Abstract：Objective To estimate the clinical value of serum cystatin C（Cys C）detection level in early diagnosis of diabetic nephropathy for type 2 diabetes mellitus and to provide clinical diagnosis basis for early diagnosis of diabetic nephropathy for type 2 diabetes mellitus. Methods 162 patients with type 2 diabetes mellitus from October 2014 to June 2015 received by our hospital were selected and they were divided into 3 groups according to urinary microalbumin（mAlb）,namely normal albuminuria group（mAlb＜30 mg/24 h,n＝68）,microalbuminuria group（mAlb 30～300 mg/24 h,n＝52）and clinical proteinuria group（mAlb＞300 mg/24 h,n＝42）.And healthy control 80 cases（normal control group）were selected randomly in healthy check-up center.The level of serum Cys C of all examinees was determined,and the level of blood urea nitrogen（BUN）,serum creatinine（SCr）and urinary microalbumin（mAlb）was determined respectively and simultaneously.The test results were counted and analyzed. Results The level of Cys C and mAlb were the lowest in normal control group and clinical proteinuria group was the highest in all examinees.There was a statistical difference of level of serum Cys C and urinary mAlb between the other 3 groups and normal control group（P＜0.05）.In addition to normal control group,there was a statistical difference of the level of Cys C and urinary mAlb among the other three groups（P＜0.05）. There was a significant positive correlation between the level of Cys C and urinary mAlb level in microalbuminuria group and clinical proteinuria group of（r＝0.107,0.152,P＜0.05）. Conclusion The level of Cys C is closely related to the degree of early renal damage in patients with type 2 diabetes mellitus,and it has clinical value in early diagnosis of diabetic nephropathy.
吴丹;关硕;李论. 血清胱抑素C检测在2型糖尿病肾病早期诊断中的临床价值[J]. 中国当代医药, 2016, 23(2): 39-41转46.
WU Dan;GUAN Shuo;LI Lun. Clinical value of detection and evaluation of serum cystatin C in early diagnosis of diabetic nephropathy for type 2 diabetes mellitus. 中国当代医药, 2016, 23(2): 39-41转46.
Zhang PP，Zhang JF，Xie HL，et al.Evaluation of glomerular filtration rate using cystatin C in diabetic pat ients analysed by multiple factors including tubular function[J].J Int Med Res，2010，38（2）：473-483.
Fried LF，Duckworth W，Zhang JH，et al.Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy（VA NEPHRON-D）[J].Clin J Am Soc Nephrol，2009，4（2）：361-368.
京公网安备 11010502046607号