不同病理特征下乳腺癌患者细胞免疫水平及血清糖类抗原153变化分析

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摘要目的探讨不同病理特征下乳腺癌患者细胞免疫及血清糖类抗原153（CA153）水平的变化。方法回顾性选取2019 年1 月至2020 年5 月菏泽市立医院收治的104 例乳腺癌患者作为研究对象，设为乳腺癌组；选取同期菏泽市立医院收治的70 例乳腺良性疾病患者作为良性组，选取同期于菏泽市立医院进行体检的70 例健康体检者作为健康对照组。比较三组免疫指标（CD4、CD8、CD4/CD8、NK）及CA153 水平，观察不同病理特征与免疫指标及CA153 的关系。结果乳腺癌组CD4、CD4/CD8、NK 水平低于良性组和健康对照组，差异有统计学意义（P＜0.05）；乳腺癌组 CD8、CA153 水平高于良性组和健康对照组，差异有统计学意义（P＜0.05）；良性组 CD4、CD4/CD8、NK 水平低于健康对照组，差异有统计学意义（P＜0.05）；良性组CD8、CA153 水平高于健康对照组，差异有统计学意义（P＜0.05）。不同年龄、有无淋巴结转移患者的 CD4、CD4/CD8 及 NK 水平比较，差异有统计学意义（P＜0.05）；不同病理类型、TNM 分期、肿瘤直径、PR、ER、HER-2 表达患者的 CD4、CD8、CD4/CD8、NK 及 CA153 水平比较，差异有统计学意义（P＜0.05）。结论乳腺癌患者的细胞免疫指标、CA153 水平与病理类型、TNM 分期、肿瘤直径大小、ER、PR、HER-2 表达有关，且能够作为区别乳腺癌与乳腺良性疾病及健康人的有效指标。

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关键词 ：乳腺癌, 免疫水平, 血清糖类抗原153, 病理特征

Abstract：Objective To explore the changes of cellular immunity and serum carbohydrate antigen 153 (CA153) levels in breast cancer patients under different pathological characteristics. Methods A total of 104 patients with breast cancer admitted to Heze Municipal Hospital from January 2019 to May 2020 were retrospectively selected as the study subjects and set as the breast cancer group, seventy patients of benign breast disease admitted to Heze Municipal Hospital at the same period were selected as benign groups, and seventy patients with physical examination in Heze Municipal Hospital in the same period were selected as the healthy control group. The immune indicators (CD4, CD8,CD4/CD8, NK) and CA153 levels of the three groups were compared, and observed the relationship between different pathological characteristics and immune indicators and CA153. Results The levels of CD4, CD4/CD8, and NK in the breast cancer group were lower than those in the benign group and the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD8 and CA153 in the breast cancer group were higher than those in the benign group and the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD4, CD4/CD8, and NK in the benign group were lower than those in the healthy control group, and the differences were statistically significant (P＜0.05). The levels of CD8 and CA153 in the benign group were higher than those in healthy control group, and the differences were statistically significant (P＜0.05). The CD4, CD4/CD8 and NK levels were compared between the patients with different age, with or without lymph node metastasis, the differences were statistically significant (P＜0.05). The CD4, CD8, CD4, CD4/CD8, NK, and CA153 levels were compared between the patients with different pathological types, TNM stage, tumor diameter, PR, ER, and HER-2 expression, and the differences were statistically significant (P＜0.05). Conclusion The cellular immunity level and CA153 level of breast cancer patients are related to clinicopathological type, TNM stage, tumor diameter size, ER, PR, HER-2 expression, and can be used as effective indicators to distinguish breast cancer from benign breast diseases and healthy people.

Key words： Breast cancer Immune level Serum carbohydrate antigen 153 Pathological characteristics

收稿日期: 2021-08-23

作者简介: 李淑敏（1969-），女，汉族，副主任技师

引用本文:

李淑敏；张业霞. 不同病理特征下乳腺癌患者细胞免疫水平及血清糖类抗原153变化分析[J]. 中国当代医药, 2021, 28(35): 192-195.
LI Shu-min ZHANG Ye-xia. Analysis of cellular immune level and serum carbohydrate antigen 153 changes in patients with breast cancer under different pathological features. 中国当代医药, 2021, 28(35): 192-195.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I35/192

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