ) HTML (47 KB)  PDF  (0 KB)  ( 7 ) 23 Analysis of mutations of mitochondrial deafness genes in pregnant women in Foshan area SONG Chun-lin；DENG Lu-sha；CHEN Shu-fen；ZHOU Cheng Objective To analyze the mitochondrial deafness gene mutation spectrum of pregnant women in Foshan area. Methods From January 2020 to April 2021, 20 299 pregnant women in the outpatient clinic of Foshan Maternity and Child Health Hospital were selected as the research objects. Flow-through hybridization was used to screen common deafness susceptibility genes, and Sanger sequencing method was used to detect mitochondrial DNA mutations.Results A total of 739 cases (3.64%) of common deafness gene mutations were detected, of which 349 cases (47.22%)were 235delC heterozygous mutations in Gap Junction β2 protein. Sanger sequencing method detected 130 cases of 24 mutation sites in mitochondria, of which m.12192G＞A, m.7443A＞G, m.7445A＞T were pathogenic mutations. Conclusion The flow-through hybridization combined with Sanger sequencing method has important value in the prevention and control of deafness. Mitochondrial gene sequencing has enriched the mutation spectrum in Foshan area, which can provide better genetic counseling and life guidance. 2021 Vol. 28 (30): 23-26 [Abstract] ( 46 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 27 Effect of Parecoxib Sodium on postoperative neuroinflammation, apoptosis and cognitive function in the old rats LIU Na；XU Yue-li；WU Ya-qi； PENG Jun-xu；ZHANG Xin；LIN Jia-xin；REN Cong-cai Objective To investigate the effect of Parecoxib Sodium, a selective inhibitor of cycde-2 (COX-2), on postoperative neuroinflammation, apoptosis and cognitive function in the old rats. Methods Forty male elderly SD rats were selected and randomly divided into four groups (n=10): control group (equal volume 0.9% Nacl intraperitoneally injected at the same time point), Parecoxib Sodium group (equal dose of Parecoxib Sodium intraperitoneally injected at the same time point), model group (left nephrectomy was used to construct the model of postoperative cognitive dysfunction in rats), and treatment group, which selected Parecoxib Sodium intraperitoneally injected for 3 consecutive days preoperatively 10 mg/(kg·d) + left nephrectomy + intraperitoneal injection of Parecoxib Sodium 2 mg/(kg·d) for 3 consecutive days after the operation, until death for samples. Morris water maze test was used to evaluate the spatial learning and memory of rats on the third day after surgery. The expression levels of COX-2 protein, contents of prostaglandin E2(PGE2), expression levels of apoptosis protein and ionic calcium junction protein molecule 1 (Iba1) in activated microglia. Results On the third day after surgery, the stay time in the target quadrant of rats in the treatment group([19.06±1.45] s) was longer than that in the model group([17.49±1.51] s), and the difference was statistically significant (P ＜0.05). On the third day after surgery, the number of platform crossing in the target quadrant of rats in the treatment group ([2.45±0.82] times) was higher than that in the model group ([1.70±0.73] times), and the difference was statistically significant (P＜0.05). On the third day after surgery, the latency of stage staging in the working memory test of rats in the treatment group([20.51±2.50]s)was shorter than that in the model group([22.65±2.77]s),the difference was statistically significant (P＜0.05). On the third day after surgery, the number of Iab1 protein labeled positive cells in the brain of microglia in the treatment group was lower than that in the model group, and the difference was statistically significant (P＜0.05). On the third day after surgery, COX-2/β-actin, cleaved caspase-3/caspase-3 levels and PGE2 contents in the hippocampal CA1 region of rats in the treatment group were lower than those in the model group, and the differences were statistically significant (P＜0.05). Conclusions Treatment with Parecoxib Sodium can improve the transient cognitive function decline in elderly rats after operation, and the mechanism is related to the down-regulation of COX-2 protein level in brain, the increase of PGE2 content, and the decrease of inflammation and apoptosis in central nervous system. 2021 Vol. 28 (30): 27-32 [Abstract] ( 53 ) HTML (55 KB)  PDF  (0 KB)  ( 6 ) 33 Research progress of post-endoscopic retrograde cholangiopancreatography pancreatitis WANG Xiang-rui；NING Bo Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is one of the most common complications after post-endoscopic retrograde cholangiopancreatography pancreatitis (ERCP). PEP is usually mild or moderate, however, some cases may develop into severe pancreatitis, resulting in serious harm to patient's health and life.Currently, there are many risk factors for PEP and a lack of standard, effective prevention to reduce its incidence. This research included more than 30 recent domestic and international studies on PEP and finds that PEP has complex pathophysiological mechanisms and numerous risk factors,including patient-related factors and procedure-related factors.With the progress of research, there is an ongoing need to remove the bias against certain traditional risk factors. In terms of prevention, both endoscopic and pharmacological prevention have been effective but it is not fully normalized yet. Basing on existing studies, this research will review the pathogenesis, risk factors, prevention, clinical manifestations and treatment of PEP. It aims to improve the level of diagnosis and treatment and the safety of ERCP. 2021 Vol. 28 (30): 33-39 [Abstract] ( 53 ) HTML (66 KB)  PDF  (0 KB)  ( 6 ) 40 Research progress of anxiety and depression in patients with inflammatory bowel disease WANG Yi-bo；CHENG Hao；JI Qing Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, was characterized by chronic relapsing intestinal inflammation. Accumulating evidence shows that IBD patients often suffered from anxiety and depression, but the specific mechanism is still unclear. It is thought that inflammatory response, oxidative and nitrosative stress (O&NS) pathways, tryptophan catabolite (TRYCAT) pathways and intestinal flora mechanism may play an important role in the development of anxiety and depression associated with IBD. Some socioeconomic, environment,physiological factors such as education, diet, gender, stress, etc. May have an effect on the development of the disease.Up to now, some clinical trials have been conducted for the treatment of anxiety and depression associated with IBD.The epidemiologic features, pathogenesis, risk factors, and treatment of anxiety and depression associated with IBD will be reviewed in this paper. 2021 Vol. 28 (30): 40-44 [Abstract] ( 56 ) HTML (52 KB)  PDF  (0 KB)  ( 8 ) 45 Research progress in diagnosis and treatment of coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction ZHAO Kai；LIU Xian-liang Acute myocardial infarction (AMI) is a common severe emergency in clinical practice. Percutaneous coronary intervention (PCI) can reduce the mortality and improve the prognosis of patients. After PCI, coronary no-reflow phenomenon (CNR) occurs in some patients, which impairs their short-term and long-term prognosis. The occurrence of CNR is related to multiple risk factors, such as ischemia, reperfusion injury, distal peripheral microembolism, and body susceptibility. However, no accurate conclusion has been made on the exact causes.CNR diagnosis includes a variety of invasive and non-invasive methods. By the risk factor analysis and systematic scoring, CNR can be predicted at the early stage. At present, various drug and non-drug methods have been proposed for clinical prevention and treatment of CNR, but no specific prevention and treatment method has been found. Therefore, further research is needed to prevent and treat no-reflow in the future. 2021 Vol. 28 (30): 45-48 [Abstract] ( 53 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 49 Study on the clearance effect and safety of holmium laser lithotripsy in the treatment of renal calculi under Shuo Tong ureteroscopy LIU Tian；LIU Ge-liang；ZHUO Lin；CHEN Liang Objective To explore the effect and safety of holmium laser lithotripsy under Shuo Tong ureteroscopy in the treatment of renal calculi. Methods A total of 80 patients with complex renal calculi admitted to Pingxiang People's Hospital from June 2019 to June 2020 were selected and randomly divided into control group and study group, with 40 cases in each group. The control group underwent percutaneous nephrolithotomy (PCNL), and the study group underwent holmium laser lithotripsy under Shuo Tong ureteroscopy. Perioperative indicators, stone clearance effect and incidence of complications were compared between the two groups. Results The operation time and hospital stay of the study group were shorter than those of the control group, the blood loss was lower than that of the control group, the stone clearance rate was higher than that of the control group, and the total incidence of complications was lower than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Renal calculi patients are treated with holmium laser lithotripsy under Shuo Tong ureteroscopy, which has better effect, high stone removal rate, less bleeding,short operation time,and low incidence of postoperative complications,which is more conducive to postoperative recovery is worthy of extensive clinical application. 2021 Vol. 28 (30): 49-51 [Abstract] ( 55 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 52 Study on the effect of stereotactic brain puncture in the treatment of hypertensive deep brain hemorrhage LUO Yun-hui Objective To study the effect of stereotactic brain puncture in the treatment of hypertensive deep brain hemorrhage. Methods A total of 78 cases of hypertensive patients with hypertensive deep brain hemorrhage in Nanchang 334 Hospital from January 2017 to January 2020 were selected and randomly divided into control group (n=39) and test group (n=39). The control group received medical conservative treatment, and the test group received stereotactic intracranial hematoma aspiration. The operation-related indicators, preoperative and 3 months postoperative neurological function, postoperative serum C-reactive protein (CRP) and postoperative complications were compared between the two groups. Results The operation and hospitalization time of the experimental group was shorter than that of the control group, the hospitalization cost was less than that of the control group, and the hematoma clearance rate was higher than that of the control group, the differences were statistically significant (P＜0.05). At 3 months after surgery, the Guslago coma scores(GCS)and the Guslago prognosis scores(GOS)of the two groups were higher than those before the operation,and the test group was higher than the control group, the differences were statistically significant (P ＜0.05). The incidence of postoperative complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The postoperative serum CRP level of the experimental group was lower than that of the control group, and the difference was statistically significant (P ＜0.05). Conclusion Stereotactic craniopuncture can effectively improve the hematoma clearance rate, improve the neurological function, reduce the serum CRP level, reduce the inflammatory reaction, and promote the postoperative recovery of patients with hypertensive deep brain hemorrhage. 2021 Vol. 28 (30): 52-54转57 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 55 Application effect of emergency treatment channels in the rescue of acute upper gastrointestinal bleeding CHENG Fang-xi ；CHENG Hao；WU Feng Objective To explore the application effect of emergency treatment channels in the rescue of acute upper gastrointestinal bleeding. Methods A total of 130 patients with acute upper gastrointestinal bleeding who were admitted to the Second People's Hospital of Jingdezhen from January 2018 to November 2020 were selected as the study subjects. According to the order of admission, they were divided into a control group (n=65) and a trial group (n=65). The control group was given conventional methods for rescue, and the experimental group was given emergency treatment channels for rescue. The recurrence bleeding rate, operation rate, disease mortality rate, hemostasis time, length of hospital stya, blood transfusion volume and hospitalization expenses were compared between the two groups of patients after treatment. Results After treatment, the recurrence bleeding rate, operation rate and disease mortality rate in the trial group were lower than those in the control group, the hemostasis time and length of hospital stay in the trial group were shorter than those in the control group, the amount of blood transfusion and hospitalization expenses of patients in the trial group were less than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The emergency treatment channels can control the development of diseases for the patients with acute upper gastrointestinal bleeding, shorten the treatment time, reduce the economic burden of patients, and provide protection for life safety. 2021 Vol. 28 (30): 55-57 [Abstract] ( 53 ) HTML (28 KB)  PDF  (0 KB)  ( 8 ) 58 Application effect of standardized management of prehospital emergency treatment on acute chest pain WU Li-ping；YE Yao-qu；ZHANG Zhe；DAI He-xing；LIN Zhen-tian Objective To investigate the application effect of standardized management of prehospital emergency treatment on acute chest pain. Methods A total of 310 cases of patients with acute high-risk chest pain admitted to Yangjiang People's Hospital by ambulance from March 2019 to March 2021 were selected as the study subjects and divided into control group with 162 cases and observation group with 148 cases according to whether accepted prehospital emergency treatment on acute chest pain. Comparing the entry-guide wire passage time of patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) treatment, the two groups of patients were diagnosed with acute coronary syndrome (ACS) time, from diagnosis to load double anti-administration time, hospitalization time, hospitalization expenses, complications occurred within one week after emergency. Results The time of diagnosis in the observation group, the time from diagnosis to the dose of the double antibody administration, the entry-guide wire passage time of STEMI patients receiving PCI treatment were shorter than those in the control group, the differences were statistically significant (P＜0.05). The hospital stay in the observation group was shorter than that in the control group, hospitalization expenses were lower than those in the control group, and the differences were statistically significant (P＜0.05); the observation group had lower incidence of complications within one week after first aid than the control group, and the difference was statistically significant (P＜0.05). Conclusion Standardized management of prehospital emergency treatment on acute chest pain can shorten the time of diagnosis and length of stay, improve rescue efficiency, and reduce complications, is worthy of clinical application. 2021 Vol. 28 (30): 58-60 [Abstract] ( 52 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 61 Application value of endoscopic submucosal dissection in treatment of gastrointestinal masses ZENG Quan-xiang；WU Zhen-hua；LI Jing-sen；HE Ying Objective To explore the application value of endoscopic submucosal dissection in the treatment of gastrointestinal masses. Methods Sixty patients with digestive tract tumors admitted to Maoming People's Hospital from January 2019 to February 2021 were selected as subjects. They were divided into control group (n=30) and study group(n=30) by random number table method. Patients in the control group were treated with endoscopic mucosal resection,while patients in the study group were treated with endoscopic submucosal dissection. The resection effect, recurrence rate, operation-related indicators and postoperative complications of the two groups were compared. Results The resection effect and recurrence rate of patients in the study group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The operation time, intraoperative bleeding rate and hospitalization time of the patients in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the study group was lower than that in the control group, and the differences were statistically significant (P＜0.05). Conclusion The application of endoscopic submucosal dissection can effectively improve clinical resection effect, reduce postoperative complications and recurrence rate, shorten operation time, and promote postoperative recovery in the treatment of gastrointestinal masses, indicating significant clinical value. 2021 Vol. 28 (30): 61-63转67 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 64 Analysis on predictive value of serum D-dimer and procalcitonin levels in prognosis of patients with pyemia and acute kidney injury treated with continuous renal replacement therapy CHENG Jie；CHEN Xin Objective To investigate the predictive value of serum D-dimer (D-D) and procalcitonin (PCT) levels in prognosis of patients with pyemia and acute kidney injury treated with continuous renal replacement therapy (CRRT).Methods The clinical data of 168 patients with pyemia and acute kidney injury who were treated with CRRT in Peking University Shougang Hospital from January 2015 to December 2020 were retrospectively analyzed. According to the prognosis of the patients, they were divided into the good prognosis group (n=108) and the poor prognosis group (n=60).Serum D-D and PCT levels of the patients were statistically analyzed for the prognostic value of serum D-D and PCT levels in patients. Results The serum levels of D-D and PCT in the poor prognosis group were higher than those in the good prognosis group (P＜0.05). According to the multiple logistic regression analysis, the high serum D-D and PCT levels were the risk factors for poor prognosis in patients with pyemia complicated with acute kidney injury (P＜0.05).Receiver operating characteristic curve (ROC) results showed that serum D-D and PCT levels before treatment predicted the poor prognosis of emergency CRRT patients with pyemia and acute kidney injury with the AUC of ＞0.70, which had ideal predictive value, and the combined predictive value was the best. Conclusion Serum D-D and PCT levels have certain value in predicting the prognosis of patients with pyemia and acute kidney injury after CRRT treatment. 2021 Vol. 28 (30): 64-67 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 68 Application of Nervonic Acid combined with Flunarizine Hydrochloride in convalescence of acute cerebral infarction CHEN Wei Objective To explore the application effect of Nervonic Acid combined with Flunarizine Hydrochloride on the recovery period of acute cerebral infarction. Methods A total of 86 patients with acute cerebral infarction at convalescence stage admitted to People's Hospital of Songzi from February 2017 to August 2018 were selected as subjects.They were divided into routine group and combined group by random number table method, with 43 cases in each group. The conventional group was treated with Flunarizine Hydrochloride, and the combined group was treated with Nervonic Acid combined with Flunarizine Hydrochloride. The cognitive function, neurological deficit degree and incidence of adverse reactions of the two groups before and after treatment were compared. Results Before treatment, there was no statistically significant difference in the Montreal cognitive assessment scale (MoCA) scores between the two groups of patients (P＞0.05). After treatment, the MoCA scores of the two groups were higher than those of the group before treatment, and the scores of the combined group were higher In the routine group, the differences were statistically significant (P＜0.05). Before treatment, there was no significant difference in the scores of the National Institutes of health stroke scale (NIHSS) between the two groups of patients (P＞0.05). After treatment, the NIHSS scores of the two groups were lower than those of the group before treatment, and the scores of the combined group Lower than the conventional group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups of patients (P＞0.05). Conclusion Nervonic Acid combined with Flunarizine Hydrochloride can improve cognitive function of patients in recovery period of acute cerebral infarction,improve nerve function, safe and reliable. 2021 Vol. 28 (30): 68-70 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 71 The Application Value and Safety Analysis of trauma-centered emergency mode in the treatment of severe trauma YE Qian-shu Objective To analyze the application value and safety of trauma-centered emergency mode in the treatment of severe trauma. Methods A total of 112 patients with severe trauma who received treatment at the Third People's Hospital of Chengdu from August 2018 to December 2020 were selected and divided into the control group and the study group according to the order of visit time, with 56 cases in each group. The control group adopted the traditional emergency model for treatment, and the study group adopted the trauma-centered emergency mode for treatment. The time for forming venous access, emergency room treatment time, total incidence of complications, and success rate of rescue were compared between the two groups of patients. Results The venous access time and emergency room treatment time in the study group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the study group was lower than that in the control group, and the success rate of rescue was higher than that in the control group, the differences were statistically significant (P＜0.05).Conclusion The application of trauma center emergency mode in the treatment of severe trauma can shorten the operation time, reduce the overall incidence of complications, and increase the success rate of rescue. It has high safety and is worthy of clinical application. 2021 Vol. 28 (30): 71-73 [Abstract] ( 57 ) HTML (28 KB)  PDF  (0 KB)  ( 8 ) 74 Clinical effect of laparoscope combined with choledochoscope in the treatment of cholecystolithiasis with hepatolithiasis WU Zhao-ping Objective To explore the clinical effect of laparoscope combined with choledochoscope in the treatment of cholecystolithiasis with hepatolithiasis. Methods From August 2018 to August 2019, 80 patients with cholecystolithiasis and hepatolithiasis admitted to department of Hepatobiliary Surgery of the First People's Hospital of Jiujiang City were selected as the study objects. They were divided into the observation group and the control group according to random number table method, 40 cases in each group. The control group was treated by traditional open surgery, and the observation group was treated with laparoscope combined and choledochoscope. The therapeutic effect, intraoperative bleeding volume, length of stay and the incidence of adverse reactions between the two groups were compared. Results There was no significant difference in the total effective rate between the two groups (P＞0.05). The intraoperative blood loss in the observation group was less than that in the control group, and the length of hospitalization in the observation group was shorter than that in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Laparoscope combined with choledochoscope is as effective as traditional open surgery in the treatment of cholecystolithiasis combined with hepatolithiasis, it can reduce the amount of intraoperative bleeding and shorten the length of hospitalization,and it doesn't increase adverse reactions, which is worthy of clinical promotion and application. 2021 Vol. 28 (30): 74-76 [Abstract] ( 50 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 77 Clinical effect of laparoscopic left lateral hepatic lobectomy in the treatment of patients with intrahepatic bile duct stones WANG Liang；JIN Xing Objective To investigate the clinical effect of laparoscopic left lateral hepatic lobectomy in the treatment of patients with intrahepatic bile duct stones (IHS). Methods A total of 82 patients with left IHS treated in the First Affiliated Hospital of Fujian Medical University from October 2017 to September 2020 were selected and divided into two groups according to the random number table method, with 41 cases in each group. The observation group was treated with laparoscopic left lateral hepatic lobectomy. The control group was treated with open left lateral hepatic lobectomy.The perioperative indicators, stress response, stone clearance rate and complications were compared between the two groups. Results The intraoperative blood loss in the observation group was (173.69±31.25) ml, less than that of the control group of (214.38±35.20) ml, the incision length, the operation time and the length of stay in the observation group were (5.01±0.85) cm, (126.46±30.08) min and (7.83±2.15) d, shorter than those of the control group of (10.94±2.13) cm, (148.97±28.41) min and (11.58±2.91) d, the postoperative cortisol (Cor), epinephrine (E) and blood glucose(Glu) in the observation group were (254.38±26.79) nmol/L, (138.44±18.24) ng/ml and (5.74±0.60) mmol/L, lower than those of the control group of (304.19±28.53) nmol/L, (151.97±23.07) ng/ml and (6.89±0.76) mmol/L, with statistical significances (P＜0.05). There were no statistical differences between the two groups in the rate of stone clearance and the overall incidence of complications (P＞0.05). Conclusion The laparoscopic left lateral hepatic lobectomy for IHS patients is mild traumatic and has a high stone clearance rate, which is beneficial to reduce the surgical stress response and promote the patients' early recovery. It is a safe and effective procedure for the treatment of IHS. 2021 Vol. 28 (30): 77-79转83 [Abstract] ( 51 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 80 Analysis of influencing factors of intestinal necrosis in emergency operation of adult incarcerated inguinal hernia ZHENG Jun-jie；YOU Zhen-hui Objective To investigate the influencing factors of intestinal necrosis in emergency operation of adult incarcerated inguinal hernia. Methods The clinical data of 76 patients with incarcerated inguinal hernia who underwent emergency surgery in Fujian Provincial Hospital from January 2015 to December 2020 were retrospectively analyzed.The patient's age, gender,white blood cell (WBC), neutrophil to lymphocyte ratio (NLR), incarceration time,course of hernia, type of hernia, location of hernia, intestinal obstruction and intestinal condition were collected. Univariate analysis and logistic regression analysis were used to analyze the influencing factors of intestinal necrosis in emergency operation. Results A total of 76 patients were included in the study, intestinal necrosis occurred in 23 cases (30.3%).Univariate analysis showed that incarceration time (≥24 hours) and intestinal obstruction had a significant impact on the occurrence of intestinal necrosis in emergency surgery (P＜0.05). Logistic regression analysis showed intestinal obstruction (β=1.732，OR=5.600, 95%CI：1.401-22.392) was the risk factor of intestinal necrosis in emergency operation of incarcerated inguinal hernia. Conclusion Intestinal obstruction can be used as a preoperative reference index for intestinal necrosis in emergency operation of incarcerated inguinal hernia. 2021 Vol. 28 (30): 80-83 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 84 Clinical effect of laparoscopic minimally invasive surgery in the treatment of acute appendicitis and its influence on stress hormones and inflammatory factors HU Jun-jun  Objective To investigate the clinical effect of laparoscopic minimally invasive surgery in the treatment of acute appendicitis and its influence on stress hormones and inflammatory factors. Methods A retrospective study of 87 patients with acute appendicitis admitted to Wuhan Seventh Hospital from June 2019 to June 2020, they were divided into laparoscopic group (45 cases) and open group (42 cases) according to the operation methods. The laparoscopic group received laparoscopic appendectomy, while the control group received open appendectomy. The perioperative indexes and postoperative complications, gastrointestinal function [gastrin (MTL) and motilin (gas)], cortisol (Cor), interleukin-6 (IL-6) and C-reactive protein (CRP) levels were compared between the two groups. Results There was no significant difference in operation time between the two groups (P＞0.05). The anal exhaust time, ambulation time and postoperative hospital stay of laparoscopic group were shorter than those of open group, the differences were statistically significant (P＜0.05). The serum levels of MLT and GAS at 3 days after operation in two groups were lower than before operation, the differences were statistically significant (P＜0.05). The total complication rate of laparoscopic group was lower than those of open group, the difference was statistically significant (P＜0.05). The levels of serum MLT and gas in laparoscopic group were higher than those in open group, the differences were statistically significant (P＜0.05). The serum levels of Cor, IL-6 and CRP in the two groups were higher than those before operation, the differences were statistically significant (P＜0.05). The serum Cor, IL-6 and CRP of laparoscopic group were lower than those of open group 3 days after operation, the differences were statistically significant (P＜0.05). Conclusion Laparoscopic appendectomy has less postoperative complications in patients with acute appendicitis, can promote the recovery of gastrointestinal function faster, and has little impact on stress-induced inflammatory response. 2021 Vol. 28 (30): 84-87 [Abstract] ( 54 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 88 Analysis of the effect and complication rate of complete laparoscopy combined with fiberoptic choledochoscope for gallstone preservation and removal of gallbladder stones ZHAO Yin-ming Objective To analyze the effect and complication rate of complete laparoscopy combined with fiberoptic choledochoscope for gallstone preservation and removal of gallbladder stones. Methods A total of 70 patients with gallbladder stones admitted to the Beijing Jingmei Group General Hospital from January 2018 to January 2020 were selected as the research objects, and they were divided into observation group (35 cases) and control group (35 cases) by computer randomization method. The observation group was treated with laparoscopy combined with fiberoptic choledochoscopy to preserve gallstones, and the control group was treated with laparoscopic cholecystectomy. The operation time, intraoperative blood loss, postoperative analgesic pump use time, total hospital stay and the total incidence of postoperative complications were compared between the two groups. Results The operation time of the observation group was longer than the control group, the amount of intraoperative blood loss was less than the control group, and the postoperative analgesic pump use time and total hospitalization time were shorter than the control group,the differences were statistically significant (P＜0.05). The patients were followed up for 6 months after operation, and the total incidence of complications in the observation group was lower than that in the control group, with statistical significance(P＜0.05). Conclusion Complete laparoscopy combined with fiberoptic choledochoscope is effective in the treatment of gallbladder stones with a low complication rate, the program is worth learning. 2021 Vol. 28 (30): 88-90 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 91 Analysis of the expression and clinical significance of aryl hydrocarbon receptor nuclear transporter-like 2 in lung adenoarinoma utilizing the Cancer Genome Atlas datasets CHEN Jin-hua；ZHAO Qiu-rong；YOU Jian-bin；CHEN Fa-lin Objective To study the expression and clinical significance of aryl hydrocarbon receptor nuclear transporter-like 2 (ARNTL2) in lung adenocarcinoma and its paraccinomal tissues. Methods RNA seq data from 337 lung adenocarcinoma tissues (lung adenocarcinoma group) and 59 adjacent tissues (adjacent cancer control group) and corresponding clinical data from lung adenocarcinoma patients were downloaded from the Cancer Genome Atlas database.The relationship between ARNTL2 expression and lung adenocarcinoma patients was compared by univariate analysis,and multivariate analysis by Cox proportional risk model to judge independent risk factors affecting prognosis in lung adenocarcinoma patients. Results The expression of ARNTL2 in the lung adenocarcinoma group was higher than that in the adjacent cancer control group, and the difference was statistically significant (P＜0.05). The results of the univariate analysis showed that the age, Stage stage, and N stage of patients with lung adenocarcinoma were relevant factors affecting ARNTL2 expression (P ＜0.05). Results of the survival prognostic analysis revealed a correlation between ARNTL2 expression and overall survival in patients with lung adenocarcinoma (P=0.001). Results of the univariate analysis showed that Stage stage and ARNTL2 expression were associated factors affecting overall survival in patients with lung adenocarcinoma (P ＜0.05). Results of the Cox proportional hazards model showed that Stage stage and ARNTL2 expression were independent risk factors for overall survival in patients with lung adenocarcinoma (P＜0.05).Conclusion ARNTL2 may promote the development of lung adenocarcinoma through multiple pathways, which then affects the prognostic survival of patients with lung adenocarcinoma. Thus, ARNTL2 can serve as a prognostic marker or a potential therapeutic target in patients with lung adenocarcinoma. 2021 Vol. 28 (30): 91-94 [Abstract] ( 49 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 95 Evaluation of the consistency and applicability test of Watson for Oncology in the treatment of patients with esophageal cancer in China and Xiamen Cancer Center CHEN Yi-de GAO Ying-qin ZHENG Wen-hui FENG Shui-tu FAN Xin Objective To explore the evaluation of the consistency and applicability test of Watson for Oncology in the treatment of patients with esophageal cancer in China and Xiamen Cancer Center. Methods From January 2016 to December 2019, a total of 200 patients with esophageal cancer treated by the expert team from Xiamen Cancer Center and finally adopted with multi disciplinary team (MDT) treatment plan were selected as the research objects. The patient's disease information was input into the WFO system, which provides personalized treatment advice for patients based on the disease information provided. The consistency and applicability of the treatment plan provided by WFO and the actual treatment plan of Xiamen Cancer Center were compared, and used Pearson correlation analysis to determine the correlation of the treatment protocol provided by WFO and the actual treatment protocol of Xiamen Cancer Center. Results The treatment regimen provided by WFO and the actual treatment protocol of Xiamen Cancer Center were compared, with consistency and applicability (P＞0.05). The results of the Pearson correlation analysis showed there was a correlation between the treatment regimen provided by WFO and the actual treatment protocol at Xiamen Cancer Center(P＜0.05). Conclusion There is a correlation between the treatment regimen provided by WFO and the actual treatment protocol at Xiamen Cancer Center. WFO has applicability in the formulation of treatment programs for Chinese esophageal cancer patients. 2021 Vol. 28 (30): 95-97转101 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 98 Short term effect of laparoscopic complete mesocolic excision on hepatoenteral circulation in patients with colon cancer YI Jian-zhong；YUAN Yu-jun；LIU Yun-geng；ZHANG Lei；XIAO He-fang；FANG Chuan-fa Objective To investigate the short-term effect of laparoscopic complete mesocolic excision (CME) on hepatoenteral circulation in patients with colon cancer(CC).Methods A total of 60 patients with CC admitted to People's Hospital of Ganzhou City, Jiangxi Province from July 2019 to July 2020 were selected as the research subjects for a prospective randomized trial. They were divided into a control group (30 cases) and an observation group (30 cases)according to the alternating grouping method. The control group was treated with traditional laparotomy, and the observation group was treated with laparoscopic complete mesocolic excision. The curative effect compared between the two groups,and the levels of serum 25 dihydroxyvitamin D3(25[OH]D3)and serum bilirubin(TBil)were compared between the two groups before operation and 1 day after operation, the incidence of postoperative complications in the two groups was counted. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the total incidence of complications was lower than that in the control group, the differences were statistically significant (P＜0.05). The serum 25(OH)D3 and TBil levels of the two groups after operation were lower than those before operation,after operation,the serum 25(OH)D3 level in the observation group was higher than that in the control group, while the TBil level was lower than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Laparoscopic CME has better curative effect in the treatment of CC, which can effectively improve the hepatointestinal circulation and has lower incidence of postoperative complications, and can provide the basis for drug selection in the short-term nutrition after operation and immunotherapy. 2021 Vol. 28 (30): 98-101 [Abstract] ( 55 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 102 Application value of 1.5T magnetic resonance multimodal imaging in the diagnosis of stage of endometrial carcinoma ZHANG Zhi-yan Objective To investigate the value of 1.5T multimodal magnetic resonance imaging (MRI) in the diagnosis of endometrial carcinoma. Methods From December 2016 to December 2019, a total of 120 patients with endometrial cancer in traditional Chinese Medicine Hospital of Jingzhou City were selected as the research objects, all of them underwent multimodal MRI examination. The multi-modal MRI findings of endometrial carcinoma were observed with postoperative pathological results as the gold standard. Results T1 weighted images (T1WI) + T2 weighted images(T2WI), T1WI+T2WI+diffuse-weighted imaging (DWI), and T1WI+T2WI+DWI+dynamical contrast-enhanced MRI(DCE-MRI) were 53.33%, 63.33%, and 83.33%, respectively, in the preoperative staging of endometrial cancer. The accuracy of T1WI+T2WI+DWI+DCE-MRI in endometrial cancer staging was higher than that of T1WI+T2WI and T1WI+T2WI+DWI, and the difference was statistically significant (P＜0.05). Conclusion Multimodal MRI (T1WI+T2WI+DWI+DCE-MRI) has a good effect in the diagnosis of endometrial carcinoma staging, which is worthy of clinical application. 2021 Vol. 28 (30): 102-105 [Abstract] ( 58 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 106 Application study of balloon occlusion of inferior segment of abdominal aorta in hysteroscopic operation of placenta accreta in second trimester pregnancy ZHOU Ai-long；WAN Yu-zhen Objective To investigate the application effect of balloon occlusion of inferior segment of abdominal aorta in hysteroscopic operation of placenta accreta in second trimester pregnancy. Methods A total of 50 cases of partial placenta accreta in second trimester pregnancy in Jiangxi Maternal and Child Health Hospital from January 2019 to October 2020 were selected as the research objects, They were divided into the control group and the study group by random number table method, 25 cases in each group. Patients in the control group were treated with hysteroscopic resection of placenta accreta, while patients in the study group were treated with abdominal aorta balloon occlusion and hysteroscopic resection of placenta accreta. The time index, intraoperative blood loss, hospitalization expenses, secondary operation rate and operation complications of the two groups were compared. Results The hysteroscopic operation time, postoperative hospital stay, blood human chorionic gonadotropin (HCG) normalization time and menstrual rehydration time of the study group were shorter than those of the control group, and the intraoperative blood loss of the study group was less than that of the control group, the differences were statistically significant (P＜0.05). The hospitalization cost of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). The total incidence of complications in the study group was lower than that of the control group, the difference was statistically significant (P＜0.05). The second operation rate of the study group was lower than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The application of the balloon occlusion of inferior segment of abdominal aorta can shorten the operation time, reduce the risk of bleeding and complications during the operation, and promote the postoperative recovery, which is worth clinical recommendation. 2021 Vol. 28 (30): 106-108转112 [Abstract] ( 54 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 109 Clinical research on the preservation of membrane sac for first newborn of pregnant women with twin pregnancy during cesarean section LUO Xu-qing；ZHANG Ji-hong；LUO Chun-yan；LIU Hai-mei Objective To investigate the effect of cesarean section with preserving membrane sac for first newborn in twin pregnancy on pregnant women and newborns.Methods A total of 50 cases of pregnant women who underwent cesarean section for twin pregnancy admitted to Xinyu Maternal and Child Health Hospital from June 2018 to December 2020 were selected as the research subjects. According to the random number table, they were divided into a study group (25 cases) and a control group (25 cases). In the study group, the first newborn was delivered by the conventional method during the cesarean section. And the other newborn was preserved with the membranous sac. It was observed that there was no placenta around the uterine incision. The newborn and amniotic fluid were completely delivered from the uterine cavity along with the amniotic sac. The control group was delivered by traditional methods. The membranes were broken, the amniotic fluid was sucked, and the newborns were taken out in sequence. Intraoperative and 24 hour postoperative uterine bleeding, and the incidence of maternal and neonatal adverse reactions were compared in the two groups. Results There was no statistically significant difference in the delivery time of the second newborn between the two groups (P＞0.05). The intraoperative and 24 h uterine bleeding in the study group were fewer than those of the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the second newborn in the study group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The cesarean section with preserving membrane sac for first newborn in twin pregnancy can reduce the intraoperative and 24 h blood loss, and reduce the clinical complications of the second newborn. 2021 Vol. 28 (30): 109-112 [Abstract] ( 51 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 113 Correlation between the expression of plasma D-dimer and the severity of the disease in children with mycoplasma pneumoniae pneumonia HU Xin Objective To investigate the correlation between plasma D-Dimer (D-D) expression and severity of disease in children with mycoplasma pneumonia(MPP) to provide reference for clinical prevention of disease aggravation in MPP children. Methods 90 children with MPP admitted to Xinyu People's Hospital from May 2019 to October 2020 were selected. According to the disease severity, they were divided into severe group and mild group with 45 cases in each group. 45 healthy infants and young children who had the physical examination in Xinyu People's Hospital at the same period were selected as the healthy group. The plasma D-D levels were compared in the three groups, the correlations between plasma D-D expression and disease severity were analyzed in the three groups. Results The plasma D-D level in the severe group was higher than the mild disease group and healthy group, the plasma D-D level in mild group was higher than that in the healthy group, and the differences were statistically significant (P＜0.05). Bivariate Pearson linear correlation test showed that pediatric critical illness score (PCIS) was negatively correlated with plasma D-D level. The receiver operating characteristic (ROC) curve was drawn and it showed that the area under the curve of plasma D-D in the diagnosis of disease aggravation of MPP was ＞0.7, the diagnostic value was high, and the difference was statistically significant (P＜0.05). Conclusion Plasma D-D level might be closely related to the severity of disease in children with MPP, MPP children with high expression of plasma D-D should be paid attention to. 2021 Vol. 28 (30): 113-115 [Abstract] ( 52 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 116 Effect of Nifedipine Controlled-release Tablets combined with low-dose Aspirin Enteric-coated Tablets in the treatment of hypertension during pregnancy ZHANG Zi-cheng；CHEN Ya-li；DAI Juan；ZHONG Jin-jing；QIU Wen-fang；LIU Ju-ying；LI Fang-ji Objective To investigate the effect of Nifedipine Controlled-release Tablets combined with low-dose Aspirin Enteric-coated Tablets in the treatment of hypertension during pregnancy. Methods A total of 80 patients with hypertension during pregnancy who were admitted to Ganzhou Maternal and Child Health Hospital of Jiangxi Province from June 2018 to April 2020 were selected as the research subjects, and they were divided into the observation group(40 patients) and the control group (40 patients) by the blind selection method. The control group was treated with Nifedipine Controlled-release Tablets alone, and the observation group was added low-dose Aspirin Enteric-coated Tablets on the basis of the control group. The total effective rates, the total incidences of adverse reactions, the total incidence of adverse pregnancy events and the cardiac function of pregnant women in the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The ejection fraction (EF), stroke volume (SV) and cardiac output (CO) in the observation group after treatment were higher than those in the control group,and the early/late diastolic peak flow rate (E/A) in the observation group after treatment was lower than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse pregnancy events of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Nifedipine Controlled-release Tablets combined with low-dose Aspirin Enteric-coated Tablets can effectively improve the cardiac function and pregnancy outcome in patients with hypertension during pregnancy with good efficacy. Simultaneously, it can also ensure the safety of medication. 2021 Vol. 28 (30): 116-119 [Abstract] ( 61 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 120 Application of modified posture in PICC catheterization of ultra (extremely) low birth weight infants ZHOU Kai-yong；WEI Xia；HE Ling-yun；LIANG Rui-juan；SONG Xiao-wa；FENG Feng-qun；PENG Jia-heng Objective To explore the application effect of modified posture in peripherally inserted central ccatheter(PICC) catheterization of ultra (extremely) low birth weight infants. Methods A total of 150 ultra (extremely) low birth weight infants admitted to the Neonatal Intensive Care Unit (NICU) in the Bo'ai Hospital of Zhongshan City from March 2019 to September 2020 were selected as the research objects. They were divided into the control group (75 infants)and the observation group (75 infants) using random number table method. The control group was given traditional posture PICC catheterization, and the observation group was given modified posture catheterization. The one-time catheterization success rate, delivery time, the total catheter ectopic rate and the total incidence of complications were observed and compared between the two groups. Results The one-time catheterization success rate in the observation group was higher than that in the control group, and the total catheter ectopic rate in the observation group was lower than that in the control group, with statistically significant differences (P＜0.01). There were no statistical differences in the delivery time and the total incidence of complications between the two groups (P＞0.05). Conclusion Modified posture can reduce PICC catheter ectopic rate in ultra (extremely) low birth weight infants, but which will not extend delivery time and increase the incidence of complications. 2021 Vol. 28 (30): 120-122转126 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 123 Effect of drawing-line puncture on blood collection from radial artery in infants JI Xin；FU Hong-jie；XING Xiu-gui；JI Jing-hua；LI Yu-jiao Objective To investigate the effect of drawing-line puncture on blood collection from radial artery in infants. Methods From March 2016 to March 2020, 256 children with radial artery blood collection needs admitted to Department of Pediatric Respiratory Medicine of Affiliated Hospital of Binzhou Medical College were selected retrospctively as observation objects. According to different blood collection methods, they were divided into observation group and control group, each group had 128 cases. In the control group, the traditional puncture method was used to collect blood, and the observation group used the drawing-line puncture method to collect blood. The success rate, puncture effect, total incidence of adverse events and family satisfaction of the two groups were compared. Results The success rate of one-time puncture in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05); the puncture time in the observation group was shorter than that in the control group,the swelling diameter was smaller than that in the control group, the differences were statistically significant (P＜0.05);the incidence of adverse events in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05), and the satisfaction degree of family members in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The application of drawingline puncture on blood collection from the radial artery in infants can not only increase the probability of one-time puncture success, but also reduce the puncture time and trauma of the infants. There are fewer adverse reactions to the puncture and higher family satisfaction, which is helpful for improving tension between nurses and patients, the overall intervention effect is significant, and it is worthy of promotion. 2021 Vol. 28 (30): 123-126 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 127 Comparison of value on serum vitamin D in different stages of newborns in the diagnosis of hypoxic-ischemic encephalopathy LI Hong-bo SHAN Qi-mi-ke XU Juan XU Jing Objective To compare the value of serum vitamin D in different stages of newborns in the diagnosis of hypoxic-ischemic encephalopathy. Methods The clinical data of 90 newborns who was born or delivered in Korla Hospital of the Second Division of Xinjiang Production and Construction Corps from May 2017 to May 2019 were analyzed retrospectively. Healthy newborns were involved as the control group (n=45), and newborns with hypoxic-ischemic encephalopathy were involved as the observation group (n=45). The levels of vitamin D in the two groups were analyzed by enzyme-linked immunosorbent assay at 1 and 7 d after birth. The critical value and the area under the curve of vitamin D in diagnosis of hypoxic-ischemic encephalopathy were compared between the two groups. Results The serum level of vitamin D in the observation group at 1 and 7 d after birth were lower than those in the control group, with statistically significant differences (P＜0.05). The level of vitamin D in the observation group at 7 d after birth was lower than that in the control group, with statistically significant difference (P＜0.05). The area under the curve at 1 and 7 d after birth were 0.681 and 0.703, respectively. The area under the curve at 7 d after birth was better than that at 1 d after birth, with statistically significant difference (Z=1.940, P=0.021). The critical value at 1 and 7 d after birth were 22.5 mmol/L and 21.5 mmol/L,respectively.When the level of vitamin D at 1 d after birth did not exceed 22.5 mmol/L,the specificity and sensitivity of the disease diagnosis were 69.9% and 66.7%, respectively. When the vitamin D level at 7 d after birth was below 21.5 mmol/L, the specificity and sensitivity of disease diagnosis were 73.3% and 80.0%,respectively. Conclusion Vitamin D has high value in the diagnosis of neonatal hypoxic-ischemic encephalopathy. The longer the onset time, the higher the diagnostic value of vitamin D. 2021 Vol. 28 (30): 127-129 [Abstract] ( 58 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 130 Clinical effect of one-time root canal filling in the treatment of cracked teeth with pulpitis DAI Yu-ping Objective To investigate the effectiveness and value of one-time root canal filling in the treatment of cracked teeth with pulpitis. Methods From January 2018 to January 2020, 62 patients with dental cryptic crack and pulpitis in the First people's Hospital of Ji'an City were selected as the research objects, and they were divided into control group (30 cases) and observation group (32 cases) by drawing lots. The control group was treated with multiple root canal filling, and the observation group was treated with one-time root canal filling. The short-term efficacy, pain grading, total incidence of adverse reactions, recurrence rate 6 months after operation and long-term efficacy were compared between the two groups. Results The total effective rate of observation group was higher than that of the control group, and the success rate of 1 year after operation was higher than that of the control group, the differences were statistically significant (P＜0.05). The pain rate, the total incidence of adverse reactions and the recurrence rate 6 months after operation in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The application of disposable root canal filling technique in the treatment of dental cleft with pulpitis has the advantages of lighter pain, higher efficacy and safety, lower recurrence rate,significant long-term efficacy and high clinical application value 2021 Vol. 28 (30): 130-132转139 [Abstract] ( 57 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 133 Effect of oral bacteriostatic ointment on chronic periodontitis and its effect on gingival index and probing depth of periodontal pocket YE Ying-xin；ZHANG Han-fei；CAI Shu-yu Objective To investigate the effect of oral bacteriostatic ointment on chronic periodontitis and its effect on gingival index and probing depth of periodontal pocket. Methods A total of 40 patients with chronic periodontitis from January 2019 to December 2020 in Department of Stomatology, Binhai Bay Central Hospital, Guangdong Province,Dongguan were selected as the research objects. They were divided into control group and observation group by random number table method, with 20 cases in each group. All patients received conventional supringival scaling and other mechanical treatments, on this basis, control group was treated with Iodine-Glycerin, observation group was treated with oral bacteriostatic ointment. The curative effect, periodontal examination index and adverse drug reaction were compared between the two groups. Results The total effective rate of the observation group was 100.00% (20/20), which was higher than that of the control group 80.00% (16/20), and the difference was statistically significant (P＜0.05). Before treatment, there were no statistically significant differences in gingival index, plaque index and probing depth of periodontal pocket between the two groups (P＞0.05). After treatment, the gingival index, plaque index and probing depth of periodontal pocket in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). There were no obvious adverse reactions in the two groups. Conclution Oral bacteriostatic ointment has an ideal effect on chronic periodontitis, and can promote the improvement of gingival index and other probing indicators. It is safe to use and worth promoting. 2021 Vol. 28 (30): 133-135 [Abstract] ( 75 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 136 Value of lower extremity venous color Doppler ultrasound combined with Caprini score to assess the risk of deep vein thrombosis in patients with chronic schizophrenia YANG Fan；WANG Xiao-yun；HUANG Li；ZHOU Long-hua Objective To explore the clinical value of lower extremity venous color Doppler ultrasound combined with Caprini score to assess the risk of deep vein thrombosis (DVT) in patients with chronic schizophrenia. Methods A total of 80 patients with chronic schizophrenia and suspected deep vein thrombosis of the lower extremities were selected from June 2019 to December 2020. According to the results of deep venography, they were divided into observation group (DVT group) and control group (non-DVT group), with 40 cases in each groups. The clinical manifestations (including lower limb pain, swelling, and color change) and indicators of coagulation function (including plasma thrombin time [TT], prothrombin time [PT], activated partial thromboplastin time [APTT], and fibrinogen [Fib]) of the two groups were compared. The ultrasound results and Caprini scores of the lower extremities were compared between the two groups. The value of the lower extremity venous color Doppler ultrasound combined with the Caprini score for DVT risk assessment in patients with chronic schizophrenia was analyzed. Results The cases of lower limb pain, swelling, and color change in the observation group were more than those in the control group, with statistically significant differences(P＜0.05). The TT, PT and APTT of the observation group were shorter than those of the control group, with statistically significant differences (P＜0.05). And the level of Fib in the observation group was higher than that in the control group,with statistically significant difference (P＜0.05). The vascular ultrasound results in the lower limbs was better than in the control group, with statistically significant difference (P＜0.05). The Caprini score of the observation group was higher than that of the control group, with statistically significant difference (P＜0.05). The sensitivity of lower limb venous color Doppler ultrasound combined with Caprini score to develop DVT diagnosis in patients with chronic schizophrenia was 97.4%, and the specificity was 50.0%. Conclusion The combination of lower extremity venous color Doppler ultrasound combined with Caprini score has high predictive sensitivity in the evaluation of lower extremity DVT in patients with chronic schizophrenia, and it has a positive significance in guiding clinical prevention and treatment. 2021 Vol. 28 (30): 136-139 [Abstract] ( 53 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 140 Comparative study of two verification methods in image-guided radiotherapy QIU Min-min；LIN Ze-huang；DENG Yong-jin；HUANG Tai-ming；MIN Meng-zhen；ZHONG Jia-jian  Objective To explore the influence of cone-beam computed tomography (CBCT) and two-dimensional kilovolt (2D-kV) on the set-up error, and find a verification method that is more suitable for clinical daily use. Methods Fifty patients receiving IMRT in First Affiliated Hospital of Sun Yat-sen University from March to October 2016 were selected, including 20 in the head and neck group, 15 in the thoracic and abdomen group, and 15 in the pelvic group.Image-guided radiotherapy was performed every day, CBCT was performed once a week, and 2D-kV was used for the remaining four days to compare the registration errors. Results A total of 1320 groups of images were obtained. There were no statistical differences in the error comparison between CBCT and 2D-kV in the three directions of vertical(Vrt), longitudinal (Lng), and lateral (Lat) (P＞0.05). Conclusion The registration accuracy of CBCT and 2D-kV verification methods are equivalent, but 2D-kV has shorter time-consuming, less shooting restrictions, suitable for clinical daily use. 2021 Vol. 28 (30): 140-142转150 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 143 Effect of Taiji Yunshou on gastrointestinal function in patients with chronic fatigue syndrome based on brain-gut axis theory CHEN Hui；CAI Lian-huan；HE Wei-xiu Objective To investigate the effect of Taiji Yunshou on gastrointestinal function of patients with chronic fatigue syndrome (CFS) based on brain-gut axis theory. Methods A total of 72 CFS patients admitted to the Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine from July 2019 to September 2020 were selected as the research objects, and were divided into control group (36 cases) and experimental group (36 cases)according to the random number table method. The control group received conventional treatment, and the experimental group was treated with Taiji Yunshou on the basis of the control group. The changes of quality of life, fatigue degree,Bristol stool traits, plasma 5-hydroxytryptophan (5-HT), neuropeptide Y (NPY), serum substance P (SP) and calcitonin gene-related peptide (CGRP) were compared between the two groups. Results After treatment, the quality of life scores of the two groups were higher than those before treatment, the fatigue scores of the two groups were lower than those before treatment and the fatigue score of the experimental group was higher than the control group, and the fatigue score was lower than the control group, the differences were statistically significant (P＜0.05). After treatment, the good rate of stool traits in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05). After treatment, the levels of 5-HT, NPY, SP and CGRP in the two groups were lower than before, and the levels of 5-HT, NPY, SP and CGRP in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Taiji yunshou has a better effect on gastrointestinal function of CFS patients, which is better than conventional therapy alone, and has a regulatory effect on 5-HT,NPY, SP, CGRP. 2021 Vol. 28 (30): 143-146 [Abstract] ( 44 ) HTML (38 KB)  PDF  (0 KB)  ( 7 ) 147 Clinical effect observation of Xiaochaihu Decoction after gynecological operation ZHANG Li；WU Min-jun；HUANG Qin Objective To explore the clinical effect of Xiaochaihu Decoction after gynecological surgery. Methods A total of 60 patients undergoing gynecological surgery in Xinyu Maternal and Child Health Hospital from August 2019 to January 2021 were selected as the research objects, and were divided into observation group (30 cases) and control group (30 cases) according to random number table method. The control group received routine treatment after gynecological operation, and the observation group was given oral Xiaochaihu Decoction 6 h after operation on the basis of the control group. The treatment effect, body temperature 72 h after operation, aerofluxus time, wound healing time,symptom score, hypersensitine C-reactive protein (hs-CRP) level and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was higher than control group, the difference was statistically significant (P＜0.05). The body temperature of the observation group was lower than that of the control group 72 h after surgery, and the exhaust time and wound healing time were shorter than those of the control group,with statistical significance (P＜0.05). There was no significant difference in syndrome score between the two groups before intervention (P＞0.05). After intervention, the syndrome scores of the two groups were lower than those before intervention, and the syndrome score of the observation group was lower than that of the control group, with statistical significance (P＜0.05). There was no significant difference in hs-CRP levels between the two groups before intervention (P＞0.05). The hs-CRP level of the two groups after intervention were lower than before, and the hs-CRP level of the observation group was lower than the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The effect of xiaochaihu decoction after gynecological surgery is good, which can improve the clinical symptoms of patients,stabilize the body temperature within 72 h after surgery, shorten the exhaust time, speed up the wound healing, improve the level of hs-CRP, high safety. 2021 Vol. 28 (30): 147-150 [Abstract] ( 52 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 151 Clinical study on treatment of cervical spondylosis with abnormal physiological curvature by traditional Chinese medicine massage combined with curvature traction ZHANG Jing-jing；ZHANG Guo-ting Objective To explore the clinical effect of the treatment of cervical spondylosis with abnormal physiological curvature by traditional Chinese medicine massage combined with curvature traction. Methods A total of 98 patients with cervical spondylosis with abnormal physiological curvature who were admitted to the Department of Traditional Chinese Medicine, Iron and Coal General Hospital of Liaoning Provincial Health Industry Group from March 2018 to March 2020 were selected as the research objects. They were divided into the control group and the observation group,with 49 patients in each group by random number table method. The control group was treated with traditional Chinese medicine massage, and the observation group was treated with traditional Chinese medicine massage combined with curvature traction. The clinical efficacy, cervical curvatures and clinical symptom scores were compared between the two groups. Results The clinical efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Before treatment, there was no statistically significant difference in cervical curvature between the two groups (P＞0.05). After treatment, the cervical curvature of the observation group was greater than that of the control group, with statistical significance (P＜0.05). Before treatment, there were no significant differences in clinical symptom scores between the two groups (P＞0.05). After treatment, the clinical symptom scores of the observation group were lower than that of the control group, the differences were statistically significant (P＜0.05).After treatment, the succinct health measurement scale score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The treatment of cervical spondylosis with abnormal physiological curvature with traditional Chinese medicine massage combined with curvature traction treatment has a significant clinical effect, can promote the relief of the abnormal physiological curvature, pains of neck,shoulder and back, muscle stiffness, headache dizziness and other symptoms. 2021 Vol. 28 (30): 151-153转167 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 154 Differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid DENG Qun；LIU Jian-feng；YAO Jia-hui-zi；HUANG Jian Objective To study the differential diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis by T cell spot test and T cell subsets of alveolar lavage fluid. Methods A total of 60 patients with pulmonary diseases admitted to the Department of Tuberculosis, Jiangxi Chest Hospital from March 2019 to March 2020 were selected as the research objects. According to the different types of disease, they were divided into observation group (pulmonary sarcoidosis, 30 cases) and control group (pulmonary tuberculosis, 30 cases). Mycobacterium tuberculosis T cell spot test and alveolar lavage fluid T-cell subsets were performed to compare the positive rate and levels of CD4+/CD8+, CD8+,CD4+ and CD3+ between the two groups. Results In the mycobacterium tuberculosis T-cell spot test in the observation group, there were 2 tuberculosis infection T-cell spot test positive patients, the positive rate was 6.67%. In the mycobacterium tuberculosis T-cell spot test of the control group, 11 patients with tuberculosis infection t-cell spot test were positive, the positive rate was 36.67%. The positive rate of mycobacterium tuberculosis T-cell spot test in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). CD4+/CD8+ (1.31±0.07) and CD8+ ([27.41±6.71] %) in observation group were lower than those in control group ([2.91±0.15]and [32.11±7.61] %), and the differences were statistically significant (P＜0.05). CD4+([63.51±7.26] %) and CD3+([88.79±5.31] %) were higher than those in the control group ([41.27±3.1], [76.19±6.21] %), and the differences were statistically significant (P＜0.05). Conclusion In the diagnosis of pulmonary sarcoidosis and pulmonary tuberculosis, mycobacterium tuberculosis T-cell spot test and alveolar lavage fluid T-cell subgroup detection can be used to identify these diseases effectively. 2021 Vol. 28 (30): 154-156 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 157 Value analysis of N-terminal pro-brain natriuretic peptide, cystatin C and hypersensitive C -reactive protein in evaluating the prognosis of chronic obstructive pulmonary disease with pulmonary infection YU Xin；DONG Nan-jun；HE Lian-qi Objective To explore the clinical application value of combined detection of N-terminal pro-brain natriuretic peptide (NT-proBNP), cystatin C (Cys C) and high-sensitivity C-reactive protein (hs-CRP) in evaluating the prognosis of chronic obstructive pulmonary disease (COPD) complicated with lung infection. Methods A total of 170 COPD patients admitted to General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group from January 2017 to March 2020 were selected as the research objects. According to the occurrence of pulmonary infection, they were divided into infection group (80 cases) and non-infection group (90 cases). According to the prognosis during hospitalization (7-14 days), the infection group was divided into death group (9 cases) and non-death group (71 cases),and 50 healthy subjects were selected as the control group. The serum levels of NT-probNP, Cys C and hs-CRP of all subjects were detected, and the diagnostic value of NT-proBNP, Cys C and hs-CRP alone and in combination in COPD with pulmonary infection was compared. Results The serum levels of NT-proBNP, Cys C and hs-CRP in infected group were higher than those in non-infected group and control group, and the differences were statistically significant (P＜0.05). The serum levels of NT-proBNP, Cys C and hs-CRP in non-infected group were higher than those in control group, and the differences were statistically significant (P＜0.05). The serum levels of NT-proBNP, Cys C and hs-CRP in the death group were higher than those in the non-death group, and the differences were statistically significant (P＜0.05). The area under the curve (AUC) of three indicators combined to evaluate the prognosis of COPD combined with pulmonary infection was higher than that of single indicator, and the difference was statistically significant (P＜0.01). Conclusion Serum NT-proBNP, Cys C and hs-CRP levels in COPD complicated with pulmonary infection gradually increase with the progression of the disease,and combined detection has a high clinical value in evaluating the prognosis. 2021 Vol. 28 (30): 157-160 [Abstract] ( 48 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 161 Relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus CAI Li-juan；REN Mei；LIU Jian-rong；PAN Xing Objective To explore the relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 80 patients with T2DM treated in Pingxiang People's Hospital between October 2019 and May 2020 were retrospectively analyzed. According to the active cytomegalovirus infection status, the patients were divided into observation group (positive cytomegalovirus infection, viral DNA load＞500 copies/ml, n=18) and control group (negative cytomegalovirus infection, viral DNA load≤500 copies/ml, n=62). The T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+) and pancreatic islet function (fasting Cpeptide [Fins], fasting 2 h C-peptide [F2CP]) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between DNA load of active cytomegalovirus infection and levels of T lymphocyte subsets and pancreatic islet function. Results The level of CD4+cells and CD4+/CD8+in observation group were significantly lower than those in control group, while the level of CD8+ cells was higher than that in control group, the differences were statistically significcant (P＜0.05). The levels of FCP and F2CP were lower in observation group than those in control group, the differences were statistically significcant (P＜0.05). The DNA load of cytomegalovirus infection was negatively correlated with CD4+, CD4+/CD8+, Fins and ISI, and was positively correlated with CD8+level (P＜0.05). Conclusion The DNA load of active cytomegalovirus infection is closely related to the T lymphocyte subsets of patients with T2DM. The more active cytomegalovirus in the body of patients, the greater the degree of body's immune imbalance and the more severe the islet function damage. It is necessary to take corresponding treatment methods to improve the cytomegalovirus infection status. 2021 Vol. 28 (30): 161-163 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 164 Analysis of common pathogens of acute bacterial conjunctivitis in children NONG Le-guan；WANG Xiao-gang Objective To analyze the distribution and drug resistance of the main pathogens of acute conjunctivitis in children and to find effective antibiotics so as to provide basis for clinical rational drug use. Methods A total of 525 children with acute bacterial conjunctivitis treated in Guidong people's Hospital of Guangxi Zhuang Autonomous Region from February 2010 to February 2021 were selected as the research objects, they were cultured and tested for drug sensitivity, and the distribution and drug resistance of pathogens were analyzed. Results Altogether 313 strains of pathogenic bacteria were isolated from 525 samples, including 132 strains of Gram-negative bacteria, accounting for 33.87%, and 181 strains of Gram-positive bacteria, accounting for 66.13%. Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus were the dominant bacteria in children with acute bacterial conjunctivitis. Gramnegative bacteria were the most sensitive to Piperacillin/Tazobactam, and Gram-positive bacteria were the most sensitive to Ofloxacin. Conclusion The antibiotic resistance of different bacteria in children with acute conjunctivitis is different, which should be analyzed and well treated. 2021 Vol. 28 (30): 164-167 [Abstract] ( 48 ) HTML (29 KB)  PDF  (0 KB)  ( 8 ) 168 Epidemiological investigation and medication analysis of HIV complicated TB infection in Jiujiang area YU Huang-peng；LIU Zhi-hong；YANG Hui；XU Huan-xin Objective To investigate the epidemiological characteristics and drug use of human immunodeficiency virus(HIV) combined with tuberculosis (TB) infection. Methods A total of 79 patients with HIV complicated with TB infection in Jiujiang Third People's Hospital from June 2019 to December 2020 were selected for investigation, and the data of marital status, gender and drug abuse were analyzed. The risk factors of HIV complicated with TB infection were analyzed by multivariate logistic analysis, and drug use was analyzed. Results Univariate analysis showed that there were statistically significant differences among patients with different age, education background, infection route, NUMBER of CD4+cells and whether they knew TB was one of the common opportunistic infections of AIDS (P＜0.05). Multivariate analysis showed that age, educational background, infection route, CD4+ cell count and whether TB is one of the common opportunistic infections of AIDS were independent risk factors for HIV with TB infection (P＜0.05). The drug resistance rates of HIV combined with TB infection to eight drugs from high to low were Isoniazid, Rifampicin, Pyrazinamide, Levofloxacin, Protionamide, Rifapentine, Sodium Aminosalicylate, Ethambutol respectively. Conclusion It is necessary to increase the screening of HIV and TB among the low-educated and older people, and use drugs for treatment in response to drug resistance. 2021 Vol. 28 (30): 168-170转174 [Abstract] ( 58 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 171 Investigation on AIDS knowledge, belief and behavior of clinical and nonclinical students in colleges and universities XIE Yu DENG；Cun-liang；MA Lin-kun Objective To investigate the cognition-attitude-behavior of AIDS among clinical and non-clinical students in Luzhou Southwest Medical University, and to provide evidence for targeted AIDS prevention and treatment. Methods A total of 246 undergraduate students from Southwest Medical University from 2015 to 2020 were selected as research objects by stratified and cluster sampling method, and anonymous questionnaire survey was conducted to analyze the knowledge, belief and practice of AIDS among the students. Results The accuracy of most questions clinical students was higher than that of non-clinical students, but the two types of students' awareness of AIDS was not comprehensive.The awareness rate of girls and boys was 93.97% and 91.54% respectively. The awareness rate of sophomores is the lowest among the five grades, 87.76%; The awareness rate of college students in love is low, 89.83%. In terms of attitude, more than 80% of the students were willing to accept anonymous HIV antibody testing and become volunteers for the prevention and treatment of infectious diseases. 80% of clinical majors and 74.4% of non-clinical majors expressed their willingness to work and study with AIDS patients. More than 90% of the students are willing to accept the learning of AIDS health education, mainly through video publicity and traditional education. Conclusions Through this survey, can understand the status quo of clinical and non-clinical college students' knowledge, belief and practice of AIDS, carry out targeted AIDS health education, implement the national AIDS prevention policy, in order to improve students' awareness of AIDS and related knowledge rate,cultivate a positive and healthy lifestyle, and enhance self-protection awareness. It is of great significance to AIDS prevention and education in the future. 2021 Vol. 28 (30): 171-174 [Abstract] ( 61 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 175 Retrospective analysis of mumps in Yizhuang Community of Daxing District, Beijing from 2005 to 2020 LEI Gan Objective To analyze the epidemic characteristics of mumps in Yizhuang Community, Daxing, Beijing from 2005 to 2020, and provide scientific basis for formulating effective prevention and control strategies. Methods The epidemiological characteristics of mumps were analyzed by using descriptive epidemiology method to collect the information of mumps report cards from 2005 to 2020 in Yizhuang Community of Daxing, Beijing. Results From 2005 to 2020,302 cases of mumps were reported in Yizhuang Community, Daxing District, Beijing, with a reported incidence of 23.22/100,000. The number of cases was highest in May (36.23/100,000) and lowest in December (16.57/100,000). The incidence was mainly concentrated in May and September, accounting for 23.20% of all cases, with the highest incidence in spring and autumn. The incidence ratio of male to female was 1.74:1, and the incidence rate of male was higher than that of female, with statistical significance (P＜0.05). Students and children living in childcare centers were the main groups, accounting for 70.53%. Conclusion While strengthening the monitoring of mumps, a reasonable vaccination plan should be adopted. It is recommended that students in kindergarten schools and the students at school should be checked for missed mumps vaccines. 2021 Vol. 28 (30): 175-177 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 178 Construction of nursing safety management index system in psychiatric closed ward LIU Juan Objective To construct the index system of nursing safety management in psychiatric closed ward. Methods By literature review method, Delphi method and analytic hierarchy process, the index weights were selected to complete the construction of nursing safety management index system in psychiatric closed wards. Results A comprehensive index system was constructed consisting of 4 first-level indexes, 10 second-level indexes and 41 third-level indexes.Conclusion The index system is highly reliable, and the weight setting is in line with actual work, but it needs further modification and improvement. 2021 Vol. 28 (30): 178-180转186 [Abstract] ( 59 ) HTML (29 KB)  PDF  (0 KB)  ( 9 ) 181 Practical measures and problem analysis of group assistance from Huadu District People's Hospital Medical Group of Guangzhou YE Jia-jun；ZHANG Wen-wei；XIA Ping；XU Jian-ping；GOU Zheng-xian；KUANG Xiao-lan Group assistance is the key measure of Huadu District People's Hospital of Guangzhou to further deepen reform of the medical and health care systems and improve the comprehensive service capacity of the grass-roots medical institutions,by integrating all kinds of superior resources from group's medical,nursing,pharmacy,medical technology,management, talent and other advantageous resources, the group assistance can effectively promote the accurate sinking of quality medical resources and achieve common integration with the grass-roots medical institutions. As a powerful grasp and innovation mechanism that promotes the implementation of hierarchical diagnosis and treatment system,group assistance is beneficial to build a high-quality, efficient, scientific and reasonable medical construction system,and further expand the accessibility and inclusiveness of superior resources, its more accurate assistance measures not only effectively help the grass-roots medical institutions to improve their medical treatment and comprehensive service ability, but also bring more timely, convenient, safe and high-quality diagnosis and treatment services to the grass-roots people. However, in the practice of exploring the reform of assistance, we still find that there are some practical problems in personnel allocation, ward management, assessment mechanism, research innovation and other aspects. We need to constantly explore the corresponding solutions, so as to more smoothly promote the construction of "two-way transfer treatment, hierarchical diagnosis and treatment" system in the medical association. 2021 Vol. 28 (30): 181-186 [Abstract] ( 60 ) HTML (48 KB)  PDF  (0 KB)  ( 5 ) 187 Exploration and practice of integrating ideological and political education into the teaching of histology and embryology curriculum YANG Tao-mei； CHEN Xiang-yun； LIU Xia ；CHU Chun-wei ；LIU Lei ；JIANG De-mei “Curriculum ideological and political education”, a kind of new education idea is aimed at integrating ideological and political education into professional knowledge. At present, the integration of “curriculum ideological and political education” into the professional curriculum is a new requirement and challenge for higher education reform in our country. The teaching of special courses should not be limited to the imparting of theoretical knowledge, but should be reflecting ideological enlightenment, value guidance and moral cultivation. This paper will take the blood section as an example to explore the application of “curriculum ideological and political education” in the teaching of histology and embryology. This will enable students to receive ideological and political education and learn professional curriculum knowledge at same time. Specifically it will cultivate students' patriotism, dedication, change and innovation consciousness. All of above is for the goal to carry out the task of “establishing morality and cultivating people” and keep consistent between knowledge imparting with value leading. 2021 Vol. 28 (30): 187-190 [Abstract] ( 59 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 191 Application effect of cross-theoretical model health education under caregiver coordination on rehabilitation in patients with stroke hemiplegia LIU Jia；CAO Yan-wen；LI Wen-jing；ZHA Tai-xiang Objective To explore the effect of cross-theoretical model health education under caregiver coordination on the rehabilitation in patients with stroke hemiplegia. Methods A total of 70 patients with stroke hemiplegia treated in the Department of Neurology in the Jiujiang First People's Hospital from January 2019 to June 2020 were selected.They were divided into the control group (35 patients) and the observation group (35 patients) using random number table method. The control group were given traditional health education, and the observation group were given crosstheoretical model health education under caregiver coordination. The rehabilitation effect, self-efficacy, self-management behavior ability and self-care ability before and after intervention were compared between the two groups. Results There were no significant differences in scores of Fugl-Meyer assessment (FMA) and modified Edinburgh scandinavian stroke scale (MESSS) between the two groups before intervention (P＞0.05). After intervention, the scores of FMA in both groups were higher than those before intervention, and the scores of MESSS in both groups were lower than those before intervention. The score of FMA in the observation group was higher than that in the control group, and the score of MESSS in the observation group was lower than that in the control group, with statistically significant differences (P＜0.05). There were no significant differences in scores of Chronic disease self-efficacy scale (CDSES), selfmanagement behavior and self-care ability (Barthel index [BI]) between the two groups before intervention (P＞0.05). After intervention, the scores of CDSES, self-management behavior and BI in both groups were higher than those before intervention. The scores of CDSES, self-management behavior and BI in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05). Conclusion The application of cross-theoretical model health education under caregiver coordination can improve rehabilitation effect, and enhance patients' self-efficacy, self-management behavior ability, and self-care ability in the rehabilitation of patients with stroke hemiplegia.The effect is ideal. 2021 Vol. 28 (30): 191-194 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 195 Application of standardized video education mode in the rehabilitation of children patients with cerebral palsy WU Xiao-yuan；SHAO Yin-jin；LIU Zhi-hong；WU Gui-hua；HUANG Yu-bin Objective To explore the application effect of standardized video education mode in the rehabilitation of children patients with cerebral palsy. Methods A total of 80 children patients with cerebral palsy who were admitted to Jiangxi Ganzhou People's Hospital from January 2019 to January 2020 were selected and given rehabilitation treatment.They were divided into two groups by the random number table method, with 40 cases in each group. The control group was given routine education, and the observation group was given standardized video education. The effectiveness of education, rehabilitation, and total nursing satisfaction of the patients' family members were compared between the two groups. Results Before nursing, there was no significant difference in health knowledge scores between the two groups(P＞0.05). After nursing, the health knowledge score of the observation group was (90.38±4.16) points, which was higher than that of the control group of (85.74±6.53) points, and the difference was statistically significant (P＜0.05). After nursing, the rehabilitation compliance score of the observation group was (10.29±1.32) points, which was higher than that of the control group of (8.64±1.27) points, the difference was statistically significant (P＜0.05). The total effective rate of the observation group was 90.00%, which was higher than that of the control group (70.00%), the difference was statistically significant (P＜0.05). The total nursing satisfaction of family members of the observation group was 95.00%,higher than that of the control group of 80.00%, the difference was statistically significant (P＜0.05). Conclusion The application of standardized video education in the rehabilitation of children patients with cerebral palsy can help improve the knowledge level of family members, improve the compliance of children patients with rehabilitation treatment,and improve the rehabilitation effect and nursing satisfaction. 2021 Vol. 28 (30): 195-198 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 199 Implementation effect of intravenous team management model combined with health education in PICC catheterization of cancer patients LUO Chen；YU Yan-min；HU Xia； CHENG Hong-bo； HU Ai-zhen ；DENG Xiu-ying  Objective To summarize the effect of intravenous team management model combined with health education in PICC catheterization of cancer patients, and to explore its value. Methods A total of 94 cancer patients who received peripherally inserted central venous catheter (PICC) catheterization in the Jiangxi Provincial People's Hospital from January 2019 to March 2020 were selected. They were divided into the control group and the study group according to the random number table method, with 47 patients in each group. The control group were given conventional nursing care, and the study group were given intravenous team management model combined with health education. The complications, catheterization compliance, self-care ability and health knowledge mastery were compared between the two groups. Results The total complication rate in the study group was lower than that in the control group, with statistically significant difference (P＜0.05). The catheterization compliance in the study group was higher than that in the control group, with statistically significant difference (P＜0.05). The scores of self-care ability and health knowledge mastery in the study group were higher than those in the control group, with statistically significant differences (P＜0.05). Conclusion Intravenous team management model combined with health education can improve catheterization compliance and reduce complications in PICC catheterization of cancer patients. It is worthy of promotion. 2021 Vol. 28 (30): 199-202 [Abstract] ( 49 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 203 Effect of psychological nursing on the mental state and periodontal health of patients with periodontal disease after orthodontic treatment XIONG Pei-wen；WU Xing-sheng Objective To explore the effect of psychological nursing on the mental state and periodontal health of patients with periodontal disease after orthodontic treatment. Methods A total of 106 orthodontic patients with periodontal disease admitted to Stomatological Hospital Affiliated to Nanchang University from May 2019 to January 2021 were selected and divided into the study group and the control group according to random number table method, 53 cases in each group. The control group was adopted routine nursing, and the study group was adopted enhanced psychological nursing on the basis of the control group. Both groups of patients were given continuous care for 4 weeks. The cooperation degree during nursing, anxiety score, depression score, pain score and periodontal health before and after nursing of the two groups were compared. Results The degree of cooperation between patients in the study group and nursing staff during nursing was higher than that in the control group, the difference was statistically significant (P＜0.05). After nursing, the pain score, anxiety, depression, gingival index, gingival bleeding index, and plaque index of the two groups were lower than before nursing, the pain score, anxiety, depression, gingival index, gingival bleeding index, and plaque index of the study group were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Psychological care can effectively improve the mental state of patients undergoing orthodontic treatment of periodontal disease, and improve patients' gum health. 2021 Vol. 28 (30): 203-205 [Abstract] ( 54 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 206 Influence of continuous nursing on treatment compliance and quality of life in school-age children with asthma NIE Qin；LUO Wu-ting Objective To explore the application value of continuous nursing in school-age children with asthma.Methods A total of 70 school-age children with asthma admitted to the Yichun Second People's Hospital from September 2019 to September 2020 were selected. They were divided into the control group (35 cases) and the observation group (35 cases) using random number table method. All children were given basic treatment such as anti-infection, oxygen inhalation, antispasmodic, and anti-asthmatic after admission. The treatment was continued for 14 days.The control group was given conventional health education and nursing, and the observation group was given continuous nursing continuously for 3 months. The treatment compliance and quality of life were compared between the two groups.Results The total compliance in the observation group was 94.29%, which was higher than that in the control group as 77.14%, with statistical significant difference (P＜0.05). Before intervention, there was no statistically significant difference in summary health status survey (SF-36) score between the two groups (P＞0.05). After intervention, the SF-36 scores in the two groups were higher than those before intervention, the SF-36 score in the observation group was(81.64±6.78) points, which was higher than that in the control group of (74.36±6.31) points，with statistical differences(P＜0.05). Conclusion Continuous nursing can improve the treatment compliance and quality of life in school-age children with asthma. It is worthy of promotion and application. 2021 Vol. 28 (30): 206-208 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 4 ) 209 Effect of Orem self-care theory nursing on psychiatric symptoms and ability of daily living in schizophrenia patients CHEN Juan；LIU Yi-feng Objective To explore the application effect of Orem self-care theory nursing in schizophrenia patients.Methods A total of 88 schizophrenia patients admitted to Jiujiang Fifth People's Hospital from February 2019 to February 2021 were selected as subjects. They were divided into the control group (44 patients) and the observation group (44 patients) using random number table method. Both groups were treated with antipsychotic drugs. The control group was given conventional nursing, and the observation group was given Orem self-care theory nursing. The intervention time was 4 weeks. The scores of psychiatric symptoms (brief psychiatric rating scale [BPRS], ability of daily living (activity of daily living scale [ADL]) and self-care ability (exercise of self-care agency scale [ESCA]) were compared between the two groups before and at 4 weeks after intervention. Results The BPRS scores in terms of excitement, anxiety, depression, thinking disorder, retardation, and hostility suspicion in the observation group were (4.63±0.25), (5.09±1.28), (10.02±1.98), （3.90±0.58）,and(9.63±1.39)points,which were lower than those in the control group of(5.26±0.34), (6.97±1.30), (12.05±2.13), (5.01±0.63), and (12.07±1.46) points, with statistical differences (P＜0.05). The ADL and ESCA scores after intervention in the observation group were (80.67±6.04) and (106.87±6.54) points, which were higher than those in the control group of (70.59±5.21) and (95.74±7.25) points, with statistical differences (P＜0.05). Conclusion Orem self-care theory nursing can alleviate the psychiatric symptoms, improve the patients' ability of daily living and self-care, and promote the fast recovery in schizophrenia patients. 2021 Vol. 28 (30): 209-211转223 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 212 Application effect of touch nursing in neonatal jaundice nursing LI Xiao-qiong Objective To analyze application effect of touch nursing in the nursing of neonatal jaundice. Methods Altogether 104 newborns with jaundice in Jiangmen Maternity and Child Health Hospital from December 2018 to December 2020 were selected as research objects and divided into the experiment group (52 cases) and the reference group (52 cases) by the random number table method. The reference group was treated with traditional nursing; while,the experiment group was treated with touch nursing on the basis of traditional nursing. The nursing effect direct bilirubin, total bilirubin, jaundice index, defecation frequency, jaundice regression time, the time of change of meconium into yellow, first defecation time were compared between two groups. Results The total effective rate of nursing effect in the experiment group (94.23%) was higher than that in the reference group (73.08%), with statistical difference (P＜0.05).After 7 days nursing, the direct bilirubin, total bilirubin and jaundice index of the experiment group were lower than those of the reference group, with statistical differences (P＜0.05). The defecation frequency of the experiment group at 1, 4 and 7 d was higher than that of the reference group, with statistical difference (P＜0.05). The jaundice regression time, the time of change of meconium into yellow and the first defecation time of the experiment group were shorter than those of the reference group, with statistical differences (P＜0.05). Conclusion Touch nursing can effectively reduce the bilirubin level and jaundice index of jaundiced newborns, increase the frequency of defecation and promote the regression of jaundice. 2021 Vol. 28 (30): 212-215 [Abstract] ( 50 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 216 Effect of hospital chronic disease management team combined with graded nursing on self-management behavior of diabetic patients in Urban areas CHEN Yuan-mei；CHEN Gui-xian；XIE Li-li；YAO Chun-jie；MAI Qiu-jun；LIU Feng-yu Objective To explore the influence of chronic disease management team combined with graded nursing on the self-management behavior of diabetic patients in urban areas. Methods The clinical data of 121 cases of diabetic patients admitted to Chaozhou People's Hospital in Guangdong Province from January 2019 to May 2020 were retrospectively analyzed and divided into the control group (61 cases) and the observation group (60 cases) according to different nursing methods. At the same time，all the patients were divided into subgroups according to the level of glycosylated hemoglobin. 26 patients whose glycosylated hemoglobin ＞4% and ≤6% were taken as group A; 20 patients whose glycosylated hemoglobin＞6% and ≤8% were taken as group B; 14 patients whose glycosylated hemoglobin ＞8%were taken as group C. The control group received routine nursing, and the observation group received hospital chronic disease management team participation and graded nursing. The self-management behavior scores of the two groups were compared; the changes of fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 h PG) and glycosylated hemoglobin (HbA1c) were observed; and the self-management behavior of patients with different blood glucose was analyzed. Results The score of self-management behavior in the observation group was higher than that in the control group, with statistical difference (P＜0.05). The levels of FPG, 2 h PG and HbA1c in the observation group were lower than those of the control group after nursing, with statistical differences (P＜0.05). There were no statistically significant differences of the SDSCA-6 scores in group A before and after nursing (P＞0.05); there were statistically significant differences of the SDSCA-6 scores in group B before and after nursing (P＜0.05); there were statistically significant differences of the SDSCA-6 scores in group C before and after nursing (P＜0.05). Conclusion After the implementation of hospital chronic disease management combined with graded nursing, patients can quickly form good self-management behavior, control the blood glucose level within the normal range, and contribute to the improvement of quality of life. 2021 Vol. 28 (30): 216-219 [Abstract] ( 54 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 220 Effect of nursing intervention on arteriovenous fistula formation in hemodialysis patients WU Li-dan；CAI Li-na Objective To investigate the influence of nursing intervention on the formation of blunt needle fistula in arteriovenous internal fistula in hemodialysis patients. Methods A total of 260 patients with hemodialysis+blunt needle puncture afterarteriovenous internal fistula admitted to Xiamen Hospital of Traditional Chinese Medicine from February 2016 to February 2018 were selected as the research objects. By envelope randomization, they were divided into the observation group (140 cases) and the control group (120 cases). The observation group was given intervention, was punctured by the same nursing staff, while the control group was given routine nursing, was punctured according to the working hours of nursing staff. The formation time of blunt needle fistula, different methods of scab removal, three times of puncture, pain score of blunt needle fistula formation, anxiety and depression scores before and after puncture were compared between the two groups. Results The formation time of blunt needle fistula in observation group was shorter than that in control group, and the difference was statistically significant (P＜0.05). The number of fistula puncture in observation group was less than that in control group, and the difference was statistically significant (P＜0.05). The scab removal time in the observation group was shorter than that in the control group after wet application of warm sterile normal saline cotton ball, and the difference was statistically significant (P＜0.05). The pain score of the observation group was lower than that of the control group after three puncture times, and the difference was statistically significant(P＜0.05). The pain score of blunt needle fistula formation in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Before puncture, there were no significant difference in anxiety and depression scores between the two groups (P＞0.05). After puncture, anxiety and depression scores in the observation group were lower than those in the control group, with statistical differences (P＜0.05）. Conclusion Nursing intervention is helpful to regulate the bad mood of patients in the formation stage of blunt needle fistula; the effect of eschar removal is more significant by wet application of warm sterile saline cotton ball; the formation time of arteriovenous fistula in hemodialysis patients can be shortened by puncturing by a nursing staff 2021 Vol. 28 (30): 220-223 [Abstract] ( 50 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 224 Clinical effect of prospective nursing on the patients receiving cardiopulmonary resuscitation LUO Yang；LIU Li-fen；CHEN Gui-hong；XUE Shui-lan Objective To explore the clinical effect of prospective nursing on the patients receiving cardiopulmonary resuscitation. Methods From February 2019 to February 2021, 60 patients receiving cardiopulmonary resuscitation who were admitted to the Putian Branch, No.900 Hospital of Joint Force of Logistic Support were selected as the study subjects.They were divided into the control group (30 cases)and the observation group (30 cases)by random number table method. The control group was given conventional nursing method, and the observation group was given prospective nursing method. The blood gas analysis index levels, Glasgow coma index (GCS) scores, and nursing satisfaction were compared between the two groups at 12 and 24 h after resuscitation. Results At 12 and 24 h after resuscitation, the blood oxygen partial pressure (PaO2) level in the observation group was higher than that in the control group, and the carbon dioxide partial pressure (PaCO2) level was lower than that in the control group, the differences were statistically significant (P＜0.05). At 6 and 12 h after resuscitation, the GCS scores in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The nursing service satisfaction score in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion Prospective nursing in the patients receiving cardiopulmonary resuscitation has the values of improving blood gas index levels, promoting the recovery of nerve function after cardiopulmonary resuscitation, and improving patients' acceptance. 2021 Vol. 28 (30): 224-226 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 9 ) 227 Application of fast track surgery concept perioperative nursing in elderly patients with brittle hip fracture HU Min Objective To analyze the application value of perioperative nursing intervention of rapid recovery surgery(FTS) in elderly patients with Brittle hip fracture. Methods A total of 80 elderly patients with Brittle hip fracture admitted to Xiaogan Center Hospital from January 2019 to August 2020 were selected as study subjects. The patients were divided into the control group and the observation group by drawing lots, 40 cases in each group. The control group was given routine nursing, the observation group was given routine nursing plus FTS perioperative nursing intervention, and the hip function (Harris), visual aralogue scale (VAS), activity of dailylivzing (ADL), incidence of complication, and the follow-up results were compared before and 1 month after nursing, incidence of complications and follow-up results. Results Before nursing, there were no significant differences in Harris, VAS and ADL scores between the two groups (P＞0.05); at 1 month after nursing, the Harris and ADL scores of two groups were higher than those before nursing, the VAS scores of two groups were lower than those before nursing, the Harris and ADL score of the observation group were higher than those of the control group, and the VAS score of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The patients were followed up for half a year, and there was no recurrence of adverse events in the two groups. There was no significant difference in the follow-up results between the two groups (P＞0.05). Conclusion The perioperative nursing of FTS concept in elderly patients with brittle hip fracture can improve hip joint function, relieve pain, improve daily living ability, and reduce the incidence of complications. 2021 Vol. 28 (30): 227-229转233 [Abstract] ( 50 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 230 Application effect of comprehensive nursing in laparoscopic high ligation of pediatric hernia HUANG Xiao-yu Objective To explore the application effect of comprehensive nursing in laparoscopic high ligation of pediatric hernia. Methods From January to December 2020, 90 children patients laparoscopic high ligation of pediatric hernia who were admitted to Sanming First Hospital were selected as the study subjects. A computerized grouping method was used to divide the children patients into the routine group and the observation group, 45 cases in each group. Children patients in the routine group were given routine nursing intervention, and those in the observation group were given comprehensive nursing intervention. The surgical indicators (duration of operation, intraoperative blood loss, length of stay), quality of life, nursing satisfaction, and clinical complications were compared between the two groups. Results After nursing, the duration of operation and length of hospital stay in the observation group were shorter than those in the routine group, and the blood loss during operation was less than that in the routine group, the differences were statistically significant (P＜0.05). Scores of quality of life, including social function, physical health,physiological function, role function and other indicators in the observation group were higher than those in the routine group, and the differences were statistically significant (P＜0.05). The total satisfaction with nursing care in the observation group was higher than that in the routine group, the total incidence rate of complications in the observation group was lower than that in the routine group, and the differences were statistically significant (P＜0.05). Conclusion Comprehensive nursing intervention in the children patients laparoscopic high ligation of pediatric hernia has a significant clinical application value and can be further applied as a reference. 2021 Vol. 28 (30): 230-233 [Abstract] ( 54 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 234 Nursing effect of strengthening health cognition model in patients with Gallstone QIU Jie-ling  Objective To observe the nursing effect of strengthening health cognition mode in patients with gallstone.Methods A total of 160 cases of patients with gallstones treated in People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from October 2018 to October 2020 were selected, they were divided into two groups according to random number table method, 80 cases in each group. The control group received conventional nursing mode,the experimental group was given strengthening health cognitive model, nursing effect, the gallbladder contraction function, anal exhaust time, length of hospital stay and postoperative satisfaction of two groups were compared. Results Before nursing, there were no significant differences in gallbladder contraction function, anal exhaust time, hospitalization time, and postoperative satisfaction between the two groups, and the difference were not statistically significant (P＞0.05). After nursing, the gallbladder contraction function of the experimental group was batter than that of the control group, the time of anal exhaust and hospitalization were shorter than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the total satisfaction of nursing in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Strengthening health cognition model has a significant nursing effect in patients with gallstones, and it is safe. More popularization and application can help improve the nursing effect and reduce the occurrence of adverse reactions. 2021 Vol. 28 (30): 234-236转240 [Abstract] ( 48 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 237 Effect of whole course nursing Intervention on postpartum depression for second-born parturients WANG Qian-qian；WANG Qiao-li；XIE Xiao-fang Objective To explore the clinical effect of whole course nursing intervention on postpartum depression for second-born parturients. Methods Altogether 110 pregnant women with second born treated in the Affiliated Hospital of Heze Medical College from January 2018 to December 2019 were selected as the research objects and divided into the control group (55 cases) and the intervention group (55 cases) according to random number table method. The control group adopted the method of basic nursing during pregnancy, and the intervention group adopted the online psychological counseling and diversified intervention methods during pregnancy and delivery and after delivery on basis of the control group. Hamilton depression scale (HAMD) and social disability screening schedule (SDSS) were used to compare the depression, social function and satisfaction with nursing services before and after intervention between two groups. Results Before intervention, there were no statistically significant difference in HAMD and SDSS score between the two groups (P＞0.05); after the intervention, the HAMD and SDSS score of the intervention group were lower than those of the control group, with statistical differences (P＜0.01). The satisfaction of nursing service in the intervention group was higher than that in the control group, with statistical difference (P＜0.05). Conclusion The whole process nursing intervention can not only effectively improve the symptoms of postpartum depression for second-born parturients, but also enhance the social function of parturients, which is worthy of popularization and application. 2021 Vol. 28 (30): 237-240 [Abstract] ( 45 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )

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