Abstract：Objective To explore the application effects of midazolam and propofol in the critical patients receiving mechanical ventilation in emergency.Methods 79 critical patients receiving mechanical ventilation in emergency who were admitted to the emergency department in our hospital from May 2014 to May 2015 were selected.They were assigned to the control group （n=39）and the observation group （n=40）according to the hospitalization order.The control group was given midazolam for sedation，and the observation group was given propofol for sedation.General vital sign changes，drug action time and adverse reactions were compared between the two groups of patients.Results 30 min after drug withdrawal，HR，BP，and PaCO2in the observation group were lower than those of control group，and PaO2was higher than that of control group （P＜0.05）.The best time of sedative effect，drug action time，and awakening time after drug administration in the observation group were significantly shorter than those of control group （P＜0.05）.The incidence rate of adverse reactions was 2.5%in the observation group，significantly lower than that of 15.4%in the control group （P＜0.05）.Conclusion Propofol has favorable sedative effects in critical patients receiving mechanical ventilation in emergency，with the characteristics of fast action，and short awakening time after drug withdrawal.However，it has larger inhibiting effects on respiration and blood circulation，but it is highly safe.Sedative drugs should be selected in combination with the specific conditions of the patients clinically.
陈健. 咪达唑仑与丙泊酚在急诊危重症机械通气患者中的应用效果分析[J]. 中国当代医药, 2016, 23(10): 147-149.
CHEN Jian. Analysis of application effects of midazolam and propofol in the critical patients receiving mechanical ventilation in emergency. 中国当代医药, 2016, 23(10): 147-149.
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