Abstract：Objective To investigate the application of Sevoflurane combined with Dexmedetomidine in pediatric cheilopalatognathus surgery.Methods A total of 50 children patients with cheilopalatognathus who received treatment between January 2018 and September 2019 in the Second Affiliated Hospital of Jinzhou Medical University were selected as the research objects.The selected children were divided into group C and group D according to random number table method, 25 cases in each group.Group C used Sevoflurane alone as inhalation anesthesia, and the group D used Sevoflurane combined with Dexmedetomidine.The heart rate (HR), mean arterial pressure (MAP) were compared between the two groups at the beginning of anesthesia (T0), at the beginning of operation (T1) and at the time of extubation (T2).The recovery time and the occurrence of adverse reactions were compared between the two groups.Results The HR and MAP at T1 and T2 in group D were lower than those in group C, the differences were statistically significant (P＜0.05).In group C, HR and MAP were higher at T1 and T2 than those at T0, the differences were statistically significant (P＜0.05).In group D, there were no significant differences in HR and MAP at T0, T1 and T2 (P＞0.05).There was no significant difference in the recovery time between the two groups (P＞0.05).The incidence of emergence agitation in group D was lower than that in group C, the difference was statistically significant (P ＜0.05).Conclusion Sevoflurane combined with Dexmedetomidine in pediatric cheilopalatognathus surgery achieves stable hemodynamics and low incidence of emergence agitation.
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