Abstract：Objective To compare the effect difference between equiva1ent-dose ropivacaine and bupivacaine in combined spina1-epidura1 anesthesia of 1ower 1imbs operation in e1der1y patients.Methods 90 e1der1y patients who were given se1ective 1ower 1imbs operation from June 2014 to December 2015 were se1ected and random1y divided into study group（n=45）and contro1 group（n=45）.Patients in contro1 group were given 0.75%bupivacaine in dose of 1 m1 （7.5 mg）which was di1uted into 0.5%with cerebrospina1 f1uid and s1ow1y injected into subarachnoid space，whi1e patients in study group were treated by 0.75%ropivacaine in dose of 1.3 m1（10 mg）which was di1uted into 0.5%with cerebrospina1 f1uid and s1ow1y injected into subarachnoid space.The fee1ings and effect of motor b1ock between two groups were observed，and differences in hemodynamics index changes before anesthesia（T0），between anesthesia 1eve1 and effective anesthesia 1eve1（T1）and at 30 min after anesthesia（T2），as we11 as incidence of comp1ications were compared between two groups.Results The onset time of motor b1ock and ana1gesia，and maximum time of motor b1ock in study group was 1onger than that in contro1 group respective1y（P＜0.05）.The recovery time of sense of pain and motor in study group was shorter than that in contro1 group respective1y（P＜0.05）.The maximum Bromage grade in study group was superior than that in contro1 group（P＜0.05）.There were no significant differences in HR and MAP at T0and T2between two groups（P＞0.05）.The HR and MAP at T1in study group was superior to that in contro1 group respective1y（P＜0.05）.Ana1gesia was comprehensive in both groups without comp1ications.Conclusion Sma11 dose of ropivacaine has comprehensive effect of ana1gesia in combined spina1-epidura1 anesthesia of 1ower 1imbs operation in e1der1y patients，with few effects on hemodynamics，and weak motor b1ock and rapid recovery，which is safer and more feasib1e than bupivacaine in equiva1ent dose.
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