Abstract：Objective To analyze the rationality of anti-neoplastic drugs in pharmacy intravenous admixture services(PIVAS)and reference for the safety and effectiveness of clinical antineoplastic drugs in the future.Methods A retrospective analysis was made on the prescriptions of 2000 groups of antineoplastic drugs prepared by PIVAS in our hospital from August 2014 to August 2017,according to the instructions of various anti-neoplastic drugs,referring to the relevant drug use standards(such as pharmacopoeia,newly compiled pharmacology,China National Prescription Collection,clinical intravenous drug dispensing and use guidelines),as well as the relevant warnings issued by the State Food and Drug Administration (CFDA)and the United States FDA,et al.The dosage and selection of solvents in prescriptions were counted,and the route,dosage,sequence and other irrational drug use of antineoplastic drugs were also counted.The choice of solvent,concentration and infusion time of common antineoplastic drugs were counted.The order of administration of antineoplastic drugs in combination was counted.Results A total of 127 out of 2000 prescriptions were unqualified,accounting for 6.35%,among them,unreasonable solvents accounted for 70.08%(89/127),which showed improper dosage and selection.The irrational rate of anti-neoplastic drugs was 22.05%(28/127),including irrational route of administration,irrational dosage and irrational order of administration.Other unreasonableness accounted for 7.09% (9/127).There were differences in the stability of solvents and liquids used in different antineoplastic drugs,so the clinical infusion time and precautions were different.There was a certain order of administration in the clinical application of antineoplastic drugs.If the order of administration was wrong,it would affect the anti-neoplastic effect of drugs or cause serious adverse reactions.Conclusion There are some unreasonable prescriptions in the use of PIVAS antineoplastic drugs,such as improper solvent dosage,improper selection,irrational route of administration,irrational dosage and irrational order of administration,et al.Hospitals need to strengthen the audit of the above issues to ensure the quality and rational use of antineoplastic drugs.
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