Research progress of microecological agents regulating intestinal microorganism of obesity
LU Lin-li1 JU Hai-bing2▲
1.Department of Endocrinology,Clinical Institute of Kunming Medical University,920th Hospital of Joint Logistic Support Force of the Chinese People′s Liberation Army,Yunnan Province,Kunming 650032,China;
2.Department of Endocrinology,920th Hospital of joint Logistic Support Force of the Chinese People′s Liberation Army,Yunnan Province,Kunming 650032,China
Abstract：Obesity has become a global epidemic disease that urgently needs to be solved.Studies have shown that obesity is related to the imbalance of intestinal microbiota in the body.The imbalance of intestinal microbiota leads to the disorder of substance and energy metabolism,metabolic endotoxemia,systemic inflammation and insulin resistance in the obese body.Prebiotics can be fermented by intestinal probiotics to produce short-chain fatty acids and other metabolites to improve the diversity and abundance of the intestinal microbiota of the obese body,increase energy consumption,and reduce fat deposition.Meanwhile,short-chain fatty acids can stimulate gastrointestinal hormones of satiety,reduce inflammation,improve insulin resistance,and reduce appetite through the microbiota-gut-brain axis.Prebiotics,probiotics and their derived microecological agents(probiotics,probiotics,synbiotics,postbiotics)have become the hot spot and new strategy for the beneficial treatment of obesity.This research reviews the effect of microbiological products in the treatment of obesity,discusses the related mechanisms,and makes a prospect for its treatment in the future.
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