Effect of epidem iology and CD4+CD25+T cells on the pathogenesis of atopic dermatitis in Pingxiang area
WU Hai-hong1 LIN Jia-kun1 LIYun-hua2 LIJie-mo2 XU Yan-ping1
1.Hospital of Traditional Chinese Medicine of Pingxiang City in Jiangxi Province,Pingxiang 337000,China;
2.Health School of Pingxiang City in Jiangxi Province,Pingxiang 337000,China
Abstract：Objective To understand the incidence of atopic dermatitis in children aged 6-13 years in Pingxiang area; on the basis of the expression level of CD4＋CD25＋T cell transcription factor Foxp3 in peripheral blood of patientswith AD,the role of this cell in the pathogenesis of AD was analyzed.M ethods AD prevalence rate questionnaire was set, from November to December in 2014 1600 pupils of 6-13 years old in Pingxiang area were chosen and investigated by stratified random samplingmethod,healthy children with age and sexmatched,and children with AD were selected and detected by flow cytometry,50 children in each group,the expression level of CD4＋CD25＋T transcription factor Foxp3 membranemolecule was calculated.Results Prevalence rate of 6-13 years old children with AD in Pingxiang area was 14.5％,higher than 10.2％of national average level;prevalence rate children in Pingxiang area was higher than that of rural children(χ2=4.63,P=0.042),there was no gender difference.Prevalence rate of＞10-13 years old children was lower than that of 6-10 years old children(χ2=5.36,P=0.039).The percentage of Treg(CD4＋CD25＋)cells of AD patientswas significantly lower than that of healthy children[(0.60＋0.18)％vs(5.95＋1.05)％],and the difference was statistically significant(t=2.306,P=0.028).Conclusion ADmay be related to environment,food sources,immunity,improving the environment and strengthening foodmanagement and so on can reduce prevalence rate of AD.
Verhagen J，Akdis M，Traidl-Hoffmann C，et al.Absence of T-regulatory cell expression and function in atopic dermatitis skin[J].JAllergy Clin Immunol，2006，117（1）：176-183.
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