Abstract：Objective To study the sedative effect of Dexmedetomidine Hydrochloride or Midazolam in mechanical ventilation.Methods 60 patients with mechanical ventilation from June 1,2016 to May 31,2017 treated in our hospital were selected and they were divided into the two group in random by computer and there were 30 cases in each group.Patients in the control group were given Midazolam,while patients in the observation group were given Dexmedetomidine Hydrochloride.The sedative effect,time to take sedation,awakening time after drug discontinuance,mechanical ventilation time,extubation time after drug discontinuance,hospital stay,related indexes,occurrence of adverse reaction were compared in patients between the two groups.Results After sedation,Ramsay score in patients of the observation group was lower than that of the control group,and time to take sedation,awakening time after drug discontinuance,extubation time after drug discontinuance,and hospital stay were shorter than those in the control group (P<0.05).The blood pressure,heart rate,and respiratory frequency after sedation were not displayed statistical differences compared with before in the observation group (P>0.05).There were statistical significance in these indicators between the observation group and control group after sedation (P<0.05).There was no statistical difference of mechanical ventilation time between inter-group comparison (P>0.05).The incidence of adverse reaction in the observation group was lower than that in the control group (P<0.05).Conclusion Compared with Midazolam,application of Dexmedetomidine Hydrochloride in mechanical ventilation exerts a more powerful sedative effect and higher safety,which is applicable for clinical promotion and application.
李辉华. 盐酸右美托咪定与咪唑安定在机械通气中镇静作用对比分析[J]. 中国当代医药, 2017, 24(36): 102-104.
LI Hui-hua. Comparative analysis of sedative effect of Dexmedetomidine Hydrochloride or Midazolam in mechanical ventilation. 中国当代医药, 2017, 24(36): 102-104.
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