Objective To approach value of old age severe erythrodermic psoriasis complicated with diabetes by comprehensive nursing model.Methods A total of 80 cases old age severe erythrodermic psoriasis complicated with diabetes patients treated in Dalian Dermatology Hospital from June 2018 to June 2020 were selected as research objects,which were divided into the control group and the detection group by random slip method,40 cases in each group.The control group was used routine nursing mode,the detection group was used comprehensive nursing model,the anxiety score,depression score,delf-nursing ability score of two group before nursing and after nursing were compared,the nursing satisfaction and nursing error rate of two group were compared.Results The anxiety score,depression score,disease knowledge,self-monitoring,daily living ability,dietary self-regulation score of two group before nursing were compared,the differences were no statistical significance(P＞0.05).After nursing,anxiety score,depression score of two group were lower than before nursing in the same group,the detection group were lower than those of the control group,the differences were statistical significance(P<0.05).After nursing,disease knowledge,elf-monitoring,daily living ability,dietary self-regulation score of two group were higher than before nursing in the same group,the detection group were higher than those of the control group,the differences were statistical significance(P<0.05).The nursing satisfaction of the detection group was higher than that of the control group,nursing error rate was lower than that of the control group,the differences were statistical significance(P<0.05).Conclusion The application of old age severe erythrodermic psoriasis complicated with diabetes by comprehensive nursing model,which could improve anxiety and depression,increase delf-nursing level and nursing satisfaction,decrease nursing error rate.