Abstract：ObjectiveTo investigate the expression and clinical significance of serum procalcitonin(PCT),interleukin-1(IL-1)and interleukin-6(IL-6)in chronic obstructive pulmonary disease.MethodsFrom January to October in 2016,30 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)were classified into the AECOPD group,30 patients with stable COPD were selected as the COPD group,and another group of 30 healthy participants for physical examination was selected as the control group in the same period.The indexes of serum PCT,IL-1 and IL-6 were tested and their correlations with pulmonary function were analyzed.ResultsIn the AECOPD group,the levels of serum PCT,IL-1 and IL-6 were significantly higher than those in the COPD group and in the control group,while in comparison of the control group,those in the COPD group were higher,which were both displayed statistical difference(P＜0.05).The level of FEV1%and FEV1/FVC in the AECOPD group was lower compared with those in the COPD group and in the control group,the level of FEV1%and FEV1/FVC in the COPD group was lower than that in the control group,with significant difference(P＜0.05).Expression levels of serum PCT,IL-1 and IL-6 were negatively correlated with FEV1%and FEV1/FVC in pulmonary function,with statistical difference (P＜0.05).ConclusionThe levels of serum PCT,IL-1 and IL-6 in COPD patients are increased with the severity of COPD,and the expression levels are in negative correlations with FEV1%and FEV1/FVC.Detection of the above-mentioned factors can reflect the severity of the COPD and assist on assessing the disease condition and guiding the clinical treatment.
Chen SP，Huang LR，Lu TM，et al.Complementary usage of rhodiola crenulata in chronic obstructive pulmonary disease patients：the effects on cytokines and T cells[J].Phytother Res，2015，29（4）：518-525.
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