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2016 Vol. 23, No. 29
Published: 2016-10-18
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Result analysis of isolation and identification of influenza virus of Heze City in 2015-2016
LIXiao-han
Objective To analyze the results of the pathogen isolation and identification of influenza virus in Heze City from 2015 to 2016，and provide scientific evidence for the prevention and control of influenza in the future. Methods The nose or throat swab specimen of influenza-like illness（ILI）caseswere collected in sentinel hospitals from October 2015 to April 2016，MDCK cellswere isolated and cultureed，and influenza viruseswere identified by influenza identification reagent.Results The positive rate of influenza virus isolation was 27.89% （140/502）.The types of strainswere type new A（H1N1），type A（H3N2），type BY and BV that appeared alternately，type BV was the dominant strains.The peak of influenza virus isolation appeared in March 2016.There was no gender difference in the incidence of influenza.People aged＜15 years were susceptible to influenza virus.Conclusion The different subtypes appeared alternately from 2015-2016 and type BV is the dominant strains.
2016 Vol. 23 (29): 4-06转11 [
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Quality standard research of Yaotongkang Capsules
XU Qian QIU Hui
Objective To establish the quality standards of Yaotongkang Capsules. Methods Radix dipsaci，angelica wolfberry，rhizoma etc.medicinalmaterials in the prescription were identified by using thin layer chromatography（TLC）；content of epimedium glycoside in Yaotongkang Capsules was detected by reverse phase high performance liquid chromatography （HPLC）method.Results TLC spotswere clear and well separated；HPLC for sample size of epimedium glycoside in the range of 0.21-2.1μg was good（r=0.998 4），average recovering rate was 99.2%（n=5），RSD was 0.25%（n= 5）.Conclusion The method has the advantages of simple operation，strong specificity，high accuracy，good precision and repeatability，and can be used as the quality control standard of the preparation.
2016 Vol. 23 (29): 7-11 [
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Study on melatonin alleviated acute kidney injury through the HIF-1α/ VEGF pathway
FENG Jie;TONG Xiao-ya;YU Jia-li;PAN Zi-yu;ZHA Yan
Objective To investigate the expression and influence ofmelatonin on hypoxia-inducible factor（HIF-1α）and vascular endothelial growth factor（VEGF）in acute kidney injury induced by lipopolysaccharide（LPS）. Methods 30 Sprague-Dawly（3-5 weeks）ratswere selected and randomly divided into the control group（n=10），the LPS group（n= 10，500μg/kg LPSwas injected intravenously）and the Mel+LPSgroup（n=10，melatonin was administrated orally，15min later，LPSwas given），followed by 48 hours，the ratswere killed.The thiobarbituric acid（TBA）testwas given to detect the level of MDA and the activity of superoxide dismutase （SOD）.The mRNAs and proteins of HIF-1αand VEGF were determined by RT-qPCR and immunohistochemistry.Results There was renal tubular epithelial cells swelling，renal interstitial edema and inflammation in the LPS group，those symptoms was attenuant in Mel+LSP group.The level of Scr and BUN in the LPS group［（35.56±1.83）mmol/L and （46.23±2.87）μmol/L］was higher than that in the control group ［（12.69±0.97）mmol/L and （16.73±1.26）μmol/L］and the Mel+LPSgroup［（23.17±1.33）mmol/L and（35.67±2.25）μmol/L］（P＜0.05）.The level of MDA in the LPSgroup ［（697.45±43.13）nmol/（mg·prot）］was higher than that in the control group ［（354.35±28.12）nmol/（mg· prot）］and the level of MDA in the Mel+LPS group ［（455.37±30.79）nmol/（mg·prot）］was lower than that in the LPS group （P＜0.05）.The level of SOD in the LPS group ［（3.75±0.23）U/（mg·prot）］was lower than that in the control group［（2.93±0.29）U/（mg·prot）］and Mel+LPSgroup［（3.20±0.27）U/（mg·prot）］（P＜0.05）.The level of HIF-1αand VEGFmRNA and protein in the LPS group was higher than that in the control group，and less than that in the Mel+LPS group.Con-clusion By inhibiting the production of MDA and up regulating the activity of SOD，Melcan regulate the expression of VEGF and HIF-1α，and plays a role in protecting LPS induced AKI renal function.
2016 Vol. 23 (29): 12-15 [
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Meta analysis of random ized controlled trials of hyperbaric oxygen in treating vascular dementia
CHENG Yuan-yuan;ZHANG Yun-dong
Objective To systematically evaluate the effect and safety about hyperbaric oxygen in treating vascular dementia. Methods Randomized controlled trials（RCT）ofhyperbaric oxygen therapy in treating vascular dementiawere comprehensive collected by using computer and manual retrieval from English database liked PubMed，Science Online and Ovid，CNKIand wanfang Chinese system.The study was conducted according to Cochrane system evaluation.The search time was up to February 2016 from the database established.Results The results showed from Meta analysis that the hyperbaric oxygen groupwasbetter than that the controlgroup in treating vascular dementia［MD=3.40，95%CI（2.75，4.05）］；7 experiments were conducted to evaluate the ability of daily life based on ADL showed that the life quality in hyperbaric oxygen group improved obviously after treatment［MD=5.45，95%CI（3.72，7.19）］；2 experimentswere conducted to evaluate the nerve function defect situation based on HDS showed that nerve function defect had no obvious improved ［MD=4.81，95%CI（2.95，6.67）］.2 of the trials reported the adverse events and weremainly of transient dizziness，palpitation，sleep disorder and diarrhea，and any serious adverse effects happened.Conclusion This system evaluation shows that hyperbaric oxygen can decrease HDS scale score effectively，enhance ADL and MMSE score，with less adverse effects and any serious adverse effects.However，due to the limitations of the quantity and quality of the included studies，further research on the high quality of the large sample is needed.
2016 Vol. 23 (29): 16-19转22 [
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Effect assessment of Raw Rhubarb p lus retention enema of lactulose treating acute pancreatitis
CHEN Yu-feng;QIAN Run-lin;YAN Xue-feng;DENG Zhi-peng;LV Xin-hua
Objective To explore the clinical effect of Raw Rhubarb plus retention enema of lactulose treating acute pancreatitis. Methods 86 caseswith acute pancreatitis treated by our hospital from January to September 2016 were selected as subject investigated，and they were randomly divide into study group and control group.Control group was treated by conventionalmethods，while research group was treated by Raw Rhubarb plus retention enema of lactulose on the base of treatment of control group.Curative effect and remission time of symptom，eating time，hospitalization time，the incidence of adverse reaction between two groupswas compared respectively.Results The total effective rate （95.35%）in patients of study group was significantly higher than that in control group（79.07%），and the difference was statistically significant（P＜0.05）.Disappeared time of abdominal pain and fever，eating time and hospitalization time was shorter than that of control group respectively，the difference was statistically significant（P＜0.01）.No serious adverse reaction occurred during the treatment in two groups.Conclusion Raw Rhubarb plus retention enema of lactulose treating acute pancreatitis can promote the recovery of gastrointestinal function in patients，promote the recovery of patients and improve the curative effect.
2016 Vol. 23 (29): 20-22 [
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Clinical observation of narrow-band ultraviolet B phototherapy combined with Epinastine Hydrochloride Tablets in the treatment of pityriasis rosea
ZHONG Rui-ping
Objective To explore the curative effect of the narrow-band ultraviolet B phototherapy combined with Epinastine Hydrochloride Tablets in the treatment of pityriasis rosea. Methods 82 patientswith pityriasis rosea from July 2013 to August 2016 in our hospitalwere selected and divided into the control group （40 cases）and the observation group（42 cases）according to the random data tablemethod.The control group was treated with Calamine Lotion on outside，and oral Epinastine Hydrochloride Tablets，the observation group was treated with narrow-band ultraviolet B phototherapy on the basis of the control group.The score of skin itching，erythema，papules，scales and other symptoms and signs，clinical curative effect in the two groupswere compared.Results The score of skin itching，erythema，papules，scales after treatment in the two groupswas lower than that before treatment，with significant difference （P＜0.05）.The score of skin itching，erythema，papules，scales after treatment in the observation group was lower than that in the control group after treatment，with significant difference（P＜0.05）.The relief time of skin itching，erythema，papules，scales in the observation group was shorter than that in the control group，with significant difference （P＜0.05）.The total effective rate of the observation group was 92.85%，which was higher than 77.50%of the control group，with significant difference （P＜0.05）. Conclusion Curative effect of the narrow-band ultraviolet B phototherapy combined with Epinastine Hydrochloride Tablets in the treatment of pityriasis rosea is distinct，which can reduce the course of the disease，it isworthy of clinical promotion and application.
2016 Vol. 23 (29): 23-25 [
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Clinical effects study of gasless and traditional pneumoperitoneum laparoscope in appendectomy appendectomy
ZHU Chang-hua;LIXiao-qin;ZHU Shao-bo
Objective To compare the clinical effects of gasless and traditional pneumoperitoneum laparoscope in appendectomy. Methods 48 patientswho conducted appendectomy from March 2012 to July 2016 in our hospitalwere selected and randomly divided into the control group and the observation group，and each group was 24 cases.The control group was given traditional pneumoperitoneum laparoscope appendectomy，the observation group was given gasless laparoscope appendectomy.The operation time，bleeding during operation，carbon dioxide binding rate before and after operation，preoperative preparation time，the incidence rate of complications，postoperative hospital stay and intestinal recovery time in the two groups were compared.Results There was no significant difference in the operation time，bleeding during operation，carbon dioxide binding rate before operation between the two groups（P＞0.05）.The preoperative preparation time in the observation group was longer than that in the control group，carbon dioxide binding rate after operation in the observation group was lower than that in the control group，with significant difference （P＜0.01）.Therewas no significant difference in the postoperative hospital stay between the two groups（P＞0.05）.The intestinal recovery time in the observation group was shorter than that in the control group，with significant difference （P＜0.01）.The incidence rate of complications in the observation group was lower than that in the control group，with significant difference （P＜0.05）. Conclusion Compared with traditional pneumoperitoneum，the conducting of gasless laparoscope appendectomy not only can decrease the interference to the machine body environment，but also not affect the heart lung function and acidbase balance.
2016 Vol. 23 (29): 26-28 [
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Analysis of clinical application value of Mammotome spiral cutting biopsy in excision of non-palpable breast lesion
HU Xiang;WANG Ji-wen;XIA Zhi-sheng;SONG Guo-lang;GUO Zhi-bin
Objective To explore the clinical application value of Mammotome spiral cutting biopsy in excision of nonpalpable breast lesion （NPBL）. Methods 196 patients diagnosised with breastmasses by Doppler ultrasonography from February 2014 to February 2016 in our hospitalwere selected and divided into the observation group（100 cases）and the control group（96 cases）according to the different treatmentmethods.The observation group was given Mammotome spiral cutting biopsy excision，the control group was given the traditionalmethod.The operation time，recovery time，incision length，intraoperative blood loss and the NRS score，patient satisfaction of the two groupswere compared.Results The operation time，recovery time and scar length of the observation group was shorter than that of the control group，the amount of bleeding in the observation group was less than that in the control group，and the NRS score in the observation group was lower than that in the control group，with significant difference（P＜0.05）.The degree of satisfaction in the observation group was 88.9%，which was higher than 73.2%in the control group，with significant difference（P＜0.05）.The recurrence rate of the observation group was 5.1%，which was lower than 15.5%of the control group，with significant difference（P＜0.05）.The incidence rate of hematoma，skin ecchymosis in the observation group was lower than that in the control group，with significant difference （P＜0.05）.Conclusion For NPBL patients，using Mammotome spiral cutting biopsy excision is better than traditional operation in the aspectof satisfaction and complications.
2016 Vol. 23 (29): 29-31 [
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Analysis of the therapeutic effect of continuous blood purification in the treatment of sepsis and its clinical application
CHEN Jie;YANG Xue;CHEN Jun-feng
Objective To explore the efficacy of continuous blood purification in the treatment of sepsis. Methods 100 cases of sepsis from January 2012 to December 2015 in our hospital were selected as the study subject，the patients were divided into the control group and the observation group by using the digital random tablemethod，each group had 50 cases.The control group was given routine treatment，and the observation group was treated with continuous blood purification on the basis of routine treatment.The hospital time，mechanical ventilation time，ICU retention time，28 days mortality was compared between the two groups，and the acute physiology and chronic health evaluationⅡscore，the indexes of inflammatory factor before and after treatment were recorded between the two groups.Results The hospital time，mechanical ventilation time，ICU retention time in the observation group was shorter than that in the control group，with significant difference（P＜0.01）.Themortality in the observation group was lower than that in the control group，with significant difference （P＜0.05）.The score of APACHEⅡand the level of TNF-α，IL-6，hs-CRP in the two groups after treatmentwas lower than that before treatment，with significant difference（P＜0.01）.The score of APACHEⅡand the level of TNF-α，IL-6，hs-CRP in the observation group after treatmentwas lower than that in the control group，with significant difference（P＜0.01）.Conclusion Using continuous blood purification in the treatment of sepsis patients has significant clinical effect，which can effectively shorten the time of the treatment of patients，reduce themortality rate and improve acute physiology and chronic health conditions of the patients.
2016 Vol. 23 (29): 32-34转38 [
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Diagnostic value of D-dimer and high-sensitivity C-reactive protein for type B aortic dissection
ZHU Peng;QIU Feng;LIU Fei HAO Xiao-bin;YANG Qian
Objective To investigate the diagnostic value of D-dimer and high-sensitivity C-reactive protein for type B aortic dissection. Methods 42 patients with type B aortic dissection treated by our hospital from June 2013 to June 2015 were selected and they were divided into typical and atypical type B aortic dissection （intramural hematoma and penetrating atherosclerotic ulcer）according to the admission examination results.D-dimer and C-reactive protein level in patients were detected respectively 12 h，24 h，72 h and two weeks after disease onset.Relationship between different type B aortic dissection and the above-mentioned two indicatorswas analyzed.Results After incidence of aortic dissection，D-dimer and C-reactive protein level in patients increased to varying degree.D-dimer of typical and atypical type B aortic dissection was （875.0±190.0）ng/ml，（1021.0±386.0）ng/ml，（2056.0±912.0）ng/ml，（6780.0±1163.0）ng/ml and （926.0±108.0）ng/ml，（989.0±320.0）ng/ml，（1478.0±825.0）ng/ml，（3568.0±1558.0）ng/ml respectively 12 h，24 h，72 h and two weeks after disease onset.C-reactive protein typical and atypical type B aortic dissection was （25.8±11.4）mg/L，（60.9±9.7）mg/L，（110.0±27.5）mg/L，（86.4±21.8）mg/L and（29.1±14.5）mg/L，（44.7±11.2）mg/L，（103.2±25.4）mg/L，（79.5± 36.3）mg/L respectively 12 h，24 h，72 h and two weeks after disease onset.D-dimer level in patients with typical type B aortic dissection was obviously higher than that of patientswith atypical type B aortic dissection（P＜0.05）.There was no statistical difference of high-sensitivity C-reactive protein between two groups （P＞0.05）.Conclusion D-dimer and high-sensitivity C-reactive protein are helpful in the diagnosis of aortic dissection，and D-dimer contribute to the differential diagnosis of type B aortic dissection.
2016 Vol. 23 (29): 35-38 [
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App lication effect of TR-Band hemostat in diagnosis and treatment of percutaneous coronary intervention
FAN Shan
Objective To compare the effect of traditional bandage and TR-Band hemostat for compression after radial artery puncture. Methods 580 patients given transradial approach for percutaneous coronary intervention by our hospital from June 2013 to March 2015 were selected for retrospective comparative analysis and according to the dressing method，the subjects were divided into bandage group （290 cases）and TR-Band hemostat group （290 cases）.The following indexeswere observed：successful rate of hemostasis，the total time of hemostasis by compression，operation time ofhemostasisby dressing，regression timeofdistalswelling，postoperativebleeding in two days，mild subcutaneouscongestion，finger tip blood oxygen saturation after compression，damage and necrosis of local skin，radial artery occlusion，vagus reflex，pain or tenderness of forearm，pain or tenderness，and time to discharge after surgery in two groups was observed respectively.Results In bandage group，there were 12 cases failed in one time having bleeding and errhysis while in TR-Band hemostat group，hemostasis was entirely successful aving no bleeding and errhysis，then there was a statistical difference between two groups （P=0.0008）.Operation time，the total time of hemostasis by compression after operation，regression time of distal swelling after operation in bandage group was obviously longer than that of TR-Band hemostat group respectively（P＜0.01）.Incidence rate of postoperative bleeding in two days，mild subcutaneous congestion in bandage group was obviously higher than thatof TR-Band hemostatgroup respectively（P＜0.01）.Therewasno statistical difference of finger tip blood oxygen saturation after surgery，pain or tenderness of forearm and time to discharge after surgery between two groups（P＞0.05）.Therewas no radial artery occlusion，vagus reflex，pain or tenderness of forearm，damage and necrosis of local skin in two groups.Conclusion Compared with compression dressing method of traditional bandage，hemostasis effect of TR-Band hemostat is reliable in hemostasis after transradial approach for percutaneous coronary intervention，and incidence rate of complication is lower.
2016 Vol. 23 (29): 39-41 [
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Study on CPAPmodel of non-invasive positive pressure ventilation in app lying invasive ventilator treating acute left heart failure
FENG Xin-hui;HU Gao-fei;LIU Fu-jin
Objective To study the clinical effect of continuous positive airway pressure （CPAP）mode of noninvasive positive pressure ventilation in applying invasive ventilator treating acute left heart failure. Methods 60 patientswith acute left heart failure treated by our hospital from January 2015 to June 2016 were selected and divided into control group and treatment group according to the random number table，and there were 30 cases in each group.Control group was treated with inhalation of oxygen via high-flow plusing conventional drug，while treatment group was treated with CPAPmodel of non-invasive positive pressure ventilation in applying invasive ventilator plusing routine drug.Treatment effect between the two groupswas compared.Results There was a statistical difference of blood gas analysis index level of treatment group compared with control group （P＜0.05）.The clinical effect of treatment group was obviously superior to control group （P＜0.05）.There was no statistical difference of incidence of adverse reaction in treatment group compared with control group （P＞0.05）.Conclusion Clinical effect of CPAPmodel of non-invasive positive pressure ventilation in applying invasive ventilator treating acute left heart failure is very obvious.
2016 Vol. 23 (29): 42-44 [
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Curative effect com paration of different dose of Rosuvastatin in the treatment of coronary atherosclerosis and its effect on the disease
ZHANG Rong-hua
Objective To compare the different dose of Rosuvastatin in the treatment of coronary atherosclerosis and its effect on the disease. Methods 100 cases with coronary atherosclerosis treated by our hospital from March 2014 to November 2015 were treated，according to the different dosage they were divided into study group（n=50）and the control group（n=50）.All patientswere given Rosuvastatin treatment，and study group was treated with high dose of rosuvastatin，but control group was treated with low dose.Carotid plaque area and carotid intima thickness before and after treatment in patients of two groupswas recorded.Blood lipid（LDL，HDL，TC and TG）level before and after treatment in patients of two groups was observed.The total effective rate of treatment in patients of two groups was analyzed.Results Carotid plaque area and carotid intima thickness in study group was significantly lower than that of control group，and there was a statistical difference（P＜0.05）.TC，LDL and TG value in study group was significantly lower than that of control group，but HDL valuewas significantly higher than that of control group，and there was a statistical difference（P＜0.05）.The total effective rate of study group （98.00%）was significantly higher than that of control group （74.00%），and therewas a statistical difference （χ2=11.9601，P＜0.05）.Conclusion The clinical effect of high-dose Rosuvastatin treating coronary atherosclerosis is better than that of low dose treatment，it can significantly improve blood lipid level in patients and improve the total effective rate of treatment.
2016 Vol. 23 (29): 45-47 [
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Significance of emergency tracheal intubation in pre-hospital first aid for patientswith severe craniocerebral injury
LAIWei-lin;CHEN Yi-wen;QIUWen-fang
Objective To investigate the clinical significance of emergency tracheal intubation in improving the success rate of pre-hospital first aid for patients with severe craniocerebral injury. Methods 172 qualified cases with severe craniocerebral injury in pre-hospital first aid from January 2010 to December 2014 were selected and studied and they were divided into two groups according to the odd and even number of admission time：pre-hospital emergency tracheal intubation group（86 cases）and post-hospital routine tracheal intubation group after admission（86 cases）.The result of GOS prognosis evaluation was compared between two groups.Results Good rate，moderate disability rate and plantation state rate for GOS prognosis evaluation in pre-hospital emergency tracheal intubation group was 13.95%，41.86%and 8.14%and itwas 4.65%，24.42%and 20.93%respectively in post-hospital routine tracheal intubation group.Good rate and moderate disability rate of pre-hospital emergency tracheal intubation group was significantly higher than that of post-hospital routine tracheal intubation group，while the plantation state rate of pre-hospital emergency tracheal intubation group was significantly lower than that of post-hospital routine tracheal intubation group（P＜0.05）.Conclusion E-mergency tracheal intubation applied in the pre-hospital emergency for patients with severe craniocerebral injury as soon as possible can greatly reduce themortality and disability rate of patients.
2016 Vol. 23 (29): 48-50 [
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Effect observation of intravascular interventional embolization in the treatment of cerebral vascular malformation
PENGMu-jian;SHEN Jian-zhong;ZHOU Liang
Objective To explore the effect of intravascular interventional embolization in the treatment of cerebral vascularmalformation. Methods 60 cases with cerebral vascularmalformation treated by our hospital from February 2012 to February 2015 were selected as research object，and they were randomly divided into control group（n=30）and observation group （n=30）.Control group was given the treatment of abnormal vascular surgery，and observation group was treated by intravascular interventional embolization.The operation time，blood loss during operation，incidence of complication and recovery after treatment between two groups was compared respectively.Results Compared with control group，the operation time was shorter，blood loss during operation was fewer，incidence rate of complication was lower and recovery after treatmentwas better in observation group （P＜0.05）.Conclusion Intravascular interventional embolization in the treatment of cerebral vascularmalformation can improve the operation index of patients，reduce the complication，it isworthy of promotion and reference.
2016 Vol. 23 (29): 51-53 [
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Clinical observasion of Shenyankangfu Tablets in treatment of patients with focal segemental glomerulosclerosis
GAO Cong-pu;BAIShou-jun;ZHU Ying-chun
Objective To observe the effect of Shenyankangfu Tablets in treatment of patients with primary focal segemental glomerulosclerosis（FSGS）. Methods From June 2012 to July 2014，61 patients diagnosed as primary FSGS in our hospitalwere divided into treatmentgroup（31 cases）and control group（30 cases）according to the order of diagnosis. Patientsin the treatmentgroupwere treatedwith Shenyankangfu Tabletsbased on routine doseofBenazaprilor Telmisartan，5 tablets/time，3 times/d，while patients in the control group were treated with conventional dose of Benazapril or Telmisartan.Results Urine protein value in 24 hours after treatment in the treatment group was （1079±843）mg，improved greatly than（1840±976）mg in the control group，and the difference was statistically significant（P＜0.01）；urine protein value in 24 hours in the treatment group after treatmentwas significantly reduced than that before treatment，and the differencewas statistically significant（P＜0.01）.The total effective rate in the treatment group was 87.1%，higher than 63.3%in the control group（P＜0.01）.Conclusion Shenyankangfu Tablets is effective in treatment of primary FSGS.
2016 Vol. 23 (29): 54-56 [
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Clinicalapplication of nicotinam ide in treatment ofmaintenance hemodialysis patientswith hyperphosphatem ia in urem ia
CHEN Dan;ZHOU Dong-lin;CHEN Yu
Objective To observe the effect of nicotinamide in the treatment of hyperphosphatemia in uremia. Methods 20 uremic patients with high phosphorus in maintenance hemodialysis admitted in Xiangya Ping Mine Cooperative Hospital Hemodialysis Center from January 2015 to January 2016 were studied and given oral nicotinamide tablets treatment，after treatment for 3 and 6months，the dataswere statisticed and effectwas evaluated.Results After treatment for3months，serum phosphorusdetection in 35%of patientswith uremia isup to the standard，after treatment for 6months 75%ofwhom.Comparedwithbefore treatment，serum phosphorusand productofcalcium and phosphorus levelweredecreased after treatment for 3 months，and the difference was statistically significant（P＜0.05）；after treatment for 3months，serum calcium and iPTH levels compared with before treatment，the difference was not statistically significant（P＞0.05）.Compared with before treatment，product of calcium and phosphorus and iPTH level after treatment for 6 months were decreased，and the difference was statistically significant（P＜0.05）；after treatment for 6months，serum phosphorus and calcium levels compared with before treatment，the difference was not statistically significant（P＞0.05）.Conclusion Oral nicotinamide tablets can effectively reduce serum phosphorus and product of calcium and phosphorus in patients with maintaining hemodialysis，which does notaffect calcium value and increase the risk of vascular calcification.
2016 Vol. 23 (29): 57-59 [
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Influence of GLP-1 receptor stimulant on the cognitive function in patients with type 2 diabetes com p licated with A lzheimer disease
HONG Shi-hua;WU Ju-qin;FANG Xiang-nan;KE Rui-qiong;LVWei-ming
Objective To observe the influence of glucagon-like peptide-1 （GLP-1）receptor agonist on the cognitive function in patients with type 2 diabetes complicated with Alzheimer disease. Methods Sixty patients with type 2 diabetes and Alzheimer disease from May 2014 to May 2015 visited our hospital were selected and evenly divided into treatment group and control group in random.In treatment group，on the basis of conventional therapies of blood glucose-reducing，depressurization，and lipid-lowering，GLP-1 receptor stimulant was added，while in control group，on the basis of regular therapies of reducing blood glucose，pressure，and lipid，blank placebo was added.The target of blood control in both groupswere fasting blood-glucose（FPG）was less than 6.1mmol/L，2-hour post-meal blood glucose（2 h PG）was less than 10.0 mmol/L，and glycosylated hemoglobin （HbA1c）was lower than 7%.After the treatment of 6 months，the scale ofmini-mental state examination（MMSE）was used to evaluate the change of cognitive function before and after therapy in the two groups.Results After therapy，FPG，2 h PG and HbA1c were greatly decreased in comparison with before treatment in two groups（P＜0.05），which were allmet the standard.After the treatment of 6months，MMSE score in treatment group was remarkably increased（P＜0.05），while MMSE score in control group was decreased greatly（P＜0.05）. MMSE score in treatment group was obviously superior to that in control group （P＜0.05）.Conclusion GLP-1 receptor stimulant can effectively improve cognitive function in patientswith type 2 diabetes combining with Alzheimer disease.
2016 Vol. 23 (29): 60-62 [
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Curative effect observation of alpha Lipoic Acid combined with anodyne treatment instrument in the treatment of diabetic peripheral neuropathy
LIU Ying;LIJin-ji;YANG Ying
Objective To observe the curative effect ofα-Lipoic Acid combined with anodyne treatment instrument in the treatment of diabetic peripheral neuropathy（DPN）. Methods From January 2010 to February 2014，179 patientswith type 2 diabetic peripheral neuropathy were randomly divided into two groups.Observation group
received α-Lipoic Acid combined with anodyne treatment instrument for 10 days and control group received
α-lipoic acid for 10 days only.The vibration perception thresholds （VPT）before and after the treatment was tested.Results Compared with before treatment，VPT （including double acrotarsium and toe）after treatment was decreased significantly in two groups，and there was a statistical difference （P＜0.05）.VPT decreasing range of left acrotarsium and toe in observation group was larger than that control group with the significant differences（P＜0.05）.After treatment，the remission rate of observation group was 83.2%（89 cases），while control group was 76.3%（55 cases），the difference was not statistically significant（P＞0.05）. Compared with control group，the improvement rate of VPT for double acrotarsium in observation group was higher，and the difference was statistically significant（P＜0.05）.Conclusionα-Lipoic Acid combined with anodyne treatment instrument in the treatment of diabetic peripheral neuropathy could relieve the symptoms and improve the VPT value.It is worthy of clinical promotion.
2016 Vol. 23 (29): 63-65 [
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Effect observation of small need le-knife therapy combining with osteo-porosis therapy apparatus in the treatment of osteoporotic com pression spine fracture
XIE Hong-gang;CHEN Nan-ping
Objective To explore the effect of small needle-knife therapy combining with osteoporosis therapy apparatus in the treatment of osteoporotic compression spine fracture. Methods 50 patients suffering from osteoporotic compression spine fracture from January 2012 to December 2015 admitted into our hospitalwere selected.They were evenly divided into control group and observation group in random，25 cases in each group.In the control group，on the basis of the conventional treatment，small needle-knife therapy was added，while in the observation group，on the basis of the control group，osteoporosis therapy apparatus was adopted.The therapeutic effect was compared in the two groups.Results The therapeutic effective rate in the observation group was better than that of control group with a statistical difference （P＜0.05）.The time of pain alleviation in the observation group was less than that of control group （P＜0.05）.The level of bonemineral density was increased a bit in the observation group after therapy，which was not displayed a great difference in comparison with that in the control group （P＞0.05）.Conclusion In the treatment of osteoporotic compression spine fracture，combination of small needle-knife therapy and osteoporosis therapy apparatus can quickly alleviate patient′s suffering and functional disorder，and effectively slow down or prevent the worsening of osteoporosis as well as the recurrence of osteoporotic compression spine fracture.
2016 Vol. 23 (29): 66-68 [
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Clinical effects of hip rep lacement and internal fixation in the treatment of femoral neck fracture in the elderly
HONG Zhong;ZHANG Zhou-ping;LIU Han-min;LIU Li-lin
Objective To explore the clinical effect of hip replacement and internal fixation in the treatment of femoral neck fracture in elderly patients，and to provide evidence for clinical treatment. Methods From February 2011 to November 2014，76 cases of elderly patientswith femoral neck fracture （＞60 years）were selected and randomly divided into control group （34 cases）and observation group （42 cases）.The control group was treated with internal fixation of fracture treatment，observation group was given hip arthroplasty.The therapeutic effect，postoperative follow-up and complicationswere compared between the two groups.Results The operation time，intraoperative bleeding volume，postoperative 24 h drainage flow and activity time of observation group were significantly better than that of control group （P＜0.01）.After 1 year of follow-up，no lost follow-up.The excellent and good rate of observation group was significantly higher than that of control group （92.06%vs 73.53%，P＜0.05）.The health self rating scale SF-36 scores observation group were significantly better than that of control group （P＜0.01）.The incidence of complications of the observation group was significantly lower than that of control group（11.90%vs 35.29%，P＜0.05）.Conclusion Hip replacement treatment of senile femoral neck fracture，post operative recovery fast fewer complications，it is a kind ofmore effective surgicalmethod
2016 Vol. 23 (29): 69-71 [
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Risk assessment of static IMRT technology on cardiac toxicity in patients with breast cancer after radicalmastectomy based on VMAT technology
GONGMin-yong;YE Wei;XIONG Chao
Objective To study dose of heart for patients with breast cancer in post-mastectomy radiotherapy by dual arc volumetric modulated arc therapy （VMAT）irradiation technique，to evaluate cardiac toxicity risk. Methods Thirty patientswith breast cancer treated withmastectomy surgery followed by radiotherapy in our hospital from June 2015 to January 2016 were given four kinds of irradiation technology，namely positive intensity-modulated radiotherapy（IMRT）（8-10 subfield），4 beam-IMRT（4B-IMRT），5 beam-field IMRT（5B-IMRT）（based 4B-IMRT in the fields increase of chestwall）and dual arc VMAT （Dual-Arc-VMAT）including the heart facing arc.Mean dose（Dmean）and V25of cardiac and themean dose of left anterior descending（LAD）coronary artery were recorded，normal tissue complication probability（NTCP）of cardiac were analyzed by statisticalmethod.Results The Dmean，V25，LAD，NTCP of heartwith tumor in right side was 2.38，3.21，4.53，2.74 Gy；0.23%，0.43%，0.61%，0.18%；2.5，3.8，3.6，3.2 Gy；0.004，0.001，0.000，0.000 respectively. Target area conformity index（CI）and homogeneity index（HI）value was 0.35，0.50，0.60，0.75；0.74，0.57，0.58，0.10 respectively.In theothersidewas8.2，7.3，10.2，6.5Gy；9.7%，8.3%，11.1%，5.2%；29.6，28.2，31.2，26.8Gy；0.030，0.010，0.010，0.009 respectively.Target area CI，HIvalue was 0.40，0.51，0.59，0.70；0.87，0.83，0.75，0.47 respectively.Compared with other static IMRT technique，CI and HI in the target area of breast cancer of VMAT technique after radicalmastectomy were better，and the difference was statistically significant（P＜0.01）.The difference was not statistically significant（P＞0.05）in the cardiac V25，Dmeanand NTCP in both the left and right tumors by VMAT technique.There was no significant difference between DmeanLAD of VMAT technique and that of other static IMRT techniques（P＞0.05）.Conclusion VMAT technology has slightly lower cardiac toxicity than other static IMRT technology，while has statistically significant benefit to improve CI and HI of target.It can be recommended as cardiac safe and efficient technique for patients with breast cancer in post-mastectomy surgery.
2016 Vol. 23 (29): 72-75转78 [
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Efficacy and toxicity reduction of Lienal Polypeptide Injection combined with chemotherapy in the treatment of pancreatic cancer
SUN Yu-shu
Objective To observe the curative effect and attenuation of Lienal Polypeptide Injection combined with chemotherapy in the treatment of pancreatic cancer. Methods Sixty patients with pancreatic cancer were randomly divided into experimental group and control group in our department from January to December 2015，30 cases in each group，30 cases were treated with GP program program in the control group，another 30 cases were treated with Lienal Polypeptide Injection combined with GP in the experimental group.The efficacy，quality of life and adverse reaction of two groupswere observed.Results Improve rate of quality of life in the experimental group was significantly higher than that in the control group（60%vs 40%）（P＜0.05）.Adverse reactions in the experimental group were lower than those in the control group（P＜0.05）.The curative effectwere not statistically significant（P＞0.05）.Conclusion Lienal Polypeptide Injection combined with GP program chemotherapy in the treatment of pancreatic cancer can significantly reduce chemotherapy bonemarrow suppression，clinical symptoms improve significantly，quality of life has improved significantly.
2016 Vol. 23 (29): 76-78 [
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Effect ofm inimally invasive laparoscopic surgery and conventional thoracotomy on lung function and inflammatory factors after operation in patientswith esophageal cancer
ZENG Xin-min;WANG Hui;ZHANG Zhi-long;HU Huo-li;XU Xing-hua;CHEN Hua
Objective To investigate the effect ofminimally invasive laparoscopic surgery and traditional thoracotomy on pulmonary function and inflammatory factors after operation in patients with esophageal cancer. Methods Patients with esophageal cancer diagnosed and underwent surgical treatment in our hospital from August 2012 to December 2015 were enrolled in the study and divided into conventional thoracotomy group（n=44）and laparoscopicminimally invasive surgery group （n=46）according to the operation plan.Improvement of forced vital capacity accounted for the proportion of expected value（FEV%），forced expiratory volume in the first second proportion of expected value（FEV1%），forced expiratory volume accounted for the proportion of expected value （FVC%）preoperative and postoperative 30 days were compared，TNF-α，IL-8 and IL-6 levels of inflammatory cytokine on the first day and on the seventh day were observed. Results The level of FEV%、FEV1%、FEV%postoperative 30 d in the conventional thoracotomy group was （72.16± 8.42）%，（70.47±6.32）%，（68.05±7.62）%respectively，and（76.43±5.35）%，（76.78±5.35）%，（73.25±6.48）%respectively in the laparoscopic minimally invasive surgery group，FEV%，FEV1%，FVC%of two groupswere all decreased，but the improvement of laparoscopic minimally invasive surgery wasmore significant（P＜0.05）.The level of TNF-α，IL-8，IL-6 on the seventh day in the conventional thoracotomy group was （3.88±0.49），（3.37±0.76），（2.58±0.53）ng/ml respectively，（2.23± 0.28），（2.34±0.51），（1.91±0.27）ng/ml respectively in the laparoscopic minimally invasive surgery group，TNF-α，IL-8，IL-6 of two groupswere all decreased than that on the first day，but the improvement of the laparoscopic minimally invasive surgery group wasmore significant（P＜0.05）.Conclusion Compared with conventional thoracotomy，laparoscopicminimally invasive surgery has advantages of less trauma，better prevention of lung function，and it isworth popularizing.
2016 Vol. 23 (29): 79-81转110 [
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Effect analysis of Oral Adm inistration of Soda W ater and routine infusion in the treatment of hyperemesis gravidarum
ZHONG Hua-lan;XIE Shan;LIU Qiong
Objective To explore the clinical effect of Oral Administration of Soda Water and routine infusion in the treatment of hyperemesis gravidarum. Methods Altogether 76 cases of pregnant women with hyperemesis gravidarumwere in our hospital from June 2013 to June 2015 were evenly divided into two groups（38 cases in control group and 38 cases in observation group）in reference to their admission time and administered with routine infusion therapy alone for control group and combination of application of Soda Water and routine infusion for observation group.The differences of treatment effects between the two groupswere statistically evaluated and measured from multiple indicators，such as complete disappearance time of hyperemesis，the overall duration of treatment，averagetimes of hyperemesis，preoperative and postoperative serum potassium，sodium，oxygen，carbon dioxide combining power and urine ketone level etc..Results The effective rate（94.7%）in the observation group was higher than that in the control group（73.7%），and the difference was statistically significant（P＜0.05）.In the observation group，vomiting symptoms disappeared，the overall treatment duration was shorter than that of the control group，the average vomiting after treatmentwas less than that of the control group，the differencewas statistically significant（P＜0.05）.Postoperative serum potassium，blood sodium，blood oxygen，carbon dioxide combining power and urine ketone level of patients in observation group showed no significant difference in contrastwith control group（P＞0.05）.Conclusion Oral Administration of SodaWater combined with routine infusion in treatment of hyperemesis gravidarum patients with significant effect，can effectively shorten the course of treatment of patients and improve the treatment effect，also has good effect on improving the body indexes of patients，is worthy of promotion.
2016 Vol. 23 (29): 82-84 [
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Clinical observation of modified laparoscopic hysterectomy in treatment with large uterus:report of 48 cases
CAIYu;DIAO Hai-dan
Objective To investigate the clinical effect of modified laparoscopic hysterectomy. Methods Retrospective analysiswas conducted on the clinical data of 108 cases of hysterectomy performed during the period of January 2013 to January 2015，including 48 patientswith modified laparoscopic hysterectomy in observation group and 60 patients of total abdominal hysterectomy in control group.The operation situation and postoperative situation were compared between the two groups.Results The procedures were completed in all the 108 patients with no postoperative complications occurred.The operation time，anal exhaust time，the time of postoperative fever，average days of hospital stay were significantly shorter than those in the control group，bleeding amount was less than that of control group［（129.5±19.6）min vs（146.8±41.4）min，（32.7±4.8）h vs（39.8±3.5）h，（1.7±0.4）d vs（2.0±0.4）d，（5.6±0.7）d vs（8.2±0.8）d，（139.8±45.5）ml vs（189.2±63.5）ml］，with statistical difference（P＜0.05）.The two groupswere followed up for 3 to 12 months，there were no serious complicatiors.Conclusion Compared with total abdominal hysterectomy，modified laparoscopic hysterectomy has the advantages ofmilders trauma，quicker recovery，shorter hospital staym，and is safe and feasible for patients with large uterus and does not increase the risk of operation and complications.
2016 Vol. 23 (29): 85-87 [
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Clinical effect of Kuntai Capsule combined with Ethinylestradiol and Cyproterone Acetate Tablets in the treatment of polycystic ovary syndrome
ZHANG Xiao-chun
Objective To investigate the clinical effect of Kuntai Capsule combined with Ethinylestradiol and Cyproterone Acetate Tablets in the treatment of polycystic ovary syndrome. Methods 68 cases of patients with polycystic ovary syndrome in our hospital from January 2015 to January 2016 were randomly divided into group A and group B，34 cases of patients in each group.Group A was given Ethinylestradiol and Cyproterone Acetate Tablets treatment，group B was given Kuntai Capsule combined with Ethinylestradiol and Cyproterone Acetate Tablets treatment.The therapeutic effect of the two groups were compared.Results Before the treatment，there was no significant difference between patientswith sex hormone levels in the two groups，after the treatment，the sex hormone level in group B was significantly better than that in group A（P＜0.05）.The endometrial thickness and the number of dayswas respectively（9.62±0.75）mm，（3.68±0.74）d in group A，and（12.35±0.38）mm，（6.87±0.46）d in group B，the two indicators in group B were better than those of the group A，with statistical difference（P＜0.05）.Conclusion Kuntai Capsule combined with Ethinylestradiol and Cyproterone Acetate Tablets in the treatment of polycystic ovary syndrome can effectively improve the clinical symptoms of patients，can be used in clinical application.
2016 Vol. 23 (29): 88-90 [
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Effect observation of loop electrical excision procedure in the treatment of cervical precancerous lesion
ZHANG Yi-feng
Objective To study the effect of loop electrical excision procedure in the treatment of cervical precancerous lesion. Methods 142 cases of patients with cerical cancer pathological changes treated in our hospital from February 2014 to June 2015，were randomly divided into two groups.The control group were treated by routine surgical treatment，observation group were treated by uterine annular cutting operation treatment.The operation time，intraoperative blood loss，hospital stay，clinical total effective rate and incidence of complications such as indicators between two groupswere compared.Results The control group patientswith operation time was（45.53±9.98）minutes，intraoperative blood losswas （45.61±16.48）ml，length of hospital stay was （6.25±1.37）days，clinical treatment the total effective rate was 77.46%，the incidence of complications was 15.49%，the observation group of patients with operation time was（8.25±3.55）minutes，intraoperative blood losswas（12.35±4.67）ml，length of hospital stay was 0 day，clinical treatment the total effective rate was 90.14%，the incidence of complications was 7.04%，the difference between the two groups was statistically significant（P＜0.05）.Conclusion For patientswith cervical cancer lesion before，using the uterine ring electricity cutmethod can not only shorten patients treated with themethod of operation time，reduce intraoperative blood loss，maintain the original shape of the cervix，facilitate postoperative review，and help to improve the patients′clinical total effective rate，reduce the incidence of complications，worthy of promotion.
2016 Vol. 23 (29): 91-93 [
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Effect of different prcoessing methods in the ovarian function after the laparoscopic ovarian cystectomy
GU Xin-hua
Objective To study the effect of different prcoessingmethods in the ovarian function after the laparoscopic ovarian cystectomy. Methods 84 patients of adopting the laparoscopic ovarian cystectomy from January 2014 to January 2015 in our hospitalwere selected and retrospectively analyzed.The subjectswere divided into electrocoagulation group and suturing group according to the different treatmentmethods.The index of E2，FSH，LH and abnormal rate ofmenstruation of two groupswere observed.Results 84 patientswere successfully completed surgery，postoperative serum E2levels of two groups patientswere decreased，FSH，LH levels increased，the difference was statistically significant（P＜0.05）；after 6 months of follow-up visit，the incidence rate of irregularmenstruation for electrocoagulation group （28.57%，12 cases）was higher than that of suturing group（4.76%，2 cases），the difference was statistically significant（P＜0.05）.Conclusion After the laparoscopic ovarian cystectomy，the different prcoessingmethods have the different effects in the patients′ovarian function.In order to recover the patients′ovarian function，the suturing method shall be firstly recommended to improve the ovarian function and reduce the incidence rate of irregularmenstruation.It is worthy of clinical promotion.
2016 Vol. 23 (29): 94-96 [
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App lication of Dexmedetom idine combined with topical anesthesia in removal of bronchial foreign bodies in children
OUYANG Ai-ping;LIU Shi-wen;LIYou-chun;LILi;HUANG Yi-sheng;LIYi-ping;GUO Li-li
Objective To evaluate the effect of Dexmedetomidine combined with topical anesthesia used for airway foreign body removal in children. Methods Ninety pediatric patients undergoing rigid bronchoscopy examination2，MAP were recorded at four time point：before inhalation anesthesia （T0），at 15min after topical anesthesia （T1），at 1 and 5min after inserting bronchoscope （T2，T3）.Adverse reaction after anesthesia，in the process of bronchoscopy and after operation，and anesthesia handle and so on.Results Compared with group R and T，HR，RR and MAP wasmore stable in group D，SpO2is not as stable as group T，but it could be acceptable level after inhaling of oxygen.Compared with group R and T，the complications such as nausea，cough，holding breath，respiratory depression，laryngospasm，bronchospasm and restlessness throughout the procedure was less in group D.The occurrence rate of bradycardia is higher in group D，but it can be prevention and treatment by Atropine injection.Conclusion Dexmedetomidine combined with topical anesthesia used for airway foreign body removal in children is a safe and feasiblemethod received
by our hospital from January 2015 to August 2016 were selected and randomly divided into three groups：Dexmedetomidine+Propofol+topical anesthesia group（group D），simple topical anesthesia group（group T）and Remifentanil+Propofol+ topical anesthesia group （group R），and there were 30 cases in each group.All patients inhaled Sevoflurane for anesthesia induction and then given topical anesthesia （Lidocaine of 2mg/kg）.In group D，Propofol of 0.15mg/（kg·min）for continuous intravenous infusion and Dexmedetomidine of 4μg/（kg·h）for intravenous infusion for loading dose，and then 4μg （kg·min）were continuously infusion until the end of surgery，the patients inhaled Sevoflurane until before surgery.In group R，Propofol of 0.10mg/（kg·min）for intravenous infusion and Remifentanil of 0.1μg/（kg·min）were administered until the end of surgery.In group T，the patients given Sevoflurane for continuousmask inhalation for 15minutes.In the whole process of anesthesia，all patients kept their own breathin.HR，RR，SpO
2016 Vol. 23 (29): 97-100 [
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App lication com parision of Sufentanil and Fentanyl in labor analgesia with in combined spinal epidural anesthesia
SUN Jin-long
Objective To explore the application effect of Fentanyl and Sufentanil in labor analgesia with in combined spinal epidural anesthesia. Methods 100 expectantmothers treated by our hospitalwere randomly selected from February 2014 to February 2015 and according to the order number of visits in which the use of Sufentanil No.1-50，No.51-100 using Fentanyl.Analgesic effect between two groupswas compared.Results VASscore in Sufentanil group at 5min，90min was lower than that of Fentanyl group，and the first dosing period of time was longer than that of Fentanyl group［（115.8±15.24）min vs （91.24±12.53）min］（P＜0.05）.Conclusion Compared with Fentanyl，effect of Sufentanil for epidural anesthesia in labor analgesia is better.
2016 Vol. 23 (29): 101-103 [
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Study on preventing sore throat using Dexmedetom idine after operation in patients scheduled for abdom inal surgery and given endotracheal intubation and general anesthesia
XIEGuo-qiang;CHEN Yin-lian;ZHANG Yang-lian
Objective To study the prevention role of Dexmedetomidine on sore throat after operation in patients scheduled for abdominal surgery and given endotracheal intubation and general anesthesia. Methods 100 patients with endotracheal intubation and general anesthesia undergoing abdominal surgery were admitted into the hospital from December 2010 to March 2016 were selected and randomly divided into two groups （observation group and control group），therewere 50 cases in each group.Two groups of patientswere treated with the same drug anesthesia.Observation group was administered with constant intravenous infusion of Dexmedetomidine 30 minutes before the completion of the surgery.Control Group was treated with intravenous infusion of sodium chloride injection.The incidence rate of sore throat，extubation time and spontaneous breathing recovery time between two groups was compared respectively.Results The incidence rate of sore throat in observation group （10.00%）was significantly lower than that of control group （40.00%）（P＜0.05）.theextubation timeand spontaneousbreathing recovery time ofobservation groupwas（12.06±1.54）min and（5.67±2.85）min without significant difference in comparison with control group［（12.12±1.29）min，（5.69±2.81）min］（P＞0.05）.Conclusion Dexmedetomidine demonstrates its great effectiveness in prevention of sore throat.
2016 Vol. 23 (29): 104-106 [
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Intervention observation and research of the Edaravone in transient ischem ic attack
LIU Jing-jing
Objective To explore the improvement of neurologic function impairment and themechanism for Edaravone in patientswith transient ischemic attack （TIA）. Methods 120 patientswith TIA admitted to the department of neurology in our hospital and met the inclusion criteria from April 2015 to April 2016 were selected and divided into the highrisk group，themedium risk group and the low risk group according to risk stratification of ABCD2，40 cases in each group.Each subgroup was divided into group A （high risk group treated with Edaravone），group B （medium risk group treated with Edaravone），group C（low risk group treated with Edaravone），group D（high risk group treated with the basis for treatment），group E（medium risk group treated with the basis for treatment），group F（low risk group treated with the basis for treatment），20 cases in each group.The score of NIHSSand the score of daily life activities ability among each group was compared in attack，after treatment at the 3rddays，14thdays，28thdays and the incidence rate of adverse reaction was recorded.Results The score of NIHSSafter treatment at the 3rddays，14thdays，28thdays in group C and group F was lower than that in group A，group B，group D，group E，the score of NIHSSafter treatment at the 3rddays，14thdays，28thdays in group A was lower than that in group D，the score of NIHSS after treatment at the 3rddays，14thdays，28thdays in group B was lower than that in group E，with significant difference （P＜0.05）.The score of NIHSS after treatment at the 3rddays，14thdays，28thdays in each group were all decreased，and the difference was statistically significant（P＜0.05）.The score of daily life activities ability after treatment at the 3rddays，14thdays，28thdays in group C and group F was higher than that in group A，group B，group D，group E，the score of daily life activities ability after treatment at the 3rddays，14thdays，28thdays in group A was higher than that in group D，the score of daily life activities ability after treatment at the 3rddays，14thdays，28thdays in group B was higher than that in group E，with significant difference （P＜0.05）.The score of daily life activities ability after treatment at the 3rddays，14thdays，28thdays in each group were all increased，and the difference was statistically significant（P＜0.05）.There was no obvious adverse reaction in each group.Conclusion Edaravone can improve the neurologic function impairment of high，moderate risk groupswith TIA，and the security is higher.
2016 Vol. 23 (29): 107-110 [
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Effect com parison observation of different doses of Atorvastatin in the treatment of coronary heart disease with heart failure
CHEN Le-hong
Objective To compare the clinical effect of different doses of Rosuvastatin in the treatment of coronary heart disease （CHD）complicated with heart failure. Methods The clinical data of 98 CHD patients complicated with heart failure from May 2014 to August 2015 in our hospital was retrospectively analyzed，all patients were randomly divided into the low dose group and the high dose group according to the different therapies，49 cases in each group.The low dose group was treated with 10 mg of Rosuvastatin each day，the high dose group was treated with 20 mg of Rosuvastatin each day.The treatment effect，left ventricular function index，plasmamarker，6-minutewalking distance and adverse reactions in the two groupswere compared.Results Therewas no significant difference in the total effective rate and the incidence rate of adverse reactions between the two groups（P＞0.05）.The level of LVEF，LVESD，LVEDD after treatment in the high dose group was better than that in the low dose group，with significant difference （P＜0.05）.The level of hs-CRP，NT-proBNP and 6-minute walking distance after treatment in the high dose group was better than that in the low dose group，with significant difference（P＜0.05）.Conclusion The high dose of Rosuvastatin has an obvious effect in CHD patients with heart failure，which can improve the clinical symptoms and promote the recovery of left ventricular function.In addition，the adverse reaction is not increased.It isworthy of clinical application and promotion.
2016 Vol. 23 (29): 111-113 [
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Effect com parison of Cefaclor Sustained-Release Capsule and Cephalexin in the treatment of cute bacterial infection of the upper respiratory tract
HUANGMing-jia
Objective To compare the effect of Cefaclor Sustained-Release Capsule and Cephalexin in the treatment of acute bacterial infection of the upper respiratory tract. Methods 110 cases of acute bacterial infection of the upper respiratory tract in our center from February 2015 to February 2016 were selected and randomly divided into the observation group and the control group，55 cases in each group.The control group was treated with Cephalexin，while the observation group was treated with Cefaclor Sustained-Release Capsules.The curative effect and improvement condition of the two groupswere compared.Results The effective rate of the observation group was 96.36%，which was higher than 85.45%of the control group，with significant difference （P＜0.05）.The disappeared time of cough，sore throat，fever and rales in the observation group was shorter than that in the control group，with significant difference （P＜0.01）.The scavenging rate of pathogenic bacteria in the observation group was 92.30%，which was higher than 82.26%in the the control group，with significant difference （P＜0.05）.The satisfaction degree of the observation group was 96.36%，which was higher than 83.63%of the control group，with significant difference （P＜0.05）.Conclusion The effect of Cefaclor Sustained-Release Capsules in the treatment of acute bacterial infection of the upper respiratory tract is significant，it is worthy of clinical promotion and application.
2016 Vol. 23 (29): 114-116 [
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Ilaprazole combined with M osapride in the treatment of reflux esophagitis in 80 cases
XU Lin-fang;LIAOWen
Objective To explore the clinical effect of Ilaprazole combined with Mosapride in the treatment of reflux esophagitis. Methods 80 cases of reflux esophagitis from December 2015 to June 2016 in our hospitalwere selected as the observation group，and who were treated with Ilaprazole combined with and Mosapride.80 cases of reflux esophagitis in the same period in our hospitalwere selected as the control group，and who were treated with Omeprazole combined with Mosapride.The treatment effect in the two groupswas compared.Results The total effective rate of the observation group was 97.5%，which was higher than 85.0%of the control group，with significant difference （P＜0.05）.The symptoms score of retrosternal burning sensation，acid regurgitation，chest pain and others after treatment in the two groups was lower than that before treatment，with significant difference （P＜0.05）.The symptoms score of retrosternal burning sensation，acid regurgitation，chest pain and others after treatment in the observation group was lower than that in the control group after treatment，with significant difference （P＜0.05）.The symptom relief time of retrosternal burning sensation，acid regurgitation，chest pain and others in the observation group was shorter than that in the control group，with significant difference （P＜0.05）.The complications of the two groups did not affect the treatment，all patients were recovered，with high safety.Conclusion Ilaprazole combined with Mosapride in the treatment of reflux esophagitis has exact clinical effect，which can promote the recovery of patients，with significant clinical application value.
2016 Vol. 23 (29): 117-119 [
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Clinical observation of different doses of Com pound G lycyrrhizin G lucoside in combination with Lam ivudine in the treatment of chronic hepatitis B viral hepatitis
MAO Hua-yun
Objective To explore the clinical effect of different doses of Compound Glycyrrhizin Glucoside in combination with Lamivudine in the treatment of chronic hepatitis B viral hepatitis. Methods 150 patientswith chronic hepatitis B viral hepatitis in our hospital from January 2013 to December 2015 were selected and randomly divided into group A，group B and group C，50 cases in each group.All patientswere treated with Lamivudine，group A was treated with 40ml Compound Glycyrrhizin Glucoside at the same time，while group B was treated with 60ml Compound Glycyrrhizin Glucoside at the same time，group C was treated with 80ml Compound Glycyrrhizin Glucoside at the same time.The therapeutic effect was compared between the three groups.Results The symptoms and signs improvement rate of liver discomfort，fatigue，loss of appetite，hepatomegaly after treatment and the incidence rate of adverse reaction in group C was higher than that in group A and group B，the symptoms and signs improvement rate of liver discomfort，fatigue，loss of appetite，hepatomegaly after treatment and the incidence rate of adverse reaction in group B was higher than that in group A，with significant difference （P＜0.05）.The level of TBil，AST，ALT after treatment in group C was lower than that in group A and group B，the level of TBil，AST，ALT after treatment in group B was lower than that in group A，with significant difference （P＜0.05）.The level of CG，PCⅢ，HA after treatment in group C was lower than that in group A and group B，the level of CG，PCⅢ，HA after treatment in group B was lower than that in group A，with significant difference （P＜0.05）.There was no significant difference in the negative conversion rate of HBV DNA，HBeAg among the three groups （P＞0.05）.Conclusion Patients with chronic hepatitis B viral hepatitis treated with Lamivudine combined with high dose of Compound Glycyrrhizin Glucoside，which can help to improve the patient′s liver function，reduce clinical symptoms and signs，with the higher clinical application value.
2016 Vol. 23 (29): 120-122转137 [
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Effect observation of Honghuaruyi Pills in the treatment of chronic pelvic pain
FENG Xiao-xia
Objective To explore the clinical effect of Honghuaruyi Pills on chronic pelvic pain. Methods 48 patients with chronic pelvic pain in the outpatients of our hospital from August 2015 to April 2016 by using a random number table were divided into treatment group and control group，with 24 cases in each group.Patients in the treatment group were treated with Honghuaruyi Pills，Po Gongyanping Capsules in the control group，and the clinical effect of two groups was evaluated after 2months.Results The effective rate in the treatment group was 87.5%（21/24），83.3%（20/24）in the control group，and the difference was not statistically significant（P＞0.05）.Before treatment，VAS score in the treatment group was comparable with that in the control group，and the difference was not statistically significant（P＞0.05）；after treatment，VASscore in two groupswas significantly lower than that before treatment，and the difference was statistically significant（P＜0.05）；VAS score in the treatment group after treatmentwas significantly lower than that in the control group，and the difference was statistically significant（P＜0.05）.Conclusion The clinical value of Honghuaruyi Pills in treating chronic pelvic pain is determined，and the analgesic effect is better than that of Gongyanping Capsules.
2016 Vol. 23 (29): 123-125 [
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Clinical observation of tim ing of moxibustion combined with Baoshen Decoction in patientswith chronic renal failure
WANG Yong-fang;LIAO Guo-qiong;OUYANGWei-jun
Objective To observe the clinical effects of timing ofmoxibustion combined with kidney preserving decoction in patientswith chronic renal failure. Methods 48 patientswith chronic renal failure（yang deficiency of spleen and kidney）in nephrology department of our hospital from October 2014 to June 2015 were selected and divided into control group（n=22）and treatment group（n=26）by random number table.Pateints in two groupswere treated with Western medicine as basic treatment，patients in treatment group were added Baoshen Decoction and timing ofmoxibustion.The prescription of Baoshen Decoction included Chinese rhubarb 10 g，Astragalusmembranaceus 30 g，Salviamiltiorrhiza 20 g and Zhishi 10 g.At the time of 9：00-11：00 and 17：00-19：00，Xuanshu，Mingmen，double Zusanli，double Shenshu and double Pishu were cauterized respectively and every moxibustion with 5 minutes.After treatment for 30 days，the improvement level of urine protein and creatinine and effects of two groups were compared.Results The level 24 h urine protein and serum creatinine in treatment group were better than those in control group（P＜0.05）；the total effective rate in treatment group was 88.46%，higher than 50.00%in the control group，and the difference was statistically significant （P＜0.05）.Conclusion Timing ofmoxibustion combined with Baoshen Decoction can protect kidney and delay renal function.
2016 Vol. 23 (29): 126-128 [
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Clinical effects on combination of traditional Chinese and W estern medicine in treating diabetes combined with fundus hemorrhage
GUWen-yi
Objective To explore the clinical effects on combination of traditional Chinese and Western medicine in treating diabetes combined with fundus hemorrhage. Methods 200 diabetic combined with fundus hemorrhage patients from January 2013 to December 2015 of our hospitalwere selected as study object.Patientswere randomly divided into observation group and control group，and each group was 100 cases.Patients in observation group were used combination of traditional Chinese and Western medicine，and patients in control group were used simple Western medicine.The clinical effects of patients between two groups were compared.Results The traditional Chinese medicine symptom between two groups before treatment had no statistical significance（P＞0.05）.After treatment，the traditional Chinese medicine symptom score in observation group was obvious lower than that of control group，and the difference was sta tistically significant（P＜0.05）.The vision between two groups before treatment had no statistical significance（P＞0.05）.After treatment，the vision in observation group was obvious better than thatof control group，and the differencewas statistically significant（P＜0.05）.The total effective rate in observation group was 84.0%，obvious better than thatwas 63.0%in con trol group，and the difference was statistically significant（P＜0.05）.Conclusion Combination of traditional Chinese and Western medicine in treating diabetes combined with fundus hemorrhage can enhance the clinical effects effective and isworth to popularize.
2016 Vol. 23 (29): 129-131 [
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The clinical effect on combination of traditional Chinese and W estern medicine in the treatment of knee osteoarthritis
ZHOU Shui-li
Objective To investigate the clinical effect on combination of traditional Chinese and Western medicine in the treatment of knee osteoarthritis. Methods 50 cases of knee osteoarthritis patients from September 2013 to September 2015 in our hospitalwere divided into treatment group（n=25）and control group（n=25）according to the random number tablemethod.Patients in the control group were treated with routine western medicine therapy，and the treatment group were treated with combination of Chinese and Western traditional medicine.The VAS score and lower limb function score of all cases were observed before and after treatment，and adverse reaction of the patients were observed.Results After treatment，the VAS score of the treatment group was lower than that of the control group，and the lower limb function scorewas higher than that of the control group，and the difference was statistically significant（P＜0.05）.In the treatment group，the effective rate（96.0%）was significantly higher than that of the control group（76.0%），and the difference was statistically significant（P＜0.05）.No adverse reactionswere found between the two groups during the treatment，and the treatment was well tolerated.Conclusion The clinical curative effect of the combination of Chinese and Western traditionalmedicine in the treatment of knee osteoarthritis is remarkable，which can reduce the clinical symptoms，improve joint function，and improve the quality of life of patients.
2016 Vol. 23 (29): 132-134 [
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App lication of multi frequency vibration therapeutic apparatus in the treatment of children with bronchial pneumonia
ZENG Li-ying
Objective To explore the application effect ofmulti frequency vibration therapy instrument in the treatment of children bronchial pneumonia. Methods 96 cases of children with bronchial pneumonia from June 2014 to June 2015 in our hospitalwere selected，and were randomly divided into two groups，48 cases in each group.Patients in the control group were given routine treatment，and the observation group was treated with multi frequency vibration therapy on the basis of conventional treatment.The clinical treatment effect of the two groups was compared.Results The cure rate of observation group was 93.75%，higher than 64.58%in the control group，with statistical difference（P＜0.05）.The suction interval of observation group was significantly longer than that of the control group，and the hospitalization time was shorter than that of control group the difference was statistically significant（P＜0.05）；the blood oxygen reduction times of observation group was less than that of the control group，the difference was statistically significant（P＜0.05）；the amount of expectoration of observation group was significantly less than that of the control group，the difference was statistically significant（P＜0.05）.Conclusion Multi frequency vibration treatment instrument in the treatment of children with bronchial pneumonia has significant effect，can effectively improve the lung function of patients，it is worth to adopt in clinical application.
2016 Vol. 23 (29): 135-137 [
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Effect analysis of Salvia m iltiorrhiza injection in the treatment of acute cerebral infarction
ZHU Qiu-yan
Objective To analyze the clinical effect of Salvia miltiorrhiza injection in the treatment of acute cerebral infarction. Methods 50 cases of cerebral infarction treated in our hospital from January 2013 to June 2014 were treated with anti platelet，intensive lipid lowering，improvement of cerebral circulation and other conventionalmethods were selected as the control group；50 patients with cerebral infarction were selected from the same period combined with Salvia miltiorrhiza injection in the treatment of hydrochloric acid polyphenols in the conventionalmethods based on the treatment of the patients in the control group.The therapeutic effect，adverse reactions and the two groups before and after treatment in patientswith the NIHSS score，C-reactive protein（CRP），tumor necrosis factor-α（TNF-α），red blood cell aggregation index of two groupswere compared.Results The treatment efficiency of the observation group （96.0%）was higher than that of the control group（76.0%），the incidence of adverse reaction（4.0%）was lower than that of the control group （24.0%），the difference was statistically significant（P＜0.05）.Before treatment，the NIHSS score，CRP，TNF-α，erythrocyte aggregation index of the two groups had no statistical difference （P＞0.05）；after treatment，the NIHSS score，CRP，TNF-α，red blood cell aggregation index of two groups were better than that of before treatment and observation group was better than control group（P＜0.01）.Conclusion Salvia miltiorrhiza injection in the treatment of acute cerebral infarction has a significant effect，can effectively improve the patients′hemodynamics，reduce the inflammatory reaction，and adverse reaction is low，can be popularized in clinic.
2016 Vol. 23 (29): 138-140 [
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Analysis the characteristicsof 28medical dispute cases——ShanxiProvince as an example
LIU Hu-zi;ZHANG Xin
Objective To understand the characteristics ofmedical dispute prosecution cases in Shanxi province，and to provide reference for the prevention ofmedical disputes，protection of the rights and interests of patients and medical personnel. Methods 28 cases（from January 2012 to April 2016）related to this study of Chinese referee instruments net were collected and arranged by comprehensive using literature analysis and statisticalmethods.Reasons for the prosecution ofmedical institutions，fault participation degree and amount of compensation were focus analyzed.Results Cases of medical disputes in Shanxi province mainly occurred in Taiyuan and the southern part of Shanxi province；the higher level ofmedical institutions，the lower fault degree of participation in the case，the higher amount of compensation and the longer time the decision to prosecute；themainly reason that Two grade hospitalswere being sued was themisdiagnosis，while mainly reason that Three grade hospitals were being sued was inadequate treatment；compensation for patients with death as the outcome weremore than those with disability.Conclusion Two grade hospitals should improve the professional skills ofmedical personnel through training and Three grade hospitals through summary experience，developing plan to dealwith the protection to protect the patients′health right and preventmedical disputes.
2016 Vol. 23 (29): 141-143 [
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Investigation of Legionella pneumophila detection and infection from different types of sam p les in pneumonia patients in Shenzhen
ZHOU Guo-hong;YU Shu-yuan;PENG Chao-qiong;FANG Dao-kui;FENG Jin-shu
Objective To investigate the infection levels of Legionella pneumophila in pneumonia patients and the detection rate of Legionella pneumophila infection from different types of samples in pneumonia patients in Shenzhen comprehensive hospitals. Methods From April to June in 2013，the sputum，urine，and serum from 81 hospitalized pneumonia patients from 3 large scale comprehensive hospitals in Shenzhen were collected.The Legionella pneumophila in sputum was detected by Chao′s PCR，and antigen of Legionella pneumophila in urine and antibody of Legionella pneumophila in serum were detected by enzyme linked immunosorbent assay.Results The positive rates of Legionella pneumophila in sputum，Legionella pneumophila antigen in urine，and Legionella pneumophila antibody in serum were 5.9% （3/51），12.1%（8/66），and 22.8%（18/79）respectively.The infection rate of Legionella pneumophila in pneumonia patients in Shenzhen comprehensive hospitalswas 32.1%（26/81）.Conclusion The infection rate in patients suffering from pneumonia in Shenzhen comprehensive hospital is high and different types of samples come out of different detection rates of Legionella pneumophila infection.
2016 Vol. 23 (29): 144-146 [
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Analysis of catheter-associated infections in ICU patients
WU Xiao-ying;SONGMin
Objective To explore the characteristics of nosocomial infection in patients with indwelling catheter in ICU and to provide evidence for the prevention and control measures through the analysis of the surveillance data of catheter-associated infections in the ICU patients. Methods The incidence of catheter related infections in hospitalized patientsweremonitored by collecting from January 2013 to December 2015.Results The nosocomial infections occurred in 269 of 2855 patientswith the infection rate of 9.42%and daily infection rate was 27.83‰；there were 174（64.88%）patientswith catheter-associated infections；the incidences of ventilator-associated pneumonia，venous catheter-associated bloodstream and urinary catheter-associated urinary tractwas 26.66‰，3.06‰，3.22‰；the annual trend of chi square test of 3 kinds of catheter related infection rate of infection of the day，the difference was statistically significant（P＜0.05）.Gram negative bacteria were themain pathogens of nosocomial infection，and the detection rate of Acinetobacter baumannii was the highest.Conclusion Catheter-associated infection is themain type of nosocomial infection in ICU，and the incidence of ventilator associated pneumonia is the highest.
2016 Vol. 23 (29): 147-149 [
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App lication effects analysis of medical-fam ily contract service system in fam ily chronic diseasemanagementmode
ZHU Li-fang1CHEN Yan-mei2
Objective To explore the application effects of medical-family contract service system in family chronic diseasemanagementmode. Methods 400 cases with single chronic disease in four neighborhood committees were randomly selected from February 2014 to February 2016 of 12 neighborhood committees in Liwan District Fengyuan Street，patientswith single hypertension or diabeteswas 200 cases respectively.Patientswith hypertension were divided into A and B group，and patients with diabetes were divided into C and D group，and each group was 100 cases.Patients in A and C group were divided into intervention group and were given chronic diseasemanagement and family chronic diseasesmanagement ofmedical-family contract service system；patients in B and D group were divided into control group and were given general chronic diseasemanagement.Selfmanagement ability and health status score between intervention group and control group were analyzed and compared.Results Understanding of hypertension related knowledge，compliance with antihypertensive drugs and rate of change in family behavior in A group was respectively 100%，85% and 96%，obviously higher than respectively 94%，67%and 93%in B group，and the difference was statistically significant（P＜0.05）；understanding of diabetes related knowledge，compliance with antidiabetic drugs and rate of change in family behavior in C group was respectively 99%，87%and 97%，obviously higher than respectively 92%，72%and 93% in D group，and the difference was statistically significant（P＜0.05）；the health status，self efficacy and management behavior score in the intervention group were obviously higher than those in the control group，and the difference was statistically significant（P＜0.05）.Conclusion Medical-family contract service system can improve patients′physical condition obviously and enhance the effects of family chronic diseasemanagement effectively.
2016 Vol. 23 (29): 150-152 [
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Discussion on the humanistic nursing mode in the nursing management of ophthalm ic clinic
WANG Fang
Objective To explore the application effect of humanized nursing mode in the nursing management of ophthalmic clinic. Methods 200 patients in our hospital from May to December 2015 were selected as the research object and randomly divided into observation group and control group according to the different nursingmanagement methods，each group of 100 cases.The observation group was given humanistic nursing interventionmode，and the control group was given routine nursing intervention.The clinical nursing intervention effect of two groups were compared. Results The satisfaction rate of patients and their families in the observation group was 100%，83%in the control group，and the difference was statistically significant（P＜0.01）.In addition，quality score of nursing work and the incidence of medical dispute in the observation group also were significantly better than those in the control group （P＜0.05）. Conclusion Implementation of humanistic nursing mode in the ophthalmic outpatient nursing management work can significantly improve patients′satisfaction rate，reduce the incidence of medical disputes and improve the quality of nursing work，it isworth promoting.
2016 Vol. 23 (29): 153-155 [
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Clinical application of the map of surgical instruments in the training of nurses in operation room
PAN Run-mei
Objective To explore clinical application of themap of surgical instruments in the training of nurses in operation room. Methods From April 2015 to April 2016，30 nurses in operation room were studied and divided into experimental group （15 persons）and control group （15 persons）according to the trainingmethods.Nurses in operation room in the control group （from April to September 2015）without the use of training instrument，intrumentwere set up according to their own personal habits，without any intervention；nurses in operation room in the experimental group（from October 2015 to April 2016）were trained in the use of surgical instruments.Using time of operation room nurses learning and mastering all surgical instruments set and evaluation qualified rate of surgical instruments set were observed between two groups，and evaluation of surgical doctors on instrument nurses between two groupswas understand.Results Nurses operating result and evaluation result in experimental group was（95.3±1.21）points，（96.7±1.47）points respectively，higher than （91.2±2.67）points，（91.0±2.05）points in the control group，and the difference was statistically significant（P＜0.05）.Conclusion The application of surgical instruments setmap training can effectively improve the quality of the operation of the instrument nurses.
2016 Vol. 23 (29): 156-158 [
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Evaluation of effect of neonatal asphyxia resuscitation technique training for specialist training base students
SUIShuang;HUANG Ying;DU Peng
Objective To evaluate the necessity and effect of neonatal asphyxia resuscitation technique training for specialist training base students. Methods 55 students in specialist training base including gynecology，obstetrics，neonatology，pediatric，anesthesiology department from August 2009 to August 2013 were centrally trained in accordance with the formerministry of health of newborn asphyxia resuscitation training course requirements and had the theory test and comprehensive simulation test，the theory test result and the examination pass rate of the students in different department were compared before and after training.Results Training improved neonatal asphyxia resuscitation knowledge and skills of students，the totalmean score before training was（60.1±1.7），the totalmean score after training was （95.4±2.3），there was significant difference before and after training （P＜0.05）；after training，general examination qualified rate was 87.3%，the highest qualified rate was 100%for the newborn Pediatrics Department，the lowest was 70%for anesthesiology department.Conclusion neonatal asphyxia resuscitation technique training for Specialist training base students is necessary and significantly effective.
2016 Vol. 23 (29): 159-161转165 [
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Study on digital innovation teaching mode of Identification of traditional Chinesemedicine
GONG Li-min;LUO Huai-hao;ZENG Xiao-yan;LIU Ta-si;XIAO Bing-mei;PAN Qing-ping
To promote active and collaborative，research-based learning，and better cultivate students′innovation and practical ability，writer has conducted the research on new digital innovative learning mode of Identification of traditional Chinese medicine，to form an open and efficient new teaching mode and to improve the professional education quality of Chinesemedicine.In addition，writer takes information technology as the cognitive tool for learning Identification of traditional Chinese medicine，and also draws on some successful exploratory modes of universities at home and abroad in recent years，such as L-from IT——"situation-inquiry"mode and L-with IT——“resource utilization-subjectmatter inquiry-cooperation learning"mode.According to the characteristics of this subject，which puts much emphasis on the students′experimental operation，phenomenon observation and scientific analysis，the paper builds digital innovative teaching mode of Identification of traditional Chinese medicine based on"situation-inquiry"mode and supplemented by"Chinesemedicinalmaterialsmarket-special inquiry-cooperative learning"mode.
2016 Vol. 23 (29): 162-165 [
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Clinical application of clinical nursing path in advanced schistosom iasis splenomegaly standardized management of patientswith type
SHEN Hai-xiang
Objective To investigate the clinical effect of clinical nursing path in patientswith advanced schistosomiasis splenomegaly standardizedmanagement. Methods 52 patientswith giant spleen type advanced schistosomiasis from May 2012 to October 2015 as object of study，according to differentways of care，they were divided into two groups.The control group（26 cases）was given routine care，the observation group（26 cases）was given the application of clinical nursing path，clinical efficacy and nursing satisfaction were compared.Results The cost of hospitalization of patients in the observation group，bed time，exhaust time，length of hospital stay was significantly shorter than that of control group （P＜0.05）；postoperative complicationsofobserved group had 2 cases（7.69%）less than thatof controlgroup of9 cases（34.62%），and patient satisfaction of observation group was 100.00%，higher than 80.77%of control group，the difference was significant（P＜0.05）.Conclusion Application of clinical nursing path，the clinical efficacy of advanced schistosomiasis patients with splenomegaly has significantly improved，and significant reduction in complications，patient′satisfaction has improved significantly.
2016 Vol. 23 (29): 166-168 [
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Effect of puerperal nutrition and health education on postpartum pecovery of parturients
LIBo;HU Shao-na;QIU Cai-xia;HUANG Hui-fen
Objective To investigate the effect of puerperal nutrition and health education on postpartum pecovery of parturients. Methods A total of 210 cases of parturients in our hospital from January 2015 to April 2016 were selected by random sampling method，all were randomly divided into observation group and control group，105 cases in each group.The control group was received routine nursing intervention in puerperium，the observation group was received nutrition and health education on the basis of routine nursing.The fundal height，lochia discharge amount，lactation amount at 5 days postpartum，the prevalence of postpartum between the two groupswere compared.Results The postpartum fundal height in observation group was significantly lower than that of control group，the lochia discharge amount was significantly less than that of control group，the lactation amount was significantly more than than that of control group，the differences were statistically significant（P＜0.05）.The prevalence of postpartum such as postpartum depression，breast pain and infection in observation group was significantly lower than that of control group（P＜0.05）.Conclusion The reasonable puerperal nutrition and health education can improve the puerperal knowledge of parturients，promote the postpartum pecovery and reduce the prevalence of postpartum，it isworthy to be popularized in clinical application.
2016 Vol. 23 (29): 169-171 [
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Analysis of the role of meticulous care in im proving the psychological state of patientswith depression
WU Lian-xia
Objective To explore detailed nursing treatment efficacy in patients with depression and the impact of psychological state. Methods 48 cases of depression from May 2015 to May 2016 in our hospital were selected，and were randomly divided into control group and observation group，24 cases in each group，the patients in the control group were given routine nursing care of depression，observation group on the basis of routine nursing was given careful nursing，two groups of patientswith therapeutic effectwere compared.Results Nursing care of two groups before the Hamilton Depression Scale （HAMD）scores，self-efficacy induction scale （GSES）score and social disability screening scale （SDSS）score had no significant difference （P＞0.05）；after nursing of two groups of patientswith HAMD score，the score of GSES and SDSSwere better than before，and the observation group was better than that of control group，the difference was significant（P＜0.05）.After nursing，treatment effect of observation group was better than that of control group，the difference between the two groups had statistical significance（P＜0.05）.Conclusion Meticulous care for patients with mental depression，self-efficacy induction has significant improvement effect，it can improve the treatment effect，and should be popularized in clinical.
2016 Vol. 23 (29): 172-174 [
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Effect of characteristic chinese traditional medicine nursing intervention on aged bronchial asthma rem ission
ZOU Fang;TAO Nan-juan
Objective To explore the curative effect of characteristic chinese traditionalmedicine nursing intervention on aged bronchial asthma remission. Methods 81 patients with bronchial asthma remission from March 2012 to December 2015 in our hospital were selected as object of study，and were randomly divided into two groups.All the patientswere treated with Budesonide from mott powder inhaler therapy according to the guide，while the control group （n=40）were accepted routine nursing intervention in additon，and the observation group（n=41）were cured with characteristic chinese traditional medicine nursing intervention in addtion.Forced expiratory volume in one second （PEV1），peak expiratory flow （PEF），etc，which the indices of lung function，asthma control test scale （ACT）scores and asthma quality of life （AQLQ），CD4+T，CD4+/CD8+T and CD8+T were compared.Nursing satisfaction and clinical curative effects of two groups were compared.Results After 3 months for treatment，scores of PEV1，PEF，ACT，and AQLQ of the control group were increased，while those of the observation group were improved more significantly（P＜0.05）.CD4+T，CD4+/CD8+T and CD8+T levels of the control group had no significant change，while CD4+T，CD4+/CD8+T of the observation group had increased，with the CD8+T was lower（P＜0.05）.The total satisfaction rate and total effective rate of the observation group was higher than that of control group（P＜0.05）.Conclusion The curative effect of the characteristic chinese traditionalmedicine nursing intervention on elderly bronchial asthma remission is significant，which can better improve the function of pulmonary and immune，it isworth promoting.
2016 Vol. 23 (29): 175-178 [
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Standardized nursing to im prove the quality of life in patients with pain enhance the effect of selfmanagement efficiency
YUWei-bing;WU Chun-feng
Objective To explore the standardization of care to improve the quality of life in patients with pain and enhance the effect of selfmanagement efficiency. Methods 60 patients from February 2015 to March 2016 in our hospital were selected as the research object，according to random number tablemethod，they were divided into control group and observation group respectively，30 cases in each group，the control group was given only routine nursing，the observation group was given standardized pain nursing intervention.The intervention effect of two groupswas compared.Results Before nursing intervention，NRS score of two groups patients had no statisticant differences （P＞0.05）；after nursing intervention，two groups ofmoderate and severe pain caseswere falled，after the intervention，the self-efficacy score and quality of life score of two groupswere improved significantly.The quality of life score of observation group was higher than that of control group，with the singinificant difference （P＜0.05）.Conclusion The standardized nursing intervention can effectively reduce the body pain，improve patients quality of life.
2016 Vol. 23 (29): 179-181 [
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Influence ofextended care in self-efficacy and com p liance of patients with coronary heart disease
FU Hong-ling
Objective To investigate the influence of extended care in self-efficacy and compliance in patients with coronary heart disease. Methods 116 patients with coronary heart disease in our hospital were selected from January 2014 to May 2015 and randomly divided into two groups，each group had 58 cases.The control group was received routine discharge guidance，the study group was received
extended care on the basis ofthe conventional discharge guidance，the self-efficacy and treatment compliance rates of two groupswere compared.Results After intervention 3 months and 6months，GSES score of the study group were higher than that of control group，there was significant difference between two groups（P＜0.05）；Themedication compliance，reasonable rest，time to review，proper diet，smoking and drinking，reasonable exercise，prevention of infection and total scores of the study group was significant higher than that of control group on the same period，there was significant difference between two groups（P＜0.05）.Conclusion Coronary heart disease patients after extended care can significantly improve the efficacy of self and compliance.
2016 Vol. 23 (29): 182-184 [
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Influence of nursing intervention on life quality of patients with artificial anus after rectal cancer surgery
JIANG Zhi-yu
Objective To investigate influence of nursing intervention on life quality of patientswith artificial anus after rectal cancer surgery. Methods 118 patientswith artificial anus after rectal cancer surgery from October 2011 to October 2014 were divided into two groups by nursing program.59 patients were treated conventional nursing as control group，59 patientswere treated nursing intervention as observation group.Before nursing and discharge 3months，psychological status and life quality were compared between two groups，recovery and complications in two groups were analyzed.Results Discharge 3 months in two groups，HAMA score and HAMD score significantly decreased （P＜0.01），life quality scores（physiological function，overall health，physiological competency，activity，mental health，physical pain，social function，emotional function）significantly increased（P＜0.01）.Hospitalization time in observation groupwas significantly less than that of control group （P＜0.01）.HAMA score，HAMD score，stoma stenosis rate，postoperative diarrhea rate in observation group was significantly lower than that of control group（P＜0.05）.Life quality scores（physiological function，overall health，physiological competency，activity，mental health，physical pain，social function，emotional function），correct usage rate ofanusbag in observation group wassignificantly higher than thatof controlgroup （P＜0.01）.Conclusion Nursing intervention can significantly improve life quality of patientswith artificial anus after rectal cancer surgery.
2016 Vol. 23 (29): 185-187转191 [
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Analyze the effect of W eChat continue nursing im prove on im p lant denture self-maintenance
LV Yan;WANGMei;LIRu
Objective To explore the effect ofWeChat continue nursing improve on implant denture self-maintenance. Methods 122 patients with implant denture from January to December 2015 were divided into experimental group and control group，according to random number table，each group had 61 people.The control group was adopted traditional general nursingmodel，while the experimental group was adopted WeChat continue nursing based on the general nursing model，the performance of two group was analyzed and compared.Results The difference between two groups had no statistical significance on the implant day（P＞0.05），including health education and bacterial plaque index.After onemonth，the experimental group was better than that of control group on health education and bacterial plaque，with statistical significant difference （P＜0.05）.Conclusion WeChat continue nursing could improve implant denture self-maintenance and keep the oral plant in long-time function.Meanwhile，it improves nurses′ability on study and communication，turns continue nursing into reality and increases nursing efficiency.
2016 Vol. 23 (29): 188-191 [
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The influence of treatment effect of com prehensive nursing care on infantile bronchitis
YUAN Xue-mei
Objective To explore the influence of treatment effect of comprehensive nursing care on infantile bronchitis. Methods 100 patients of bronchitis from June 2014 to June 2016 in our hospital for clinical treatmentwere selected as the research object，according to random number tablemethod were divided into two groups，each group has 50 cases respectively，two groups bronchitis children were given conventional clinical treatment，and the control group children were given routine nursing care，the research group children were given comprehensive care，nursing care satisfaction effect and the parents of the patients of the two groups bronchitis children were compared.Results The average time for body temperature back to normal of the research group children was （1.47±0.23）d，compared to the control group children（3.62±0.65）d，with the significant difference（P＜0.05），the clinical total effective rate of the research group children was 96.00%，compared to the control group（84.00%），with the significant difference（P＜0.05），the parents nursing satisfaction of the research group children was 94.00%，compared to the control group （82.00%），with the significant difference（P＜0.05）.Conclusion The effect of children with bronchitis implement comprehensive nursing on the basis of conventional treatment is good，it can help the patient′s body temperature back to normal，and parents care satisfaction is higher.
2016 Vol. 23 (29): 192-194 [
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Observation on the clinical effect of nursing intervention in the treatment of schizophrenia with Ziprasidone
XU Mei-juan
Objective To explore Ziprasidone treatment of schizophrenia and nursing adverse effects. Methods 80 patients with schizophrenia from March 2014 to March 2015 in our hospital were treated，according to double-blind method were divided into two groups，the control group was received
Ziprasidone for treatment，the observation group was received nursing intervention，efficiency，satisfaction and adverse eventswere observed.Results The efficient of observation group was higher than that of control group，the difference was significant（P＜0.01）；degree of satisfaction of observation group was better than that of control group，the difference was significant（P＜0.05）；the reactions incidence of control group was significantly higher than that of observation group，the difference was significant（P＜0.05）.Conclusion Ziprasidone combined nursing intervention in the treatment of schizophrenia，the clinical effect is better，not only can improve treatment efficiency and satisfaction，but also reduce the incidence of adverse reactions in patients，it has important clinical value.
2016 Vol. 23 (29): 195-封面 [
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