Abstract：ObjectiveTo inbestigate the clinical effect of Metformin in the treatment of polycystic ovary syndrome(PCOS).MethodsFrom January 2012 to August 2013,58 PCOS patients treated in our hospital were selecteded into PCOS group and 85 healthy women were into control group.The PCOS patients were treated with 850 mg Metformin,twice daily for 24 weeks,53 patients completed the treatment finally.The levels of serum insulin and LH,FSH,T,E2,PRL,PROG,DHEA-S,SHBG were compared between the PCOS group and control group.The changes of indexes mentioned above before and after therapy were compared in PCOS group.The improvement of the menstrual cycle during the treatment and the pregnancy rate after medication by follow-up visits were monitored.ResultsIn the PCOS group,the body weight,BMI,FIns,2 h Ins,HOMA-IR,LH,LH/FSH,and T were higher than those in the control group,and the SHBG level was lower than that in the control group,and the differences were statistically significant(P＜0.05).The other indicators of the two groups were compared,and the differences were not statistically significant(P＞0.05).The indexes including BMI,LH,LH/FSH,T,FIns,2 h Ins and HOMA-IR were lower than those before treatment,and SHBG was higher than before treatment,the differences were statistically significant(P＜0.05).The FSH,DHEA-S,E2,PRL and PROG before and after treatment were compared,and the differences were not statistically significant(P＞0.05).In PCOS group,11 patients(20.75%)had regular menstrual cycle before treatment,after 3 months of therapy,the proportion of menstrual regularity was 69.81%,and the proportion of menstrual regularity was 75.47%after the 6 months of treatment,which were all higher than before treatment,the differences were statistically significant(P＜0.05).Besides,the pregnancy rate was 46.67%in the sixth months after treatment.ConclusionThe levels of sex hormones,menstrual and reproductive status in PCOS patients were significantly varied from those of normal women.Metformin could effectively improve the sex hormone level,adjust the menstrual cycle disorder,and improve the pregnancy rate.It is a good choice for the treatment of PCOS.
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