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2016 Vol. 23, No. 23 Published: 2016-08-18

	4	Preparation and quality evaluation of Breviscapine oral fast dissolving films
		ZHANG Li-hua ；SONG Jian ；CHENWei-wei ；ZHANG Jing-wu
		Objective To prepare Breviscapine oral fast dissolving films and to evaluate the quality. Methods The solvent castingmethod was used to prepare Breviscapine oral fast dissolving films，the films evaluation and dissolution of themembranewere used as the evaluation index，the L9（34）orthogonal experimental design method was used to optimize the prescription.Results Themain factors influenced the appearance of the oral fast dissolving filmswere the proportion of film formingmaterial（E5 PVA/HPMC）and the dosage of plasticizer，while themain factors influenced the dissolution were the proportion of film forming material and the amount of the disintegrating agent used.The optimal prescription was determined considering both the appearance and dissolution index，the samples prepared according to the optimal prescription had good uniform of thickness，appropriate flexibility and tensile properties，the disintegrating time was less than 30 secondswith fast dissolving profile and good content.Conclusion The preparation of the Breviscapine oral fast dissolving films is objective，the product quality is stable，and themethod can be used as reference to related studies.
		2016 Vol. 23 (23): 4-7 [Abstract] ( 138 ) HTML (40 KB) PDF (0 KB) ( 25 )

	8	Regulation effect of burdock oligosaccharide GF13 on blood glucose in tumor-bearing rats
		LIU Jian-xiu；CHEN Xiao-rong；REN Jin-yu

		2016 Vol. 23 (23): 8-11 [Abstract] ( 145 ) HTML (44 KB) PDF (0 KB) ( 17 )

	12	Contents change of dencichine before and after Ginseng processed with Gardenia
		SUN Yuan-yuan；JIA Tian-zhu
		Objective to determine the contents of dencichine before and after Ginseng processed with Gardenia.Methods The contents change of dencichine before and after Ginseng processed with Gardenia was determined by HPLC. Results The contents of dencichine of Ginseng raw product was 2.1‰，red Ginseng was 0.9‰，Ginseng processed with Gardenia was 0.5‰.Compared with Ginseng raw product，the contents of dencichine of red Ginseng reduced 57%，Ginseng processed with Gardenia reduced 76%.Conclusion After Ginseng processed with Gardenia，the contents of dencichine reduce.
		2016 Vol. 23 (23): 12-14转18 [Abstract] ( 140 ) HTML (37 KB) PDF (0 KB) ( 10 )

	15	Influence of Resveratrol supp lement on behavior of zebrafish larvae to acute ethanol exposure
		CHEN Hao-jun1；LIN Jia；LIQiang；GUO Ning
		Objective To explore the influence of Resveratrol supplement on behavior of zebrafish larvae to acute ethanol exposure induced by different concentrations of ethanol under varying light conditions.Methods 300Wild-type AB strain zebrafish larvae（0 day post fertilization，0 dPF）without eggmembrane were randomly divided into two groups，and were treated with system water or resveratrol for 4 days，respectively.Each group was divided into 4 teams　（36 per team）at 5 dpf，and acutely exposed under alcohol（0.0%，0.5%，1.0%，2.0%）.Distancemoved perminute was recorded under alternating 1ight-dark challenges，and the data was analyzed by two-factors analysis of variance.Results Acute exposure to 0.0%and 0.5%alcohol，the locomotor activity was decreased in Resveratrol supplement-treated zebrafish larvae in darkness.In the startle response to light changes，the swimming distance ratio of Resveratrol supplement under 0.5%alcohol exposured was significantly increased.The swimming distance ratio was showed over 1 in 2.0%alcohol treated groups without Resveratrol supplement.Conclusion Resveratrol supplement in early development of zebrafish larvae can exert significant influences on the behavior changes induced by acute ethanol exposure.
		2016 Vol. 23 (23): 15-18 [Abstract] ( 155 ) HTML (40 KB) PDF (0 KB) ( 35 )

	19	Short and long term effect observation of primary surgery in the treatment of tetralogy of Fallot during infant period
		LIU Zhi-yuan；　ZHANG Jian-bin　；XU Chong-fei
		Objective To study short and long term effect of primary surgery on treating tetralogy of Fallot during infant period.Methods From March 2011 to May 2015，72 patients with tetralogy of Fallot during infant period admitted into our hospitalwere selected as research objects.Based on patient′s age，they were divided into two groups，babieswith age nomore than 6 months were classified into observation group A　（n=36），babies with age ranging from 7 to 12 months were categorized into observation group B（n=36），all participantswere treated by primary surgeries.The surgical related indexes，occurrence of complications and follow-up result in the two groups were compared.Results In the observation group A，time ofmechanical ventilation and time of intensive care weremuch longer than those in the observation group B with statistical differences（P＜0.05）.There was no great difference in the occurrence of complications in two groups （P＞0.05）；During follow-up visits，there were no death，reoperation，decline of left heart function and severe residual obstruction of outflow tract of right ventricle occurring，every baby was in a good development；incidences in residual shunt of interventricular septum，and medium-severe residual obstruction of outflow tract of right ventricle between two groups were not displayed statistical significance（P＞0.05）.Conclusion Babieswhose ages are nomore than 6 months suffering from tetralogy of Fallot during infant period can accept primary surgery，which can obtain a great short and long term effectwith a favorable prognosis.
		2016 Vol. 23 (23): 19-21 [Abstract] ( 155 ) HTML (33 KB) PDF (0 KB) ( 34 )

	22	Clinical significance of sputum procalcitonin testing in acute exacerbation of chronic obstructive pulmonary disease
		ZHANG Cai-xia
		Objective To explore the clinical value of sputum procalcitonin　（PCT）and serum PCT testing in acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 80 patientswith AECOPD（A group）and 40 patients in stable period（B group）in our hospital from June 2014 to December 2015 were randomly selected，patients in A group were divided into bacterial infection group（A1 group，n=40）and non bacterial infection group（A2 group，n=40），the level of sputum and serum PCT，serum CRP of each group were tested.The results of sputum PCT，serum PCT and serum CRP of each group were compared，the relationship between sputum PCT and serum PCT was analyzed.Results The sputum and serum PCT in A1 group were higher than those in A2 group and B group，and the difference was statistical significance　（P＜0.05）；the sputum and serum PCT in A2 group were higher than those in B group，and the difference had no statistical significance（P＞0.05）.The difference of CRP between A group and B group was statistical significance（P＜0.05），while CRP between A1 group and A2 group had no statistical significance（P＞0.05）.The positive detection rate of sputum PCT was slightly higher than that of serum PCT，and the positive detection rate of sputum and serum PCT were obvious higher than that of serum CRP.The relationship analysis of sputum PCT and serum PCT showed well　（r=0.721，P＜0.05）.Conclusion Sputum and serum PCT can be used as inflammatory index in early prediction of AECOPD and is better than CRP.In reflecting local bacterial infection of respiratory tract，sputum PCT is better than serum PCT，and sputum PCT has the advantages of convenient detection，fast and easy to obtain specimens，which is suitable for clinical promotion.
		2016 Vol. 23 (23): 22-24 [Abstract] ( 156 ) HTML (33 KB) PDF (0 KB) ( 21 )

	25	Clinical effects of different pancreatic duct drainage in pancreaticoduodenectomy
		ZHAOMing-xun；ZHANGWen-zhi；LENG Jian-jun
		Objective To analyze the correlations of different pancreatic duct drainage　（external vs internal）with postoperative complications including pancreatic fistula，biliary fistula，intraperitoneal hemorrhage and infection，and explore treatment strategy for pancreatic fistula.Methods 81 cases who received pancreatic duct drainage in pancreaticoduodenectomy in the General Hospital of PLA from May 2013 to January 2015 were selected and divided into group A（n= 49）and group B　（n=32），receiving internal and external drainage respectively.The rates of complicationswere compared including pancreatic fistula，biliary fistula，intraperitoneal hemorrhage，gastroplegia，infection，incision complications and chylous fistula etc.Results The time of operation in group A was shorter than that in group B with statistical significance　（P＜0.05）.The levels of alanine transaminase，total bilirubin and albumin before surgery，as well as intraoperative blood loss between two groups showed no significant differences（P＞0.05）.The rates of postoperative complications including pancreatic fistula，biliary fistula，intraperitoneal hemorrhage and infection in group A were not significantly different from those in group B　（P＞0.05）.Conclusion Internal pancreatic duct drainage is simpler and spends less time than that of external drainage.Careful operation and complete drainage after opration are essential for reducing the rates of postoperative complication and death rate，safely spenting perioperation.
		2016 Vol. 23 (23): 25-27 [Abstract] ( 122 ) HTML (35 KB) PDF (0 KB) ( 15 )

	28	Research of relevant factor of clinical judgment in treatment of traumatic sp lenic rupture
		WANG Jian-yong ；ZHOU Zhi-hong ；ZHANG Hai-yan
		Objective To study the related factors influencing clinical judgment in treatment of traumatic splenic rupture.Methods 139 cases of traumatic spleen rupture treated in our hospital from March 2012 to September 2015 were selected，and the factors influencing the treatment plan were analyzed by Logistic regression analysis.Results Causes of injuries，pulse，amount of bleeding，abdominal puncture，injury classification and whether complicated with organ injury were closely related with therapeutic scheme；while themulti factor Logistic regression analysis confirmed that the difference of gender，hospitalization time and treatment scheme was not statistically significant.55 cases in conservative treatment patientswere gradeⅠ，gradeⅡpatients，accounting for 39.6%　（55/139），84 cases surgical patients accounted for 60.4%　（84/139），spleen excision rate was 47.6%in patientswith gradeⅠandⅡ，100.0%in patientswith gradeⅢandⅣ；Success rate of surgical treatmentwas 90.8%，success rate of conservative treatment with 89.1%，the difference was not statistically significant（P＞0.05），success rate of conservative treatment for traumatic splenic rupture was higher，close to success rate of surgical treatment.Conclusion The whole spleen resection ismain therapeutic method of traumatic splenic rupture，and operation protecting spleen or nonoperative treatment is a safe and effectivemethod of treatment according to causes of injuries，pulse，amount of bleeding，abdominal puncture，injury classification，whether complicated with organ injury and other factors.
		2016 Vol. 23 (23): 28-30转35 [Abstract] ( 143 ) HTML (35 KB) PDF (0 KB) ( 2 )

	31	The curative effect analysis of long-term home noninvasive positive pressure ventilation combined with tiotropium brom ide and seretide in treatment of patients with severe COPD in stable period
		XU Jian-qiang；　DAIYue；　FENG Juan；　CAO Nian；　DAI Li-li ；YUAN Xia
		Objective To observe the effect of long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide in treatment of patients with severe stable COPD.Methods 178 cases of severe stable COPD patients discharge in our department of respiratory from January 2011 to June 2014 were selected as the research object and divided into control group and experimental group，with 89 cases in each group，patients in two groups were discharged from the hospital after using the general treatment in stable period，on basis of general treatment，patients in the experimental group were treated with long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide，and patients in the control group were treated with tiotropium bromide and seretide.Patientswere followed up for 1 year，and the respiratory function，blood gas analysis，times of hospitalization，sixminutes walk test（6MWT）.St.George life quality（SGRQ）score，Modified Version of the British Medical Research Council Respiratory Questionnaire　（mMRC）of discharged from the hospital and 1 years followed-up were observed and compared.Results ThemMRC scores，6MWT，SGRQ score，times of hospitalization in the experimental group were significantly lower than those in the control group　（P＜0.05）；The lung function and PaCO2，PaO2in the experimental group was significantly improved，and the differenceswere statistically significant（P＜0.05）.Conclusion Long-term home noninvasive positive pressure ventilation combined with tiotropium bromide and seretide can effectively improve the pulmonary function of patientswith severe COPD in stable period，significantly improve blood gas and the quality of life，less times of hospitalization，which isworthy of clinical promotion.
		2016 Vol. 23 (23): 31-35 [Abstract] ( 162 ) HTML (41 KB) PDF (0 KB) ( 23 )

	36	The clinical curative effect analysis of cyproheptadine，sulfasalazine and bismuth pectin in treatment of patients with ulcerative colitis
		ZHENG Shuai；WANG Tong-tong；LIJing；ZHAO Yu-mei；Na Li-sha
		Objective To explore clinical curative effect of cyproheptadine，sulfasalazine and bismuth pectin in treating ulcerative colitis.Methods From January 2013 to December 2015，according to visit order of admission and drug regimens，50patientswithulcerativecolitisbysulfasalazinemonotherapy（controlgroup），while50 casespatientswithulcerative colitis by sulfasalazine，cyproheptadine and colloidal bismuth pectin combination therapy　（observation group）were retrospectively and comparatively studied.Total efficiency，relief time of hematochezia and abdominal pain，incidence of adverse reaction were compared between two groups.Results The clinical total effective rate in the observation group was 96%，higher than 80%in the control group　（P＜0.05）.Compared with the control group，relief time of hematochezia and abdominal pain in the observation group were significantly shortened（P＜0.05）.Incidence of adverse reactions in the observation group was 4%，significantly lower than 18%in the control group　（P＜0.05）.Conclusion In the clinical treatment of patients with ulcerative colitis by sulfasalazine，cyproheptadine and colloidal bismuth pectin combination therapy has significant curative effect and can effectively promote the relief of clinical symptoms，reduce adverse reactions.
		2016 Vol. 23 (23): 36-38 [Abstract] ( 141 ) HTML (34 KB) PDF (0 KB) ( 31 )

	39	Influence of physical exercise combining with deanxit on depressive disorder in patients with type 2 diabetesmellitus
		ZHONG Jin-jun
		Objective To explore the influence of physical exercise combining with deanxit on depressive disorder in patients with type 2 diabetesmellitus　（T2DM）. Methods 120 T2DM patients hospitalized and from outpatient clinics from January 2013 to October 2014 in our hospitalwere selected and randomly divided into the observation group one，the observation group two，the observation group three and the control group，30 cases in each group.The control group was only treated with insulin，the observation group one was given deanxit on the basis of the control group，the observation group two was given physical exercise on the basis of the control group，the observation group three was given deanxit on the basis of the observation group two.The course of treatmentwas lasted for 4 weeks.The homeostasismodel assessment of insulin resistance　（HOMA-IR）before and after therapy，the score of self-rating depression scale（SDS）and Hamilton depression scale（HAMD）were compared.The effect evaluation was performed after score standardization by nimodipinemothed.Results Except the control group，the values of HOMA-IR，the scores of SDS and HAMD before and after therapy，and the curative effect were all improved，All indexes in the observation group three were improved more remarkably compared with the other groups，with statistical difference（P＜0.01）.Conclusion Comprehensive therapy of physical exercise with early-stage anti-depression has an obvious effect on improving each index in T2DM with depressive disorder patients aswell as quality of life，it isworthy of clinical promotion and application.
		2016 Vol. 23 (23): 39-42 [Abstract] ( 111 ) HTML (39 KB) PDF (0 KB) ( 10 )

	43	Influence of mobile phone shortmessage education on cognitive behavior management in patientswith type 2 diabetesmellitus
		LIXiao-yan；　YANG Guang；　ZHONG Shu-mei ；ZHANG Qiu-pin
		Objective To explore the influence ofmobile phone shortmessage education on cognitive behavior ability in patientswith type 2 diabetesmellitus（T2DM）. Methods 80 patientswith T2DM in our hospital from April 2014 to June 2015 were selected and randomly divided into themobile phone shortmessage education group　（group A，44cases）and the regular group　（group B，36 cases）.Group A was given themobile phone shortmessage education with the conventional health education，group B was only given conventional health education.The cognitive ability in patientswith diabetesmellitus knowledge，the changes of blood glucose，self-efficacy and quality of life in the two groupswas compared. Results After 1 years of follow-up，the diabetes cognitive ability，blood glucose control，self-efficacy and quality of life in the two groupswere significantly improved（P＜0.05）.The improvement of the indexes of group A was significantly better than that of group B，with significant difference　（P＜0.05）.Conclusion Management of diabetic patients with mobile phone shortmessage education and conventional education can prompt not only blood glucose control level but also the knowledge level of patientswith diabetesmellitus，behavioral change，the ability of self-management and quality of life.
		2016 Vol. 23 (23): 43-45 [Abstract] ( 147 ) HTML (31 KB) PDF (0 KB) ( 21 )

	46	Clinical diagnostic value of detection of ultrasound combined with ank le brachial indexes by ultrasound in diabetic vascular lesions
		HUANGWei
		Objective To explore the clinical diagnostic value of detection of ultrasound combined with ankle brachial indexes in diabetic vascular lesions. Methods 100 patients with diabetes in our hospital from September 2014 to December 2015 were selected as the research group，all patientswere diagnosed by coronary angiography.The detection results of coronary angiography was selected as the control group，the ABI testwas used as the observation group.The inner diameter of posterior tibial artery and foot dorsal artery，the formation of atherosclerotic plaques and the proportion of stenosis and occlusion was compared between the two groups.Additionally，the positive diagnosis rate by using ultrasound in combination of ABI values was analyzed.Results The inner diameter of posterior tibial artery and foot dorsal artery in the observation group was larger than that in the control group，with significant difference　（P＜0.05）.There was no significant difference in the proportion of formation of artery plaques，stenosis and occlusion between the two groups （P＞0.05）.There was no significant difference in the positive diagnosis rate and negative diagnosis rate between the two groups（P＞0.05）.Conclusion Ultrasound combined with ABI can effectively determine the diameter of the lower limb artery，especially in the diagnosis of themorphological changes of the lumen of the artery，the positive diagnosis rate is higher.
		2016 Vol. 23 (23): 46-48 [Abstract] ( 123 ) HTML (33 KB) PDF (0 KB) ( 30 )

	49	Comparative study of indocyanine green and methylene blue sentinel lym ph node biopsy in breast cancer surgery
		LIShang-qin；　SU Guo-sen；　ZHAN Jian-wei ；HUANG Guo-xing；　CHENG Shao-ping
		Objective To compare the indocyanine green and methylene blue sentinel lymph node biopsy in breast cancer clinical effect，clinical breast cancer sentinel lymph node biopsy performed provide a basis. Methods 128 cases patients with breast cancer from January to August 2015 were treated in our hospital for the study，according to the order of treatment numbers，and were digital randomly assigned into 64 cases of observation group and 64 cases of the control group.The observed group was used indocyanine green as a tracer tracer sentinel lymph node surgery looking ipsilateral upper outer quadrantof the breast area of real-time imaging of lymphatic drainage，photographs and mark the position of the body surface，re-modified radical mastectomy，and routine axillary lymph node dissection（ALND），after sentinel lymph node biopsy and axillary lymph node；the control group was used methylene blue as a tracer tracer sentinel lymph node，intraoperative blue dye to look for lymph nodes，remove themark sent to pathological examination，re-modified radicalmastectomy and ALND，after sentinel lymph node biopsy and axillary lymph nodes，sentinel lymph node metastasis detection and axillary lymph nodes were the same or not.Result s The group of 64 patients，sentinel lymph node biopsy（SLN）detection rate of 95.31%，a total of 157 successfully detected SLN，2.57 per average number of detected cases，the sensitivity was 93.33%and the accuracy 96.77%false negative rate was 6.67%；the control group of 64 patients，SLN detection rate of 89.06%，a total of 127 successfully detected SLN，the average number of cases detected in 2.23，the sensitivity of 85.19%accuracy 92.98%，the false negative rate was 14.81%.The sensitivity of observation group was higher than that of the control group，the false negative rate was lower than that of the control group，the differencewas significant（P＜0.05）.Conclusion Indocyanine green tracer as a tracer for sentinel lymph node biopsy has success rate，false negative rate，the clinical effect is better than methylene blue，which is expected to be applied individually to sentinel lymph node biopsy.
		2016 Vol. 23 (23): 49-51转71 [Abstract] ( 156 ) HTML (35 KB) PDF (0 KB) ( 23 )

	52	The clinical significance of the treatment of early breast cancer in the adjuvant radiotherapy after modified radicalmastectom y ER（-）and PR（-）
		CHEN Feng-wu
		Objective To explore postoperative auxiliary radiotherapy for ER（-）and PR（-）improved radical postoperative patientswith early breast cancer reduced the local recurrence rate（LRR），distantmetastasis rate（DM），disease-free survival（DFS）and overall survival rate（OS）of clinical value. Methods From January 2011 to January 2013 collected in our hospital 80 cases of patients with complete medical records.Breast cancer modified radical mastectomy，based on condition and the willingness of patients divided into postoperative adjuvant chemotherapy group，postoperative auxiliary chemotherapy group.Postoperative radiotherapy for patients with postoperative adjuvant radiotherapy was performed on the side of the side of the chestwall，and the patientswere followed up once every threemonths.Observation of the patient's breast echocardiogram，chest radiographs，tumor index to observe the patients three years LRR，DM，DFS and OS，difference to display the postoperative adjuvant radiotherapy to the clinical significance and the observation of radiotherapy of bonemarrow suppression，radiation pneumonitis，radiation injury of heart and other side effects.Results Postoperative adjuvant chemotherapy group，postoperative adjuvant radiotherapy and chemotherapy group，three years of LRR rate were 25%（10/40），10%（4/40），DM rate were 45%（18/40），30%（12/40），DFSwere 30%（12/40），60%（24/40），OS rate respectively（24/40）60%and（32/40）80%.Conclusion Postoperative adjuvant radiotherapy for ER（-）and PR（-）ofmodified radicalmastectomy for early breast cancer patients to reduce the LRR，DM rate，and improve DFS and OS rate has important clinical significance.
		2016 Vol. 23 (23): 52-54 [Abstract] ( 131 ) HTML (30 KB) PDF (0 KB) ( 29 )

	55	Retrospective analysis of risky factors for lym ph nodemetastasis in undifferentiated early gastric cancer
		TAO Yuan-sheng；XU Ping；　XU Kai； MA Rui-rui
		Objective To evaluate the riskyfactors for lymph nodemetastasis in undifferentiated early gastric cancer and to provide the direction in clinical for the choice of treatment.Methods From January 2009 to Semptember 2015，Clinicopathologic factors including age，gender，tumorsize，location，ulceration，depth of tumor invasion and vascular involvement of 62 patientswhowere diagnosed as undifferentiated early gastric cancer by surgery in our hospitalwere retrospectively analyzed.Results 21 of 62 patients were confirmed positive for lymph nodemetastasis.The incidence of lymph node metastasis was 33.87%in undifferentiated early gastric cancer.Single-factor analysis revealed that depth of tumor，vasculor involvementand ulceration were significantly associated with lymph nodemetastasis.Multivariate analysis revealed that vasculor involvementand ulceration were independent riskyfactors of lymph node metastasis.Only 5%of the patients negative for vasculor involvementand ulceration have lymph node metastasis，while 75%for patient with positive vasculorinvolvementand ulceration.Conclusion Endoscopic resection can be considered in undifferentiated intramucosal early gastric cancer less than or equal to 2 cm and without ulceration with a careful analysis of vascular involvement，and a surgery should be conducted when it is confirmed positive.
		2016 Vol. 23 (23): 55-57转63 [Abstract] ( 136 ) HTML (31 KB) PDF (0 KB) ( 22 )

	58	Evodia rutaecarpa vom it inhibition mechanism of clinical observation and research to chemotherapy
		ZENG Lin　；YANG Shui-Xiu； YUAN Hai-Zhen
		Objective To explore application of evodia rutaecarpa soup during chemotherapy in patients with cancer，in order to prevent drug intervention chemotherapy vomiting to study the clinical effect of the incident. Methods From June 2014 to June 2016 of our hospital chemotherapy of tumor patients，80 cases of disease，were randomly divided into control group and treatment group，40 cases in each group.Control group patients during chemotherapy were given gamla SiQiong preventive chemotherapy vomiting；The treatment group patients during chemotherapy in the control group on the basis of application of evodia rutaecarpa soup to prevent chemotherapy vomiting.Compared to two groups number of vomiting events during the period of chemotherapy in cancer disease，tumor disease chemotherapy effect，the duration of the symptoms of vomiting，chemotherapy for cancer，the implementation of total time.Results Observation group the number of people vomiting events during chemotherapy in cancer disease　（7 cases），significantly less than that of control group　（19 cases），the significant difference between groups（P＜0.05）；Tumor diseases chemotherapy effect total effective rate 82.5%is slightly better than thatof control group 77.5%，no difference between groups（P＞0.05）；The duration of the symptoms of vomiting and tumor diseases chemotherapy regimens to implement total time significantly shorter than that of control group，significant difference between groups（P＜0.05）.Conclusion Application of evodia rutaecarpa soup during chemotherapy for patients with tumor disease prevention drug intervention chemotherapy episode of vomiting，clinical effect is very obvious.
		2016 Vol. 23 (23): 58-60 [Abstract] ( 135 ) HTML (34 KB) PDF (0 KB) ( 6 )

	61	Observation on the clinical curative effect of xeloda combined with docetaxel in the treatment of advanced gastric cancer
		ZHANG Li-hong
		Objective To explore the clinical curative effect of xeloda combined with docetaxel in the treatment of advanced gastric cancer.Methods 84 cases of patientswith advanced gastric cancer from August 2010 to August 2013 in our hospitalwere researched and divided randomly into observation and control groups.42 cases in each group，The observation group were treated with xeloda combined with docetaxel，The control group were treated with oxaliplatin combined with docetaxel，Observation of two groups of patientswith adverse reactions after treatment，curative effect.Results After treatment，Incidence rate of adverse reactions in the observation group4.76%（2/42）less than that of control group45.23%（19/42），the difference was statistically significant（P＜0.01）；Total effective rate of observation group80.95%（34/42）better than that of control group 52.38%（22/42），the difference was statistically significant（P＜0.01）.Conclusion Xeloda in combination with docetaxel has significant clinical curative effect in the treatment of patientswith advanced gastric cancer，can reduce the number of patientswith adverse reactions，patientswith delayed life，improve curative effect，safe and effective，it isworth promoting.
		2016 Vol. 23 (23): 61-63 [Abstract] ( 108 ) HTML (31 KB) PDF (0 KB) ( 28 )

	64	Com p lications and survival of pancreatic pancreatoduodenectomy with type 2 diabetes
		LV Xiu-juan；CHEN Xin；WANG Yan；YU Shan；HUANG Chao
		Objective To investigate the complications and survival of pancreatic pancreatoduodenectomy with Type 2 diabetes. Methods 80 caseswith pancreatic cancer from December 2013 to January 2015 in our hospitalwere choosed，the diabetes group（40 cases）with type 2 diabetes，without diabetes group（40 cases）for explicitly exclude diabetesmellitus.then suffered surgical complications related complications occurred two groups and cardiovascular the median survival time and quality of life after surgery in onemonth were compared.Results Type 2 diabetes group with postoperative pancreatic leak，bile leakage，intra-abdominal infections and lung infections overall incidence were significantly higher than that of non-diabetic group　（P＜0.05），type 2 diabetes group with hypotension，hypertension，angina pectoris or myocardial infarction and cerebral embolism proportion were significantly higher than that of non-diabetic group　（P＜0.05），diabetic group with themedian survival timewas shorter than that of non-diabetic group（P＜0.05），life quality was worse than that of non-diabetes group　（P＜0.05）.Conclusion Type 2 diabetes is the cause of pancreatic cancer pancreatoduodenectomy postoperative complications related tomajor risk factors and it is seriously affect the survival time and life quality.
		2016 Vol. 23 (23): 64-66 [Abstract] ( 146 ) HTML (32 KB) PDF (0 KB) ( 28 )

	67	Diagnosis and treatment strategy for huge primary retroperitoneal tumor
		LIZuo-an；ZHANG Xiao-yan；QIAN Chang-chun；ZHAWen-zhang
		Objective To investigate the diagnosis and treatment strategy for huge primary retroperitoneal tumor（PRT）. Methods Clinical data of 58 patientswith huge PRT treated from January 2010 to February 2014 in the First People′s Hospital of Yancheng City were retrospectively analyzed including clinicalmanifestation，image examination，tumor site，pathologic examination，operativemethod，follow-up and postoperative adjuvant therapy etc.Results Abdominalmass and pain were themost common clinical features.USG，CT and MRIare themainmeans in confirming the diagnosis of PRT. 20（34.5%）cases were benign tumors，38（65.5%）cases were malignant tumors，All 20 cases of benign tumor were resected completely.Of the 38 cases ofmalignant tumor，7（18.4%）cases underwent complete resection，23（60.5%）of the patients underwent combined resection with the involved organs that included colon，intestine，kidney，spleen，pancreas and bladder，respectively.6（15.8%）cases quasi-radical resection and 2（5.3%）cases palliative resection.15（39.5%）patients weremalignant tumors underwent reoperation due to recurrence.23 cases ofmalignant tumor patients received R0 resection，the duration of operations was　（190±45）min，the volume of operative blood loss was　（420±210）ml，and length of postoperative hospital stay ranged from 15 to 29 d.Operations were successfully performed in all the 58 patients.There was no perioperative death.The median follow-up period was（26±1.5）months，during which 1 case developed intra-abdominal lymph leakage and 1 case had hydrothorax or ascites.Conclusion Preoperative image examination，especially 3D-CT and MRI are crucial for the diagnosis of huge PRT，which are location，nature of the tumor and selection of operative modus.Completed resection and combined multiple organs resection is the essential procedure for the treatment of huge PRTs.
		2016 Vol. 23 (23): 67-71 [Abstract] ( 131 ) HTML (42 KB) PDF (0 KB) ( 17 )

	72	Paclitaxel and　nedaplatin　chemotherapy　radiotherapy　for advanced esophageal cancer clinical observation
		YIJun
		Objective To explore paclitaxel and nedaplatin chemotherapy sequential radiotherapy for advanced esophageal cancer clinical effect. Methods Select January 2014 and 2015 January in our hospital were advanced esophageal cancer patientswith 80 cases，and randomly divided into control group and observation group，each group of 40 cases.The control group treated with radiotherapy alone in the treatment，the observation group were given paclitaxel，nedaplatin chemotherapy sequential therapy，compared two groups of treatment effect and side reaction.Results In the observation group of short-term effective rate was 87.5%，control group of the short-term effective rate was 60.0%，the treatment efficiency of observation group is higher than that of control group，the difference has statistical Significant （P＜0.05）.In the observation group，the white blood cell count decreased，decreased platelet count，nausea and vomiting，liver function damage and oralmucositis incidence rate were 35.0%、22.5%、27.5%、7.5%、45.0%，the control group of white cell count decreased，platelet count decreased，nausea and vomiting，liver function damage and oralmucositis incidence were 67.5%，55.0%，70.0%，35.0%，77.5%.Observation group of toxic or adverse reaction occurred rate was significantly lower than that of control group，the difference is statistically significant（P＜0.05）；after one year follow-up observation group survival rate was 80.0%.The control group survival rate was 47.5%，the survival rate was higher than that of control group（P＜0.05）.Conclusion Paclitaxel，nedaplatin chemotherapy sequential radiotherapy for significantly advanced esophageal cancer clinical effect，less adverse reaction，it isworth clinical promotion.
		2016 Vol. 23 (23): 72-74 [Abstract] ( 154 ) HTML (33 KB) PDF (0 KB) ( 32 )

	75	Com parative study on application of ambroxol and dexamethasone in patients with gestational diabetes prevention of neonatal respiratory distress syndrome
		LIU Qing；　LAIHai-li ；LIU Gui-rong；　KE Ying
		Objective To explore clinical effects of application of ambroxol and dexamethasone in patients with gestational diabetes prevention of neonatal respiratory distress syndrome. Methods Gestational diabetes complicated with premature labor（150 cases）treated in our hospital from January 2014 to July 2015 were randomly divided into 3 groups and given ambroxol intravenous injection　（mucosolvan treatment group 50 cases），dexamethasone intravenous injection （dexamethasone treatment group 50 cases）and no treatment（control group 50 cases），incidence of patientswith premature neonatal with respiratory distress syndrome among three groups was compared，intrauterine infection rate，neonatal infection rates，elevated maternal blood glucose and other indicators of patients in three groupswere counted.Results Incidence rate of premature infants with neonatal respiratory distress syndrome was 3.3%in ambroxol treatment group，with 10.0%in dexamethasone treatment group，with 24.0%in control group，the incidence of premature infants with neonatal respiratory distress syndrome in ambroxol treatment group lower less than that in dexamethasone treatment group，and the incidence in dexamethasone treatment group was lower than that in the control group，the difference both were significant（P＜0.05）.The rate of intrauterine infection and neonatal infection rate in ambroxol treatment group were lower than those in dexamethasone treatment group，with significant difference　（P＜0.05）；at the same time，the rate of intrauterine infection and neonatal infection rate in dexamethasone treatment group were less than those in control group，and the difference was significant（P＜0.05）.Ambroxol treatment group compared with control group，after medication fasting blood glucose level and postprandial 2 h blood glucose level had no significant difference　（P＞0.05），and dexamethasone treatment group compared with control group，aftermedication postprandial 2 h blood glucose levelwas significantly elevated，the difference was significant（P＜0.05）.Conclusion Ambroxol can effectively reduce incidence of gestational diabetes patientswith neonatal respiratory distress syndrome，and reducematernal intrauterine infection rate and neonatal infection rate，blood glucose level has not been affected，which isworthy of clinical promotion.
		2016 Vol. 23 (23): 75-77 [Abstract] ( 151 ) HTML (33 KB) PDF (0 KB) ( 19 )

	78	Role research of different adm inistration ways of recombinant human interferonα1b in treating pediatric hand footmouth disease
		LIU Hui-bao　；FUWei-min　；AO Xiao-dong
		Objective To explore the role of differentadministration ways of recombinant human interferonα1b in treating pediatric hand footmouth disease，and to provide clinical evidence-based reference for recombinant human interferonα1b in treating pediatric hand footmouth disease.Methods According to the order of hospitalized time，150 children diagnosed hand footmouth disease in our department from July 2014 to January 2016 were divided into control group （30 cases），intramuscular injection group［n=30，1μg/（kg·time）and 2μg/（kg·time），two dosage subgroupswere for once a day］，atomizing inhalation group　［n=30，2μg/（kg·time）and 4μg/（kg·time），two dosage subgroupswere for twice a day），and the course was 5 days.All of the patientswere given symptomatic treatment liked routine nursing and pyretolysis，for patients with bacterial infection，antibiotic was used.Clinical effects of pyretolysis time，erythra regression time，Oral herpes regression time and average length of stay of children in each group were compared.Results The difference of clinicalmanifestation and effects of recombinant human interferonα1b among intervention groups and control group were statistical significance　（P＜0.01）；The difference of clinicalmanifestation and effects between recombinant human interferonα1b small or large dosage intramuscular injection group and small or large dosage atomizing inhalation group had no statistical significance　（P＞0.05）；The difference of clinicalmanifestation and effects of recombinant human interferon α1b intramuscular injection group and atomizing inhalation group within the group to compare were statistical significance（P＜0.05）.Conclusion Recombinant human interferonα1b in treating pediatric hand footmouth disease can shorten the course of disease and with definite effects；Recombinant human interferonα1b atomizing inhalation in treating pediatric hand footmouth disease can achieve the same effects with intramuscular injection；for same administration way，large dosage recombinant human interferonα1b hasmore obvious effects than small dosage.
		2016 Vol. 23 (23): 78-80 [Abstract] ( 156 ) HTML (34 KB) PDF (0 KB) ( 2 )

	81	Clinical experience of low dose aspirin combined with calcium in the prevention of preeclampsia in high risk pregnantwomen
		LIU Ai-hua；　LIU Dong-mei； BAIJun-li
		Objective To observe the clinical effect of low dose aspirin combined with calcium in the prevention of preeclampsia in high risk pregnantwomen. Methods 160 cases of pregnantwomen with high risk factors of preeclampsia in our perinatal outpatient service from October 2014 to October 2015 were selected and divided into observation group and control group according to the wishes of the pregnant women，with 80 cases in each group.Pregnant women in the observation group started Po dose of 100mg/d aspirin　（aspirin）and ricard calcium amino acid chelate 2 g/d from 14-20 weeks pregnant，generally to 36 gestationalweeks，while pregnantwomen in the control group did not take any drugs. Pregnantwomen in two groups all were given standardized perinatal care，at the same time pay attention to reasonable diet，suitable rest and moderate exercise.Blood pressure and ponderal growth weremonitored，blood routine urine routine，liver and kidney function，blood coagulation function and serum calcium were detected，condition of mother and fetal were regularly antenatal monitored.The incidence of preeclampsia and the maternal and infant outcomes in the two groupswere observed.Results Pregnantwomen in two groups have been followed up to the end of delivery，the incidence of preeclampsia in the observation group was 6.25%，with mild preeclampsia and no early onset preeclampsia.In the control group，the incidence of preeclampsia was 25.00%，mild with 11.25%，severe with 7.50%，early onset preeclampsia with 6.25%，there was significant difference　（P＜0.05）；incidence of postpartum hemorrhage，fetal intrauterine growth restriction　（FGR），fetal distress，neonatal asphyxia in the observation group were significantly lower than those in the control group with statistical significance（P＜0.05）.Conclusion The early application of low-dose aspirin and calcium in the early stage of pregnancy after the end of early pregnancy to prevent occurrence of preeclampsia，improvematernal and neonatal outcomes，the effect is significant.
		2016 Vol. 23 (23): 81-83 [Abstract] ( 143 ) HTML (29 KB) PDF (0 KB) ( 26 )

	84	Clinical effect analysis of cervical LEEP surgery combined with interferon in the treatment of refractory cervicitis
		CHENMei-mei ；WEICang-mei ；ZHANG You-hong
		Objective To study the clinical effect of cervical LEEP combined with interferon in the treatment of refractory cervicitis. Methods 83 cases of patients with refractory cervicitis in our hospital from March 2014 to November 2015 were collected and diagnosed.According to the random number tablemethod，83 caseswere divided into operation group and operation and drug group.Patients in the operation group were treated by cervical LEEP surgery，while patients in operation and drug group were given cervical LEEP combined with interferon treatment.Clinical therapeutic effect，occurrence ofwound exudates and cervical hyperplasia etc，time of vaginal average bleeding，time of average row liquid，time ofwound average healing and hospitalization timewere compared in two groups.Results Compared with operation group，clinical therapeutic effectwasmore higher（P＜0.01），occurrence ofwound exudates and cervical hyperplasia etc were lower（P＜0.05）），time of vaginal average bleeding，time of average row liquid，time ofwound average healing and hospitalization time were shorter（P＜0.05）in operation and drug group.Conclusion The clinical effect of LEEP combined with interferon therapy in refractory cervicitis is exact，after operation drugs treatment effectively improving the condition of wound，reducing discharge and bleeding，accelerating wound healing，so as to effectively improve the therapeutic effect，accelerate postoperative recovery and is effective and safe in treatment of refractory cervicitis.
		2016 Vol. 23 (23): 84-86 [Abstract] ( 112 ) HTML (30 KB) PDF (0 KB) ( 37 )

	87	Clinical effects of palatopharyngop lasty combined with Repose tongue traction fixation in treating sleep apnea hypopnea syndrome
		XIONG Shan-shan；　CHEN Zhi-peng；　PENGWei； LIWen-sheng
		Objective To study the curative effect of palatopharyngoplasty combined Repose tongue traction fixation in the treatment of sleep apnea hypopnea syndrome.Methods 80 patients diagnosed as sleep apnea hypopnea syndrome from June 2013 to May 2015 of our hospitalwere selected and were divided into single group（n=40）and union group （n=40）according to the disease.Patients in single group were used palatopharyngoplasty，and patients in union group were used Repose tongue traction fixation on the basis of single group.The incidence of postoperative adverse effects and patients′evaluation for effects between two groupswere observed.Results The clinical effective rate in union group reached to 92.5%，which was only 80.0%in single group，and the effects in union group was better than that of single group（P＜0.05）.The incidence of postoperative nasopharyngeal reflux，pharyngalgia and open rhinolalia in union group was less than that of single group respectively（P＜0.05），but the oral cavity body sensation between two groups had no obvious difference（P＞0.05）.Conclusion Palatopharyngeal plasty combined with repose tongue traction fixation in treating obstructive respiratory sleep apnea hypopnea syndrome，patients with less adverse reaction and long-term curative effect good.
		2016 Vol. 23 (23): 87-89 [Abstract] ( 128 ) HTML (29 KB) PDF (0 KB) ( 19 )

	90	The com parison of the effect of m icro im plant anchorage and extraoral arch strengthening anchorage orthodonticmethod in orthodontic treatment
		WANG Shuang-xi
		Objective To compare the effect ofmicro implant anchorage and extraoral arch strengthening anchorage orthodontic method in orthodontic treatment.Methods 80 cases ofmalocclusion deformity patients from February to October 2014 were selected as the research object，they were randomly divided into two groups.The control group were treated with extraoral arch strengthening method of anchorage orthodontic treatment，and the study group were treated with micro implant anchorage for treatment.The success rate，periodontal tissue protective element treatment of the expression level of upper incisor protruding gap，incisor inclination index value and adverse reaction after the occurrence condition between the two groups of patientswere detected and recorded.Results After treatment，the success rate of the study group was 87.5%，higher than that of the control group（65.0%），the difference was statistically significant（P＜0.05）. After treatment for 4 weeks，the protection of periodontal tissues of the two groups of patients the expression levelswas not obvious difference（P＞0.05），the protection of periodontal tissues of 8 weeks after treatment，the study group of expression levelswere significantly higher than that of the control group（P＜0.05）.The study group of the upper central incisors protruding distance difference in incisor inclination，inferior alveolar angle seatwere significantly greater than the control group，and displacement ofmolar，upper groove angle seatwas less than the control group，the difference was statistical significance（P＜0.05）.The incidence of adverse reactions in the study group was 10.0%，which was significantly lower than that of the control group（25.0%），and the difference was statistically significant（P＜0.05）.Conclusion Micro implant supported anti technique in the treatment ofmalocclusion deformity disease can greatly improve the patient cure rate，it can significantly decrease the patientswith adverse reaction incidence，it is safety.
		2016 Vol. 23 (23): 90-92 [Abstract] ( 112 ) HTML (35 KB) PDF (0 KB) ( 5 )

	93	Clinical research of am ygdala removal combined with endoscopic adenoid resection in treatment of children with snoring
		ZHOU Yi-bing　；TAO Yue-jin
		Objective To investigate clinical effect of amygdala removal combined with endoscopic adenoid resection in the treatment of children with snoring.Methods 132 children with snoring were selected in hospital from November 2013 to November 2015，who were divided into two groups by random number tablemethod.66 patients received routine amygdala removal combined with adenoid curettage as control group.66 patients received amygdala removal combined with endoscopic adenoid resection as observation group.Surgical indications，postoperative adenoid residue，clinical effect，postoperative complicationswere compared between two groups.Results Operation time［（65.8±10.7）min］，postoperative hospitalization time［（6.3±0.9）d］in observation group was shorter than　［（121.9±13.4）min，（8.4±1.1）d］in the control group respectively，intraoperative blood loss［（78.6±11.7）ml］in observation group was less than（108.5±13.2）ml in control group.Postoperative adenoid residual rate（4.5%），complication rate（3.0%）in observation group was lower than 18.2%，12.1%in the control group respectively.Total effective rate（98.5%）in observation group was higher than 89.4% in control group.Differenceswere statistically significant（all P＜0.05）.Conclusion Amygdala removal combined with endoscopic adenoid resection has significant effect in the treatment of children with snoring，which has advantages of smallerwound，faster recovery，higher safety.It isworthy of clinical application.
		2016 Vol. 23 (23): 93-95 [Abstract] ( 133 ) HTML (34 KB) PDF (0 KB) ( 34 )

	96	Therapeutic effect of photocoagulation and vitrectom y combined with western medicine in the treatment of retinal vein peripheral inflammation
		WU Li-juan ；WANG Zi-wen； GAOWu-qin ；WANG Shu-na； DENG Hai-bo ；WANG Hui-zhen
		Objective To investigate the therapeutic effect of light coagulation and vitrectomy combined with traditional Chinese and western medicine in the treatment of retinal vein peripheral inflammation. Methods 80 cases of patients with retinal vein in our hospital from January 2013 to December 2015 were selected，and were randomly divided into observation group and control group，each of 40 cases.The control group was treated with photocoagulation and vitrectomy combined with routine western medicine treatment.The observation group was given TCM treatment on the basis of the control group.Results The total effective rate in the observation group was 90.0%，higher than 62.5%in the control group，with statistical difference（P＜0.05）.Comparison of the therapeutic effect of traditional Chinesemedicine，the total efficiency in the observation group and the control group was 87.5%and 67.5%respectively，with statistical difference （P＜0.05）.After treatment，TCM syndrome score between two groupswere decreased，the observation group compared with the control group decreased significantly，with statistical difference（P＜0.05）.Conclusion The therapeutic effect of photocoagulation and vitrectomy combined with traditional Chinese and western medicine in the treatment of retinal vein peripheral inflammation is accurate.
		2016 Vol. 23 (23): 96-98 [Abstract] ( 113 ) HTML (34 KB) PDF (0 KB) ( 22 )

	99	Observation of low-dose gentam icin intratym panic for Meniere′disease with hearing and psychological
		WANG Hai-yan；　FANG Yong-shan
		Objective To investigate the effect of low-dose gentamicin intratympanic for Meniere′disease with hearing and psychological. Methods 80 caseswith Meniere′disease vertigo from June 2011 to March 2015 in our hospitalwere randomly divided into two group，each 40 cases.The observation group were implemented intratympanic gentamicin，the control group were implemented with conservative treatment，such as the use of chlorpromazine，sulfa vinegar azole，methimazole and B vitamins，than hearing threshold change before and after treatmentwere compared and vertigo，tinnitus and hearing improvement symptoms and changes in anxiety and depression scores were statisticed.Results The intervention group with audiometry thresholdswere significantly lower than that of before（P＜0.05），and after the intervention in the observation group with audiometry threshold was lower than that of control group（P＜0.05）.The ratio of vertigo improvement in the observation group was higher than thatof control group　（P＜0.05），and improvement of hearing and tinnitus improvementwas significantly higher than that of control group respectively（P＜0.01）.The intervention of anxiety and depression scoreswas significantly lower than that of control group respectively（P＜0.01）.Conclusion Intratympanic gentamicin can effectively alleviate the clinical symptoms of Meniere′disease with vertigo，and the hearing threshold can be reduced，so it can improve patient coping skills.
		2016 Vol. 23 (23): 99-101 [Abstract] ( 115 ) HTML (34 KB) PDF (0 KB) ( 30 )

	102	Application effect of combined spinal-epidural anesthesia by lateral approach method in elderly patients undergoing lower limb surgery
		XIAO Yao ；CHANG Qing ；ZHANG Zhen-zhen
		Objective To explore the application effect of combined spinal-epidural anesthesia by lateral approach method in elderly patients undergoing lower limb surgery. Methods 80 elderly patients over 75 years old undergoing lower limb surgery from January to December in 2015 in our hospitalwere selected and randomly divided into group A and group B，40 cases in each group.Group A was given lateral approach method，group B was given straight puncture method.The time of puncture，puncture times，the success rate，the onset time of anesthesia，the incidence rate of puncture injury and related complications in the two groups was compared respectively.Results The puncture time of group A was shorter than that of group B，with significant difference　（P＜0.01）.The puncture success rate of group A was higher than that of group B，with significant difference（P＜0.01）.The success rate of one time，two times and three times in group A was higher than that in group B，with significant difference　（P＜0.01）.The proportion of the onset number of affected side ahead of the healthy side in group A was higher than that in group B，with significant difference（P＜0.01）.The incidence rate of low back pain after puncture in group A was lower than that in group B，and the duration of pain in group A was shorter than that of group B，with significant difference　（P＜0.05）.Conclusion The application effect of combined spinal-epidural anesthesia by lateral approach method in elderly patients is significant，the puncture time is short，the puncture success rate is high，and the incidence rate of low back pain after puncture is low，it isworthy of clinical promotion and application.
		2016 Vol. 23 (23): 102-104 [Abstract] ( 107 ) HTML (36 KB) PDF (0 KB) ( 36 )

	105	Clinical app lication of etom idate emulsion combined with butorphanol in painless gastroscopy
		YUANWen-qiang ；ZHONG Yi-ping
		Objective To explore the application effects of etomidate emulsion combined with butorphanol in painless gastroscopy.Methods 120 patients who voluntary implemented painless gastroscopy from October 2015 to March 2016 in our hospitalwere selected and divided into the control group and the observation group according to different anesthesia medication，60 cases in each group.The control group was given etomidate emulsion，and the observation group was further given butorphanol on the basis of the control group.The anesthesia effects and incidence rate of adverse reaction in the two groups was compared respectively.Results There was no significant difference in the disappearance time of consciousness between the two groups（P＞0.05）.The sleep time，waking time in the observation group was shorter than that in the control group，with significant difference　（P＜0.05）.There was no significant difference in the preoperative，intraoperative and postoperative indexes of MAP，HR and SpO2between the two groups（P＞0.05）.The incidence rate of the adverse reaction in the observation group was 6.67%，which was lower than 20.0%in the control group，with significant difference　（P＜0.05）.Conclusion The application effects of etomidate emulsion combined with butorphanol in painless gastroscopy is ideal，which has little impact on patients and with low incidence rate of adverse effects.It is worth to popularize and application.
		2016 Vol. 23 (23): 105-107 [Abstract] ( 127 ) HTML (32 KB) PDF (0 KB) ( 25 )

	108	App lication effect of combined spinal epidural anesthesia in pregnant women of labor analgesia and its influence on the outcome of pregnancy
		WU Dong-peng；ZHANG Yan-xiang；LINGeng-sheng
		Objective To explore the application effect of combined spinal epidural anesthesia　（CSEA）in pregnant women of labor analgesia and its influence on the outcome of pregnancy. Methods 200 primipara from December 2013 to November 2015 in our hospital were selected as the research group，50 primiparae unenforced labor analgesia was selected as the control group，150 primiparae implemented CSEA labor analgesiawere selected as the observation group. The observation group was divided into groupⅠ　（50 cases），groupⅡ　（49 cases），groupⅢ　（51 cases）according to the random numbers tablemethod.When the uterinemouth in the three groups of pregnantwomen was opened to 1，2，3 cm，the anesthesia and analgesia was implemented.The VAS score，birth process，oxytocin use rate，delivery outcome was compared among the four group.Results The VAS score of each period in groupⅠ，groupⅡ and groupⅢ was lower than that in the control group，the VAS score of each period in groupⅠ，groupⅡwas lower than that in groupⅢ，with significant difference　（P＜0.05）.The first birth time of groupⅠ，groupⅡ and groupⅢ was shorter than that of the control group，the first birth time of groupⅠ，groupⅡwas shorter than that of groupⅢ，with significant difference　（P＜0.05）.The utilization rate of oxytocin in groupⅠ，groupⅡand groupⅢwas higher than that in the control group，with significant difference　（P＜0.05）.The scores ofmaternal satisfaction in groupⅠ，groupⅡand groupⅢwas higher than that in the control group，with significant difference　（P＜0.05）.The cesarean section rate of the observation group was lower than that of control group，with significant difference　（P＜0.05）.Conclusion The use of CSEA for labor analgesia can significantly shorten the first labor process，reduce the cesarean section rate，analgesia effect are better，and the maternal satisfaction score is higher.
		2016 Vol. 23 (23): 108-110 [Abstract] ( 110 ) HTML (35 KB) PDF (0 KB) ( 20 )

	111	Clinical effect observation of Xiaoke pill combining with insulin glargine in new ly-diagnosed type 2 diabetesmellitus patients
		ZENG Jie；LUO Yi-guo；GUO Zu-sen；CHEN Li-li；ZHANGWang-wang；QIN Yong-zhang；WANG Chang
		Objective To explore the clinical effect of Xiaoke pill combining with insulin glargine in newly-diagnosed type 2 diabetic patientswhose glycosylated hemoglobin wasmore than 9.0%.Methods 60 newly-diagnosed type 2 diabetesmellitus patients in our department of endocrinology from March to September in 2015 were selected and randomly divided into the treatment group（group A）and the control group（group B），30 cases in each group.On the basis of the dietary control and exercise in the two groups，oral administration of Xiaoke pill in group A and glibenclamide in group B at 30 minutes before threemeals was provided respectively.Injection of insulin glargine in fixed time at night was implemented in the two groups.The course of treatment was lasted for 12 weeks.The fasting blood-glucose（FPG）and 2-hour postprandial glucose （2 h PG），glycosylated hemoglobin　（HbA1c），bodymass index　（BMI），and occurrence condation of hypoglycemia before and after treatment in the two groupswas compared.Results The level of FPG，2 h PG，and HbA1c after treatment in the two groupswas lower than that before treatment，with significant difference　（P＜0.05）. The level of FPG，2 h PG，and HbA1c after treatment in the group A was lower than that in the group B after treatment，with significant difference　（P＜0.05）.There was no significant difference in BMI before and after therapy in the two groups（P＞0.05），and therewas no hypoglycemia occurred in the two groups.Conclusion Xiaoke pill combining with insulin glargine can effectively reduce the blood glucose in newly-diagnosed type 2 diabetesmellitus patients with little influence on body weight at advantages of safety，convenience，and high compliance，it isworthy of clinical promotion and application.
		2016 Vol. 23 (23): 111-113 [Abstract] ( 107 ) HTML (31 KB) PDF (0 KB) ( 17 )

	114	Efficacy and safety analysis of carboprost trometham ine injection in the treatment of postpartum hemorrhage caused by uterine inertia
		LINa
		Objective To explore the efficacy and safety of carboprost tromethamine injection in the treatment of postpartum hemorrhage caused by uterine inertia. Methods 100 cases of postpartum hemorrhage caused by uterine inertia in our hospital from January 2015 to May 2016 were selected and divided into the control group and the observed group according to the order of admission，50 cases in each group.The control group was given intravenous infusion of oxytocin 20 U combined with uterine intramuscular injection of oxytocin 20 U after childbirth，the observation group was given intravenous infusion of oxytocin 20 U combined with uterine intramuscular injection of carboprost tromethamine 250μg after childbirth.The treatment effect，postpartum hemorrhage and incidence rate of adverse reaction was compared between the two groups.Results The incidence rate of adverse reaction in the observation group was 6.0%，which was lower than 32.0%in the control group，with significant difference　（P＜0.05）.The total effective rate of the observation group was 98.0%，which was higher than 66.0%in the control group，with significant difference　（P＜0.05）.The amount of postpartum hemorrhage after delivery of 2 and 24 hours in the observation group was lower than that in the control group，with significant difference　（P＜0.05）.Conclusion Postpartum hemorrhage caused by uterine inertia patients are treated with carboprost tromethamine injection，which can effectively reduce the incidence rate of postoperative adverse reaction，improve treatment effect，improve postoperative bleeding condition，it isworthy of clinical promotion and application.
		2016 Vol. 23 (23): 114-116 [Abstract] ( 117 ) HTML (33 KB) PDF (0 KB) ( 17 )

	117	Clinical study on detoxification of antipyretic decoction in the treatment of severe hand footmouth disease
		HUA Yan-mei； LIZhao-zhong ；CHEN Quan
		Objective To investigate the clinical effect of combined treatment of severe hand footmouth disease detoxifies decoction of traditional Chinesemedicine and western medicine.Methods 100 cases of severe hand，foot and mouth disease in our hospital from March 2013 to September 2014 were randomly divided into the control group and the treatment group.The control group were given conventional treatment，the treatment group was treated with antipyretic detoxification decoction on the basis of routine treatment.The improvement of symptoms and signs in two groups were observed and compared.Results The body temperature time，mental state，sleep time，nausea/vomiting and irritability/ tremor in the treatment group ameliorated faster，and white blood cells decreased significantly（P＜0.01）.Total score of the treatment group after treatmentwas（1.1±1.84）points，lower than（5.52±2.410）points the control group（P＜0.01）.The total effective rate of treatment group was 96%，higher than 70%in the control group，the difference was statistically significant（P＜0.01）.Adverse reactionswere not found in clinical treatment.Conclusion The antifebrile detoxification decoction of traditional Chinesemedicine and westernmedicine combined treatment of severe hand，foot and mouth disease curative effect is distinct，effectively improve the patients′clinicalmanifestations，shorten the course of disease.Antifebrile detoxification decoction is safe in clinical application.
		2016 Vol. 23 (23): 117-119转122 [Abstract] ( 122 ) HTML (36 KB) PDF (0 KB) ( 33 )

	120	Clinical effect analysis of arthroscopic release combining with herbal steam ing and washing in the treatment of fiber rigidity of the knee joint
		ZHOU Zhao-hui； YANGGuo-hua； YANG Ling； YIJian-jian
		Objective To explore the clinical effect of arthroscopic release combining with herbal steaming and washing in the treatment of fiber rigidity of the knee joint.Methods From January 2014 to June 2015，164 patients with fiber rigidity of the knee joint admitted into our hospital were selected.They were evenly divided into research group and control group in random.In the research group，integration of traditional Chinese and western medicine was used.The main therapeuticmethod was arthroscopic release combining with herbal steaming and washing.In the control group，only arthroscopic release was applied.The clinical therapeutic effect and postoperative functional recovery of knee joint activity in both groups were compared.Results The therapeutic excellent and good rate in the research group was 82.92%，higher than 67.07%in the control group，with a statistical difference（P＜0.05）.After treatment，the VASscorewas （4.38±0.61）points，lower than　（5.28±0.77）points in the control group，with a statistical difference（P＜0.05）.After treatrnent，the degree of knee flexion in the research group was better than that of control group，with a statistical difference （P＜0.05）.Conclusion Fiber rigidity of the knee joint leads to patientwho cannotwalk in normal.Active application of arthroscopic release to clear tissue in the focus and combination of herbal steaming and washing can improve rehabilitation effect，prognosis as well as postoperative activity ability of the knee joint，which has a high clinical value and is worthy of promotion.
		2016 Vol. 23 (23): 120-122 [Abstract] ( 112 ) HTML (30 KB) PDF (0 KB) ( 37 )

	123	Retrospective analysis of the monitoring results of levetiracetam blood drug concentration in 824 Cases（1495 case-times）
		BAO Dan-dan　；ZHANG Zhen
		Objective To investigate the adherence of blood drug concentration monitoring in children patients so as to make an evaluation of the therapeutic window rate and influence of levetiracetamon renal functions and provide a basis for clinically safer，effective and rational use of levetiracetam.Methods The clinical data of children patients who were diagnosed by department of out-patient or the ward room in our hospital as epilepsy from January 2014 to January 2016 and accepted the levetiracetam blood drug concentration monitoring were retrospectively analyzed.Results Both differentmonitoring arrays and different age groups showed statistically significant differences in the therapeutic window rate and blood drug concentration（P＜0.05）；statistically significant difference was seen in the creatinine abnormal rate of different frequency ofmonitoring（P＜0.05）.Conclusion Levetiracetam blood drug concentration varies greatly among different individuals.In consideration of the fact，it is of great necessity to improve the adherence of blood drug concentration monitoring for children patients，ensure regularmonitoring of blood drug concentration and individualized administration.As a consequence，reduced adverse reactions and improved therapeutic effectwill be realized.
		2016 Vol. 23 (23): 123-125 [Abstract] ( 119 ) HTML (34 KB) PDF (0 KB) ( 42 )

	126	Clinical significance analysis of detections of p lasma catecholam ine，5-hydroxytryptam ine on type A behavior in patient with coronary heart disease
		GONG Chu-ping
		Objective To explore the significance of the relationship between detections of plasma catecholamine and 5-hydroxytryptamine and type A behavior in patientwith coronary heart disease（CHD）.Methods From January to December in 2015，60 CHD patients admitted into our hospitalwere selected as research objects.According to patients′behaviors，they were evenly divided into group type A group and type B group，which were corresponded with type A behavior of CHD and type B behavior of CHD.The level of renin-angiotensin-aldosterone system，the concentrations of 5-hydroxytryptamine，epinephrine，and norepinephrine were detected.Results At premise of the same cardiac function，the concentrations of 5-hydroxytryptamine，epinephrine，and norepinephrine in group A were greatly different from those in group B，which were displayed statistical differences（P＜0.05）.In type A group，the rate of ventricular premature beat was 33.33%，much higher than thatwas 6.67%of the type B group，which was displayed a statistical difference after intergroup comparison（P＜0.05）.There was difference in the level of renin-angiotensin-aldosterone system among patients with different cardiac functions（P＜0.05）.The higher the cardiac function was，the higher the level of renin-angiotensinaldosterone system became.Conclusion Detections of plasma catecholamine and 5-hydroxytryptamine can provide reliable and objective experimental basis for diagnosis and treatment of type A behavior of CHD.
		2016 Vol. 23 (23): 126-128 [Abstract] ( 133 ) HTML (33 KB) PDF (0 KB) ( 7 )

	129	Significance of joint detection of Cys C，RBP，BUN，and Cr in early diagnosis of renal diseases
		ZHOU Hua-qiang；BAIZhi-yang；WU Shang-hua
		Objective To discuss the significance of joint detection of Cys C，RBP，BUN，and Cr in early diagnosis of renal diseases，and to provide guidance for diagnosis of early renal function impairment.Methods 150 patients with renal diseases treated in our hospital from March 2014 to March 2015 were selected as the study group，and another 60 healthy volunteerswere selected as the control group.Venous blood sampleswere collected and the serum was isolated，and then the sampleswere analyzed by a TBA-120 fully automatic biochemical analyser for levels of Cys C，RBP，BUN，and Cr.The renal disease conditions and positive rate of disease diagnosis were analyzed.Results The levels of Cys C，RBP，BUN，and Cr in patients with glomerulonephritis，hypertensive nephropathy，diabetic nephropathy，and kidney failure were significantly higher than those in the control group（P＜0.05）.The positive rates of these four indicatorswere significantly higher in those patients than in the control group（P＜0.05），and the positive rates showed in RBP＞Cr＞BUN＞Cys C，which indicated that RBP had the best diagnostic effect in early renal diseases，followed by Cys C，and the positive rate of joint detection of the 4 indicatorswere high.Conclusion The joint detection of Cys C，RBP，BUN，and Cr has high application value in early diagnosis of renal diseases，showing a guiding significance for diagnosis of early renal function impairment.
		2016 Vol. 23 (23): 129-131 [Abstract] ( 116 ) HTML (33 KB) PDF (0 KB) ( 21 )

	132	Investigation of chronic disease health know ledge and behavior life style in patients with hypertension
		SHUIKe-dong；　LU Yun；　FEIXiu-xia；　WANG Ling；　XIE Shun-ming；　ZHANG Meng-qian；　YUAN Fang-cen； SHEN Zhen-hai
		Objective To investigate the awareness and behavior life style of chronic disease health knowledge in patientswith hypertension，and to provide reference basis for formulation of health education measures.Methods 577 patients with hypertension participating in health examination and aged from 18 to 60 years old，from April to May 2015 were selected to conduct questionnaire survey.Results The awareness rate of normal blood pressure range and the ideal body temperature range of investigation objects were higher，and the awareness rate was above 70.0%；Awareness of the daily intake of salt for adultswas less than 50.0%，the awareness rate of ideal total cholesterol level in adultswas only 12.3%；In addition to the adult ideal body temperature range and the adult daily best intake of the salt，the awareness rate of health knowledge among men was higher than that of women；The number of know entries in bachelor degree or above was obvious higher than that in below bachelor degree.In the diet taste，the salty taste was up to 26.0%；10.7% of the respondents drank milk more than 6 times a week，and 28.4%of the respondents did not drink milk；Only 15.1%of the respondents ate fruits every day；45.1%of the investigated subjects ate vegetables less than 200 g every day；36.9%of the subjects smoked every day，and 1.7%of them often passively smoking；55.1%of the investigated subjects drank alcohol；Only 17.7%of respondents exercised more than 5 times a week，and up to 22.0%of the respondents did not normally exercise；Only 16.8%of the respondents whose siting time was less than 2 h apart from studying and working，and 19.8%of the respondentswhose siting timewasmore than 4 h apart from studying and working；75.8%of the subjects′sleep time was less than 7 h every day and 7.3%of the subjects′sleep time was less than 5 h every day.Conclusion The subjects of this study are lack of knowledge about hypertension risk factors of best salt intake，overweight or obesity and other risk factors，the dietary structure is not reasonable and with unhealthy behavior liking smoking，drinking and lacking of exercise.
		2016 Vol. 23 (23): 132-135 [Abstract] ( 126 ) HTML (35 KB) PDF (0 KB) ( 21 )

	136	Application analysisof Chinesepatentmedicine in children patients with upper respiratory infection in pediatric outpatientdepartmentofour hospital
		ZHANG Yi-qiong
		Objective To understand the application situation of Chinese patentmedicine in children patients with upper respiratory infection　（URI）in pediatric outpatient department of our hospital and put forward to reasonable suggestions for using Chinese patentmedicine.Methods From October to December 2015，492 children patients with URI in the first week of these three months in our pediatric outpatient department were selected.The usage rate of Chinese patentmedicine，route of administration，drug variety and condition of drug combination in these participantswere statistically analyzed.Results The usage rate of Chinese patent medicine in pediatric outpatient department was 86.79%. There were 14 varieties of Chinese patentmedicines，the dosage forms were based on oral liquid and granula in oral administration.Drug combination of Chinese patentmedicines took 25.06%，mainly two varieties accounting for 24.12%. Conclusion The application of Chinese patentmedicine in children patients with URI in pediatric outpatient department is reasonable.
		2016 Vol. 23 (23): 136-138 [Abstract] ( 122 ) HTML (33 KB) PDF (0 KB) ( 29 )

	139	App lication effect of the differential management method in the nursing management of obstetric operation
		LIU Gui-ping；　FU Hong-qun；　LIXu-hui
		Objective To investigate the practice effect of differentialmanagementmethod in the nursingmanagement of obstetric operation. Methods 50 nursing staff of operating room in hospital from February 2014 to December 2015 were selected as the research object，and they were randomly divided into two groups，25 nursing staff in control group were managed with routine nursingmanagement intervention，25 nursing staff in observation group weremanaged with differentialmanagementmethod，then the job burnout and job performance of two groups before and after the management were respectively evaluated and compared with Maslach Job Burnout Questionnaire and GSES scale，the job satisfaction degree for the two groups were compared.Results The Maslach Job Burnout Questionnaire and GSES scale evaluation results′differences of two groups before themanagementwere not obvious，with no statistical differenc（all P＞0.05），the Maslach Job Burnout Questionnaire and GSES scale evaluation results of observation group was better than that of control group respectively，job satisfaction degree for the observation group was higher than that of control group respectively，with statistical difference（all P＜0.05）.Conclusion The practice effect of differentialmanagementmethod in the nursingmanagement of obstetric operation is better，and the recognition of nursing staff for themanagementmethod is higher，so it iswelcomed by all aspects.
		2016 Vol. 23 (23): 139-141 [Abstract] ( 105 ) HTML (30 KB) PDF (0 KB) ( 35 )

	142	Research the role of chief resident in medical adm inistration
		QIANMing-ping ；FEIHong-xiang ；YUAN Jing ；YEHong-mei ；ZHUWei-hong ；SHEN Jia-yong ；ZUO Ke-qiang
		Chief resident is an important part of the hospital，the hospital professional technical force，in the hospital management play an important role.Scientific management from the employment，training and examination of the resident general doctors has great role in improving the management efficiency of the hospital，enhancing the quality of medical service and ensuringmedical safety.
		2016 Vol. 23 (23): 142-144转148 [Abstract] ( 117 ) HTML (38 KB) PDF (0 KB) ( 28 )

	145	App lication of information management system to im prove the management level of respiratory medicine
		SONG Lei ；LIU Hong； WANG Xiang-ying
		Objective To explore the application of information management system in the management of respiratory medicine. Methods From January to December 2015，the implementation of informationmanagement of hospitalmedical staff and patients，contrast the implementation informationmanagement and taking delivery time，payment time，treatment waiting time，dispensing average time，medical errors，and so on related indexeswere observed the satisfaction ofmedical staff and patients.Results The taking delivery time，payment time，treatment waiting time，the average dispensing time of after taking information management shortered than that of informationization management before respectively，with statistical difference（P＜0.05）.Therewere nomedical errors after the implementation of the informationmanagement，significantly decreased compared with that before its implementation，with statistical difference（P＜0.05）.After the implementation of the informationmanagement，patient satisfaction was 97.0%，implements（83.0%）improved significantly，with statistical difference（P＜0.05）；After the implementation of the information management，medical and nursing staff satisfaction（86.1%）compared with thatbefore its implementation（55.6%）improved significantly，the differencewas statistically significant（P＜0.05）.Conclusion The information management system can improve themanagement level of respiratory medicine.
		2016 Vol. 23 (23): 145-148 [Abstract] ( 121 ) HTML (37 KB) PDF (0 KB) ( 12 )

	149	Status and suggestion of sanitation management on secondary water supp ly in high-rise buildings in Beipiao city
		XIE Pu-zhi
		In recent years，the pace of urbanization is in rapid growth and high-rise buildings are in constant increase，and secondary water supply has become an important issue in urban water supply management.Managementmodels across the country vary greatly and management levels are in great difference.Such problems like non-clear regulatory responsibilities，non-standardized water services，incomplete protection facilities，and responsibilities of operation and maintenance being not in place are widely existent，which influence on quality of domestic water in residents.Therefore，strengthening sanitation supervision and management of secondary water supply and implementation of secondary water-related standards and norms are extremely urgent.The paper analyzed the status of secondary water supply in our city after investigation and put forward suggestions on existed problems.
		2016 Vol. 23 (23): 149-151 [Abstract] ( 97 ) HTML (38 KB) PDF (0 KB) ( 38 )

	152	Analysis of common statistical problem s in medical papers on cohort study
		CHIDian-yuan；XUE Hai-feng
		Objective To understand the application of statistical methods in papers adopting cohort study design in medical journals，uncover some important issues，and put forward the corresponding countermeasures，furthermore，to improve the data processing and writing level of such papers.Methods Papers published on cohort study from 2014 to 2015were retrieved in China National Knowledge Infrastructure andWanfang Database，and were analyzed systematically by statisticalmethods.Results Common statistical problems found in these papers included the followings:misuses of chi-square test and Logistic regression，no clear description of study subjects，and no comprehensive description of outcomesand its judgmentstandard.Conclusion The papers′authors should fully realize the significance of epidemiology and health statistics，and master the relevant theoretical knowledge；the editorial departments should strengthen epidemiological and statistical examination onmedical papers.
		2016 Vol. 23 (23): 152-154 [Abstract] ( 108 ) HTML (35 KB) PDF (0 KB) ( 30 )

	155	Exp loration and Reflection on the teaching of Medical Biochem istry
		FENG Li-ya
		Medical biochemistry is an important basic course ofmedicine，the pathogenesis ofmany major diseases at themolecular level to explain.At the same time，this subject in clinical practice is widelyused in clinical disease diagnosis，disease monitoring，drug curative effect，prognosis judgement and disease prevention，etc，so the course is a bridge between basicmedicine and clinicalmedicine.But because this course is one of the difficulties of basic medical teaching course，in order to solve the teaching process of traditional chinesemedicine students said hard to understand，hard tomemory，generally difficult to application problem，to stimulate the learning interest of the students，guide students to active learning，constantly improve the quality of teaching，formedical students in clinicalmedicine courses in the future study to lay a solid foundation，therefore combined with years of teaching experience，respectively from the choice of teaching content，the use ofmedical knowledge reserve of teachers，teachingmethods and the importance of experiment teaching and so on has carried on the exploration and reflection on teaching.
		2016 Vol. 23 (23): 155-157转161 [Abstract] ( 98 ) HTML (33 KB) PDF (0 KB) ( 16 )

	158	Exploring training models for working pathologist and studentsmajor in Pathology in the trend of Precision Medicine
		LIYun-yuan　；WANG Liang-zhe；　LIU Hui-min；　YU Hong-yu
		Precision medicine is developed with medical treatment to the individual characteristics of each patient，combining with the latestmolecular genetic testing technology，which accurate diagnosis is an important guarantee.In the era of precision medicine，pathology residents play a necessitous and irreplaceable role.This paper mainly discusses some measures for cultivating the molecular pathology residents′ability.There are a few measures:urgently，in-service pathologists had better to train through the network，lectures or joint training，such as to improve their theoretical level as soon as possible.From long-term development perspective，it is better to change traditional education mode，increase the molecular pathology course，strict appraisal system，and gradually achieve the specialization culture.The aim is better to serve for the clinic.
		2016 Vol. 23 (23): 158-161 [Abstract] ( 122 ) HTML (35 KB) PDF (0 KB) ( 21 )

	162	Research and practice of clinical simulation for oral doctor skills training
		ZHANG Xiao-min； MIAO Yu；FANG Hui
		Objective To study the feasibility of clinical simulation for oralmedical treatment skills training，by compared the before and after skills assessment results of the students training in our hospital.Methods 176 studentswho participated in the training center for oral training were choosed，and the results of the training before and after were compared with.Results It was significantly improved for the oral doctors in periodontal disease treatment，dental pulp disease treatment and repair prosthodontic surgery treatment，through clinical simulation training（P＜0.01）.Conclusion Clinical simulation teaching could improve the students′oral clinical skills.It has the advantage of the traditional clinical teachingmethod in preclinical training.
		2016 Vol. 23 (23): 162-164 [Abstract] ( 105 ) HTML (33 KB) PDF (0 KB) ( 5 )

	165	App lication of PBL combined with flipped classroom teaching mode in pathology teaching
		LIYue-mei ；ZHENG Xin-hua
		Objective To explore the application effect of problem-based learning combined with flipped classroom teaching mode in pathology teaching.Methods There were 201 students in the first grade nursing，that were selected and randomly divided into experiment group and control group.In addition，our study period was a total of 1 semester from March to June 2015.The experimental group were used the PBL combined with the Flipped classroom teaching method and control group were used traditional teachingmethod.Finally，The exam results of two groups and the degree of recognition on our teachingmethodswere analyzed.Results The experimental group（74.67±8.88）scores，was significantly higher than that of control group　（69.49±11.45）scores at the end of the test results.Similarly，the experimental group students teaching evaluation was significantly higher than that of control group.The differences were all significant（P＜0.05）.Conclusion PBL combined with flipped classroom could sufficiently improve the self-study ability and the enthusiasm of the students.Moreover，our teaching quality could be significantly enhanced.
		2016 Vol. 23 (23): 165-167 [Abstract] ( 119 ) HTML (31 KB) PDF (0 KB) ( 32 )

	168	A prelim inary study of neurobiology extracurricular scientific research practice on the seven-year program medical students
		LIXiao-guang ；DUAN Hong-mei ；GAO Yu-dan；　ZHAOWen；　YANG Zhao-yang
		The class teaching can notmeet the needs of the compound talents.In order to develop the seven-yearmedical students innovative consciousness and practical ability，we try to carry out rich and colorful extracurricular scientific research practice activities to cultivate the students scientific research ability of seven-year program，at the same time inspired its innovative scientific thinking.According to the experiences ofmyself and my colleagues in guidingmedical students extracurricular scientific activities，to explore through research and practice activities to enhance the importance ofmedical students comprehensive quality and methods.Scientific research practice activities can not only consolidate the textbook knowledge，stimulate students′interest in learning，also can cultivate students innovation consciousnessand practice ability，eventually improve the comprehensive quality of students.
		2016 Vol. 23 (23): 168-170 [Abstract] ( 129 ) HTML (30 KB) PDF (0 KB) ( 22 )

	171	App lication of W eChat and network teaching p latform to build a new teachingmodel of clinical pathology on undergraduate
		TANGQiong-lan；MAILi-bin；HUANGHai；XU Bing；YAN Li
		As a clinical applied courses，clinical pathology is an important bridge of clinicalmedicine.Learning clinical pathology plays an important role in understanding the process of occurrence and development of human diseases，and also choosing an appropriate treatment.It is also essential to consolidate the basic knowledge for seniormedical undergraduates，and to develop pathological literacy work in the future.On the basis of our innovative classroom teaching，WeChatplatform and network teaching platform（online courses and autonomous learning E-learning platform）were used to build a new teachingmodel of clinical pathology on undergraduate，which created a good teaching effect.
		2016 Vol. 23 (23): 171-173 [Abstract] ( 117 ) HTML (33 KB) PDF (0 KB) ( 8 )

	174	App lication and nursing of Power PICC double lumen catheter in hematopoietic stem cell transp lantation
		PENG Qun-ying
		Objective To investigate the effect of Power PICC double lumen catheter in hematopoietic stem cell transplantation，and to analyze the nursingmethods.Methods 52 patientswith allogeneic hematopoietic stem cell transplantation were selected in our department from July 2015 to April 2016，all patients were treated with ultrasound guided implantation of 5Fr dual chamber high-pressure injection PICC catheter of the United States，and the patients were treated as the observation group.Comparison of 50 patientswith allogeneic hematopoietic stem cell transplantation with internal carotid CVC from July 2014 to June 2015 in our department as the control group.Compared the completion time，a success rate of tube，catheter indwelling time，complication rates of two groups.Results The operation completion time of observation group and control group respectively was（23.1±2.3）min，（24.0±2.5）min，a success rate of tube in observation group and control group respectively was 100.0%（52/52），84.0%（42/50），catheter indwelling time of observation group and control group respectively was（79.8±4.2）d，（42.8±3.5）d.The other indicators were compared，observation group was significantly better than the control group with statistical difference（P＜0.05），in addition to the operating time of completion.The blockage of the catheter，catheter ectopia/shift，accident off tube，catheter site infection，puncture oozing blood occurred rate of observed group was also significantly lower than that of the control group with statistical difference（P＜0.05）.Conclusion The Power PICC double lumen catheter in hematopoietic stem cell transplantation has the characteristics of convenient operation，high intubation success rate，less pain，high comfort，but also need through the full range of nursing intervention for，themaximum reduce the incidence rate of the complications.
		2016 Vol. 23 (23): 174-176 [Abstract] ( 91 ) HTML (32 KB) PDF (0 KB) ( 21 )

	177	The effect of com prehensive nursing model on asthma control and rehospitalization rate in patients with asthma
		SU Hui-min；　HUANG Shu-di； CHEN Guang-xue； LIANG Yong-xiang
		Objective To explore the effect of comprehensive nursingmodel on asthma control and rehospitalization rate of asthma patients.Methods 96 cases choosed from January 2013 to 2016 June to newly diagnosed asthma patients in our hospital for treatment，which were randomly divided for the control group and the observation group，the control group were treated with routine nursing，the observation group adopted comprehensive nursing，a comparative analysis of two groups of patients with asthma control and discharged after 3 months rehospitalization rate differences.Results Patients in the observation group asthma control efficiency was 100%，higher than that was 81.25%in the control group with statistical difference（P＜0.05）；After the patientswere discharged from hospitalwithin 3months of rehospitalization rate in observed group was 4.17%better than thatwas 22.92%in the control group with statistical difference（P＜0.05）；Readmission in patientswith the predisposing factors were investigated，which the observation group due to poormedication compliance again admitted to the occurred rate was 2.08%lower than thatwas 37.50%in the control group with statistical difference（P＜0.05）.Conclusion The comprehensive nursingmode for patientswith asthma can not only control the symptoms of asthma，but also effectively reduce the short-term asthma recurrence rate，reduce the rate of hospitalization of two times，it isworthy of clinical application.
		2016 Vol. 23 (23): 177-179 [Abstract] ( 111 ) HTML (32 KB) PDF (0 KB) ( 22 )

	180	Nursing research of radiotherapy combined with concurrent chemotherapy by low dose 5-FU plus cisp latin in treatment of advanced uterine cervical cancer
		GUIFang
		Objective To study the nursing of radiotherapy combined with concurrent chemotherapy by low dose 5-FU plus cisplatin in treatment of advanced uterine cervical cancer.Methods 33 patientswith locally advanced uterine cervical cancer in our hospital from January to December in 2015 were selected，and all patientswere treated with radiotherapy combined with concurrent chemotherapy by low dose 5-FU plus cisplatin and given our hospital standard cervical cancer chemotherapy nursingmeasures.The treatment and adverse reactions of patientswere observed，and the improvement of quality of life before and after treatment of patients were analyzed.Results In the course of treatment，the incidence of adverse reactions was 21.21%.The quality of life score after the treatment of 23 patients discharged were significantly higher than before treatment，10 cases of treatment in patientswith quality of life also improved with statistical difference（P＜0.05）.After treatment，the SDSand SAS scoreswere significantly better than that before the treatment with statistical difference（P＜0.05）.Conclusion The clinical effects of radiotherapy combined with concurrent chemotherapy by low dose 5-FU plus cisplatin in treatment of advanced uterine cervical cancer are better.Although there are some adverse reactions in the actual treatment，and the treatment time is slightly longer.But after reasonable caremeasures and symptomatic treatment，the adverse reaction of patients decreased，and the prognosis is better.
		2016 Vol. 23 (23): 180-182 [Abstract] ( 115 ) HTML (35 KB) PDF (0 KB) ( 5 )

	183	Evaluation and analysis of the value of traditional Chinesemedicine nursing for patients with herpes zoster
		YAO Feng-ping；　RUAN Yan-hong
		Objective To study and discuss the value of traditional Chinese medicine nursing for patients with herpes zoster.Methods 100 cases of herpes zoster patients from December 2013 to April 2016 in our hospitalwere selected as the research object，the patientswere randomly divided into the control group and the observation group，and each group had 50 cases.The control group was given routine nursing，the observation group was given routine nursing and the nursing of traditional Chinese medicine.The pain relief time，simplex subsided，skin crusting time were compared between two groups，and the pain score，the score of anxiety and sleep quality index were compared of two groups before and after the intervention.Results The pain relief time，simplex subsided，skin crusting time of the observation group was　（3.47± 1.19）d，（3.96±1.27）d，（6.52±1.95）d，shorter than thatwas（4.72±1.33）d，（5.53±1.24）d，（9.87±2.31）d of control group（t= 4.953，6.255，7.836，P=0.000，0.000，0.000）.Compared with before intervention，after the intervention，the pain score，the score of anxiety and sleep quality index of two groupswas respectively decreased（P＜0.05）.After the intervention，the pain score，the score ofanxiety and sleep quality index the indicatorsof the observation group was（2.23±1.16）score，（6.17±1.82）score，（8.23±1.74）score，lower than thatwas（3.86±1.49）score，（9.42±2.05）score，（11.69±2.09）score of control group（P＜0.05）.Conclusion In the clinical nursing of herpes zoster，the implementation of traditional Chinese medicine nursing can effectively improve the clinical symptoms of patients，relieve pain and negativemood，improve the sleep quality of patients.
		2016 Vol. 23 (23): 183-185转188 [Abstract] ( 117 ) HTML (36 KB) PDF (0 KB) ( 20 )

	186	The app lication effect of psychological nursing intervention in magnesium sulfate treats pregnancy-induced hypertension
		LILi-mei
		Objective To discover application effect of psychological nursing intervention in that magnesium sulfate treats pregnancy-induced hypertension.Methods 88 cases of pregnantwomen with pregnancy-introduced hypertension，who was admitted into our hospital between June 2014 to January 2015，the patients had been randomly divided two groups，control group and observation group，and each group contained 44 cases.The women under control group were given by routine nursing and observed body indicators.The observation group were not only offered by routine nursing but also were intervened by psychological nursing.The treatment efficacy，adverse effect rate and nursing satisfaction level of the two groups under the different nursingmodes were compared.Results The result showed that the total efficacy rate of 44 cases of pregnant women under observation group who received psychological nursing intervention reached 93.18%，the total treatment efficacy rate of control group was 77.27%.The adverse effect rate of observation group was 6.82%，compared to the control group whose adverse effect rate was 20.45%.The nursing satisfaction rate of observation and control group were 95.45%，77.27%respectively.The total treatment efficacy rate of observation group was significantly higher than that in control group，which showed significant difference between the two groups（P＜0.05）. The adverse effect rate of observation group was significantly lower than that of the control group patients，which showed significant difference between the two groups（P＜0.05）.Nursing satisfaction level of the observation group was significantly higher than the control group.Conclusion The application of psychological nursing intervention in treatment of pregnancy-induced hypertension withmagnesium sulfate can greatly improvematernal treatment efficacy，relievematernal tension and reduce drug adverse effect，which has high clinical application value.
		2016 Vol. 23 (23): 186-188 [Abstract] ( 110 ) HTML (32 KB) PDF (0 KB) ( 18 )

	189	Im pact of details nursing intervention on sleep quality and negative emotion of pregnantwomen
		LICai-xia　；LIWei-ling　；CHEN Yi
		Objective To explore the impact of details nursing intervention on sleep quality and negative emotion of pregnant women. Methods 103 pregnant women who were confined in our hospital from January 2015 to March 2016 were selected and were randomly divided into control group　（n=51）and observation group　（n=52）.Pregnantwomen in control group were given routine nursing intervention，and pregnant women in observation group were given details nursing intervention.Patients′satisfaction to nursing work in two groups was counted.The changes of sleep quality and mentality in two groups before and after nursing were compared.Results The nursing satisfaction of nursing care process，language expression，service attitude and professional technology in observation group was obvious higher than that of control group　（P＜0.05）.Before nursing，sleep quality indicators，SAS and SDS score between two groups had no statistical significance（P＞0.05）.After nursing for 5 days，the sleep quality in observation group obvious increased，SASand SDSscoreobviousdecreased，whichwereobviousbetter than thatof controlgroup（P＜0.01）.Conclusion Using detailsnursing can enhance the satisfaction that pregnantwomen to nursing work，obvious improve sleep quality of pregnantwomen and decrease the negative emotion of postpartum anxiety and depression.
		2016 Vol. 23 (23): 189-191 [Abstract] ( 107 ) HTML (33 KB) PDF (0 KB) ( 17 )

	192	Effect of continuous nursing on self-care ability and health behavior of patients with COPD
		LIAO Zao-rong；　SHAO Hong；　LISi-ming；　CHEN Li-jun
		Objective To study and discuss the effect of continuous nursing on self-care ability and health behavior of patientswith chronic obstructive pulmonary disease.Methods 200 cases of patients with chronic obstructive pulmonary disease from January 2013 to June 2015 in our hospitalwere selected as the research object，the patientswere randomly divided into the control group and the observation group，and each group had 100 cases.The control group was given routine nursing intervention，and the observation group was given continuous nursing intervention on the basis of the control group.The total score of life quality and the score of self-care ability，health behavior and self efficacy was respectively compared between the two groups.Results The total score of life quality and the score of self-care ability，health behavior in the observation group was（80.24±6.71）score，（157.61±12.09）score，（184.69±11.87）score，respectively higher than thatwas（67.82±6.03）score，（144.27±11.85）score，（172.56±11.05）score in the control group（P＜0.05）.The score of self-efficacy in the observation group was higher than that in the control group（P＜0.05）.Conclusion In the patients with chronic obstructive pulmonary disease after discharge，the implementation of continuous nursing can effectively improve the life quality of patients，and can improve the patient′s self-care ability，self-efficacy and health behavior.
		2016 Vol. 23 (23): 192-194 [Abstract] ( 113 ) HTML (33 KB) PDF (0 KB) ( 21 )

	195	App lication ofmental nursing in children intravenous puncture
		LAN Hong
		Objective To explore the experience of usingmental nursing enhancing successful rate of intravenous puncture in children.Methods 300 children patients with outpatient treatment from January to June in 2015 of transfusion room were selected，and they were randomly divided into intervention group and control group.Each group was 150 cases.Children patients，their parents and nurses in intervention group were given psychological evaluation and corresponding psychological nursing，while patients in control group were given routine transfusion.Infusion coordination degree，successful rate of intravenous puncture and satisfaction rate of children′patients in two groupswere compared.Results The treatment compliance rate（71.10%）and successful rate（90.40%）of once intravenous puncture（90.40%）in intervention group were obvious higher than control group（57.20%，72.90%），the satisfaction rate of children′patients （93.96%）was higher than control group（85.41%），and the difference was statistical significance when compared between two groups（P＜0.05）.Conclusion Mental nursing is suitable in pediatrics，the emotion of children patients，their parents and nurses is direct influence on the success rate of vein puncture.Using differentmental intervention can improve the successful rate of children intravenous puncture effectively.
		2016 Vol. 23 (23): 195-197 [Abstract] ( 111 ) HTML (36 KB) PDF (0 KB) ( 2 )

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