Abstract：Objective To analyze the clinical characteristics and medication characteristics of risperidone-induced extrapyramidal side effect(EPS).Methods The general data(sex,age,weight),medication methods(indications,dosage of medication,time of medication,combined medication)and clinical symptoms,treatment measures and outcome of 60 cases of Risperidone-induced EPS reported from Mental Hospital of Guangzhou Civil Affairs Bureau to the National Adverse Drug Reaction Monitoring Center from 2010 to 2019 were retrospectively analyzed.Results From the perspective of age distribution,among 60 adverse drug reaction(ADR)reports,the proportions of prime of life(41-50 years old),youth(21-30 years old)and middle-aged(31-40 years old)were relatively high,18%,17% and 13%,respectively.From the perspective of sex,the incidence of EPS caused by Risperidone was higher in female patients,which was 65.00%.According to the analysis of different types of tablets,the number of adverse reactions caused by oral tablets was the largest in 26 cases(43.33%),followed by orally disintegrating tablets of 24 cases(40.00%).From the dose analysis,when the daily dose of Risperidone was in the range of 4-6 mg,the risk of EPS was relatively high,and we did not observe the occurrence of EPS with a daily dose of 6 mg or more.From the perspective of the way of medication,there were more EPS in 39 cases(65.00%)when Risperidone was used alone.From the analysis of the time of occurrence,53.33% of the cases of EPS occurred within 1 month of medication,and 30.00% cases occurred within 10 days of medication.Among the 60 cases of EPS in this study,Parkinson′s syndrome was the main type(n=43,71.67%);increased muscle tone of the extremities(n=38,63.33%)was also common.After the occurrence of EPS,41.67% of the patients′ clinical symptoms subsided spontaneously as the treatment continued,11 patients improved after symptomatic treatment and dose reduction,and 7 patients needed to be replaced with other antipsychotic drugs.Conclusion The incidence of EPS caused by Risperidone is relatively high in middle-aged patients and mostly occurs within one month of medication.It is more likely to occur with a single medication.Symptomatic treatment and dose reduction can help alleviate the clinical symptoms of EPS.It is recommended to strengthen clinical monitoring of high-risk patients to avoid the occurrence of adverse reactions.
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