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2016 Vol. 23, No. 28
Published: 2016-10-08
4
Evaluation of the preparation quality of genomic DNA from PBMC by using 36B4 geneam plification efficiency
ZHOU Dan；CUIXiao-xian；SUN Shu-hui；JIANG Lin；RONG Xing-yu；WANG Hui-jing；ZHAO Chao；SHIHong-li
Objective To establish a simple and effectivemethod for evaluating the preparation quality of the genomic DNA from PBMC. Methods In this study，real-time quantitative PCR technique was used to amplify the single copy gene 36B4 in a sample to investigate the relationship between the amplification efficiency and the quality of samples.Results The amplification efficiency of 36B4 in the genomic DNA treated by DNaseⅠ was significantly lower than that of the untreated sample.By using this method，the blood samples from 18 healthy volunteers were detected and analyzed，the results showed that the preparation quality of blood sample genome was effectively evaluated.Conclusion The method can be used to evaluate the influence of the process and operation on the physical examination in the sample collection of health examination，and to improve the accuracy of the test item of the genomic DNA.
2016 Vol. 23 (28): 4-7 [
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Clinicopathological analysis and review of literatures of malignant gastrointestinal neuroectodermal tumor
LIU Hai-ling； FAN Xin-juan ；LIU Jun ；HUANG Yan
Objective To investigate clinicopathological features，immunophenotype，molecular genetics and differential diagnosis ofmalignant gastrointestinal neuroectodermal tumor. Methods A case of rare malignant gastrointestinal neuroectodermal tumor in December 2015 in our hospitalwas analyzed and reviewed the related literature.The histological and immunohistochemical results were observed，and the fusion status of EWSR1 gene was detected by fluorescence in situ hybridization（FISH）.Results The tumorwas located in the small intestine，the poor-circumscribed lesion located in the entire thickness of the bowelwall extending into themucosal layer with a significant infiltrative growth patterns.The tumors cells composed of round，short spindle or round epithelium-like cells arranged in sheets or nests.A number of multinucleated osteoclast-like giant cells had also been observed.The nuclei thatwas surrounded by variable amounts of eosinophilic cytoplasm showed vesicular chromatin with generally distinct to nucleoli and variable mitotic activity were easy to seen.The tumor cellswere strongly positive for S-100 and Vimentin，and positive for CD99，CD56 and Syn，and weak positive for CR，the Ki-67 proliferating index was about 30%in the aspect of immunohistochemistry.Fluorescence in situ hybridization results showed EWSR1 gene rearrangement.Conclusion Malignant gastrointestinal neuroectodermal tumor is an additionally rare tumorwith high aggressive and poor prognosis.The definite diagnosis for itmainly depends on the histology，immunophenotype，at the same time，need to be differentiated from othermalignant tumors.The rearrangement analysis of EWSR1 gene is helpful for pathologic diagnosis.
2016 Vol. 23 (28): 8-11转15 [
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Study on quality standard of Anisochilus carnosus Fructus
SHANG Chun-li；LIYun-xia；DUAN Shu-qing；ZHANG Ning；LU Yu
Objective To establish and revise the quality standard of Anisochilus carnosus Fructus. Methods Anisochilus carnosus Fructus was qualitatively identified by morphological，macroscopic and TLC methods，and referring to Chinese Pharmacopoeia of 2015 edition，water content，total ash，acid-insoluble ash and extractwere also determined.Results The microscopic characteristics and the spots of TLC were clear and evident.The water content，total ash，acid-insoluble ash and extract of 10 Anisochilus carnosus Fructus samples varied in the ranges of 6.0%-9.5%，0.8%-10.0%，0.3%-2.1%，and 4.3%-10.7%，respectively.Conclusion This study provides a reference for improving the quality standard of Anisochilus carnosus Fructus.
2016 Vol. 23 (28): 12-15 [
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Ultrastructural change of lung in rats poisoned by smoke inhalation of Chloroacetic Acid
ZHANG Chun-ying； TIAN Bao-xiang ；YANG Xiong ；LIN Hai-long； FAN Hua ；LIU Feng-bin； ZHANG Ke-chuan
Objective To explore the toxicity with inhalation of Chloroacetic Acid （CA）smoke inhalation injury in rats and its ultrastructural change of the lung. Methods 60 ratswere divided into 3 groups to observe poisoning changes in breathing the smoke of CA，sulpharic acid and heating water，and after 6 hours，the rats were killed and the lungs were taken tomicroscopical and electronmicroscopical examinations.Results There were 2 rats（10%）died in CA smoking group，with the pulmonary changes of pathologic bronchitis and ultrastructural changes of the alveolar cell swelling，intracytoplasmic vacuoles，widened alveolar septum and capillary thrombus.Conclusion CA smoking inhalation injury would induce absorpton poisoning and cause death，so it should be closed production，handling should put an end to" run，ooze，drip，leak"，the scene should wear protectivemask，to avoid the smoke inhalation.
2016 Vol. 23 (28): 16-18 [
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Pathological and clinical factors study of influencing the accuracy of intraoperative frozen diagnosis of breast cancer
WANG Yong-xuan
Objective To analyze the pathological and clinical factors of influencing the accuracy of intraoperative frozen diagnosis in the operation of breast cancer patients，so as to improve the diagnostic accuracy. Methods The clinical data of 85 cases of breast cancer（45 cases of histological tumormore than 3 cm，40 cases of histological tumor less than 3 cm）patients from June 2013 to October 2015 in our hospital undergoing clinicalmedical records were retrospectively analyzed.The results of frozen diagnosis and professional grade breast cancer diagnosis were compared to evaluate the accuracy of frozen diagnosis.The pathological factors and clinical factors affecting the accuracy of frozen diagnosiswere discussed in detail.Results The diagnostic accuracy of frozen section in the diagnosis of breast cancerwas 67.06%，Kappa valuewas 0.592，which was consistentwith the results of postoperative pathological diagnosis.Aftermultiple factors Logistic regression analysis，age，calcification，tumor diameter and pathological grading were the factors influencing the accuracy of intraoperative frozen diagnosis of breast cancer.Conclusion The effect of breast cancer patients with frozen diagnostic accuracy of factors is complex，therefore the related factorsmust be payed attention in the process of clinical diagnosis to improve the diagnostic accuracy and to provide scientific guidance for surgical treatment of patientswith breast cancer.
2016 Vol. 23 (28): 19-21转25 [
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Clinical study on evaluating the efficacy and prognosis of dynamic monitoring of C reactive protein in patients with severe community acquired pneumonia
XU Yi-long；LIYu-fen；ZHOU Rong-ming
Objective To explore the application value of dynamicmonitoring of C reactive protein in evaluating the curative effect and prognosis of severe community acquired pneumonia. Methods 62 patients with serious community acquired pneumonia from March 2014 to January 2016 in the ICU at our hospital were selected and divided into the death group and the survivors group according to the ending when discharged.The death group was 17 cases，the survivors group was 45 cases.The level of Creactive protein （CRP），white blood cell（WBC）and procalcitonin（PCT），sequential organ failure assessment（SOFA）score，C reactive protein ratio（CRP-ratio）and the relevant indexeswas compared between the two groups respectively.Results The acute physiology and chronic health（APACHEⅡ）score，the risk factor of death，the original value of calcitonin and SOFA score of the death group was greater than that the survivors group，therewas statistical significance（P＜0.05）.The CRP，PCT and SOFA was able to assessed the effect and prognosis，but the sensibility of CRP-ratio was higher，there was statistical significance （P＜0.05）.Conclusion The CRP-ratio has higher sensibility that compared with the PCT and SOFA，which can assess the treatment effect and prognosis on the 3rdday of anti-infective therapy.
2016 Vol. 23 (28): 22-25 [
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Effect of oraladministration of Mesalazine combined with retention enema in the treatment of ulcerative colitis
MA Gui-ping；LIYing；DU Juan
Objective To explore the clinical effect of oral administration of Mesalazine combined with retention enema in the treatmentofmild tomoderate ulcerative colitis. Methods 46 patientswithmild tomoderate ulcerative colitis from April 2012 to October 2014 in our hospital were selected and divided into the observation group （26 cases）and the control group（20 cases）according to the random number tablemethod.The control group was treated with oral administration of Mesalazine.The observation group was treated with retention enema with drug on the basis of the control group.after treatment.The clinical efficacy and the recurrence rate followed up for 6 month and 1 year between the two groupswas compared.Results The total effective rate of the observation group was 92.3%，which was higher than 80.0% of the control group，with significant difference（P＜0.05）.The recurrence rate followed up for 6months and 1 year of the observation group was respectively 12.5%and 20.8%，which was lower than 31.3%and 50.0%of the control group，with significant difference（P＜0.05）.Conclusion The clinical effect of oral administration of Mesalazine combined with retention enema ismore precise than that of a simple oral treatment in the treatment ofmild tomoderate ulcerative colitis，and the recurrence rate can be significantly reduced after treatment，it isworthy of clinical promotion and application.
2016 Vol. 23 (28): 26-28 [
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Application value of CRP and PCT in the elderly patients with hospital acquired pneumonia
ZHANG Li-juan； LIYu-rong； JILong
Objective To explore the the clinical value of serum C-reactive protein （CRP）and procalcitonin （PCT）in the early diagnosis of hospital acquired pneumonia（HAP）in elderly patients. Methods 72 elderly patientswith HAP in our hospital from November 2013 to December 2015 were selected as the observation group，65 normal healthy individuals with the same period were selected as the control group.Blood samples of the observation group were extracted when patients hospitalized and early clinicalmanifestation arising and diagnosis determined，which of the control group were extracted on the day of physical examination.The level of CRP and PCT was compared between the observation group on admission and the control group，and the level of CRP and PCT in the observation group on admission，early clinical manifestation arising，diagnosis determined was compared.Results There was no significant difference in the serum CRP and PCT levels between the control group and the observation group who hospitalized （P＞0.05）.The serum CRP and PCT levels of the observation group when early clinicalmanifestation arising was higher than that in the same group when patients hospitalized，with significant difference （P＜0.05）.The serum CRP and PCT levels of the observation group when early clinicalmanifestation arising was lower than that in the same group when diagnosis determined，with significant difference（P＜0.05）.Conclusion The serum CRP and PCT levels in elderly patientswith HAP in early clinicalmanifestations but not yet confirmed can significantly increase，which have an important clinical significance in early diagnostic value on elderly patientswith HAP.
2016 Vol. 23 (28): 29-31 [
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App lication of quality control circle in improving the wear rate of the wrist-band in the elderly hospitalized patients
ZHANG Dong-ying； GUO Ting
Objective To explore the application effect of quality control circle（QCC）activity in improving the wearing rate of wrist-band in elderly hospitalized patients. Methods Elderly hospitalized patients in our hospital from August 2015 to March 2016 were selected as the research subjects，216 hospitalized patients from August 25 to October 31 in 2015 were selected as the control group（before carrying out the QCC activity），356 hospitalized patients from December 1 in 2015 to March 31 in 2016 were selected as the observation group （after carrying out the QCC activity）.The wear condition and the medical errors and accidents caused by improper identification in the two groups was compared.Results The incidence rate of non-wearing wrist-band and inconsistent information of wrist-band in the observation group was lower than that in the control group（2.00%vs 12.04%，0 vs 3.24%），with significant difference（P＜0.05）.There was no significant difference in the incidence rate of not clear identification wrist-band and wrist-band shedding between the two groups（P＞0.05）（0.84%vs 3.32%，2.25%vs 2.30%）.The incidence rate ofmedical errors and accidents caused by improper identification of the observation group was lower than that of the control group （16.67%vs 64.29%），with significant difference （P＜0.05）.Conclusion Carrying out QCC activity is an effective way to improve the wearing rate of the wrist-band in elderly hospitalized patients，which can reduce the incidence of errors.
2016 Vol. 23 (28): 32-34 [
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Clinical effect observation of laparoscope combined with bile duct endoscope in the treatment of gallstones
YANG Yan-jin
Objective To explore the clinical efficacy of laparoscope combined with bile duct endoscope in the treatment of gallstones. Methods 80 patients with gallstones in our hospital from March 2008 to March 2016 were selected and divided into the conventional group and the double mirror group according to the different treatmentmethods，40 cases in each group.The conventional group was given conventional open surgery，and the double mirror group was treated by laparoscope combined with biliary endoscope.The operation time，intraoperative blood loss，gastrointestinal recovery time，analgesic use cases，hospital days，treatment effect and the incidence rate of postoperative complications in the two groupswas compared.Results The operation time，recovery time of gastrointestinal tract and hospital days in the doublemirror group was shorter than that in the conventional group，the amount of blood loss and the use of analgesics in the doublemirror group was less than that in the conventional group，with significant difference （P＜0.01）.The cured and markedly effective rate in the double mirror group was 90.0%，which was higher than 67.5%in the conventional group，with significant difference（P＜0.05）.The incidence rate of total complications in the doublemirror group was 5.0%，which was lower than 25.0%in the conventional group，with significant difference （P＜0.05）.Conclusion Laparoscope combined with bile duct endoscope can significantly improve the therapeutic effect of gallstones，promote postoperative recovery of patients，reduce the incidence of complications.It can be used as one of the important surgical treatment of gallstones.
2016 Vol. 23 (28): 35-37 [
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Clinical study of perioperative Amiodarone for preventing atrial fibrillation after pulmonary resection
LIU Xiao-xiong；XIONG Han-peng；LI Hui
Objective To evaluate efficacy and safety of Amiodarone for preventing atrial fibrillation after pulmonary resection. Methods 130 cases of accepting lobectomy or pneumonectomy in the hospital from April 2014 to June 2015 were randomly divided into Amiodarone group （prophylactic use of Amiodarone，n=65）and control group （n=65），incidence of atrial fibrillation during hospitalization in need of treatment and atrial fibrillationmore than 30 s，stay in intensive care unit and total length of hospital stay between two groupswere compared.Results The incidence of atrial fibrillation in the Amiodarone group was 13.8%，significantly lower than 32.3%in the control group（P＜0.05），incidence of atrial fibrillationmore than 30 s in the Amiodarone group was 13.8%，lower than 33.8%in the control group （P＜0.01）；in the Amiodarone group，stay in intensive care unit and the total length of hospital stay was significantly shorter than that in the control group respectively，the difference was statistically significant（P＜0.05）；incidence of postoperative adverse eventswas not statistically significant（P＞0.05）.Conclusion Prophylactic use of Amiodarone can significantly reduce incidence of atrial fibrillation after pulmonary resectio，and significantly reduce residence time in intensive care unit.
2016 Vol. 23 (28): 38-40 [
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Clinical application of Tirofiban hydrochloride in treating ST-elevation acutem yocardial infarction
LIXue-feng； LIU Li-mei ；LICun-ren ；GU Xian-fang
Objective To explore the clinical effects of Tirofiban hydrochloride in treating ST-elevation acute myocardial infarction. Methods 116 patientswith ST-elevation acutemyocardial infarction treated in our hospital from January 2013 to February 2016 were selected as study objects and divided into two groups by using random number table，58 patients were in each group.Patients in control group were given percutaneous coronary intervention alone，and patients in observation group were given intravenous injection Tirofiban hydrochloride before intervention and continuous micro pump injection during operation and postoperative for 24-36 hours.The treatment effects of patientswere evaluated，the incidence rate of adverse cardiovascular events and bleeding situation during treatment between were counted.Results The ratio ofpostoperative thrombolysis inmyocardial infarction（TIMI）blood flow classification 3 degreeand MBG 3 degree in the observation group were higher than those in the control group，and the differenceswere obvious（P＜0.05）.The incidence rate of adverse cardiovascular events during treatment in the observation group was 1.7%，lower than 15.5%in the control group；the incidence rate of bleeding events in the observation group was 1.7%，lower than 12.1% in the controlgroup，the differenceswere statiscally significant（all P＜0.05）.Conclusion Tirofiban hydrochloride in treating ST-elevation acutemyocardial infarction has obvious effects and high safety，and it isworth to popularize in clinic.
2016 Vol. 23 (28): 41-43 [
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Relation of adiponectin，homocysteine and hypersensitive C-reactive protein with hypertension
LI Jing ；MA Yu-hong； CHENGWen-jun
Objective To explore the relations between adiponectin（ADPN），Homocysteine（Hcy）and hypersensitive C-reactive protein（hs-CRP）with the essential hypertension. Methods 245 patientswith essential hypertension（hypertension group）and 180 healthy subjects（control group）were collected in cardiovascular departmentof our hospital from July 2014 to March 2016.Blood pressure was evaluated by sphygmomanometer，ADPN and Hcy levels of serum were detected by ELISA，hs-CRP levels of serum weremeasured by turbidimetry.Results Blood pressure，Hcy and hs-CRP levels of serum in hypertension group were significantly higher than those in control group （P＜0.01），but the level of ADPN in Hypertension group was（8.01±3.93）mg/dl，lower than（13.48±3.34）mg/dl in control group（P＜0.01）.Level of serum ADPN in each hypertension group was lower than that in the control group（P＜0.05），level of serum ADPN between gradeⅠhypertension group and gradeⅡhypertension group had no statistical difference（P＞0.05）.Level of serum Hcy had statistical difference among all groups，with the grade increase of blood pressure group，the level of Hcy was significantly higher than that of the latter group（P＜0.05）.Level of serum hs-CRP had no statistical difference between gradeⅠhypertension group and control group，other two groups compared with control group，the difference was statistically significant（P＜0.05）；there was no significant difference in hs-CRP level between gradeⅠhypertension group and gradeⅡhypertension group （P＞0.05），which in gradeⅢ hypertension group was significantly higher than that in other groups （P＜0.05）.Conclusion ADPN，Hcy and hs-CRP level of serum are closely related to hypertension.
2016 Vol. 23 (28): 44-46 [
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Observation of clinical effect of invasivemechanical ventilation combined with Propofol，muscle relaxant in treatment of acutem yocardial infarction and pump failure
LUO Jian-li
Objective To explore clinical effect of invasive mechanical ventilation combined with Propofol and muscle relaxant in treatment of acute myocardial infarction and pump failure. Methods 48 patients with acute myocardial infarction and pump failure accepted treatments in ICU of our hospital from June 2014 to August 2016 were taken as research objects，24 patients treated with invasivemechanical ventilation combined with Propofol and Atracurium were as observation group，while 24 patients only treated with conventional drugs because some reason as control group.Heart rate，noninvasivemean arterial pressure （MAP），blood gas analysis and other indicators，pulmonary rales and other signs change，left ventricular ejection fraction（LVEF）on 7 days of cardiac ultrasound dynamic graph and average hospitalization time between two groups were compared.Results The illness of patients after treatment in the observation group was significantly improved，and respiratory frequency was slower，heart rate was significantly decreased，pulmonary rales was significantly decreased or disappeared，hypoxemia was quickly corrected，patients in the control group were also improved，but the effectwas significantly lower than that in the observation group（P＜0.05）.Average hospitalization time in the observation group was（20.5±4.9）d，in the control group of（36.6±10.3）d，with a significant difference（P＜0.05）.The incidence of adverse reactions in the observation group was significantly lower than that in the control group （P＜0.05）.Conclusion Effect of invasivemechanical ventilation combined with Propofol，muscle relaxant in treatment of acutemyocardial infarction and pump failure is better than that conventional drug treatment，which it is helpful to improve the survival rate of patients，reduce the average hospitalization time，reduce the economic burden of the patients and the society，thus ithas the promotion significance in clinical treatment.
2016 Vol. 23 (28): 47-49 [
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Clinical observation of Atorvastatin combined with Trimetazidine in treatment of coronary heart disease
XIE Yan-jun
Objective To observe the clinical effect of Atorvastatin combined with Trimetazidine in treatment of coronary heart disease（CHD）. Methods 180 caseswith CHD in the hospital from February 2015 to March 2016 were divided into Atorvastatin group（n=60），Trimetazidine group（n=60）and Atorvastatin combined with Trimetazidine comprehensive treatment group（n=60）according to different therapeuticmeasures，clinical efficacy among three groupswere compared.Results The total effective rate of comprehensive treatment group was 93.3%，significantly higher than 63.3%，68.3%of Atorvastatin group and Trimetazidine group respectively，and the difference was statistically significant（P＜0.05）；triacylglycerol（TG），total cholesterol（TC）and low density lipoprotein cholesterol（LDL-C）before treatment in three groups had no significant difference（P＞0.05）；after treatment，TG，TC and LDL-C in the comprehensive treatment group was lower than those of in the other 2 groups.Frequency of angina attack and duration of angina pectoris attack in the comprehensive treatmentgroup were less than those in the other 2 groups（P＜0.05）；the remission rate of adverse reaction in the comprehensive treatment group was significantly higher than that in the other 2 groups（P＜0.05）.Conclusion A-torvastatin combined with Trimetazidine in treatment of CHD hasmore ideal clinical curative effect，can improve the quality of life of patients and high safety，and it isworth popularization and application.
2016 Vol. 23 (28): 50-52转55 [
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The result detection of treatment TIA by Xueshuantong injection compared with low molecular weight heparin calcium injection
LIANG Li-yan；LIAO Jian-jun
Objective To explore result of treatment TIA by Xueshuantong injection compared with Low molecular weight heparin calcium injection. Methods The 45 cases clinical data of TIA patients in the ICU from March 2014 to February 2016 were analyzed，which was to be divided into two groups by different treatmentmethods，control group（15 cases）and combined with treatment group（30 cases），the ATPP，PLT，PT，clinical treatment total effective rate of two groups TIA patients before treatment and after treatment were detected.Results The ATPP，PLT，PT of two groups TIA patients before treatment had no difference（P＞0.05），the ATPP，PLT，PT of control group before treatment and after treatment had no difference（P＞0.05），the ATPP，PT of detection group after treatmentwere higher than before treatment，PLT was lower than before treatment，the ATPP，PT of detection group after treatmentwas higher than that of control group，PLT was lower than that of control group，the clinical treatment total effective rate of detection group was higher than that of control group，the differencewas statistically significant（P＜0.05）.Conclusion The treatment TIA by Xueshuantong injection compared with low molecular weight heparin calcium injection，clinical result is obviously，prognosis is good，which is to be used.
2016 Vol. 23 (28): 53-55 [
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Clinical application advantage of early skull repair in the treatment of brain injury
LUO Cheng； ZHONG Yong-sheng
Objective To explore the early bone repair clinical application advantages for the treatment of traumatic brain injuries. Methods 100 patients with traumatic brain injuries in our hospital from May 2013 to May 2015 were selected.The patients were divided into 2 groups bymeans of drawing，50 patients in each group.Patients in the control group were treated with advanced skull repair，and the observation group was treated with early skull repair.The treatment effect，clinical scores and adverse event rates between the two groupswere compared.Results Treatment effect，neurological impairment score，Glasgow score，functional status score，adverse events of observation group patients were better than those of the controlgroup，［100.00%vs92.00%（10.76±1.54）points vs（19.65±1.78）points，（12.75±1.86）points vs （9.73±1.75）points，（92.36±2.43）points vs（72.43±1.32）points，2.00%vs24.00%］，the differenceswere statistically significant （P＜0.05）.Conclusion Early skull repair in the treatmentof brain trauma patientswith significant effect.
2016 Vol. 23 (28): 56-58 [
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Clinical study on expanding time window of arteriovenous thrombolysis in treatment of acute cerebral infarction
WANG Hong-sheng； WEIJi-qiang
Objective To investigate the clinical efficacy of expanding time window of arteriovenous thrombolysis in treatment of acute cerebral infarction（ACI）. Methods The clinical data of 60 ACI patients treated in the neurology department of hospital from January 2015 to June 2016 were retrospectively analyzed，and they were randomly divided into control group and research group，30 cases in each group.Control group took routine time window（onset time within 4.5 h）of arteriovenous thrombolysis；research group took expanding time window （onset time within 4.5-10 h）of arteriovenous thrombolysis.NIHSS，BI scores and occurrence of complications of two groups were compared，and clinical efficacy of two groups were evaluated.Results Before treatment，7 d and 14 d after treatment，there was no statistical difference in NIHSS scores compared between the two groups（P＞0.05）；after treatment 2，24 h，the NIHSS score of two groups was compared，the difference was statistically significant（P＜0.05）.14 d after treatment，there was no statistical difference in clinical efficacy and incidence of complications compared between the two groups（P＞0.05）；28 d after treatment，there was no statistical difference in BI compared between the two groups （P＞0.05）.Conclusion Compared with routine time window of arteriovenous thrombolysis，expanding timewindow of arteriovenous thrombolysis for treating ACI equally can effectively improve patients′neurologic impairment and increase activity of daily living，it has low incidence of complications and significant efficacy，which isworthy of generalization.
2016 Vol. 23 (28): 59-61 [
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Effects evaluation and analysis of cerebral infarction comprehensive rehabilitation therapy
CHEN Chao-yun；WU Jie-xian；HONG An-hui；CHEN Jin-xin
Objective To study the application meaning of cerebral infarction rehabilitation therapy. Methods 88 cerebral infarction patients who were admitted in our hospital from March 2014 to February 2015 were randomly selected as the object.The above 88 cerebral infarction patientswere randomly divided into routine rehabilitation group（44 cases）and comprehensive rehabilitation group（44 cases）.Patients in routine rehabilitation group were used routine rehabilitation therapy and patients in comprehensive rehabilitation group were used comprehensive rehabilitation therapy.The rehabilitation effects of nerve function，differences in nerve function defect score and cognitive function score before and after intervention，differences in motor function score and activities of daily living score before and after intervention were compared.Results①Comprehensive rehabilitation group had higher nerve function rehabilitation effect compared with routine rehabilitation group（P＜0.01）.②Before intervention，the two groups had similar nerve function defect score and cognitive function score（P＞0.05）.After intervention，comprehensive rehabilitation group improved more obvious in nerve function defect score and cognitive function score compared with routine rehabilitation group（P＜0.05）.③Before intervention，the two groups had similarmotor function score and activities of daily living score（P＞0.05）.After intervention，comprehensive rehabilitation group improved more obvious in motor function score and activities of daily living score compared with routine rehabilitation group（P＜0.05）.Conclusion The application effects of cerebral infarction comprehensive rehabilitation therapy are definitely，which can improve nerve function and cognitive function effectively，promote the enhancing ofmotor function and activities of daily living，is helpful to patients′progress and worth to popularize.
2016 Vol. 23 (28): 62-64转68 [
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Diagnosis and consideration of secondary hemorrhage after cerebral hemorrhage surgeries as vascular am yloidosis
LIN Hai； LIHui-zhong ；HUANGMei-fei
Objective To investigate the diagnosis and treatment of secondary hemorrhage after cerebral hemorrhage surgeries as vascular amyloidosis. Methods A retrospective analysiswas performed on 3 patients from July 2014 to August 2015 with secondary hemorrhage after cerebral hemorrhage surgeries in our hospital.The causes，diagnosis and treatment of secondary cerebral hemorrhage with vascular amyloidosis were analyzed.Results 3 cases of patients with secondary hemorrhage underwent imaging examinations and were radiologically diagnosed as cerebral vascular amyloidosis.Conclusion Prior to the autopsy pathology diagnosis，imaging examinations can be used as the preferred and highdiagnostic-ratemethod for diagnosis of cerebral hemorrhage with vascular amyloidosis；vascular amyloidosis is the risk factor for secondary hemorrhage in post-operative patients with cerebral hemorrhage and can obtain better prognosis after treatment.
2016 Vol. 23 (28): 65-68 [
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Correlation study between cortisol and insulin resistance in patients with type 2 diabetesmellitus
LIAO Fang-qing ；LV Shun-rong
Objectiv e To explore the relationship between plasma cortisol and insulin resistance in patientswith type 2 diabetesmellitus （T2DM）. Methods 57 newly diagnosed T2DM patients in our hospital from March to December in 2015 were selected as the observation group，61 physical examination personswere selected as the control group at the same period.The biochemical index of fasting blood-glucose （FBG），total cholesterol（TC），fasting insulin（FINs），plasma cortisol，insulin resistance index（HOMA-IR）and insulin secretion index（HBCI）wasmensurated，respectively.The correlation between plasma cortisol and insulin resistance were analyzed by Pearson statisticalmethod.Results There was no significant difference in the gender，age，body mass index，systolic blood pressure and diastolic blood pressure between the two groups （P＞0.05）.The proportion of smoking and drinking in the observation group was higher than that in the control group，with significant difference（P＜0.05）.The level of FBG，TC，FINs，plasma cortisol，HOMA-IR in the observation group was higher than that in the control group，with significant difference （P＜0.05）.Therewas no significant difference in the level of HBCIbetween the two groups（P＞0.05）.Conclusion Plasma cortisol is closely related to insulin resistance in patientswith T2DM.
2016 Vol. 23 (28): 69-71 [
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Clinical observavtion of Sitagliptin Phosphate combined with Metform in in the treatment of new ly diagnosed type 2 diabetesmellitus
DING Xiao-hui
Objective To explore the effect of combination of Sitagliptin Phosphate and Metformin in the treatment of newly diagnosed type 2 diabetesmellitus. Methods 40 cases of newly diagnosed type 2 diabetesmellitus from December 2014 to December 2015 in our hospitalwere selected and randomly divided into the control group and the observation group，20 cases in each group.The control group was given Metformin，the observation group was given Sitagliptin and Metformin.The indexes changes of fasting blood glucose（FBG），2 hours postprandial blood glucose（2 h PG），glycated hemoglobin（HbA1c），bodymass index（BMI），fasting insulin（FINs），HOMA-insulin resistance（HOMA-IR）and the incidence rate of adverse reactions in the two groupswas compared respectively.Results The levels of FBG，2 h PG，HbA1C，BMIafter 12 weeks of treatment in the two groupswas lower than that before treatment，the level of FINs after 12 weeks of treatment in the the two groupswas higher than that before treatment，with significant difference（P＜0.05）.The levels of FBG，2 h PG，HbA1C，BMI after 12 weeks of treatment in the observation group was lower than that in the control group after treatment，the level of FINs after 12 weeks of treatment in the observation group was higher than that in the control group after treatment，with significant difference （P＜0.05）.There was no significant difference in the incidence rate of adverse reactions between the two groups（P＞0.05）.Conclusion Combination of Sitagliptin Phosphate and Metformin used in the treatment of newly diagnosed type 2 diabetesmellitus is better than Metformin monotherapy in the clinical efficacy of blood glucose control.
2016 Vol. 23 (28): 72-74 [
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162
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The significance of iodine intake and TRAb in the pathogenesis and clinical outcome of Graves disease
XU Yuan-hui；CHENG Dao-xiang；JIN Yun-shun；QIU Feng-lin；LUOMao-zai；LIU Li-hua；HUANGWei；YU Xiao-chun
Objective To study the significance of iodine intake and TRAb （thyrotrophin receptor antibody）in the pathogenesis and clinical outcome of Graves（GD）disease.Methods 89 patients GD hyperthyroidism from January 2014 to January 2015 in our hospitalwere selected，80 cases of the resthyperthyroidism group.the free thyroxine index 3（FT3），FT4，thyrotropin，thyroid stimulating hormone（TSH），TRAb，thyroid peroxidase antibody（TPO-Ab），thyroglobulin antibody （TG-Ab）were compared in two groups.The follow-up for 1.5 years of GD patients with hyperthyroidism，and the guidance of the iodine intake，the changes of FT4，FT3，TSH，TRAb，TPO-Ab，TG-Ab levels and thyroid volume were observed.Results In the follow-up of 89 patients with GD group，a total of 40 patients were followed up，and the guidance of the iodine intake，the thyroid function of 22 patients
returned：
to normal，TRAb was negative for two consecutive times，and the thyroid volume was significantly reduced，the level of TG-Ab and TPO-Ab was basically normal；a total of 36 patients were followed up for the rest of the 80 patients with hyperthyroidism，and to guide the iodine intake，in which 20 cases of patients with thyroid function
returned：
to normal，thyroid function was not significantly improved in the remaining 16 patients，TRAb has been negative，and the thyroid gland was slightly smaller，TPO-Ab，TG-Ab level was still higher.In the correlation analysis，GD hyperthyroidism patients for the TRAb were positively correlated with TSH，FT3，TRAB，FT4，thyroid volume.Conclusion Iodine intake，TRAb in the pathogenesis and clinical outcome of GD is of great significance，can provide reference for future clinical treatment.
2016 Vol. 23 (28): 75-77 [
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167
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App lication of pedicle vertebral osteotom y in thoracolumbar protrusion deform ity correction
LUOQi ；YOU Hui
Objective To explore the application value of pedicle vertebral osteotomy in thoracolumbar protrusion deformity correction. Methods 32 patients treated with pedicle vertebral osteotomy for thoracolumbar protrusion deformity from May 2013 to January 2015 were selected.The pain score［using visual analogue scale（VAS）］before and 6 months after operation，sagittal Cobb angle and the improvement situation of Oswestry disability index （ODI）of patients were observed.Results Before treatment，the VAS score，sagittal Cobb angle and ODI index level of patients were respectively （7.64±1.26）points，（45.79±12.43）°and（58.67±7.50）%；after treatment，the VAS score，sagittal Cobb angle and ODI index level of patientswere respectively（3.25±0.78）points，（10.52±6.85）°and（26.98±5.40）%，all of that decreased than those before treatment，and the difference was statistical significance （P＜0.01）.Conclusion Pedicle vertebral osteotomy has great application value in thoracolumbar protrusion deformity correction，which can correctmalformation better，alleviate pain and isworth to popularize.
2016 Vol. 23 (28): 78-80 [
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108
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81
Effect observation of PFNA internal fixation in the treatment of intertrochanteric fracture of femur in the elderly
JIANG Zhu-sheng ；YU Kun-min； PAN Bin-wen
Objective To evaluate the effect of PFNA internal fixation in the treatment of intertrochanteric fracture（IFF）in the elderly. Methods There were 106 elderly patientswith IFF in our hospital from January 2012 to June 2015 were selected，and divided into control group（53 cases）and observation group（53 cases）.The control group was given dynamic hip screw （DHS）treatment，and observation group was given femoral proximal anti rotation intramedullary nail（PFNA）internal fixation.The treatment effect was compared.Results Operative time，activities and fracture healing time of observation group were significantly shorter than those of control group，blood loss was less than that of control group，with statistical difference（P＜0.01）.Harris score of observation group after 3 months and 6 months respectively（84.25± 10.68）and（89.50±11.71），significantly higher than those of control group（P＜0.01）.Postoperative complication occurrence rate of observation group was significantly lower than control group（7.55%vs 30.19%，P＜0.01）.Conclusion PFNA treatment of elderly patientswith IFF has the advantages of less trauma，faster postoperative recovery，less complications and other advantages，and can be used in clinical application.
2016 Vol. 23 (28): 81-83 [
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139
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84
Clinical study of surgical effect and relevant complications on acetabular fracture with the complications of posterior dislocation of hip joint
SU Ru-hong ；ZHANG Jin-jiao； HUANG Xin-rong
Objective To study the clinical effect of applyingmodified Gibson surgical approach in the treatment of acetabular fracture combined with posterior dislocation of hip joint. Methods 92 acetabular fracture patientswith posterior dislocation of hip joint admitted into our hospital from March 2010 to March 2016 were selected and evenly divided into control group（n=46）and treatment group（n=46）in random.In the control group，conventional surgical approach was used，while in the treatment group，modified Gibson surgical approach was adopted.The number of cases with complications during perioperative period，surgical effect，improvement amplitude of Harris score before and after surgery，time of be off the bed after surgery，total time of hospital stay after surgery，and time of returning to normal on physiological function by hip joint after surgery were compared between the two groups.Results The incidence of complications in the treatment group was lower than that in the control group with a statistical difference based on inter-group data（P＜0.05）.The surgical effect on treating acetabular fracture combined with posterior dislocation of hip joint in the treatment group wasmuch superior to that in the control group，with a statistical difference（P＜0.05）.The improvement amplitude of Harris score before and after surgery was higher than that in the control group，which was displayed a statistical difference（P＜0.05）.Posterior time of being off bed，total hospital stay after surgery，and time of returning to normal on physiological function by hip joint after surgery were allmuch shorter in comparison with those in the control group with statistical differences（P＜0.05）.Conclusion Application ofmodified Gibson surgical approach can obtain a favorable effect on treating acetabular fracture combining with posterior dislocation of hip joint.
2016 Vol. 23 (28): 84-86 [
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The clinical application of double joint center pressure suction tube drainage in breast cancer modified radical surgery
XIAOWei-mu ；WU Hong； TANG Feng； LITao
Objective To compare the clinical effect of two different drainage bandage ways after themodified radical mastectomy of the breast cancer.Methods A total of 120 female caseswith breast cancerwho
received：
modified radical mastectomy from the General Surgery Department of Xiangya Pingkuang Cooperation Hospital from January 2011 to December 2014 were collected，including 60 cases of double tube group treated with double tube drainage and continue central negative pressure attraction，60 cases of single pipe group were treated with the traditional single tube drainage and compression bandage after breast cancer surgery，the hospitalization time，drainage time，the incidence rate of subcutaneous effusion and skin flap necrosiswere compared and analyzed between two groups.Results The incidence of subcutaneous effusion treated with double tube drainage and continue central negative pressure attraction and single tube drainage and compression bandage was 3.3% （2/60）and 13.3% （8/60）respectively，the incidence rate of flap necrosis was 1.7%（1/60）and 13.3%（8/60）respectively，the drainage timewas respectively（7.0±2.2）and（12.0±2.0）days respectively，the hospitalization time was（12.0±4.5）and（21.0±5.5）days respectively，the differences were statistically significant（P＜0.05）.Conclusion Using double tube drainage and continue central negative pressure attraction can reduce the incidence rate of subcutaneous effusion and flap necrosis，shorten the drainage time and the hospitalization time，which has a better clinical effect，and isworthy ofwide popularization and application.
2016 Vol. 23 (28): 87-90 [
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120
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91
Clinical study of Bailing Capsule on mmunomodulatory effects concurrent radiochemotherapy for patientswith nasopharyngeal carcinoma
YANG Jing
Objective To explore the effect of Bailing Capsule on immune function concurrent radiochemotherapy for patientswith nasopharyngeal carcinoma in the same period. Methods The clinical data of 80 patientswith nasopharyngeal carcinoma were retrospectively analyzed in our hospital from December 2010 to December 2014，40 cases（control group）were treated with concurrent radiotherapy and chemotherapy，while 40 cases （experimental group）were treated with the combination of Bailing Capsule and concurrent radiotherapy and chemotherapy.Peripheral blood T lymphocyte subsets and immunoglobulin levels before treatment，after treatment and follow-up for 3 months，6 months，adverse drug reactionswere compared between two groups.Results After treatment，follow-up 3 months and 6months，CD4+，CD8+and CD4+/CD8+level of the experimental group were better than those of the control group（P＜0.05）.After treatment，follw-up 3months and 6months，IgG，IgA and IgM level of the experimental group were better than those of the control group（P＜0.05）.In the experimental group，the ratio of bonemarrow suppression （27.5%），oral cavity and pharyngealmucosal congestion and erosion（20.0%）was significantly lower than that of the control group（52.5%，47.5%）respectively（P＜0.05）.Conclusion Concurrent radiotherapy and chemotherapy can enhance the immune function，reduce side effects of radiotherapy and chemotherapy，improve the therapeutic effect，and the value of clinical application is remarkable.
2016 Vol. 23 (28): 91-94 [
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Clinical efficacy of Gem citabine or Vinorelbine combined with Cisp latin in the treatment of patientswith advanced non small cell lung cancer
KUANG Shu-gen； LIU Xia ；LIU Tie-bing ；ZHANG Shi； WEN Qin-sheng
Objective To explore the clinical effect of Gemcitabine or Vinorelbine combined with Cisplatin in the treatment of advanced non small cell lung cancer. Methods 80 patientswith non small cell lung cancer treated in our hospital from January 2015 to June 2016 were selected as the research objects and divided into observation group and control group according to treatmentmethod，patients in the observation group were given Vinorelbine combined with Cisplatin treatment，patients in the control group were given with Gemcitabine combined with Cisplatin treatment，clinical curative effect，occurrence of adverse reaction，symptom improvement and occurrence ofmyelosuppression were compared between two groups.Results Compared with the control group，total improvement rate and adverse reactions occurrence in the observation group had no significant difference（P＞0.05）.Score of hemoptysis，cough，fatigue and pain in the observation group were significantly better than those in the control group（P＜0.01），occurrence ofmyelosuppression in the observation group was 30.0%，lower than 72.5%in control group，and the difference was statistically significant（P＜0.01）.Conclusion Gemcitabine combined with Cisplatin in the treatment of patientswith advanced non small cell lung cancer can get a good clinical effect，but the symptoms of Vinorelbine combined with Cisplatin in the treatment of patientswith advanced non small cell lung cancerwere significantly improved.
2016 Vol. 23 (28): 95-97 [
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131
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Study on the efficacy and safety of docetaxel combined with chemotherapy as first-line therapy for advanced gastric cancer
LIU Hao；HUANG Jian-ling；DAIJian-lan；YICheng-hui
Objective To explore the effective and safety of using docetaxel combined chemotherapy as first-line chemotherapy in advanced gastric cancer. Methods General data of 60 patientswith advanced gastric cancer in the hospital from March 2015 to March 2016 were retrospectively analyzed.According to different treatmentmethods，60 patientswith advanced gastric cancerwere divided into observation group （DOF program:Docetaxel，Oxaliplatin and Fluorouracil treatment）and control group （DCX program:Docetaxel，Cisplatin combined with Capecitabine treatment）.The treatment effects and occurrence of adverse reactions in two groupswere compared.Results Total effective rate and total control rate between two groups had no obvious difference （P＞0.05）；the adverse reactions in two groupsweremainly of thrombocytopenia，white blood cell decline，nausea and vomiting，diarrhea and neutrophil decline，and the adverse effects in the observation group were better than those in the control group，and the difference was statistically significant（χ2= 4.81、14.70，P=0.028、0.000）.Conclusion The DOF program and DCX program have similar short-term effects in treating advanced gastric cancer，while DOF program has less adverse reactions and higher safety than DCX program，which isworth to further research and extension.
2016 Vol. 23 (28): 98-100 [
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Analysis of prognostic factors of Thalidom ide，Lenalidom ide，Bortezom ib in the treatment ofmultiplem yeloma
HAN Xue ；JIANG Su-yu；WANG Jian-ning； HOU Yan-qiu；ZHANG Liu-bo
Objective To explore overall survival（OS）and progression free survival（PFS）Thalidomide，Lenalidomide and Bortezomib in the treatment of patients with multiple myeloma and analyze prognosis related factors. Methods A retrospective analysis wasmade on 42 cases ofmultiplemyeloma in our hospital from January 2010 to January 2015.The parameterswere analyzed by single factor，the single factor analysiswas carried out by Coxmodel，and the parameters of statistical significance were analyzed by multiple factors regression analysis，and the survival curve was constructed.Results Median survival time was 43.36 months，OS rate for 2 years was 76.19%，with 42.86%for 3 years.In single factor analysis，age，serum creatinine，LDH，β2-MG，ISS stage，serum free light chain ratio of normal or not after treatment and effect were associated with OS，age and effect were associated with PFS.Conclusion Serum free light chain ratio and the depth of treatment are associated with OS after treatment for patients with multiple myeloma，Thalidomide，Lenalidomide and Bortezomib treatment can significantly improve OSof patients.
2016 Vol. 23 (28): 101-104 [
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Effect evaluation of Reduning injection combined with Latamoxef disodium in treatment of children with bronchial pneumonia
LIN Jin-di ；CHEN De-wei
Objective To discuss the effect of Reduning injection combined with Latamoxef disodium in treatment of children with bronchial pneumonia. Methods 200 children with bronchial pneumonia from April 2014 to April 2016 in our hospital were researched.They were randomly divided into observation and control groups，with 100 cases in each group.Two groups were given conventional anti-inflammatory，asthma，phlegm treatment，the control group were treated with Latamoxef disodium，the observation group based on the control group were given Reduning injection.Clinical symptoms and signs disappeared time，clinical effect and adverse reactions of the two groups were compared.Results The time of fever，cough，pulmonary rales，chest X-ray showed complete absorption in observation group were shorter than those in the control group［（2.48±0.64）d vs（4.32±1.12）d，（2.84±0.83）d vs（4.20±1.07）d，（2.32±0.43）d vs（4.85±1.20）d，（4.02±0.52）d vs（6.87±1.47）d］（P＜0.01）；after treatment，the total effective rate in the observation group was significantly higher than that in the control group（94.00%vs 82.00%），the differencewas significant（P＜0.01）；there were no significant adverse reactions in the treatment of the two groups.Conclusion In children with bronchial pneumonia given Reduning injection combined with latamoxef sodium treatment of the reatment has effect significant，and the safety ofmedication is high，it′sworthy of application and promotion.
2016 Vol. 23 (28): 105-107 [
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123
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108
Comparison of curative effect of Creatine phosphate sodium and high dose Vitam in C on the treatment of Rotavirus enteritis complicated with myocardial damage
CONG Xuan；ZHAO Xin
Objective To investigate the therapeutic effect of Creatine phosphate sodium and large dose of Vitamin C in the treatment of Rotavirus enteritis complicated with myocardial damage. Methods 90 children with Rotavirus enteritis complicated with myocardial damage were randomly divided into two groups in our hospital from September 2015 to March 2016，the two groups were given antiviral，fluid infusion，correction of electrolyte disorders and acid poisoning and other conventional treatment.On this basis，the control group was treated with large doses of Vitamin C，the observation group was treated with Creatine phosphate sodium 0.25-0.5 g/times.The curative effect，changes in myocardial enzymes and myocardial troponin，electrocardiogram（ECG）changes，etc.of two groups of children were compared.Results The treatment effective rate of observation group was 93.33%，significantly higher than the 77.78%in the control group，the difference was statistically significant（P＜0.05）.After treatment，the AST，LDH，CK，CK-MB，α-HBDH of observation group decreased than those of the control group significantly，the difference was statistically significant（P＜0.05）.After treatment，the level of cTnI in the observation group was significantly lower than that of the control group，the difference was statistically significant（P＜0.05）；the recovery rate of ECG in the observation group was higher than that in the control group （P＜0.05）.Conclusion Creatine phosphate sodium treatment Rotavirus enteritis complicated with myocardial damage effect significantly，can quickly relieve symptoms and promote the recovery of heart function，has positive clinical significance.
2016 Vol. 23 (28): 108-110 [
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The value Mediterranean anem ia of non invasive prenatal diagnosis of fetal free DNA in maternal blood
CHEN Fang ；ZHU Bin ；ZHOU Ping
Objective To study the value of non invasive prenatal diagnosis of fetal free DNA inmaternal blood. Methods From 2014 January to 2016 January，10 cases of pregnantwomen with thalassemia patientswere selected as the research object.Compared with the traditional diagnosis of amniotic fluid puncture，the detection rate of fetal free DNA in peripheral blood of pregnantwomen was analyzed，and the detection rate，misdiagnosis rate and missed diagnosis rate of high throughput sequencingmethod were analyzed.Results Twomethods of detection rate，misdiagnosis rate，missed diagnosis rate，fetal free DNA high-throughput sequencing detection rate，the rate ofmisdiagnosis and missed diagnosis rate were 90.0%（9/10），0.0%（0/10）and 10.0%（1/10），compared with the gold standard was basically consistent，which was used for the diagnosis of Mediterranean anemia.Conclusion High accuracy rate of non invasive prenatal diagnosis of Mediterranean anemia using fetal free DNA sequencing，it can be used for the detection of Mediterranean anemia.
2016 Vol. 23 (28): 111-113 [
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119
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Effects observation of Methylprednisolone combined with Erythrom ycin on lobar pneumonia after Mycoplasma infection
PENG Jun-juan； JIHai-juan ；ZHUWei
Objective To observe the treatment effect of Methylprednisolone combined with Erythromycin on lobar pneumonia after Mycoplasma infection. Methods From May to November 2014，in the First People′s Hospital of Zhen-Jiang，50 cases of Mycoplasma pneumonia children were selected and divided into treatment group （24 cases）and control group （26 cases）.The control group was treated with Erythromycin and Intravenous dexamethasone therapy adding regular cough phlegm.Treatment group was treated with Erythromycin plus Methylprednisolone therapy.The treatment effect of the two groups was compared.Results The total effective rate of treatment group was 100.0%，higher than 88.5%in the control group，with statistical difference（P＜0.05）.Conclusion The curative effect of Methylprednisolone combined with Erythromycin on lobar pneumonia after Mycoplasma infection is valuable，in the aspect of drug use is safe and isworthy to promote in clinical using.
2016 Vol. 23 (28): 114-116 [
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140
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Com parative study of tym panicmembrane puncture and drug injection to im prove bone conduction audiometry in patients with chronic secretory otitismedia
LIU Hui-lan
Objective To observe effect of tympanic membrane puncture and different drugs injection to improve bone conduction threshold in patientswith chronic secretory otitismedia. Methods 198 hospitalized patientswith chronic secretory otitismedia in our department from January 2014 to December 2015 were randomly divided into 99 cases in observation group （Tympanostomy and clear ear fluid injection）and 99 cases in the control group （tympanostomy and Dexamethasone+Ambroxol+Chymotrypsin injection）.The 0.250，0.500，1.000，2.000，4.000 kHz bone conduction hearing threshold were recorded by 10-liter five-drop method of bone conduction audiometry，which were compared in each group before and after treatment and between two groups after treatment.The clinical efficacy was compared between two groups.Results 0.250，0.500，1.000，2.000，4.000 kHz bone hearing thresholds had statistical difference in each group before and after treatment（P＜0.01），therewas no significant difference between two groups after treatment（P＞0.05）.Total effective rate in the observation group was 92.93%，in the control group with 90.91%，there was no significant difference in clinical efficacy （P＞0.05）.Conclusion The injection of clear ear fluid and Dexamethasone+Ambroxol+Chymotrypsin in tympanostomy could improve bone conduction hearing threshold for patients with chronic otitismedia.The clinical efficacy of injecting clear ear fluid in tympanostomy is slightly higher than Dexamethasone+Ambroxol+Chymotrypsin，and clear ear fluid is not toxic side effects，which isworthy of clinical application.
2016 Vol. 23 (28): 117-119转122 [
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Effect observation on ultrasonic emulsification combined with iol implantation in the treatment of diabetic cataract
ZHOUMei-lan
Objective To explore the clinical effect of ultrasonic emulsification combined with iol implantation in the treatment of diabetic cataract. Methods During the period from November 2013 to November 2015 in our hospital，40 cases of diabetic cataract patientswere grouped by digital way，and divided into two groups with each of 20 cases.The observation group and the control group were treated with traditional operation and phacoemulsification combined with intraocular lens implantation in the treatment group.The effect was compared between two groups.Results The visual acuity，fasting blood glucose［（4.69±1.48）mmol/L vs（5.89±1.66）mmol/L］，postprandial blood glucose［（6.64±1.85）mmol/L vs（8.66±1.49）mmol/L］，incidence of complications（10.0%vs 75.0%）in the observation group and the control group had obvious differences（P＜0.05）.Conclusion Phacoemulsification and iol implantation has obvious effect in patients with diabetic cataract.
2016 Vol. 23 (28): 120-122 [
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The clinical effects of Levodopa combined with comprehensive therapy in treatment of youth with ametropia amblyopia and the effects on patients′visual function and P-VEP level
LOU Shang JIANG Yi
Objective To explore the effects of Levodopa combined with comprehensive therapy in treatment of youth with ametropia amblyopia and the effects on patients′visual function and P-VEP level. Methods 84 cases youth which were diagnosed as ametropia amblyopia in Department of Ophthalmology of our hospital from August 2012 to March 2015 were selected and randomly divided into two groups.41 patients in control group were treated with combined therapy，while 43 patients in treatment group were treated with Levodopa combined comprehensive therapy，6 months as a course of treatment.After 6months，the visual acuity，P-VEP，visual function before treatment and after treatment，clinical effects and adverse reactions between two groupswere compared.Results After treatment，the patients′P-VEP P100 amplitude and the contrast in different spatial frequency increased，while P-VEP P100 wave latency shortened，the improvement of the treatment group wasmore significant（P＜0.05）.After treatment，corrected amplitude range，corrected separate range in the treatment group were both larger than those in the control group，while corrected near stereoacuity was less，there were significant differences between two groups （P＜0.05）.The total efficiency in the treatment group was 93.15%，79.17%in the control group，the difference was statistically significant（χ2=5.961，P＜0.05）.No Adverse reactionswere founded in the control groups，with 1 case eye dry in the treatment，incidence of adverse reactions had no statistical difference between two groups（P＞0.05）.Conclusion There is significant effect of Levodopa combined with comprehensive therapy on ametropia amblyopia of the youth.Themethod can improvesmore visual function and isworth popularizing.
2016 Vol. 23 (28): 123-125转138 [
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Observation of preventive effect of Eco-s and SDI Conseal sealant for caries in children
DAI Xin； WENG Yan
Objective To compare the preventive effect of SDIConseal and Eco-s pit and fissure sealant for caries in children. Methods 200 children （463 permanent teeth）aged 7 to 9 in the department from January 2014 to December 2015 were selected to perform sealant technique on their firstmolars and randomly divided into two groups，firstmolar in trial group wassealed with SDIConseal sealant and in control group was sealed with Eco-s sealant.Sealant retention rate and caries prevalence were observed follow-up for 6 months to 2-years.Results At 6 months follow-up，there was no statistical difference in sealant retention rate between two groups（P＞0.05），at 1 year and 2 years follow-up，the retention rate in the trial group were significantly higher than those in the control group（P＜0.05）.However，caries prevalence in the trial group were significantly lower than those in the control group at 1 and 2 years follow-up （1.3%vs 2.6%，3.0%vs 4.3%），the difference was statistically significant（P＜0.05）.Conclusion SDIConseal sealant is superior to Eco-s sealant to prevent caries in children.
2016 Vol. 23 (28): 126-128 [
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Comparative observation of clinical effect of Zengshineng training software and pen nib training for the ability to correct the small degree of concom itant exotropia of pilots
ZHANGMing-yue； LI Xin；LIShao-jun
Objective To compare and study the clinical effects of Zengshineng training software and pen nib training for the ability to correct the small degree of concomitant exotropia of pilots.Methods 40 cases of in-service pilots diagnosed concomitant exotropia in Department of Ophthalmology of our hospital from June 2015 to June 2016 were checked the range of fusion in the same Synoptophore and randomly divided into Zengshineng training group （n=20）and pen nib training group（n=20），and which were underwent the fusion training.In the Zengshineng training group were taken the intelligent training system for the subject of the convergence function training，3 times a day，each time 10 minutes，while in the pen nib training group were taken pen nib training for 3 times a day，each time 30 times.Then，range of fusion for 1 month，3months and 6monthswere checked by the same Synoptophore，and each group were compared.Results In the Zengshineng training group，the range of convergence for 1month，3months and 6 monthswere significantly improved than that before training（P＜0.05）.In the pen nib training group，the convergence range for 1month was not significantly improved than that before training（P＞0.05），and 3months and 6monthswere significantly improved than that before training（P＜0.05）.The range of convergence for 1month，3months and 6months in the Zengshineng training group were significantly higher than those in the pen nib training group（P＜0.05）.Conclusion The clinical effects of Zengshineng training software and pen nib training for the ability to correct the small degree of concomitant exotropiaare are exact，and Zengshineng software for the ability to correct collection are more faster and efficient than that in the pen nib training.
2016 Vol. 23 (28): 129-131 [
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Application value of cognitive behavior intervention in patients with oral cavity tooth extraction
LI Li
Objective To explore the clinical application value of cognitive behavior intervention in patients with oral cavity tooth extraction. Methods From September 2014 to September 2015，140 patients with tooth extraction in our hospitalwere randomly divided into control group and intervention group，and each group with 70 cases.Patients in control group were given routine tooth extraction perioperative care，and others in the intervention group were given cognitive behavioral intervention based on the control group nursing.The pain degree of two groups were evaluated by visual analogue scale （VAS），the changes of heart rate and blood pressure before and after tooth extraction were compared between two groups.Results The anxiety scores of the intervention group were significantly decreased（P＜0.05）before and after nursing，and the scores after nuring were significantly lower than those of the control group，the difference was statistically significant（P＜0.01）.After nursing，the self pain degree（3.23±2.49）scores of patients in intervention group after tooth extraction was significantly lower than（11.16±4.17）scores in the control group，the difference was statistically significant（P＜0.05）.Compared with that at 10 min before operation，blood pressure and heart rate value of two groups in tooth extraction were significantly larger in the control group，blood pressure and heart rate increased most obviously，the difference was statistically significant（P＜0.01）；compared with that at 10 min before operation，there was no significant difference in heart rate value in the intervention group （P＞0.05），and there was significant difference in blood pressure value （P＜0.01）.Blood pressure and heart rate value between two groupswere compared，and the difference was statistically significant（P＜0.05）.Conclusion Cognitive behavioral intervention can alleviate anxiety and pain of patientswith tooth extraction to a certain extent，prevent heart rate and blood pressure changes significantly and increase the safety of operation.
2016 Vol. 23 (28): 132-134 [
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135
Curative effect observation of Com pound Methylene Blue Injection in the analgesia of postoperative breast abscess incision
TANG Liang-zhen；LIGui-qin；WANG Yun-hong；ZHANG Jing-jing
Objective To explore the analgesic effect of Compound Methylene Blue Injection in postoperative incision of breast abscess. Methods 64 cases of breast abscess undergoing surgery from January 2014 to January 2016 in our hospitalwere selected and randomly divided into the Methylene Blue group and the control group，32 cases in each group.The Methylene Blue group was given Compound Methylene Blue Injection for analgesia，there was no other analgesic，while the control group was given analgesics orally or intramuscular injection.Analgesic effect of incision and the incidence rate of complication was compared between the two groups.Results The score of VASafter surgery for 6 hours，24 hours，72 hours and 7 days in the Methylene Blue group was lower than that in the control group，with significant difference（P＜0.05）.Therwas no significant difference in the incidence rate of complication between the two groups.Conclusion Compound Methylene Blue Injection has good analgesic effect on postoperative incision of breast abscess，with high safety and simple operation，it isworthy of clinical promotion and application.
2016 Vol. 23 (28): 135-138 [
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138
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139
Observation and analysis of Sevoflurane on agitation performance in pediatric anesthesia recovery period
XIE Yue-tao
Objective To explore the agitation performance of pediatric Sevoflurane anesthesia recovery period. Methods 60 cases of preschool children and 60 cases of school-age children undergoing operation in our hospital from January 2013 to December 2015 were selected and divided into group A and group B.According to the patient′s different anesthesia induction way，the patients of group A and group B were randomly divided into group A1（29 cases），group A2（31 cases），group B1（32 cases），group B2（28 cases）.Group A1 and group B1 were given Midazolam+Propofol+Sufentanil for induction of anesthesia，and were used Sevoflurane for anesthesia maintenance，group A2 and group B2 were given Sevoflurane for induction and maintenance of anesthesia.The postoperative eye opening time，swallowing reflex recovery time，extubation time and extubation agitation score was compared between four groups.Results There was no significant difference in the postoperative eye opening time，swallowing reflex recovery time and extubation time among four groups（P＞0.05）.The score of extubation agitation in group A2 was higher than that in group A1，with significant difference（P＜0.01）.The score of extubation agitation in group B2 was higher than that in group B1，with significant difference （P＜0.01）.The score of extubation agitation in group A1 was higher than that in group B1，with significant difference （P＜0.01）.The score of extubation agitation in group A2 was higher than that in group B2，with significant difference （P＜0.01）.Conclusion Pediatric patients with sevoflurane anesthesia，agitation is easy to happen agitation during postoperative anesthesia recovery period，and the risk of younger children agitation is higher.
2016 Vol. 23 (28): 139-141 [
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106
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142
Com parative study of contrast-enhanced ultrasound and conventional ultrasound on superficial lym ph node biopsy
KUANG Yong-pei ；XIE Yu-huan； LIXia ；CHEN Jun-jun
Objective To investigate themerits of contrast-enhanced ultrasound and conventional ultrasound on superficial lymph node biopsy. Methods 48 patientswith superficial lymphadenopathy were enrolled into study from September 2014 to October 2015.Patients were detected by conventional/contrast-enhanced ultrasonography and pathological biopsy.They were divided into contrast-enhanced ultrasound group（n=27）and conventional ultrasound group（n=21）.Biopsy success rate，diagnostic accuracy rate and incidence of complications between two groupswere compared.Results Incidence of complications in contrast-enhanced ultrasound group（0.00%）was significantly lower than that in conventional ultrasound group（14.29%），with statistical difference（P=0.043）.There were on significant differences in biopsy success rate and diagnostic accuracy rate between two groups（P＞0.05）.Conclusion Contrast-enhanced ultrasound can reduce the incidence of complications on superficial lymph node biopsy，but can not improve biopsy success rate，diagnostic accuracy rate.
2016 Vol. 23 (28): 142-144 [
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143
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145
The classification method and clinical significance of spiral CT in diagnosis of the severity of renal injury
GONGMin ；QIU Guo-hua
Objective To investigate the classification method and clinical significance of spiral CT in diagnosis of the severity of renal injury. Methods The clinical data of 50 cases of renal injury were collected from April 2014 to April 2016 in our hospital for examination and treatment as the object of study.50 cases with renal injury were included in the study，the patients were given spiral CT in bilateral renal，the classification method and clinical significance were investigated.Results 50 patients，the results of spiral CT scan were consistent with the clinical，the diagnostic accuracy was 100%.Among them 26 patientswith renal contusion，14 patientswithmild renal laceration，9 patientswith renal full thickness laceration，1 patientwith renal artery injury，4 patients with combined with other types of damage.Conclusion Spiral CT has a rapid，accurate diagnosis rate，trauma and other advantages，in the renal injury severity of clinical diagnosis and can provide objective imaging evidence for clinical diagnosis of renal injury，is very important for the diagnosis of renal injury，and on renal injury in the clinical treatmentand prognosis.
2016 Vol. 23 (28): 145-148 [
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140
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149
The value of microcalcification in mammography findings in diagnosis breast cancer
ZHU Hai-gen；YUAN Jin-gang
Objective To investgate the diagnostic significance ofmicrocalcifications in breast cancer. Methods 38 female individuals of breast cancerwithmicrocalcifications confirmed by pathology and biopsy from April 2010 to March 2016 were included in this study retrospectively.The characteristics of microcalifications，relation with mass and histopathology in breast cancer were analyzed and compared.Rusults In mammography，mostmicrocalcifications were usually sand-shaped，pinpoind-shaped，pole-shaped，fork-shaped，clusteringly-shapde.Themiddle and low densemicrocacifications with halo sign were seen in most breast cancer.31 cases had 5 minutes calcifications per square centimeter.IDC with microcalfications were often seen in breast cancer.These microcalcitionsmost were sand-shaped or pinpoint-shaped.4 caseswere caicinomas in stitu with puremicrocalcifications.Pure calcifications 15 cases，calcification in mass 14 cases，calcification near mass 9 cases.Conclusion In mammography，X-ray indication of microcalcification is important finding in diagnosis of breast cancer especially caicinomas in situ and IDC onmcrography.
2016 Vol. 23 (28): 149-152 [
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132
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153
A comparative study of the treatment of elderly depressive episode with the degree of the treatment of the degree of Duloxetine and Escitalopram
ZANG Shuang-jiu； HOU Cheng-ye
Objective To explore the efficacy and adverse effects of Duloxetine and Citalopram in the treatment of senile depression. Methods 82 cases of senile depression patients from June 2013 to June 2016 were randomly divided into two groups，42 cases in the study group and were given Duloxetine for treatment，40 cases in the control group and were given Escitalopram for treatment，6 months of observation.Before treatment and at 1，2，6 weeks，Patients of two groupswere assessed by Hamilton Anxiety Scale（HAMA），side effects scale（TESS），Hamilton Depression Scale（HAMD）.Results A total of 80 cases completed，the completion rate was 97.6%；2 cases of loss，the loss rate was 2.4%，occurred in the control group；after 2 weeks of treatment，two groups had obvious curative effect，the control group was better than that of study group（P＜0.05）；after 6 weeks，HAMD，HAMA of two group were compared to before treatment，the difference was siginificant（P＜0.05）；TESSside effects scale assessment of two groups of patientswith adverse drug reactions in the treatment process，the adverse reaction rate of study group was significantly lower than that of control group，the difference was significant（P＜0.05）.Conclusion The treatment of senile schizophrenia with the Duloxetine has a significant effect and less side effects，it isworth to apply.
2016 Vol. 23 (28): 153-155 [
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150
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Research on treatment of glucose and lipid metabolism disorder in patientswith Quetiapine-induced schizophrenia with Metform in
WANG Yang-guo ；HUANG La-gen
［Abstract］
Objective To explore the influence of Metformin on glucose and lipid metabolism disorder in patients with Quetiapine-induced schizophrenia，and discuss its possible mechanism of action. Methods 105 cases of obese patients （BMI＞25 kg/m2）with oral Quetiapine-induced schizophrenia in Jiangxi Kangning Hospital from May 2011 to August 2013 were selected （strictly in accordance with CCMD-3 diagnostic criteria），and divided into the treatment group （n= 53）and control group （n=52）according to the random number representation.The patients in treatment group，based on the use of Quetiapine and dietary behavior intervention，
received：
the Metformin treatment，while those in control group
received：
the Quetiapine and dietary behavior intervention.Patients in both groups were treated for 6 months，and the blood pressure，body mass index（BMI），waist circumference（WAIST），waist-to-hip ratio（WHR）and other body weight indexes weremeasured before the treatment（0 month）and at the 2nd，4thand 6thmonth after treatment，and a series of serological examination was conducted，mainly including the fasting blood glucose （FBG），low density lipoprotein cholesterol（LDL-C），triacylglycerol（TG），high-density lipoprotein cholesterol（HDL-C），fasting insulin（INS），alanine aminotransferase（ALT），aspertate aminotransferase（AST）and prolactin（PRL）；positive and negative syndrome scale（PANSS）were evaluated，followed by curative effect rating.Results There was no obvious difference in various examination indexes of patients in both groups before treatment（0month），and the differences had no statistical significance （P＞0.05）；except HDL-C and TG，the differences had statistical significance （P＜0.05）inmostof laboratory examination values at the 2nd，4thand 6thmonth after treatment，compared with those before treatment（0month）；except HDL-C，there were large difference in the laboratory examination values in treatment group after 6 month，compared with those in control group in the same period；the data comparison had statistical significance （P＜0.05）.Conclusions The single treatment or combined treatment of Metformin and dietary behavior intervention have good curative effect on glucose and lipid metabolism disorder in patientswith Quetiapine-induced schizophrenia，but the combined treatment of Metformin and dietary behavior intervention has the best curative effect.
2016 Vol. 23 (28): 156-159 [
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Evaluation of the effectiveness of application of head nurses inspection work in nursingmanagement of the operation room
OUYANG Zhi ；XIONG Zhao-xia
Objective To explore the effectiveness of application of the head nurses′inspection work in nursing managementof the operation room. Methods Gastrointestinal surgeries thatwere performed in the operation room of the hospital from January to December 2015 were taken as the reference object.Among surgeries performed in the first 6 months according to the routine surgical procedures，50 surgeries were randomly selected as control group；among surgeries performed in the latter 6 months with head nurses′strengthened inspections，50 surgeries were randomly selected as observation group.The adverse events of two groups were observed and recorded，and the resultswere compared and analyzed.Results Comparison of the postoperative adverse events of two groups of patients showed that，including illprepared operation items，none-up-to-standardsurgical instrument preparations，leaving dressing or equipment in patient＇s body，intraoperative infections，asphyxia and drug allergies and other serious illness changes in patients，falling down from bed，pressure ulcers and burns.the occurrence of all unexpected situations of observation group was significantly lower than that of control group，with sicinificant differences （P＜0.05），Conclusion The head nurses′inspections in the operation room can significantly reduce the incidence of nursing adverse events and have significant effectsin elimination of security risks，ensurance of the safety of patients，improvement of the success rate of surgeries，which is worthy of clinical application.
2016 Vol. 23 (28): 160-162 [
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Effects observation of comprehensive nursing management in preventing operation room infection
LIYing
Objective To explore the effects of comprehensive nursingmanagement in preventing operation room infection. Methods 86 patients who conducted operation in our hospital operation room from June 2015 to December 2015 were retrospective analyzed，and dividied into experimentgroup and control group.43 cases in each group.Patients in experiment group were given comprehensive nursingmanagement and patients in control group were given routine nursing.The hospital stay，hospitalization expenses，operation room infection and complications in two groups were observed Results The hospital stay in experiment group was（12.06±0.53）days，obvious lower than that（16.17±0.61）days of control group，and the difference was significance difference（P＜0.01）；The hospitalization expenses in experiment group was （13236.45±289.83）yuan，obvious less than that（17683.28±293.74）yuan of control group，and the difference was significant（P＜0.01）；The operation room infection in experiment group was 2.33%，obvious lower than that 13.95%of control group，and the difference was significant（P＜0.05）；the incidence rate of complications in experiment group was 0.00%，obvious lower than that 9.30%of control group，and the difference was significant（P＜0.05）.Conclusion Using comprehensive nursingmanagement in preventing operation room infection can obvious decrease the incidence rate of operation infection and worth to popularize.
2016 Vol. 23 (28): 163-165 [
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113
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Control action of quality management-level operating room nurses in the prevention of intraoperative body cavity foreign body left
YAN Xian-jiao ；XIANGMei-yan； CHEN Pin
Objective To study the effect of operating room nurses hierarchicalmanagement approach in the prevention of intraoperative body cavity foreign body left control action.Methods 32 people of operating room nurses from January 2014 to December 2015 were seleted，according to thework experience，education，job title and the actual ability to work，were level N1，N2，N3，N4，management level to protect long→level N1→N2→N3→N4 grade level.Surgery for different situations，the appropriate level of nursing staff with the surgery was completed.For all levels of nursing staff were trained to carry out intraoperativemanagement knowledge，layer by layer supervise and check the body cavity surgery foreign body left higher part.In the day before surgery，N1-level nurses was needed intraoperative body cavity foreign body residual risk assessment and vigilant subordinate nurse.After some time，before and after the implementation of the operating room nurse level management comparative of results were analyzed.Results After inconsistentmanagement body cavity before closing number，foreign body looking over 30min，to find foreign bodies bymeans of X-rays than the formermanagement had improved significantly，the difference was statistically significant（P＜0.05）；after the first surgery management implementation rate was 95%，far much higher than the rate of implementation of continuous operations （78%），the difference was statistically significant（P＜0.01）.Conclusion The effect of operating room nurses hierarchical management approach in the prevention of intraoperative control body cavity foreign body left obvious effect，can effectively prevent foreign objects left behind a body cavity surgery to improve the safety of surgery，it should be popularized.
2016 Vol. 23 (28): 166-168 [
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Analysis of personalized nursingmeasures on stomatitis after chemotherapy in leukemia patients
JIN Feng-zhen ；WEN Fu-gang
Objective To explore the personalized nursingmeasures on stomatitis after chemotherapy in leukemia patients. Methods From March 2012 to June 2015，60 leukemia patients for chemotherapy admitted into our hospital were randomly divided into observation group and control group by drawing lots.In the control group，conventional nursing was used，while in the observation group，personalized nursing was adopted.The hospital stay，disease remission time，and incidence of stomatitis after nursing in the two groupswere compared.Results In the observation group，the hospital stay and disease remission time were both greatly better than those of control group.The incidence of stomatitis in leukemia patients in the observation group was 16.67%，much lower than that of control group accounting for 50.00% （P＜0.05）.Conclusion For leukemia patients，application of personalized nursing can obtain a favorable effect，which is worthy of further promotion and application in clinical nursing after chemotherapy.
2016 Vol. 23 (28): 169-171 [
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App lication of quality control circle activity in im proving the retention rate of sputum specimens of patients
HUANG Cha-ying； HU Xue-dan
Objective To explore the application effect of the circle of products in improving the retention rate of sputum specimens of hospitalized patients. Methods From February 2015 to June 2015，288 cases of patients with sputum samples were collected for the study and analysed of sputum samples in our hospital.Observation quality control circle of subjectswas selected，affecting the quality of sputum samples was collected from hospitalized patientswith the cause analysis，quality control circle activities before and after the sputum samples collected in hospital.Results After quality control circle，the highest score of quality of sputum samples collected in patientswas 18.7 scores，the quality of improve patientswith sputum specimen collection was selected as the subjects；a total of 288 cases of sputum culture were collected，unqualified specimens of 162 cases，accounted for 56.25%；before the qualified rate of sputum culture specimen was 42.70%（123/288），less than after the event of 97.01%（293/302），the difference was significant（P＜0.01）.Conclusion Through the quality control circle activities，sputum culture specimen collection analysis，can improve the rate of sputum，the quality of sputum specimen collection and quality inspection，the application effect is good in hospitalized patients.It isworthy promoting.
2016 Vol. 23 (28): 172-174 [
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Effect observation of evidence based nursing and simpleaccom panying nursing pattern in obstetric delivery
LIU Xin-ping； LU Ying-yi
Objective To investigate effect of evidence based nursing and simple accompanying nursing pattern in obstetric delivery. Methods 264 pregnantwomen from December 2012 to December 2014 were divided into two groups by random number tablemethod.132 pregnantwomen were treated simple accompanying nursing pattern as control group.132 pregnantwomen were treated evidence based nursing pattern as observation group.Nursing effect of two groupswas compared.Results After nursing，SAS score and SDS score decreased in two groups（P＜0.05）.SAS score，SDS score，incidence of adverse events in observation group were lower than that of control group（P＜0.05）.Natural labor rate，nursing satisfaction in observation group were higher than that of control group（P＜0.05）.First labor time，second labor time，third labor time，postpartum 24 h bleeding volume of natural labor in observation group were less than that of control group （P＜0.01）.Postpartum 24 h bleeding status of natural labor in observation group was better than that of control group（P＜0.05）.Postpartum 24 h bleeding volume of cesarean section in observation group was less than that of control group（P＜0.01）.Postpartum 24 h bleeding status of cesarean section in observation group was better than that of control group（P＜0.05）.Conclusion Application effect of evidence based nursing pattern in obstetric delivery is better than simple accompanying nursing pattern.
2016 Vol. 23 (28): 175-178 [
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Role of predictive nursing in enhancing the treatment effects of children with severe pneumonia and decreasing the incidence rate of complications
ZENG Ping-fang ；HUANG Hai-bo； ZHOU Yan
Objective To explore the role of predictive nursing in enhancing the treatment effects of children with severe pneumonia and decreasing the incidence rate of complications. Methods 66 children with severe pneumonia from January 2012 to May 2016 of our hospitalwere selected and were randomly divided into study group and control group.33 cases in each group.Patients in control group were used routine nursingmeasures，and patients in study group were given predictive nursing on the basis of control group.Improvement of pulmonary function，clinical symptom and signs improvement time and complications before and after treatment of children patients in two groups were comprehensive compared.Results After treatment for 7 days and 14 days，the artery PaCO2of study group was lower than that of control group（P＜0.01），the PaO2and SpO2ofstudy group washigher than thatof controlgroup（P＜0.01），the symptom disappearance time of cough，shortnessofbreath and wheeze of study group were shorter than those of controlgroup （P＜0.01）；the hospital stay of study group was shorter than thatof control group（P＜0.01）；therewere 4 cases（12.1%）of pulmonary edema，1 case （3.0%）bronchiectasia and 1 case （3.0%）septic shock in control group，while no complications appeared in study group and which was better than that of control group （P＜0.05）.Conclusion Using predictive nursing in children with severe pneumonia with definitely effects，which can improve pulmonary function effectively，enhance treatment effects，decrease incidence rate of complications，improve prognosis of children patients and isworth to popularize in clinical.
2016 Vol. 23 (28): 179-181 [
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127
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Acute pancreatitis patientswith details of the feasibility study nursing
CHEN Yun-yu
Objective To explore the details of patientswith acute pancreatitis care effect，for clinical reference and research. Methods 110 patientswith acute pancreatitiswere selected from December 2014 to February 2016 in the hospital，and were randomly divided into two groups，the control group，55 cases of acute pancreatitiswere treated with routine care intervention，55 patients of observed group were given nursing intervention details，all patients with differentmethods of treatment of disease-related knowledge and awareness，quality of care score，total effective rate and the difference between the incidence were compared.Results Disease-related knowledge of observation group was higher than thay of control group，with the significant difference（P＜0.05），the total effective care rate and satisfaction scores of the observation group were significantly better than those of control group （P＜0.05），while the incidence of complications observed in patientswas significantly lower than that of control group （P＜0.05）.Conclusion Application of details acute care for patients has a certain effect，can effectively improve patient outcomes，so as to stabilize the patient′s condition can be applied to promote.
2016 Vol. 23 (28): 182-184 [
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App lication analysis of cluster intervention measures in preventing ICU multi drug resistant bacteria infection
LIU Shan； ZOU Ping； PAN Yi； XIA Miao
Objective To explore the application value of cluster intervention measures in preventing ICU multi drug resistant bacteria infection. Methods 100 patients from May 2015 to April 2016 of ICU in our hospitalwere prospective selected.Patients were divided into two groups according to cluster intervention mode，and each group was 50 cases.Patients in control group were used routine nursingmethod，and patients in observation group were used cluster interventionmeasures.The rate ofmulti drug resistant bacteria infection，incidence rate of complications and hospital stay in two groupswere compared.Results The incidence rate of infection in observation group was obvious lower than that of control group，and the difference was statistical significance（P＜0.01）；themean hospital stay in observation group was lower than that of control group，and the difference was statistically significant（P＜0.05）.The incidence rate of complications in observation group was obvious lower than that of control group，and the difference was statistically significant（P＜0.05）.Conclusion Using cluster intervention measures for ICU patients can preventmulti drug resistant bacteria infection effectively，decrease the incidence rate of complications and with obvious clinical effects.
2016 Vol. 23 (28): 185-187 [
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130
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Effect of individualized rehabilitation nursing on renal function and quality of life in patientswith diabetic nephropathy
YANG Shui-feng
Objective To investigate the effect of individualized rehabilitation nursing on patients with diabetic nephropathy renal function and quality of life in patientswith diabetic nephropathy. Methods 106 patients from January to August 2013 in our hospital were selected as the research object，according to the admission time were divided into two groups.The control group（53 cases）were given conventional rehabilitation nursing，the observation group（53 cases）were given individualized rehabilitation nursing care on the basis of conventional care，the determination of the two groups before and after treatment in patientswith serum creatinine（Scr），blood urea nitrogen（BUN），differences in renal function index 24 h urine protein，and quality of life scale （SF-36）were compared.Results After nursing care after，the observation group of patients with Scr，BUN，renal function indexes 24 h urine protein were compared with the control group showed no significant difference （P＞0.05）.Two groups of patients after nursing SF-36 quality of life score were significantly changed good，compared with the score before nursing has significant difference （P＜0.05）.Patients in the observation group after the nursing quality of life scorewas significantly higher than that of control group，the difference was significant（P＜0.05）.Conclusion Individualized rehabilitation nursing can effectively improve the blood of patients with diabetic nephropathy quality of lifemore significantly，it isworthy of clinical promotion.
2016 Vol. 23 (28): 188-190 [
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Efficacy of families health interventions combined attendance for community diabeteswith depression patients
ZHONG Ju ；CHEN Ruo-feng； HUANG Bi-yun ；XIE Qin-bing ；GUOGui-mei
Objective To investigate efficacy of families health interventions combined attendance for community diabetes with depression patients. Methods In our community，112 cases of diabetes with depression patients as object of study from October 2014 to December 2015，and were divided into research group and control group，according to differentmethod of nursing，56 cases in each group.The control group were treated with routine primary care，while research group were treated with families health interventions based on routine primary care.HAMD scale was used to assess patients′depression level.The fasting blood glucose（FBG），2 h postprandial blood glucos（PBG），glycated hemoglobin level and HAMD score of two groups were compared.Results Before attendancethere was no significant difference between two groups in FBG，2 h PBG，glycated hemoglobin level and HAMD score（P＞0.05）.The FBG［（5.76±1.23）mmol/L］，2 h PBG［（7.61±1.82）mmol/L］，glycated hemoglobin level［（5.01±1.04）%］of research group were lower than that of control group after attendance（P＜0.01）.The HAMD score of research group after attendance was lower than those of control group（P＜0.01）.Conclusion Families health interventions combined attendance has exact effect for community diabetes with depression patients.It helps to decrease blood sugar level and relieve depression.It′sworthy of clinicalwidely used.
2016 Vol. 23 (28): 191-193 [
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Study on the application of liaisons of pressure ulcerin themanagement of pressure ulcer in hospital
LILiang-lan ；WANG Hong-mei
Objective Study pressure sores liaison in hospitalmanagement，the application of pressure ulcers effect，improve themanagement level，to ensure the safety of patients. Methods Since January 2013 to December 2015，to set up the pressure ulcer liaisonmanagement team，establish pressure ulcermanagement system，responsibilities and the liaison for special training，assessment，organization and liaison officer to clinical to carry out inspection work instruction regularly or not on a regularly，improve processmanagement，continuous improvement of nursing qualitycontrol.Hospitalized patients outside into the pressure ulcer heal，the hospital of cure and improvement rate，hospital of inevitable pressure sores declare percent of pass，hard to avoid pressure ulcers heal，the situation of hospitalized patients with outside into the pressure ulcer heal wer compared.Results The hospital of cure and improvement rate has risen from 85.14%in 2013 to 94.50%in 2015，in the hard to avoid pressure sores declare qualified rate from 87.27%in 2013 to 97.56%in 2015，in the hard to avoid pressure sores declare to cure rate from 40%in 2013 to 97.56%in 2015.Conclusion Liaison officers of pressure sores at the hospital standardizedmanagement played a professional role.
2016 Vol. 23 (28): 194-197 [
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