Abstract：Objective To investigate the clinical value of prenatal ultrasound screening for fetal severe cardiac malformations at 11-13+6 weeks of gestation.Methods From January 2016 to December 2018,5128 pregnant women in the prenatal diagnosis center of our hospital were selected as the study subjects.The pregnant women were screened by NT ultrasound standardized structure at 11-13+6 weeks of gestation.All patients were screened for fetal heart with fourchamber(4CV)and three-vessel tracheotomy(3VVT).The results of severe cardiac malformations detected by the two methods alone and in combination were analyzed retrospectively.Results Among the 5128 pregnant women who underwent NT examination in our hospital since 11-13+6 weeks of gestation,the rates of obtaining 4CV,3VVT,4CV+3VVT by three methods were 91.56%,78.91%and 95.82%,respectively.A total of 26 cases of severe fetal heart malformations were examined,with the incidence of 0.5‰.Among them,14,7 and 22 cases of abnormal cardiac structure were detected by 4CV,3VVT and 4CV+3VVT respectively.The specificity of the three methods in the diagnosis of severe fetal heart malformation was similar,and there was no statistical difference (P＞0.05).The sensitivity of 4CV+3VVT in the diagnosis of severe fetal heart malformation was higher than that of the other two methods,but the rate of missed diagnosis was lower than that of the other two methods(P<0 05).Conclusion Prenatal ultrasound examination in pregnant women at 11 to 13+6 weeks of gestation is of great clinical value in screening for severe fetal heart deformities,especially,the combined screening of 4CV and 3VVT can effectively improve the diagnosis rate of severe cardiac malformations of fetus during the first trimester of pregnancy.
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