Abstract：Objective To investigate the influence of laparoscopic radical surgery on T lymphocytes and serum cortisol levels in elderly patientswith colorectal cancer.Methods A total of 90 elderly patientswith colorectal cancer who were admitted to our hospital from May 2017 to June 2019 were enrolled in the study.They were divided into the experimental group and the control group according to the random number table methods,45cases in each group.The experimental group underwent laparoscopic radical surgery,and the control group underwent open surgery.Perioperative indicators,serum cortisol levels,the level of T lymphocytes and the total incidence of complication were compared between the two groups.Results There was no significant difference in operation time between the two groups (P＞0.05).The blood loss in the experimental group was lower than that in the control group,the hospitalization time,feeding time and anus exhaust time in the experimental group were shorter than those in the control group,the differenceswere statistically significant(P＜0.05).The levels of cortisol,CD3+,CD4+,CD4+/CD8+in the experimental group were(11.43±3.09)μg/ml,(54.19±6.68)%,(34.21±4.88)%,1.13±0.25,whichinthecontrolgroupwere(15.28±2.76)μg/ml,(48.26±6.09)%,(29.15±5.04)%,0.97±0.27,the differenceswere statistically significant(P＜0.05).Therewas no significant difference in the level of postoperative CD8+between the two groups(P＞0.05).The total incidence of postoperative complications in the experimental group was 4.44%,which was lower than that in the control group(22.22%),the difference was statistically significant(P＜0.05).Conclusion Laparoscopic radical operation is safe for patientswith elderly colorectal cancer,which can effectively reduce intraoperative blood loss,relieve stress response,regulate immune function and shorten postoperative recovery time.
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