Objective To explore efficiency of ulinastatin combined high-dose ambroxol on patients with severe pneumonia.Methods Clinical datas of patients in our hospital diagnosed with severe pneumonia from 2013-2016 were selected, from which a random sample of 80 cases were selected and divided into the control group and the observation group according to the intervention methods,with 40 cases in each group.Patients in the control group were received：the general treatment for severe pneumonia,while patients in the observation group were received ulinastatin combined high-dose ambroxol on the basis of the control group.The chilical effect,the level of blood gas index and the walking distance of patients between two groups were compared.Results The effective rate of patients in the observation group(95.0%)was higher than that in the control group(82.5%).After treatment,the levels of blood oxygen pressure and oxygenation index of patients in the observation group[(61.2±10.3),(296.3±23.1)mmHg]were higher than those in the control group[(56.2±10.3), (159.1±25.7)mmHg];6 minutes walking distance in of patients in the observation group[(2.89.1±20.21)m]were longer than that in the control group[(256.9±19.8)m].All the differences were statistically significant(P＜0.05).Conclusion The prognosis of severe pneumonia patients with severe pneumonia poor quality,intervention plans for such patients in addition to consider to improve the condition,also should be to focus on the indicators and the quality of rehabilitation,ulinastatin combined high-dose ammonia bromine,the disease can not only control the condition and blood gas index and 6 minutes walking distance is relatively more obvious increase,also has comprehensive advantages,is worth promoting.