Abstract:Objective To compare the different dose of Rosuvastatin in the treatment of coronary atherosclerosis and its effect on the disease. Methods 100 cases with coronary atherosclerosis treated by our hospital from March 2014 to November 2015 were treated,according to the different dosage they were divided into study group(n=50)and the control group(n=50).All patientswere given Rosuvastatin treatment,and study group was treated with high dose of rosuvastatin,but control group was treated with low dose.Carotid plaque area and carotid intima thickness before and after treatment in patients of two groupswas recorded.Blood lipid(LDL,HDL,TC and TG)level before and after treatment in patients of two groups was observed.The total effective rate of treatment in patients of two groups was analyzed.Results Carotid plaque area and carotid intima thickness in study group was significantly lower than that of control group,and there was a statistical difference(P<0.05).TC,LDL and TG value in study group was significantly lower than that of control group,but HDL valuewas significantly higher than that of control group,and there was a statistical difference(P<0.05).The total effective rate of study group (98.00%)was significantly higher than that of control group (74.00%),and therewas a statistical difference (χ2=11.9601,P<0.05).Conclusion The clinical effect of high-dose Rosuvastatin treating coronary atherosclerosis is better than that of low dose treatment,it can significantly improve blood lipid level in patients and improve the total effective rate of treatment.
张榕华. 不同剂量瑞舒伐他汀治疗冠状动脉粥样硬化效果对比及对病症的影响[J]. 中国当代医药, 2016, 23(29): 45-47.
ZHANG Rong-hua. Curative effect com paration of different dose of Rosuvastatin in the treatment of coronary atherosclerosis and its effect on the disease. 中国当代医药, 2016, 23(29): 45-47.