摘要目的探讨胎盘早剥对孕妇凝血功能指标和血小板形态学参数的影响。方法 随机抽取我院妇产科2015年4月～2017年9月收治的50例胎盘早剥孕妇作为A组，将50例妊娠期高血压孕妇作为B组，选取同期我院接收的100例健康孕妇作为对照组，对三组的临床资料展开回顾性分析，三组孕妇均采用全自动凝血分析仪检测、评估三组受试者凝血功能指标水平与血小板形态学参数。结果 ①三组在血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）指标中差异有统计学意义，以B组＜对照组＜A组（P＜0.05）；三组在凝血酶时间（TT）中表现差异无统计学意义（P＞0.05）；在 D-二聚体（D-D）中以 B 组＞A 组＞对照组（P＜0.05）；在血浆纤维蛋白原（FIB）水平中 B 组＞对照组＞A组（P＜0.05）。②由三组受试者血小板形态学参数指标可见，三组中血小板体积分布宽度（PDW）、血小板平均容积（MPV）、大血小板比率（P-LCR）水平可见 B 组＞A 组＞对照组（P＜0.05）；在血小板（PLT）水平中则可见B组＜A组＜对照组（P＜0.05）。结论 胎盘早剥孕妇与妊娠期高血压可对其机体凝血功能指标与血小板形态学参数产生较大影响，从另一个角度说明通过对这两类指标动态观察，有助于早期发现异常情况，及时给予相应的处理。
Abstract：Objective To explore the effect of placental abruption on coagulation function indexes and platelet morphology parameters in pregnant women.Methods Altogether 50 pregnant women with placental abruption who were treated in our hospital from April 2015 to September 2017 were randomly selected as group A;while,50 patients with pregnancy induced hypertension were selected as group B;100 cases of healthy pregnant women who were treated in our hospital at the same period of time were selected as control group.The clinical data of three groups of patients were analyzed retrospectively.The coagulation function indexes and platelet morphological parameters of the three groups were detected and evaluated by using fully automated coagulation analyzer.Results①It was revealed from the coagulation function indexes of the two groups of subjects that the prothrombin time(PT)and activated partial thromboplastin time(APTT)indexes of group B＜ control group＜group A,with statistically significant difference among three groups(P＜0.05）;there was no statistically significant difference between the three groups in thrombin time (TT)(P＞0.05）;D-dimer(D-D)of group B＞group A＞control group(P＜0.05）;the fibrinogen(FIB)of group B＞control group＞group A(P＜0.05）;②According to the platelets morphology parameters of the three groups,the platelet distribution width(PDW),mean platelet volume(MPV)and platelet-large cell ratio(P-LCR)of group B＞group A＞control group(P＜0.05）;and the platelet counts(PLT)of group B＜group A＜control group(P＜0.05）.Conclusion Placental abruption and pregnancy induced hypertension have a great influence on the blood coagulation function indexes and the platelet morphology parameters.It indicates from another point of view that the dynamic observation of these two kinds of indexes can help to find abnormal conditions in early stage and give appropriate treatment in time.
京公网安备 11010502046607号