Abstract：Objective To compare and study the clinical efficacy of low-dose Misoprostol and Oxytocin for the induced labor due to premature rupture of membranes in full-term infants.Methods A total of 220 pregnant women with fullterm premature rupture of membranes who met the inclusion criteria treated in our hospital from March 2015 to October 2017 were selected as objects.They were divided into the observation group and the control group according to the induction method,with 110 cases in each group.Patients in the observation group were given a small dose of Misoprostol(25 μg)for treatment,and the Oxytocin was administered to the patients in the control group.The success rate of induction of labor,time from drug use to labor,time from drug use to delivery,total labor,postpartum hemorrhage and the incidence of amniotic fluid contamination and fetal distress of patients in two groups were compared.Results The success rate of induced labor in the observation group and the control group was 88.18%and 76.36%respectively,the success rate of induced labor in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The time from drug use to labour of the observation group was(6.7±1.4)h,the time from drug use to delivery was(11.3±1.6)h and the total labor duration was(6.0±1.3)h;the time from drug use to delivery of the control group was(8.9±1.1)h,the time from drug use to delivery was(17.1±1.2)h and the total labor duration was(8.3±1.4)h.The observation group was significantly shorter than the control group and the differences were statistically significant(P＜0.05).The amniotic fluid contamination rate(7.27%)and the fetal distress rate(8.18%)in the observation group were significantly lower than those in the control group(26.35%,19.10%),the differences were statistically significant(P＜0.05).The amount of postpartum hemorrhage of the observation group ([125.3±74.2]ml)was significantly lower than that of the control group([159.2±52.1]ml),the difference was statistically significant(P＜0.05).Conclusion The application of low-dose Misoprostol for the pregnant women with premature rupture of membranes in full-term infants can achieve a more significant effect than that of Mxytocin,resulting in a higher successful rate of induced labor,which can significantly shorten the stage of labor,reduce fetal distress and amniotic fluid contamination rate,and has a significant clinical and application value.
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YAO Xuan. Comparison of the curative effect of low-dose Misoprostol and Oxytocin for the induced labor due to premature rupture of membranes in fullterm infants. 中国当代医药, 2018, 25(21): 105-107.
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