Abstract：Objective To explore the clinical effect of argatroban combined with clopidogrel in the treatment of large artery atherosclerotic cerebral infarction.Methods 60 cases of large artery atherosclerotic cerebral infarction in our hospital from January 2015 to March 2016 were selected and randomly divided into the observation group and the control group，30 cases in each group.The observation group was treated with combination of argatroban and clopidogrel，the control group was treated with clopidogrel.The total effective rate and the score of NIHSS before and after treatment in the two groups was compared.Results The score of NIHSS after treatment for 1 and 2 weeks in the observation group was lower than that before treatment，with significant difference（P＜0.05）.The score of NIHSS after treatment for 1 and 2 weeks in the observation group was lower than that in the control group，with significant difference（P＜0.05）.The total effective rate of the observation group was 87.50%，which was higher than 70.00%of the control group，with significant difference（P＜0.05）.There was no significant difference in the incidence rate of adverse reaction between the two groups （P＞0.05）.Conclusion Combination of argatroban and clopidogrel in the treatment of large artery atherosclerotic cerebral infarction can achieve perfect clinical effect，which is worthy of popularization and application.
孙贵祥;孙培丽;张爱萍. 阿加曲班联合氯吡格雷治疗大动脉粥样硬化性脑梗死的临床研究[J]. 中国当代医药, 2016, 23(19): 72-74.
SUN Gui-xiang;SUN Pei-li;ZHANG Ai-ping. Clinical study on argatroban combined with clopidogrel in the treatment of large artery atherosclerotic cerebral infarction. 中国当代医药, 2016, 23(19): 72-74.
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