Abstract：Objective To explore the application value of ultrasound-guided thoracic wall nerve block in modified radical mastectomy for breast cancer. Methods A total of 80 patients underwent modified radical mastectomy for breast cancer under general anesthesia and endotracheal intubation in Dalian Central Hospital from June 2019 to April 2020 were selected as the research subjects. They were divided into an observation group (40 cases) and a control group(40 cases) according to the random number table method. The observation group received ultrasound-guided thoracic wall nerve block, and the control group received ultrasound-guided thoracic paravertebral nerve block. The relative indexes of anesthesia resuscitation, subjective and objective indexes of anesthesia resuscitation and analgesic effect within 48 hours after anesthesia were compared between the two groups. Results The recovery time of breathing,consciousness and tracheal catheter removal time were shorter in the observation group than those in the control group,the differences were statistically significant (P<0.05). When they woke up from anesthesia, the numerical rating score(NRS) of the observation group was lower than that of the control group, and the serum levels of substance P (SP) and serum neuropeptide (NPY) were lower than those of the control group, the differences were statistically significant (P<0.05). In the observation group, the frequency of additional pressure on postoperative analgesia pump was less than that in the control group, and the interval of additional pressure was longer than that in the control group, the differences were statistically significant (P<0.05). Conclusion For breast cancer patients undergoing modified radical mastectomy,the application of ultrasound -guided thoracic wall nerve block can provide definite analgesic effects, reduce postoperative opioid dosage, and improve the quality of resuscitation after anesthesia.
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