Abstract：Objective To investigate the effect of magnesium sulfate in the treatment of neonatal hypoxic-ischemic encephalopathy.Methods A total of 64 asphyxia neonates born in the Department of Obstetrics and Gynecology of Fukuang General Hospital from February 2018 to August 2019 were selected as the research subjects.They were randomly divided into the treatment group(n=32)and the control group(n=32).The control group was given conventional treatment.The treatment group was additionally given magnesium sulfate treatment on the basis of the control group.The clinical efficacy,clinical symptoms improvement time,Mg2+ level,pH level of arterial blood gas and human S100-B protein(S100-B)level,the pediatric growth and development(Gesell developmental scale score),and the occurrence of adverse reactions of the two groups were observed.Results The total effectiveness rate of the treatment group was 93.75%,higher than that of 71.88% of the control group,with statistical significance(P＜0.05).The improvement time of muscular tension,primitive reflex and state of consciousness in the treatment group was shorter than that of the control group,with statistical significance(P＜0.05).The comparison of arterial blood gas pH,Mg2+ level,and S100-B level before treatment between the two groups of children was not statistically significant(P＞0.05).The arterial blood gas pH and Mg2+ levels in the treatment group at 2 and 6 d after treatment were higher than those before treatment and the control group,and the level of S100-B was lower than that before treatment and the control group,with statistical significance(P＜0.05).The arterial blood gas pH and Mg2+ of the control group at 6 d after treatment were higher than those before treatment,and the level of S100-B was lower than that before treatment,with statistical significances(P＜0.05).After 8 months of follow-up,the Gesell score of the treatment group was higher than that of the control group,with statistical significance(P＜0.05).One case of hypotension occurred in the treatment group,and the control group had no adverse reactions,total incidence of adverse reactions was compared between the two groups,the difference was not statistically significant(P＞0.05).Conclusion Magnesium sulfate can effectively improve the clinical symptoms of neonates with hypoxic-ischemic encephalopathy,shorten the course of the disease,promote the recovery of nerve function in high safety.
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