Effects observation of high flux hemedialysis and hemoperfusion com-bined with hemodialysis in the treatment of patients with end-stage dia-betic nephropathy
CHEN Kai-jun YEWen-jie WANG Huan
Blood Purification Room,People's Hospital of Longchuan County in Guangdong Province,Longchuan 517300,China
Abstract:Objective To compare effects of high flux hemedialysis (HFHD)and hemoperfusion combined with hemodialysis(HP+HD)in the treatment of end-stage diabetic nephropathy.Methods 86 cases of patients with endstage diabetic nephropathy from May 2011 to April 2015 in our hospital were selected and randomly divided into the research group and the control group,43 cases in each group.The control group was treated with HFHD,the research group was treated with HP+HD.The improvement situation of nutrition indicators,micro-inflammation state and blood lipid in the two groups was compared.Results The levels of red blood cells(RBC),hemoglobin (HGB),serum albumin (Alb),vitamin B12and folic acid after treatment of 6months in the two groupswas higher than that before treatment,with significant difference (P<0.05).The level of RBC and HGB in the research group after treatment of 6monthswas lower than that in the control group after treatment of 6 months,the levels of Alb,vitamin B12and folic acid in the research group after treatment of 6 monthswas higher than that in the control group after treatment of 6 months,with significant difference(P<0.05).The levels of high sensitive C reactive protein(hs-CRP),β2microglobulin(β2-MG)and interleukin-6 (IL-6)after treatment of 6months in the two groupswas lower than that before treatment,with significant difference(P<0.05).The level of hs-CRP,β2-MG and IL-6 in the research group after treatment of 6 months was lower than that in the control group after treatment of 6 months,with significant difference (P<0.05).The levels of total cholesterol(TC),triglyceride (TG),low density lipoprotein cholesterol(LDL-C)after treatment of 6 months in the two groupswas lower than thatbefore treatment,the levels of high density lipoprotein cholesterol(HDL-C)after treatment of 6months in the two groupswas higher than that before treatment,with significant difference (P<0.05).The level of TC,TG,LDL-C in the research group after treatment of 6monthswas lower than that in the control group after treatment of 6 months,the levels of HDL-C in the research group after treatment of 6 months was higher than that in the control group after treatment of 6 months,with significant difference (P<0.05).Conclusion HFHD and HP+HD are both effective for patients with end-stage diabetic nephropathy,each have advantages and disadvantages.In clinical practice,the treatment should be selected according to the specific circumstances.
陈凯均;叶文捷;王欢. 高通量血液透析和血液灌流联合血液透析治疗终末期糖尿病肾病患者的效果观察[J]. 中国当代医药, 2016, 23(27): 52-54转57.
CHEN Kai-jun;YEWen-jie;WANG Huan. Effects observation of high flux hemedialysis and hemoperfusion com-bined with hemodialysis in the treatment of patients with end-stage dia-betic nephropathy. 中国当代医药, 2016, 23(27): 52-54转57.