Abstract:Primary aldosteronism refers to a syndrome that the adrenocortical lesions lead to increased aldosterone auto-secretion and renin-angiotensin system inhibition,together with hypertension with or without hypokalemia mainly characterized by plasma high aldosterone levels and low renin levels.It is a leading cause for secondary hypertension.The syndrome can be screened by using plasma aldosterone/renin ratio(ARR),adrenal ultrasound,adrenal computed tomography(CT)and enhanced,adrenal magnetic resonance imaging(MRI).The key treatment is actively control of blood pressure and actively potassium supplementation to correct electrolyte imbalances.For aldosteronoma patients,the preferred therapy is total unilateral adrenalectomy or tumor resection under laparoscope.This paper analyzed and summarized the diagnosis and treatment of three patients with hypertensive cerebral hemorrhage caused by primary aldosteronism in order to intensify awareness of the disease,enhance the clinical experience,and guide the clinical diagnosis and treatment.
戴培;宋桂芹. 原发性醛固酮增多症致高血压脑出血3例诊治分析[J]. 中国当代医药, 2018, 25(18): 153-157.
DAI Pei;SONG Gui-qin. Analysis of diagnosis and treatment of hypertensive cerebral hemorrhage caused by primary aldosteronism in three cases. 中国当代医药, 2018, 25(18): 153-157.
Young WF Jr.Minireview:primary aldosteronism-changing concepts in diagnosis and treatment[J].Endocrinology,2003,144(6):2208-2213.
[5]
Calhoun DA,Nishiaka MK,Zaman MA,et al.Hyperaldosteronism among black and white subjects with resistant hypertension[J].Hypertension,2002,40(6): 892-896.
[6]
Galati SJ.Primary aldosteronism:challenges in diagnosis and management[J].EndocrinolMetabClinNorthAm,2015,44(2):355-369.
Zhang X,Zhu Z,Xu T,et al.Factors affecting complete hypertension cure after adrenalectomy for aldosterone-producing adenoma:outcomes in a large series[J].Urol Int,2013,90(4):430-434.
[16]
Rossi GP,Bernini G,Caliumi C,et al.PAPY Study Investigators.A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients[J].Am Coll Cardiol,2006,48(11):2293-2300.
[17]
Mulatero P,Stowasser M,Loh KC,et al.Increased diagnosis of primary aldosteronism,including surgically correctable forms,in centers from five continents[J].Clin Endocrinol Metab,2004,89(3):1045-1050.
[18]
Rossi GP,Bernini G,Caliumi C,et al.A prospective study of the prevalence of primary aldosteronism in 1 125 hypertensive patients[J].J Am Coll Cardiol,2006,48(11):2293-2300.