Abstract：Objective To investigate the clinical effect of Compound Lactobacillus acidophilus combined with Silibinin Capsules in the treatment of non-alcoholic fatty liver disease (NAFLD).Methods A total of 120 patients with NAFLD admitted to our hospital from April 2017 to October 2018 were selected as the study subjects.The enrolled patients were divided into observation group and control group according to different treatment methods, with 60 cases in each group.In the observation group, the Compound Lactobacillus acidophilus combined with Silibinin Capsules was adopted, and in the control group, patients were treated with Silibinin Capsules alone.Both groups were treated continuously for 12 weeks.The biochemical indicators (total cholesterol [TC], alanine aminotransferase [ALT], aspartate aminotransferase [AST], γ-glutamyltransferase [GGT]) of the two groups before and after treatment were compared and the levels of fatty liver before and after treatment were measured in order to evaluate the clinical effect of the two methods in the treatment of NAFLD.Results There were no significant differences in biochemical indicators between the two groups before treatment (P>0.05).The levels of biochemical indicators in the two groups after treatment were significantly lower than those before treatment, and the differences were statistically significant (P<0.05).The levels of biochemical indicators in the observation group after treatment were significantly lower than those in the control group, and the differences were statistically significant (P<0.05).The total effective rate of the treatment in the observation group was 91.67%, which was significantly higher than that in the control group (76.67%), and the difference was statistically significant (P<0.05).There was no significant difference in the severity of fatty liver between the two groups before treatment (P>0.05).The severity of fatty liver after treatment in both groups was lighter than that before treatment, and the difference was statistically significant (P<0.05).The severity of fatty liver after treatment in the observation group was significantly lighter than that in the control group, and the difference was statistically significant (P<0.05).Conclusion Compound Lactobacillus acidophilus combined with Silibinin Capsules is safe and effective in the treatment of NAFLD, which can markedly improve the liver function of patients.It is expected to be a new method for the prevention and treatment of NAFLD.
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