Abstract：Objective To observe clinical effect compound Bismuth Magnesium Granules combined with Esomeprazole, Amoxicillin and Clarithromycin in the treatment of Hp-related peptic ulcer.Methods 172 patients with Hp infectionpositive peptic ulcer disease in People′s Hospital of Baise City from June 2014 to May 2016 were randomly divided into 3 groups,60 cases in standard triple therapy group,56 cases in compound Bismuth Magnesium quadruple therapy group,56 cases in colloidal bismuth pectin quadruple therapy group.Patients in the standard triple therapy group were given Esomeprazole,Clarithromycin,Amoxicillin for 10 days,and then with oral Esomeprazole for another 28 days.The other two groups was added compound Bismuth Magnesium Granules and colloidal bismuth pectin for 10 days on the basis of the standard triple therapy treatment respectively.The remission of pain symptoms,ulcer healing,Hp eradication rates,ADR of three groups were observed.Results Hp eradication rate(94.6%,53/56),remission rate of pain symptoms (85.7%,48/56),ulcer healing rate(89.3%,50/56)of compound Bismuth Magnesium quadruple therapy group was significantly better than that of standard triple therapy group(68.3%,41/60;43.3%,26/60;70.0%42/60),ADR rate(14.3,8/56) was significantly lower than(31.7%,19/60)of standard triple therapy group(the former two items were P＜0.05,the latter two items were P＜0.01).There was no statistical significance between four items results of colloidal bismuth pectin quadruple therapy group(83.9%,47/56;58.9%,33/56;83.9%,47/56;19.6%,11/56)and standard triple therapy group(P＞0.05),while remission rate of pain symptoms had statistical significance between compound Bismuth Magnesium quadruple therapy group and colloidal bismuth pectin quadruple therapy group(P＜0.01).Conclusion Compound Bismuth Magnesium quadruple therapy in the treatment of Hp-related peptic ulcer has better effect in remission of pain symptoms, and significant effects on ulcer healing and Hp eradication.What′s more,it does not add ADR.So it has a certain advantage and a better safety in the treatment of peptic ulcer.
Qian Li，Nina Wang，Fulian Hu，et al.Study of compound bismuth and magnesium granules on clearance of helicobacter pylori infection in KM mice[J].Int J Clin Exp Med，2016，9（7）：12888-12895.
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