Objective To investigate the clinical effect of nebulized inhalation of Budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods From January 2018 to December 2019, 100 patients with acute exacerbation of chronic obstructive pulmonary disease in Liaoning Health Industry Group Iron Coal General Hospital were selected as subjects.The patients were divided into control group(50 cases)and observation group(50 cases) by random number table method.Ambroxol Hydrochloride was given in the control group, and on the basis of control group, observation group was additionally treated with nebulized inhalation of Budesonide.The clinical symptom remission time, pulmonary function indexes, arterial oxygen indexes and the total effective rate of treatment were compared between the two groups.Results The total effective rate of observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and peak expiratory flow (PEF) of the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05);and the symptoms of chronic obstructive pulmonary disease (CAT) score of the observation group was lower than that of the control group, the difference was statistically significant (P＜0.05).After treatment, the arterial partial pressure of oxygen (PaO2) in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05).The arterial partial pressure of carbon dioxide (PaCO2) in observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).The asthma relief time, rale disappearance time and cough relief time in observation group were all shorter than those in the control group, with statistically significant differences (P＜0.05).Conclusion Nebulized inhalation of Budesonide has a good clinical effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease, which can effectively improve the treatment efficiency of patients, improve the pulmonary function indexes and arterial oxygen indexes of patients, and shorten the remission time of clinical symptoms, which has important clinical research value.