强的松、硫唑嘌呤联合乙酰半胱氨酸治疗特发性间质性肺炎的效果

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摘要目的探讨特发性间质性肺炎患者给予强的松、硫唑嘌呤联合乙酰半胱氨酸进行治疗的临床效果。方法选取2012年12月～2017年12月于我院接受治疗的62例特发性间质性肺炎患者作为研究对象，按照随机数字表法将其分为对照组和观察组，每组各31例。对照组患者给予强的松、硫唑嘌呤进行治疗，观察组患者在对照组的基础上加用乙酰半氨酸治疗。比较两组患者的临床疗效、治疗前后肺功能指标[肺活量（VC）、第1秒用力呼气容积占用力肺活量比值（FEV1/FVC）及弥散系数（DICO）]，并记录两组治疗期间的不良反应发生情况。结果观察组患者的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。两组患者治疗前的肺功能指标水平比较，差异无统计学意义（P＞0.05）；两组患者治疗后的VC、FEV1/FVC及DICO 均高于本组治疗前，且观察组治疗后的VC、FEV1/FVC及DICO 均高于对照组，差异有统计学意义（P＜0.05）。两组患者均未发生明显的不良反应。结论对特发性间质性肺炎患者实施强的松、硫唑嘌呤联合乙酰半胱氨酸治疗的临床效果优于使用强的松、硫唑嘌呤治疗，可以改善患者的肺功能指标，且安全性较为可靠。

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	季尚明

关键词 ：特发性间质性肺炎, 强的松, 硫唑嘌呤, 乙酰半胱氨酸, 肺功能

Abstract：Objective To investigate the clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia.Methods A total of 62 patients with idiopathic interstitial pneumonia who were treated in our hospital from December 2012 to December 2017 were selected as the research subjects.They were divided into the control group and the observation group according to the random number table method,with 31 cases in each group.The control group was treated with Prednisone and Azathioprine,patients in the observation group were treated with Acetylcysteine on the basis of the control group.The clinical efficacy and pulmonary function indicators (vital capacity [VC],forced expiratory volume in one second occupying forced vital capacity[FEV1/FVC]and dispersion coefficient [DICO]) before and after treatment were compared in the two groups.The incidence of adverse reactions during the treatment of the two groups was recorded.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in the pulmonary function indicators between the two groups before treatment (P＞0.05).The VC,FEV1/FVC and DICO after treatment in the two groups were higher than those before treatment,and the VC,FEV1/FVC and DICO in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).No significant adverse reactions occurred in the two groups of patients.Conclusion The clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia is better than that of Prednisone and Azathioprine,and it can improve the pulmonary function indicators of patients,with reliable safety.

Key words： Idiopathic interstitial pneumonia Prednisone Azathioprine Acetylcysteine Pulmonary function

引用本文:

季尚明. 强的松、硫唑嘌呤联合乙酰半胱氨酸治疗特发性间质性肺炎的效果[J]. 中国当代医药, 2020, 27(5): 37-39.
JI Shang-ming. Effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of idiopathic interstitial pneumonia. 中国当代医药, 2020, 27(5): 37-39.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I5/37

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