Abstract：Objective To explore the application effect of Tolvaptan in the treatment of heart failure in elderly patients.Methods From September 2017 to September 2020, 80 elderly patients with heart failure admitted to Hongshan District Hospital of Traditional Chinese Medicine in Wuhan City were selected as the research objects, and the patients were divided into the observation group (40 cases) and the control group (40 cases) by random number table method. Patients in the control group were given conventional anti-heart failure treatment, and the observation group was given Tolvaptan on the basis of the control group. The recovery of heart function, related laboratory indicators and 24-hour urine output between the two groups of patients before and after treatment were compared. Results After treatment, the left ventricular ejection fraction (LVEF) of the observation group was higher than that of the control group, while the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), and heart rate (HR) of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). After treatment, the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and serum galectin (Gal-3) of the observation group were lower than those of the control group, and the serum sodium ion (Na+) concentration, the 24-hour urine output of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no statistical difference in the serum potassium ion (K+) concentration between the two groups after treatment (P＞0.05). Conclusion Tolvaptan can significantly improve the heart function of patients with heart failure, promote the increase of urine output and blood sodium concentration in patients, and the effect is significant.
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