Abstract：Objective To compare the effect of 4% Sodium Citrate and heparin sodium on the sealing of continuous renal replacement therapy (CRRT) hemodialysis catheters.Methods A total of 100 critically ill patients who were treated with bedside CRRT treatment in the Department of Intensive Care Unit (ICU) of Chen Xing-hai Hospital in Zhongshan City from March 2018 to May 2019 were selected as the subjects of the study.The patients were divided into observation group and control group by the random number table method,with 50 patients in each group.In the observation group,4% Sodium Citrate was used to seal the tube,while in the control group,100 U/ml Heparin Sodium saline was used to seal the tube.Catheter indwelling time and ICU stay time were compared between the two groups.The incidence rates of pipe blockage,blood volume>15 ml withdrawn 6 s before extubation,ionic calcium<1.0 mmol/L,catheteral-related infection,bleeding and hematomas around the puncture point were compared between the two groups.Results There was no significant difference in the time of catheter indwelling between the observation group and the control group(P>0.05).There was no significant difference in the time of ICU stay between the observation group and the control group (P>0.05).The incidence rate of pipe blockage in the observation group was lower than that in the control group,the difference was statistically significant (P<0.05),and the incidence rate of blood volume >15 ml withdrawn 6 s before extubation in the observation group was higher than that in the control group,the difference was statistically significant (P<0.05).There were no significant differences in the incidence rates of ionic calcium <1.0 mmol/L,catheteralrelated infection,bleeding and hematomas around the puncture point between the two groups (P>0.05).Conclusion The application of 4% Sodium Citrate sealing tube in the treatment of CRRT can effectively reduce the incidence of adverse events under the premise of ensuring the therapeutic effect,which is worth popularizing in clinical practice.
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