新发2型糖尿病患者血清C肽与动脉粥样硬化的相关性研究

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摘要目的探讨新发2型糖尿病患者动脉粥样硬化的危险因素，分析血清C肽与动脉粥样硬化的相关性及其意义。方法收集2013年11月～2014年11月来我院就诊的新发2型糖尿病患者73例，根据是否合并动脉粥样硬化分为合并动脉粥样硬化组31例和单纯2型糖尿病组42例，另选取30例健康体检者作为健康对照组，检测3组患者的血清C肽水平以及分析其与动脉粥样硬化之间的相关性。结果单纯2型糖尿病组患者的血清C肽水平显著高于健康对照组、合并动脉粥样硬化组，差异有统计学意义（P＜0.05）；合并动脉粥样硬化组与健康对照组的血清C肽水平差异无统计学意义（P＞0.05）。血清C肽水平与患者动脉粥样硬化程度呈负相关（r＝-0.328，P＜0.05）。血清C肽水平下降是新发2型糖尿病患者并发动脉粥样硬化的独立危险因素（P＜0.05）。结论新发2型糖尿病患者血清C肽水平与动脉粥样硬化并发症的发生密切相关，血清C肽水平下降可能造成2型糖尿病患者易发动脉粥样硬化等血管并发症。

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	王荔

关键词 ：新发2型糖尿病, 血清C肽, 动脉粥样硬化, 相关性研究

Abstract：Objective To explore the risk factor of atherosclerosis in patients with new-onset type 2 diabetes mellitus, and analyze the correlation and significance between serum C-peptide and atherosclerosis. Methods From November 2013 to November 2014,73 patients with new-onset type 2 diabetes mellitus visited our hospital for treatment were selected.According to whether there was atherosclerosis or not,they were divided into combination of atherosclerosis group （n＝31）and simple type 2 diabetes mellitus group（n＝42）.30 healthy people after physical examination were selected into healthy control group.The level of serum C-peptide in three groups were tested and the correlation between serum C-peptide and atherosclerosis was analyzed. Results The serum C-peptide level in simple type 2 diabetes mellitus group was obviously higher than that of healthy control group and combination of atherosclerosis group,and there was a statistical difference（P＜0.05）.There was a statistical difference of serum C-peptide level between combination of atherosclerosis group and healthy control group（P＞0.05）.There was a negative correlation between serum C-peptide level and degree of atherosclerosis（r＝-0.328,P＜0.05）.Decrease of serum C-peptide level was an independent risk factor in patients with new-onset type 2 diabetes mellitus complicated with atherosclerosis（P＜0.05）. Conclusion The level of serum C -peptide in patients with new -onset type 2 diabetes mellitus is closely related with complications of atherosclerosis,and decrease of serum C-peptide level may cause easily complication such as atherosclerosis and other vascular complication in patients with type 2 diabetes.

Key words： New-onset type 2 diabetes mellitus Serum C-peptide Atherosclerosis Correlation research

引用本文:

王荔. 新发2型糖尿病患者血清C肽与动脉粥样硬化的相关性研究[J]. 中国当代医药, 2016, 23(2): 36-38.
WANG Li. Correlation research on serum C-peptide and atherosclerosis in patients with new-onset type 2 diabetes mellitus. 中国当代医药, 2016, 23(2): 36-38.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2016/V23/I2/36

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