地衣芽孢杆菌佐治儿童幽门螺杆菌感染的疗效观察

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摘要目的探讨地衣芽孢杆菌佐治儿童幽门螺杆菌（Hp）感染的效果。方法选取2014年3月～2016年3月我院收治的168例符合Hp感染诊断标准患儿作为研究对象，采用随机序列法将其分为实验A组、实验B组和对照组，每组各56例。所有患儿均给予四联疗法常规治疗2周：阿莫西林克拉维酸钾50 mg/（kg·d），分2次服用，克拉霉素 20 mg/（kg·d），分 2 次服用，奥美拉唑 0.8 mg/（kg·d），晨起服用，胶体次枸橼酸铋剂，8 mg/（kg·d），分 3次饭前服用。实验A组患者在常规治疗基础上给予地衣芽孢杆菌活菌治疗，3次/d，0.5 g/次，饭后口服。实验B组在常规治疗基础上给予胃苏颗粒治疗，3次/d，0.5 g/次。比较三组患儿治疗2周的治疗效果、治疗2周和4周后的Hpδ值变化以及复发率。结果治疗2周后，三组患儿的症状均好转，实验A、B组患儿的治疗总有效率均明显高于对照组，差异有统计学意义（P＜0.05）。实验A组患儿的治愈率明显高于对照组和实验B组，差异有统计学意义（P＜0.05），而实验B组和对照组患儿的治愈率比较，差异无统计学意义（P＞0.05）。治疗2周后和4周后，实验A组患儿的Hpδ值均低于对照组和实验B组，差异有统计学意义（P＜0.05），实验B组患儿的Hpδ值与对照组比较，差异均无统计学意义（P＞0.05）。实验A组患儿的复发率明显低于对照组及实验B组，差异均有统计学意义（P＜0.05），实验B组患儿的复发率与对照组比较，差异无统计学意义（P＞0.05）。结论地衣芽孢杆菌辅助治疗儿童Hp感染，效果显著，可提高根除率，降低复发率，值得应用推广。

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关键词 ：地衣芽孢杆菌, 儿童, 幽门螺杆菌

Abstract：ObjectiveTo observe the efficacy of Bacillus licheniformis in the assistant treatment of Helicobacter pylori(Hp)infection in children.MethodsFrom March 2014 to March 2016,168 children meeting the diagnostic criteria of Hp infection treated in our hospital were selected as subjects.By random sequence method,they were evenly divided into experimental group A and experimental group B and control group,56 cases in each group.All patients were provided with conventional quadruple therapy for 2 weeks:50 mg/(kg·d)Amoxicillin and Clavulanate Potassium(divide the drug into two times),20 mg/(kg·d)Clarithromycin (divide the drug into two times),0.8 mg/(kg·d)Omeprazole (take in the morning),and 8 mg/(kg·d)Colloidal Bismuth Subsitrate(divided into 3 times,before meals).In the experimental group A,live Bacillus licheniformis was used besides the conventional treatment,0.5 g each time,thrice a day,oral administration after meals.In the experimental group B,on the basis of the conventional treatment,Weisu Granule was added with 5 g each time,3 times per day.The treatment effect of 2 weeks after treatment was compared with that of the three groups,and the change of Hpδ value and the recurrence rate of 2 weeks and 4 weeks after treatment were compared.ResultsAfter 2 weeks of treatment,the symptoms of the three groups were all improved,and the total effective rate of treatment for children in group A and group B was significantly higher than that in the control group,and the differences were statistically significant(P＜0.05).The cure rate of the experimental group A was significantly higher than that of control group and experimental group B,the differences were statistically significant(P＜0.05),while the cure rate of experimental group B was compared with the control group B,the difference was not statistically significant(P＞0.05).After 2 weeks and 4 weeks after treatment,the experimental group A with Hpδ value was lower than the control group and experimental group B,the differences were statistically significant(P＜0.05),the experimental group B with Hpδ value was compared with control group,the difference was not statistically significant(P＞0.05).The recurrence rates of experimental group A was significantly lower than that of the control group and experimental group B,the differences were statistically significant(P＜0.05),the recurrence rate of experimental group B was compared with control group,the difference was not statistically significant(P＞0.05).ConclusionBacillus licheniformis assisted treatment of Hp infection in children obtains a remarkable effect,which can increase the eradication rate and reduce the recurrence rate.It is worthy of application and promotion.

Key words： Bacillus licheniformis Children Helicobacter pylori

基金资助:山东省潍坊市卫生计生委科研项目（2016wsjs 066）

通讯作者: 李臣芳(1979-)，女，山东诸城人，本科，主治医师，主要从事小儿内科工作

作者简介: 李化兵(1979-)，女，山东德州人，硕士，主治医师，主要从事小儿内科工作

引用本文:

李化兵 ;岳军 ;李臣芳. 地衣芽孢杆菌佐治儿童幽门螺杆菌感染的疗效观察[J]. 中国当代医药, 2018, 25(4): 106-108.
LI Hua-bing; YUE Jun; LI Chen-fang. Efficacy observation of Bacillus licheniformis in the assistant treatment of Helicobacter pylori infection in children. 中国当代医药, 2018, 25(4): 106-108.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2018/V25/I4/106

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