Abstract：Objective To investigate the effect of Spironolactone combined with Amlodipine Mesylate Tablets in the treatment of elderly hypertensive heart disease.Methods A total of 148 elderly patients with hypertensive heart disease treated in our hospital from January 2014 to January 2017 were selected and they were divided into the control group(n=74)and the observation group (n=74)according to the random digital table method.The control group was treated with routine treatment and nursing,and the observation group was treated with Spironolactone and Amlodipine Mesylate Tablets on the basis of the control group.The blood pressure (SBP,DBP),curative effect and LVEDVI,LVESVI,LVEDD,IVST,LVPWT indicators,VE/VA,LVEF,Tei index and other indicators before and after treatment of patients in the two groups were statistically analyzed.Results Before treatment,there is no significant difference in blood pressure between the two groups(P＞0.05).After treatment,the improvement of SBP and DBP level of the observation group is significantly higher than that in the control group (P＜0.05).The total effective rate of the observation group is 86.49%,which was obviously higher than that of the control group (59.46%)(P＜0.05).Before treatment,there are no significant differences in LVEDVI,LVESVI,LVEDD,IVST and VE/VA,LVEF,LVPWT index and Tei index(P＞0.05),after treatment,all parameters in the observation group were significantly improved (P＜0.05),only LVEDVI,LVESVI and LVEF index in the control group were improved significantly (P＜0.05),the degree of improvement in the observation group was higher than that of the control group (P＜0.05).Conclusion Spironolactone combined with Amlodipine Mesylate Tablets can effectively improve left ventricular hypertrophy and remodeling in hypertensive patients,is beneficial for relieving diastolic dysfunction,reduce blood pressure,and ensure the treatment effect of patients.
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