Curative effects of escitalopram in the treatment of elderly depression and its effects on life quality
LIU Lin-lin1 DUAN Ni2 WANG Dong-ming3▲ SUN Ping3
1.Open Ward，Qingdao Mental Health Center，Qingdao 266034，China；
2.No.3 Department of Psychiatry，Qingdao Mental Health Center，Qingdao 266034，China；
3.No.2 Department of Geriatrics，Qingdao Mental Health Center，Qingdao 266034，China
Abstract：Objective To understand the effectiveness of escitalopram in the treatment of elderly depression and its effects on life quality.Methods 60 outpatients and inpatients with elderly depression from October 2010 to October 2015 were randomly assigned to two groups，with 30 patients in each group.The two groups were given the treatment of escitalopram and citalopram respectively.HAMD was applied before the treatment，at the end of the first week，second week，fourth week，eighth week and twelfth week after the treatment to evaluate the curative effects，GQOLI-74 was applied to evaluate patients′life quality，and adverse reactions were observed.Results The differences of total scores of HAMD before the treatment in escitalpram group and citalpram group were not statistically significant（P＞0.05）；At the end of the first week until the twelfth week after the treatment，the total score of HAMD in both groups was gradually reduced respectively，and the difference compared with that before the treatment was statistically significant（P＜0.05）；At the end of the twelfth week，compared with citalpram group，the total score of HAMD in escitalpram group was reduced more greatly，and the difference between the two groups was statistically significant（P＜0.05）；Compared with the situation before the treatment，at the end of the twelfth week，physical function，mental function and social function in both groups was significantly improved respectively（P＜0.01）；At the end of the twelfth week，the improvement of physical function and social function in escitalpram group was better than that in citalpram group（P＜0.01）；The adverse reactions in both groups were slight.Conclusion Escitalpram is helpful for enhancing long-term curative effects and improving life quality in patients with elderly depression.
刘琳琳； 段妮； 王东明； 孙平. 艾司西酞普兰治疗老年抑郁症的效果及其对生活质量的影响[J]. 中国当代医药, 2016, 23(17): 139-141转151.
LIU Lin-lin；DUAN Ni； WANG Dong-ming； SUN Ping. Curative effects of escitalopram in the treatment of elderly depression and its effects on life quality. 中国当代医药, 2016, 23(17): 139-141转151.
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