Application effect observation of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients
ZHOU Ke-ting GUO Neng-qi ZHU Xiao-bing LIU Jian XIAO Zhi-heng
Department of Anesthesiology,Hospital of Traditional Chinese Medicine of Zhongshan City in Guangdong Province, Zhongshan 528400,China
Abstract：ObjectiveTo explore the clinical effect of Sufentanil combined with Flurbiprofen Axetil in postoperative controlled intravenous analgesia in hypertensive patients.Methods60 patients with hypertension underwent abdominal surgery(ASAⅠ-Ⅱ)under general anesthesia from April 2013 to April 2016 in our hospital were selected and randomly divided into group A and group B,30 cases in each group.Group A was given Sufentanil+Tropisetron+Normal Saline, group B was given Sufentanil+Flurbiprofen+Tropisetron+Normal Saline.The VAS score,sedation rating and nausea and vomiting rating at different time of 4,8,24,48 hours after operation in the two groups were compared,and the ratio of PCA effective/actual compression times,the arterial systolic blood pressure,heart rate and consumption of analgesics were recorded at each time point.ResultsThe VAS score,the ratio of PCA effective/actual compression times and the arterial systolic blood pressure at different time of 8,24,48 hours after operation in group B was lower than that in group A,with significant difference(P＜0.05).The proportion of patients who reached 2 or above sedation level at different time of 4,8,24,48 hours after operation in group A was higher than that in group B,with significant difference(P＜0.05).ConclusionIn hypertensive patients,postoperative use of Sufentanil combined with Flurbiprofen Axetil to analgesia can significantly reduce the dose of Sufentanil and adverse reaction,reduce the incidence of hypertension in perioperative period.
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