Effect of low dose Dexmedetomidine on postoperative stress response and delirium in patients undergoing laparoscopic radical resection of colon cancer
GUAN Xiao-juan1 LUO Hong2
1. Department of Anesthesiology, Xinfeng People′s Hospital
2. Department of Anesthesiology, the Second Affiliated Hospital of Gannan Medical University
Abstract：Objective To analyze the effect of low dose Dexmedetomidine on postoperative stress response and delirium in patients undergoing laparoscopic radical resection of colon cancer. Methods A total of 68 patients with colon cancer treated in Xinfeng People′s Hospital from February 2018 to March 2020 were selected as the research objects, and they were divided into two groups according to the principle of randomization, with 34 cases in each group. Both groups underwent laparoscopic radical resection of colon cancer under general intravenous anesthesia. Patients in the observation group received low-dose Dexmedetomidine during the induction period and continued to be pumped during the operation, and patients in the control group received 0.9% normal saline with equal volume. The stress response indexes and postoperative delirium (POD) were compared between the two groups. Results Plasma adrenocorticotropic hormone(ACTH), angiotensin-Ⅱ(Ang-Ⅱ) and cortisol (Cor) levels after induction of anesthesia, during extubation, and 1 hour after extubation in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). The incidence of POD in the observation group was 11.76%, which was lower than 32.35%in the control group, and the difference was statistically significant (P<0.05). The duration of POD in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Low dose Dexmedetomidine can reduce stress response and incidence of POD in patients undergoing laparoscopic radical resection of colon cancer.
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