Abstract：ObjectiveTo investigate the effect of different doses of Atorvastatin Calcium in the treatment of acute cerebral infarction(ACI).MethodsFrom June 2014 to July 2016,150 ACI patients admitted to our hospital were selected as research subjects.According to different dosage of atorvastatin calcium,they were evenly divided into three groups(10 mg,20 mg,and 40 mg)50 cases in each group.The medication was continued for 90 days.The indicators of low density lipoprotein cholesterol(LDL),total cholesterol(TC),triglyceride(TG),high sensitivity C-reactive protein(hs-CRP),intima-medial thickness(IMT),high density lipoprotein cholesterol(HDL),stroke scale(NIHSS),creatinine(Cr),uric acid(UA),blood urea nitrogen (BUN),and white blood cell(WBC)were compared before treatment,30 day,and 90 day after treatment.ResultsThe 30 day and 90 day treatments was compared with prior treatment,the levels of LDL,TC,and TG in three groups were all decreased significantly(P<0.05).However,after the treatment of 90 days,the LDL and TC levels in the 20 mg and 40 mg groups were significantly different than those in the 10 mg group(P<0.05).There was great difference in HDL level among three groups(P<0.05),while for TG level,it was not significant(P>0.05).After treatment for 30 and 90 days,the NIHSS scores were displayed statistical differences in comparison with that prior treatment among three groups(P<0.05).The score in 20mg and 40 mg groups was greatly different from that in 10mg group after 90 day treatment,but for the comparison of 20 mg and 40 mg groups,they were not obvious(P>0.05).After 30 day therapy,thehs-CRP level in 20 mg and 40 mg groups was displayed a statistical difference compared with that in 10mg group(P<0.05),but no statistical significance between 20 mg group and 40 mg group(P>0.05).On day 90,there was no significant difference in hs-CRP level among three groups (P>0.05).No significant change was detected in IMT,Cr,UA,BUN,or WBC before and after treatment among three groups(P>0.05).ConclusionAtorvastatin calcium in 20 mg can treat ACI in safe and effective,also reduces the hs-CRP level.
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