小剂量阿司匹林联合钙剂在高危人群预防子痫前期的临床体会

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Abstract Objective To observe the clinical effect of low dose aspirin combined with calcium in the prevention of preeclampsia in high risk pregnantwomen. Methods 160 cases of pregnantwomen with high risk factors of preeclampsia in our perinatal outpatient service from October 2014 to October 2015 were selected and divided into observation group and control group according to the wishes of the pregnant women，with 80 cases in each group.Pregnant women in the observation group started Po dose of 100mg/d aspirin　（aspirin）and ricard calcium amino acid chelate 2 g/d from 14-20 weeks pregnant，generally to 36 gestationalweeks，while pregnantwomen in the control group did not take any drugs. Pregnantwomen in two groups all were given standardized perinatal care，at the same time pay attention to reasonable diet，suitable rest and moderate exercise.Blood pressure and ponderal growth weremonitored，blood routine urine routine，liver and kidney function，blood coagulation function and serum calcium were detected，condition of mother and fetal were regularly antenatal monitored.The incidence of preeclampsia and the maternal and infant outcomes in the two groupswere observed.Results Pregnantwomen in two groups have been followed up to the end of delivery，the incidence of preeclampsia in the observation group was 6.25%，with mild preeclampsia and no early onset preeclampsia.In the control group，the incidence of preeclampsia was 25.00%，mild with 11.25%，severe with 7.50%，early onset preeclampsia with 6.25%，there was significant difference　（P＜0.05）；incidence of postpartum hemorrhage，fetal intrauterine growth restriction　（FGR），fetal distress，neonatal asphyxia in the observation group were significantly lower than those in the control group with statistical significance（P＜0.05）.Conclusion The early application of low-dose aspirin and calcium in the early stage of pregnancy after the end of early pregnancy to prevent occurrence of preeclampsia，improvematernal and neonatal outcomes，the effect is significant.

Key words： Preeclampsia Aspirin Calcium Fetal intrauterine distress Fetal intrauterine growth restriction Asphyxia neonatorum

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	LIU Ai-hua
	LIU Dong-mei
	BAIJun-li

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LIU Ai-hua,　LIU Dong-mei,BAIJun-li. Clinical experience of low dose aspirin combined with calcium in the prevention of preeclampsia in high risk pregnantwomen[J]. 中国当代医药, 2016, 23(23): 81-83.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I23/81

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