肿痛安内服外用与肿痛安结合重组牛碱性成纤维细胞生长因子凝胶治疗口腔溃疡的效果对比

摘要
图/表
参考文献(15)
相关文章 (9)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的比较肿痛安内服外用与肿痛安结合重组牛碱性成纤维细胞生长因子凝胶治疗口腔溃疡的效果。方法选取2019年6月至2020年6月江西省赣州市人民医院收治的78 例口腔溃疡患者作为研究对象，按照奇偶数分组法将其分为A 组与B 组，每组各39 例。A 组患者采用内服肿痛安加重组牛碱性成纤维细胞生长因子凝胶外用方法，B 组患者采用内服肿痛安加肿痛安粉末外用方法。比较两组患者的疗效和治疗前后口腔溃疡疼痛程度、溃疡面积、溃疡个数。结果两组患者的治疗总有效率比较，差异无统计学意义（P＞0.05）。治疗前，两组患者的视觉模拟评分法（VAS）评分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者的VAS 评分低于治疗前，差异有统计学意义（P＜0.05）；治疗后；B 组患者的VAS 评分低于A 组，差异有统计学意义（P＜0.05）。治疗前，两组患者的溃疡面积、溃疡个数比较，差异无统计学意义（P＞0.05）；治疗后，两组患者的溃疡面积小于治疗前，溃疡个数少于治疗前，差异有统计学意义（P＜0.05）；治疗后，B 组患者的溃疡面积小于A 组，溃疡个数少于A 组，差异有统计学意义（P＜0.05）。结论肿痛安结合重组牛碱性成纤维细胞生长因子凝胶与肿痛安内服外用治疗口腔溃疡的疗效均较显著，但肿痛安内服外用对减轻疼痛及控制溃疡程度的效果更佳。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	张秋芳
	兰旭
	罗新年

关键词 ：肿痛安, 重组牛碱性成纤维细胞生长因子凝胶, 口腔溃疡

Abstract：Objective To compare the effect of internal and external use of Zhongtongan and Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in the treatment of oral ulcer.Methods A total of 78 patients with oral ulcer admitted to Ganzhou People′s Hospital of Jiangxi Province from June 2019 to June 2020 were selected as the research subjects, and they were divided into group A and group B according to odd and even grouping method, with 39 cases in each group.Group A took Zhongtongan orally and used Recombinant Bovine Basic Fibroblast Growth Factor Gel externally, while group B took Zhongtongan orally and used Zhongtongan powder externally.Therapeutic effect, pain degree, area and number of oral ulcer before and after treatment were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups (P＞0.05).Before treatment, there was no statistically significant difference in visual analogue scale (VAS) score between the two groups (P＞0.05).After treatment, the VAS scores of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the VAS score of the group B was lower than that of the group A, and the difference was statistically significant (P＜0.05).Before treatment, there were no statistically significant differences in area and number of ulcers between the two groups (P＞0.05).After treatment, the area and number of ulcers in the two groups were smaller than those before treatment, and the differences were statistically significant (P＜0.05).After treatment, the area and number of ulcers in the group B were smaller than those in the group A, and the differences were statistically significant (P＜0.05).Conclusion Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel and internal and external use of Zhongtongan are both effective in treating oral ulcers, but internal and external use of Zhongtongan is more effective in reducing pain and controlling ulcers.

Key words： Zhongtongan Recombinant Bovine Basic Fibroblast Growth Factor Gel Oral ulcer

基金资助:江西省赣州市指导性科技计划项目（GZ2020ZSF 210）。

引用本文:

张秋芳；兰旭；罗新年. 肿痛安内服外用与肿痛安结合重组牛碱性成纤维细胞生长因子凝胶治疗口腔溃疡的效果对比[J]. 中国当代医药, 2021, 28(29): 146-148.
ZHANG Qiu-fang；LAN Xu；LUO Xin-nian. Comparison of oral ulcer effect between internal and external use of Zhongtongan and Zhongtongan combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel. 中国当代医药, 2021, 28(29): 146-148.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I29/146

[1]	王莉，赵瑛.贝复新凝胶联合肿痛安胶囊治疗口腔溃疡的疗效观察[J].临床医药实践，2019，28（7）：486-489.
[2]	王治国，程军.口腔溃疡局部用药应注意的问题[J].人民军医，2017，12（60）：77-78，82.
[3]	林勇红，龚辉.口腔溃疡药膜治疗口腔溃疡120 例疗效分析[J].临床医药文献电子杂志，2018，5（22）：55.
[4]	钱苏林，魏敦双，殷奇，等.贝复新促进伤口修复的临床效果观察[J].医药前沿，2020，10（1）：134-136.
[5]	丁玲.肿痛安胶囊联合醋酸地塞米松粘贴片治疗复发性口腔溃疡的临床疗效分析[J].世界最新医学信息文摘（电子版），2019，19（58）：154-155.
[6]	严俊，赵润成，李丽娜.贝复新与明胶海绵联用预防下颌埋伏智齿拔除术后干槽症的效果[J].临床医学，2020，40（4）：89-91.
[7]	陈乐，王东.肿痛安胶囊联合醋酸地塞米松粘贴片治疗复发性口腔溃疡的临床研究[J].现代药物与临床，2018，33（11）：2906-2909.
[8]	刘建香.肿痛安胶囊联合重组牛碱性成纤维细胞生长因子外用凝胶对口腔溃疡患者VAS 评分及复发率的影响[J].中国实用医药，2020，15（14）：10-13.
[9]	温芳芳，何莹华，张凤英，等.基于藻酸盐银离子敷料与贝复新的综合护理改善肠造口黏膜皮肤分离的临床效果[J].广东医学，2019，40（9）：153-156.
[10]	罗剑，史翠平，童庆春.贝复新凝胶治疗复发性阿弗他溃疡的临床疗效观察[J].口腔材料器械杂志，2017，26（4）：222-225.
[11]	李民.维生素C 联合盐酸雷尼替丁胶囊治疗复发性口腔溃疡的效果[J].中国当代医药，2018，25（27）：114-116.
[12]	刘涛杰.肿痛安胶囊对老年肱骨干骨折伴桡神经损伤患者VAS 评分、临床症状及神经功能的影响[J].药品评价，2017，16（26）：57-60.
[13]	吴妍青，尹晓华.肿痛安胶囊联合替硝唑治疗牙周炎的临床研究[J].现代药物与临床，2018，33（12）：3331-3334.
[14]	张晓蕊，周春红，杨锦菊.肿痛安胶囊外用联合喜炎平静点治疗小儿疱疹性口腔炎50 例疗效观察[J].世界最新医学信息文摘（电子版），2016，16（18）：172-173.
[15]	张树鹰，段大波.口腔溃疡患者应用贝复新凝胶联合肿痛安胶囊治疗的临床研究[J].中国现代药物应用，2020，14（13）：198-200.