Abstract：Objective To investigate the effect of Cyclophosphamide and Tacrolimus in the treatment of male nephrotic syndrome.Methods Seventy male patients with nephrotic syndrome admitted to our hospital from February 2017 to December 2018 were selected as subjects,they were divided into group A and group B according to the random number table method,with 35 cases in each group.Group A was given hormone combined with Tacrolimus,and group B was given hormone combined with Cyclophosphamide.Both groups were treated for 3 months,serum albumin levels,24 h urine protein ration and serum sex hormone levels were compared between the two groups before and 3 months after treatment.Results After 3 months of treatment,the 24 hour urine protein ration of group A was lower than that of group B,the serum albumin level was higher than that in group B,the differences were statistically significant (P＜0.05).Before treatment,there were no significant differences between the two groups in hormone levels (P＞0.05).At 3 months after treatment,the levels of estradiol (E2) and testosterone (T) in the two groups were lower than those before treatment,with statistically significant differences (P＜0.05).At 3 months after treatment,follicle-stimulating hormone (FSH) and luteinizing levels in group A were higher than those before treatment,with statistically significant differences (P＜0.05).At 3 months after treatment,E2 and T levels in group A were higher than those in group B,while FSH level was lower than that in group B,with statistically significant differences (P＜0.05).Conclusion Compared with Cyclophosphamide,Tacrolimus combined with hormone therapy has better curative effect on male nephrotic syndrome,and has less influence on serum sex hormones,which is suitable for clinical application.
吴娱； 孙晓梅. 环磷酰胺与他克莫司治疗男性肾病综合征的效果比较[J]. 中国当代医药, 2020, 27(1): 99-101.
WU Yu； SUN Xiao-mei. Comparison of the effects of Cyclophosphamide and Tacrolimus in the treatment of male nephrotic syndrome. 中国当代医药, 2020, 27(1): 99-101.
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