Abstract：At present, cervical cancer is still the most common reproductive system malignant tumor in women worldwide, and 90% of patients with cervical cancer are infected with Human papillomavirus (HPV), among which high-risk HPV types 16 and 18 are the main types. High-risk HPV E6/E7 gene is the main cause of cell immortalization and tumor progression. The integration of the viral genome into the host genome is a key step for oncogenes E6 and E7. A large number of studies have confirmed that E6 and E7 genes can lead to the inactivation of two important tumor suppressor genes, like p53 and pRb, the latest researches have shown these two genes can act on more cytokines, such as cell methylation status, PI3K AKT pathway, matrix metalloproteinases (MMPs), and interleukin-18 (IL-18), and different effect on these factors ultimately lead to the occurrence, metastasis and immune escape of cancer.
李明秀； 刘志强； 许振； 杨世慧. 人乳头瘤病毒E6/E7基因在宫颈癌发展过程中作用机制的研究[J]. 中国当代医药, 2020, 27(16): 23-26转30.
LI Ming-xiu； LIU Zhi-qiang； XU Zhen； YANG Shi-hui. Study on the mechanism of Human papillomavirus E6/E7 gene in the development of cervical cancer. 中国当代医药, 2020, 27(16): 23-26转30.
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