术前血液中性粒细胞与淋巴细胞比值在结肠癌患者中的表达及临床意义

摘要
图/表
参考文献(24)
相关文章 (15)

全文: PDF (0 KB) HTML (37 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨术前血液中性粒细胞与淋巴细胞比值（NLR）在结肠癌患者中的表达及临床意义。方法选取2019年1～8月浙江省肿瘤医院收治的230 例结肠癌患者作为结肠癌组，选取同期161 例健康人群作为健康对照组。比较两组的血液NLR，同时收集结肠癌患者术后常规病理，比较不同病理特征的血液NLR。结果结肠癌组的血液NLR 高于健康对照组，差异有统计学意义（P＜0.01）。 M1 期结肠癌患者的血液NLR 高于M0 期，差异有统计学意义（P＜0.05）。肿瘤最大直径≥5 cm 的结肠癌患者血液NLR 高于最大直径＜5 cm 的患者，差异有统计学意义（P＜0.01）。不同发生位置、分化类型、形态特征结肠癌患者的血液NLR 比较，差异无统计学意义（P＞0.05）。结论术前检测结肠癌患者的血液NLR 可反映患者与肿瘤相关的炎症状态，并提示肿瘤远处转移情况和肿瘤大小，对结肠癌的治疗和预后分析具有临床意义。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	吴宇辰
	王胜
	周云
	梁忠

关键词 ：结肠癌, 中性粒细胞与淋巴细胞比值, 病理特征, 远处转移, 肿瘤大小

Abstract：Objective To analyze the expression and clinical significance of blood neutrophil-to-lymphocyte ratio (NLR)in colorectal cancer patients before surgery.Methods A total of 230 patients with colorectal cancer admitted to Zhejiang Cancer Hospital from January to August 2019 were selected as the colorectal cancer group, and 161 healthy subjects during the same period were selected as the healthy control group.The blood NLR in each group was compared.At the same time, routine pathology of colorectal cancer patients was collected and the blood NLR of different pathological features was compared.Results The blood NLR of the colorectal cancer group was higher than that of the healthy control group, and the difference was statistically significant (P＜0.01).The blood NLR of patients with colorectal cancer of stage M1 was higher than that of stage M0, and the difference was statistically significant (P＜0.05).The blood NLR of colorectal cancer patients with the maximum tumor diameter ≥5 cm was higher than that of patients with the maximum tumor diameter ＜5 cm, and the difference was statistically significant (P＜0.01).There was no statistically significant difference in blood NLR of colorectal cancer patients with different occurrence locations,differentiation types, and morphological characteristics (P＞0.05).Conclusion Preoperative detection of blood NLR in patients with colorectal cancer is not only a surrogate marker for tumor related inflammatory status, it also provides information regarding tumor size and presence of distant metastasis, which has clinical implications on treatment planning and disease prognosis.

Key words： Colorectal cancer Neutrophil-to-lymphocyte ratio Pathological characteristics Distant metastasis Tumor size

引用本文:

吴宇辰；王胜；周云；梁忠. 术前血液中性粒细胞与淋巴细胞比值在结肠癌患者中的表达及临床意义[J]. 中国当代医药, 2020, 27(22): 16-19.
WU Yu-chen；WANG Sheng；ZHOU Yun；LIANG Zhong. Expression and clinical significance of blood neutrophil-to-lymphocyte ratio in colorectal cancer patients before surgery. 中国当代医药, 2020, 27(22): 16-19.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I22/16

[1]	Bray F，Ferlay J，Soerjomataram I，et al.Global Cancer Statistics 2018：GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J].CA Cancer J Clin，2018，68（6）：394-424.
[2]	Pesic M，Greten F R.Inflammation and cancer：tissue regeneration gone awry[J].Curr Opin Cell Biol，2016，43：55-61.
[3]	Simon K.Colorectal cancer development and advances in screening[J].Clin Interv Aging，2016，11：967-976.
[4]	Wilhelmsen M，Christensen IJ，Rasmussen L，et al.Detection of colorectal neoplasia：Combination of eight blood-based，cancer-associated protein biomarkers[J].Int J Cancer，2017，140（6）：1436-1446.
[5]	Wu F，Hou XQ，Sun RR，et al.The predictive value of joint detection of serum amyloid protein A，PCT，and Hs-CRP in the diagnosis and efficacy of neonatal septicemia[J].Eur Rev Med Pharmacol Sci，2019，23（13）：5904-5911.
[6]	Miyamoto R，Inagawa S，Sano N，et al.The neutrophil-tolymphocyte ratio （NLR） predicts short-term and long-term outcomes in gastric cancer patients[J].Eur J Surg Oncol，2018，44（5）：607-612.
[7]	Pan XB，Huang ST，Zhu XD.Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma[J].Cancer Manag Res，2019，11：8269-8275.
[8]	Lochowski M，Lochowska B，Zawadzka I，et al.Prognostic value of neutrophil-to-lymphocyte，platelet-to-lymphocyte and lymphocyte-to-monocyte ratio ratios in patients operated on due to non-small cell lung cancer[J].J Thorac Dis，2019，11（8）：3377-3384.
[9]	Townsend MH，Felsted AM，Piccolo SR，et al.Metastatic colon adenocarcinoma has a significantly elevated expression of IL-10 compared with primary colon adenocarcinoma tumors[J].Cancer Biol Ther，2018，19（10）：913-920.
[10]	Amin MB，Greene FL，Edge S，et al.AJCC cancer staging manual[M].8th ed.New York：Springer，2017：268-269.
[11]	Qian BZ.Inflammation fires up cancer metastasis[J].Semin Cancer Biol，2017，47：170-176.
[12]	魏智民，孙玉发，李刚，等.癌症相关性炎症与肿瘤微环境相关研究进展[J].中国肿瘤临床，2018，45（21）：1117-1121.
[13]	Ghanghas P，Jain S，Rana C，et al.Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer[J].Biomed Pharmacother，2016，78：239-247.
[14]	Shaw E，Warkentin MT，McGregor SE，et al.Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug （NSAID） use and the incidence of colorectal polyps in a population screened for colorectal cancer[J].J Epidemiol Community Health，2017，71（10）：961-969.
[15]	Kim J，Ba e JS.Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment[J].Mediators Inflamm，2016，2016：6 058 147.
[16]	SenGupta S，Subramanian BC，Parent CA.Getting TANned：How the tumor microenvironment drives neutrophil recruitment[J].J Leukoc Biol，2019，105（3）：449-462.
[17]	李佳庆，王清莹，程忠.瘤相关性中性粒细胞促肿瘤转移机制的研究进展[J].中国肿瘤临床，2019，46（10）：524-527.
[18]	江慧洪，王晖，李阿建，等.中性粒细胞/淋巴细胞比值对局部进展期结直肠癌患者预后的影响[J].中华胃肠外科杂志，2017，20（5）：550-554.
[19]	梁铭，张辉，陈福雄，等.肿瘤浸润性淋巴细胞在血液肿瘤中作用的临床研究进展[J].中国实验血液学杂志，2016，24（4）：1241-1247.
[20]	沈金闻，刘鲁迎，李德川，等.术前系统性炎症反应与结直肠癌临床病理特征的相关性探讨[J].中国现代医学杂志，2016，26（21）：87-93.
[22]	童国俊，严强，张贵阳，等.肿瘤大小分类对0～Ⅲ期结直肠癌预后的影响[J].浙江医学，2017，39（19）：1664-1666，1734.
[23]	王淑强，钟文洲.结直肠癌患者住院费用构成分布及其影响因素分析[J].中国医药导报，2019，16（23）：118-121.
[24]	肖英著.胃肠肿瘤标志物诊断大肠癌的临床效果与价值分析[J].现代消化及介入诊疗，2018，23（A2）：59-60.
[21]	Huang B，Feng Y，Mo SB，et al.Smaller tumor size is associated with poor survival in T4b colon cancer[J].World J Gastroenterol，2016，22（29）：6726-6735.