血清雌二醇、β-绒毛膜促性腺激素及孕酮水平检测在早期先兆流产结局预测中的应用价值

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摘要目的探讨血清雌二醇（E2）、β-绒毛膜促性腺激素（β-HCG）及孕酮（P）水平检测在早期先兆流产结局预测中的应用价值。方法回顾性分析2019年8月～2020年7月广东省英德市妇幼保健计划生育服务中心收治的52例早期先兆流产孕妇的临床资料，根据妊娠结局的不同将其分为继续妊娠组（36例）与妊娠失败组（16例），另选取同期在广东省英德市妇幼保健计划生育服务中心行常规产检的36例正常妊娠孕妇作为对照组，入组时采集三组5 mL 空腹静脉血，测定血清E2、β-HCG、P水平。比较三组孕妇血清E2、β-HCG、P水平和三者单项、联合诊断预测早期先兆流产阳性率，分析E2、β-HCG、P单项和联合诊断预测早期先兆流产结局的价值。结果妊娠失败组孕妇的E2、β-HCG、P水平低于继续妊娠组和对照组，继续妊娠组孕妇的E2、β-HCG、P水平低于对照组，差异有统计学意义（P＜0.05）。妊娠失败组、继续妊娠组E2、β-HCG、P单项和联合诊断阳性率高于对照组，差异有统计学意义（P＜0.05）；妊娠失败组E2、β-HCG、P单项和联合诊断阳性率高于继续妊娠组，差异有统计学意义（P＜0.05）。E2、β-HCG、P 联合诊断预测早期先兆流产结局的敏感度（93.24%）和特异性（89.10%）高于单一诊断，差异有统计学意义（P＜0.05）。结论 E2、β-HCG、P 均是判断早期先兆流产和预测孕妇妊娠结局的有效指标，联合诊断能提高诊断符合率，可作为预测早期先兆流产和妊娠结局的有效指标。

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关键词 ：早期先兆流产, 雌二醇, &beta, -绒毛膜促性腺激素, 孕酮

Abstract：Objective To explore the application value of serum estradiol (E2),β-chorionic gonadotropin (β-HCG) and progesterone (P) levels detection in predicting the outcomes of early threatened abortion.Methods Clinical data of 52 pregnant women with early threatened abortion who were admitted to Maternity and Child Health Family Planning Service Center in Yingde City,Guangdong Province from August 2019 to July 2020 was selected and divided into continued pregnancy group (36 cases) and pregnancy failure group (16 cases) according to the different pregnancy outcomes.Another 36 normal pregnant women who underwent routine check-ups in Maternity and Child Health Family Planning Service Center in Yingde City,Guangdong Province during the same period were selected as the control group.During enrollment,participants in the three groups were collected 5 mL fasting venous blood for measuring the serum E2,β-HCG and P levels.The serum E2,β-HCG and P levels of the three groups of pregnant women were compared.The positive rate of early threatened abortion predicted by the serum E2,β-HCG and P levels alone or in combination as well as its value was compared and analyzed among the three groups.Results The levels of E2,β-HCG and P in the pregnancy failure group were lower than those in the continued pregnancy group and the control group,the levels of E2,β-HCG and P in the continued pregnancy group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The diagnostic positive rates of E2,β-HCG and P alone and in combination in the pregnancy failure group and continued pregnancy group were higher than that of the control group,and thedifferences were statistically significant (P＜0.05).The diagnostic positive rate of E2,β-HCG and P alone and in combination in the pregnancy failure group was higher than that in the continued pregnancy group,and the difference was statistically significant (P＜0.05).The sensitivity (93.24%) and specificity (89.10%) in combined diagnosis of E2,β-HCG and P for early threatened abortion prediction were higher than those in single diagnosis,and the differences were statistically significant (P＜0.05).Conclusion E2,β-HCG and P are all effective indicators for judging early threatened abortion and predicting pregnancy outcomes.Combined diagnosis can increase the diagnostic accordance rate and can be used as an effective indicator for predicting the occurrence of early threatened abortion and pregnancy outcome.

Key words： Early threatened abortion Estradiol &beta -chorionic gonadotropin Progesterone

基金资助:广东省清远市科技计划项目（190917084569839）

引用本文:

吴碧云;毛文礼;张美婵;胡红英. 血清雌二醇、β-绒毛膜促性腺激素及孕酮水平检测在早期先兆流产结局预测中的应用价值[J]. 中国当代医药, 2021, 28(6): 149-152.
WU Bi-yun MAO Wen-li ZHANG Mei-chan HU Hong-ying. Application value of serum estradiol,β-chorionic gonadotropin and progesterone levels detection in predicting the outcomes of early threatened abortion. 中国当代医药, 2021, 28(6): 149-152.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I6/149

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