Abstract：ObjectiveTo investigate the efficacy and safety of Clopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke.Methods96 patients with progressive ischemic stroke who were treated in our hospital from March 2014 to December 2016 were selected and randomly divided into the observation group and the control group,each group had 48 cases.The control group was treated with Low Molecular Heparin Calcium,while the observation group was treated with Clopidogrel on the basis of the control group.And the curative effects,neurological deficit score(NIHSS)and the changes of plasma viscosity,fibrinogen,platelet aggregation rate and other hemodynamic parameters before and after treatment of the two groups were compared.Then the adverse reactions of the two groups were observed.ResultsThe total effective rate of the observation group was 93.75%,and it was significantly higher than that of the control group(79.17%),and the difference was statistically significant(P<0.05).NIHSS of the observation group was significantly lower than that of the control group after the treatment,and the difference was statistically significant(P<0.05).In terms of hemodynamics,the plasma viscosity,fibrinogen and platelet aggregation rate in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).there was no significant difference in the total incidence rate of adverse reactions between the two groups after treatment(P>0.05).ConclusionClopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke is effective and safe,and it has a higher application value in clinic.
方明. 氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中的有效性及安全性[J]. 中国当代医药, 2017, 24(11): 134-136.
FANG Ming. The efficacy and safety of Clopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke. 中国当代医药, 2017, 24(11): 134-136.
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